KEGG   PATHWAY: pcoq05022
Entry
pcoq05022                   Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Propithecus coquereli (Coquerel's sifaka)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
pcoq05022  Pathways of neurodegeneration - multiple diseases
pcoq05022

Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105804919  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
105804942  BCL2L1; bcl-2-like protein 1 [KO:K04570]
105804954  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
105804976  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
105805081  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105805182  DNAL4; dynein light chain 4, axonemal [KO:K10412]
105805232  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105805267  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105805276  [KO:K08960] [EC:2.7.11.1]
105805290  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105805355  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
105805391  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105805497  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
105805667  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
105805895  CALM2; calmodulin [KO:K02183]
105805900  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105805979  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105806035  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
105806040  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
105806139  RAB1A; ras-related protein Rab-1A [KO:K07874]
105806167  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105806182  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105806197  PRNP; major prion protein [KO:K05634]
105806237  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105806239  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
105806291  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
105806400  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
105806404  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
105806434  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105806450  TOMM40L; mitochondrial import receptor subunit TOM40B [KO:K11518]
105806582  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
105806589  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
105806701  [KO:K02271]
105806913  APP; amyloid beta A4 protein isoform X1 [KO:K04520]
105806914  ATP5J; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
105807023  [KO:K02266]
105807057  STX1A; syntaxin-1A [KO:K04560]
105807087  [KO:K04559]
105807089  FZD9; frizzled-9 [KO:K02842]
105807119  CALM1; calmodulin [KO:K02183]
105807267  [KO:K02264]
105807308  [KO:K02136]
105807364  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
105807375  [KO:K08738]
105807458  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
105807521  DNAH12; LOW QUALITY PROTEIN: dynein heavy chain 12, axonemal [KO:K10408]
105807545  KRAS; GTPase KRas [KO:K07827]
105807577  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
105807599  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105807933  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
105807952  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105808078  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
105808138  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
105808139  WNT3A; protein Wnt-3a [KO:K00312]
105808189  PSMA8; proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
105808219  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
105808222  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
105808252  FZD4; frizzled-4 [KO:K02354]
105808354  [KO:K02265]
105808355  ACTR1B; beta-centractin [KO:K16575]
105808432  [KO:K21421] [EC:1.-.-.-]
105808520  ATP5C1; ATP synthase subunit gamma, mitochondrial [KO:K02136]
105808623  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
105808667  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105808762  WNT10A; protein Wnt-10a [KO:K01357]
105808766  WNT6; protein Wnt-6 [KO:K00445]
105808789  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
105808883  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105808886  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
105808941  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
105808983  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105809316  BAX; apoptosis regulator BAX [KO:K02159]
105809322  [KO:K02267]
105809381  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105809459  ATXN1; ataxin-1 [KO:K23616]
105809466  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105809556  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105809569  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105809719  [KO:K03946]
105809747  [KO:K02268]
105809796  FZD6; frizzled-6 isoform X1 [KO:K02376]
105809797  [KO:K00417]
105809975  [KO:K04553] [EC:2.3.2.23]
105810108  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105810111  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105810116  DNAH14; LOW QUALITY PROTEIN: dynein heavy chain 14, axonemal [KO:K10408]
105810132  CSNK1A1L; casein kinase I isoform alpha-like [KO:K08957] [EC:2.7.11.1]
105810138  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
105810175  NEFH; LOW QUALITY PROTEIN: neurofilament heavy polypeptide [KO:K04574]
105810190  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
105810198  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105810204  [KO:K00419]
105810258  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
105810299  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105810348  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
105810391  [KO:K10435]
105810413  PSEN2; presenilin-2 [KO:K04522] [EC:3.4.23.-]
105810548  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
105810555  [KO:K08738]
105810591  NRAS; GTPase NRas [KO:K07828]
105810592  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105810742  [KO:K02272]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105810895  [KO:K00415]
105810898  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
105810924  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105810930  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
105810946  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105811066  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
105811072  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105811079  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
105811088  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
105811110  [KO:K02270]
105811149  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
105811230  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
105811286  [KO:K00420]
105811289  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
105811299  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
105811413  WNT11; protein Wnt-11 [KO:K01384]
105811699  IFT57; LOW QUALITY PROTEIN: intraflagellar transport protein 57 homolog [KO:K04638]
105811799  [KO:K02270]
105811880  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
105811892  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105811965  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105811986  [KO:K23609]
105812010  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
105812112  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105812168  [KO:K02263]
105812191  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
105812227  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105812318  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105812321  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
105812371  PARK2; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
105812491  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
105812493  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105812509  [KO:K08738]
105812563  [KO:K00411] [EC:7.1.1.8]
105812612  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
105812661  SNCA; alpha-synuclein isoform X1 [KO:K04528]
105812700  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105812706  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
105812910  WNT5B; protein Wnt-5b [KO:K00444]
105812967  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
105813016  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
105813050  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105813187  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105813220  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
105813404  [KO:K00413]
105813504  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
105813564  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
105813565  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
105813610  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105813709  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
105813718  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
105813949  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105813961  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105814072  [KO:K00416]
105814216  RYR3; ryanodine receptor 3 [KO:K04963]
105814245  SPG11; spatacsin [KO:K19026]
105814301  [KO:K05864] [EC:5.2.1.8]
105814447  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
105814456  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105814510  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105814556  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105814601  CAT; catalase [KO:K03781] [EC:1.11.1.6]
105814632  [KO:K02128]
105814677  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105814705  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105814707  [KO:K05611] [EC:3.4.19.12]
105814728  [KO:K04570]
105814731  [KO:K02730] [EC:3.4.25.1]
105814740  DCTN6; dynactin subunit 6 [KO:K10428]
105814769  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
105814920  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
105814986  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
105815072  [KO:K02266]
105815191  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
105815261  TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
105815299  GPR37; prosaposin receptor GPR37 [KO:K04243]
105815301  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105815312  [KO:K04857]
105815384  TUBA1A; tubulin alpha-1A chain isoform X1 [KO:K07374]
105815399  [KO:K07374]
105815409  [KO:K07374]
105815495  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105815498  [KO:K07374]
105815572  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105815609  [KO:K08738]
105815675  WNT4; protein Wnt-4 [KO:K00408]
105815718  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105815768  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
105815791  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105815811  TUBA8; tubulin alpha-8 chain [KO:K07374]
105815816  BID; BH3-interacting domain death agonist [KO:K04726]
105815844  PRPH; peripherin isoform X1 [KO:K07607]
105815880  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
105815885  [KO:K07374]
105815896  [KO:K03237]
105815903  WNT10B; protein Wnt-10b [KO:K01357]
105815999  [KO:K04440] [EC:2.7.11.24]
105816029  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105816045  [KO:K00418]
105816062  [KO:K07375]
105816099  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105816116  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
105816214  [KO:K02270]
105816235  [KO:K02267]
105816363  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105816385  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
105816408  KIF5A; kinesin heavy chain isoform 5A isoform X1 [KO:K10396] [EC:5.6.1.3]
105816458  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
105816477  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
105816542  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
105816545  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105816581  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105816683  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105816719  PSMD1; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
105816783  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105816800  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
105816815  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105816836  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105816974  UBE2G1; LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
105817018  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
105817091  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
105817103  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
105817130  WNT2; protein Wnt-2 [KO:K00182]
105817162  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
105817257  [KO:K03030]
105817283  TUBB; tubulin beta chain [KO:K07375]
105817329  GRIA2; glutamate receptor 2 [KO:K05198]
105817487  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
105817554  [KO:K02136]
105817598  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105817634  CALM3; calmodulin [KO:K02183]
105817645  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
105817696  KLC3; kinesin light chain 3 [KO:K10407]
105817755  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105817852  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
105817894  CSNK2B; casein kinase II subunit beta [KO:K03115]
105817905  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105817917  ATG101; autophagy-related protein 101 [KO:K19730]
105817968  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105817990  [KO:K02270]
105818062  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
105818097  [KO:K02927]
105818146  [KO:K02927]
105818168  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
105818236  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
105818469  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
105818472  FRAT1; proto-oncogene FRAT1 [KO:K03069]
105818541  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
105818550  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
105818686  TUBB4B; tubulin beta-4B chain [KO:K07375]
105818690  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105818713  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105818745  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
105818751  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
105818818  FZD3; frizzled-3 [KO:K02329]
105818861  SEPT5; septin-5 [KO:K04557]
105818911  HTT; huntingtin isoform X1 [KO:K04533]
105818927  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
105818941  ALS2; alsin [KO:K04575]
105818963  DKK2; dickkopf-related protein 2 [KO:K02165]
105819002  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105819043  [KO:K02273]
105819075  WNT9B; protein Wnt-9b [KO:K01064]
105819079  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105819080  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
105819128  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
105819191  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105819291  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
105819328  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
105819386  DLG4; disks large homolog 4 [KO:K11828]
105819390  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
105819421  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
105819434  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105819437  FZD7; frizzled-7 [KO:K02432]
105819477  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105819510  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
105819542  PSMD14; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
105819572  TANK; LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator [KO:K12650]
105819624  [KO:K07374]
105819679  DKK4; dickkopf-related protein 4 [KO:K02165]
105819681  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
105819705  DNAI1; dynein intermediate chain 1, axonemal isoform X1 [KO:K10409]
105819753  DNAL1; dynein light chain 1, axonemal [KO:K10411]
105819851  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
105819854  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
105819858  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105819915  ZFYVE1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
105819976  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
105820072  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
105820089  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
105820137  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
105820147  DCTN3; dynactin subunit 3 [KO:K10425]
105820245  BECN1; beclin-1 isoform X1 [KO:K08334]
105820269  ATXN3; ataxin-3 [KO:K11863] [EC:3.4.22.-]
105820319  IL1A; interleukin-1 alpha [KO:K04383]
105820326  IL1B; interleukin-1 beta [KO:K04519]
105820356  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105820421  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105820430  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
105820495  RYR1; ryanodine receptor 1 [KO:K04961]
105820583  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
105820593  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
105820609  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
105820631  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
105820645  [KO:K07375]
105820727  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
105820827  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
105820831  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
105820913  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105820930  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
105820951  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
105821032  FZD10; frizzled-10 [KO:K02842]
105821039  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
105821070  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
105821114  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105821432  DNAH8; LOW QUALITY PROTEIN: dynein heavy chain 8, axonemal [KO:K10408]
105821478  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
105821488  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
105821498  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
105821522  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
105821524  CSNK1A1; casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
105821573  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
105821574  DCTN4; dynactin subunit 4 [KO:K10426]
105821611  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
105821681  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105821682  DAXX; death domain-associated protein 6 [KO:K02308]
105821684  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105821892  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
105821915  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
105822085  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105822110  FZD2; frizzled-2 [KO:K02235]
105822174  GRIA4; glutamate receptor 4 [KO:K05200]
105822197  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
105822308  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
105822336  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
105822425  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
105822445  IL6; interleukin-6 [KO:K05405]
105822459  KIF5C; kinesin heavy chain isoform 5C [KO:K10396] [EC:5.6.1.3]
105822551  APC; adenomatous polyposis coli protein [KO:K02085]
105822607  AXIN1; axin-1 isoform X1 [KO:K02157]
105822663  DKK1; dickkopf-related protein 1 [KO:K02165]
105822665  HAP1; huntingtin-associated protein 1 [KO:K04647]
105822691  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105822738  [KO:K00572]
105822845  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
105822860  [KO:K11828]
105822913  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
105823056  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
105823069  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
105823096  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105823163  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
105823270  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
105823339  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
105823344  ATXN1L; ataxin-1-like [KO:K23616]
105823442  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
105823587  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
105823593  DERL1; derlin-1 [KO:K11519]
105823643  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105823667  FZD8; frizzled-8 [KO:K02375]
105823688  OPTN; optineurin isoform X1 [KO:K19946]
105823905  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105823952  FZD5; frizzled-5 [KO:K02375]
105823955  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
105823972  [KO:K02263]
105824001  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
105824035  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105824092  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
105824114  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105824126  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
105824183  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105824210  RAB39B; ras-related protein Rab-39B [KO:K07925]
105824291  WNT8B; protein Wnt-8b [KO:K00714]
105824299  ACTR1A; alpha-centractin [KO:K16575]
105824308  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
105824355  [KO:K00414]
105824605  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
105824685  AXIN2; axin-2 [KO:K04385]
105824696  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
105824710  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105824734  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105824768  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105824794  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
105824798  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
105824812  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
105824864  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105824883  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105824910  PARK7; protein deglycase DJ-1 [KO:K05687] [EC:3.5.1.124]
105824944  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
105824956  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
105824987  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
105825008  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105825063  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105825189  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
105825262  NEFL; neurofilament light polypeptide [KO:K04572]
105825278  NEFM; neurofilament medium polypeptide [KO:K04573]
105825283  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
105825287  [KO:K05687] [EC:3.5.1.124]
105825335  CTNNB1; catenin beta-1 [KO:K02105]
105825452  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
105825486  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
105825488  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
105825498  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105825513  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
105825541  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105825547  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105825561  UBC; polyubiquitin-C [KO:K02927]
105825563  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
105825610  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
105825624  ATXN2; ataxin-2 [KO:K23625]
105825671  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
105825706  RAB8A; ras-related protein Rab-8A [KO:K07901]
105825819  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
105825831  ACTR10; actin-related protein 10 [KO:K16576]
105825847  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
105825876  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
105825918  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
105826018  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
105826075  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
105826090  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105826139  [KO:K04849]
105826189  [KO:K02271]
105826272  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105826277  FZD1; frizzled-1 [KO:K02432]
105826315  SNCAIP; synphilin-1 isoform X1 [KO:K04558]
105826365  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
105826377  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
105826386  RAB5A; ras-related protein Rab-5A [KO:K07887]
105826451  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
105826559  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
105826626  WDR41; LOW QUALITY PROTEIN: WD repeat-containing protein 41 [KO:K23610]
105826811  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
105826816  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
105826829  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
105826841  WNT7A; protein Wnt-7a [KO:K00572]
105826892  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105826912  CALML3; calmodulin-like protein 3 [KO:K02183]
105826917  CALML5; calmodulin-like protein 5 [KO:K02183]
105826943  [KO:K04857]
105826962  SMCR8; smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
105827070  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
105827162  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105827242  [KO:K07375]
105827296  BAD; bcl2-associated agonist of cell death [KO:K02158]
105827297  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
105827324  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105827335  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
105827373  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
105827383  RELA; transcription factor p65 isoform X1 [KO:K04735]
105827391  KLC2; kinesin light chain 2 [KO:K10407]
105827410  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
105827413  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105827450  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
105827462  CCS; copper chaperone for superoxide dismutase [KO:K04569]
105827473  FADD; FAS-associated death domain protein [KO:K02373]
105827532  [KO:K00237]
105827572  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
105827579  PDYN; proenkephalin-B [KO:K15840]
105827580  [KO:K02263]
6458115  COX2; cytochrome c oxidase subunit II [KO:K02261]
6458116  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
6458117  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
6458118  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
6458119  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
6458120  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
6458121  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
6458122  CYTB; cytochrome b [KO:K00412]
6458123  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
6458124  COX3; cytochrome c oxidase subunit III [KO:K02262]
6458125  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
6458126  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
6458127  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
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Nat Neurosci 21:1300-1309 (2018)
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Reference
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Pathology of Neurodegenerative Diseases.
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Basic mechanisms of neurodegeneration: a critical update.
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Recent advances in our understanding of neurodegeneration.
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Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
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Front Mol Neurosci 7:70 (2014)
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PMID:25413678
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Neurodegener Dis 14:161-75 (2014)
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Park H, Kang JH, Lee S
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Int J Mol Sci 21:E3369 (2020)
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PMID:31783880
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Malik BR, Maddison DC, Smith GA, Peters OM
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Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
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Mol Brain 12:100 (2019)
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Reference
PMID:29734735
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Metaxakis A, Ploumi C, Tavernarakis N
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Autophagy in Age-Associated Neurodegeneration.
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Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
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Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
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Trends Pharmacol Sci 35:583-91 (2014)
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Reference
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  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
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Neuron 93:1015-1034 (2017)
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Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
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Related
pathway
pcoq00190  Oxidative phosphorylation
pcoq03050  Proteasome
pcoq04020  Calcium signaling pathway
pcoq04120  Ubiquitin mediated proteolysis
pcoq04137  Mitophagy - animal
pcoq04140  Autophagy - animal
pcoq04141  Protein processing in endoplasmic reticulum
pcoq04142  Lysosome
pcoq04210  Apoptosis
pcoq04310  Wnt signaling pathway
pcoq04724  Glutamatergic synapse
pcoq04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   

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