KEGG   PATHWAY: phas04014
Entry
phas04014                   Pathway                                
Name
Ras signaling pathway - Phyllostomus hastatus (greater spear-nosed bat)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
phas04014  Ras signaling pathway
phas04014

Other DBs
GO: 0032318
Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123804414  NRAS; GTPase NRas [KO:K07828]
123804470  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
123804521  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
123804625  NGF; beta-nerve growth factor [KO:K02582]
123804635  RAP1A; ras-related protein Rap-1A [KO:K04353]
123804682  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
123804735  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123804815  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
123804847  EFNA1; ephrin-A1 [KO:K05462]
123804859  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
123805160  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
123805416  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
123805534  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
123805628  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123805718  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
123806278  [KO:K01047] [EC:3.1.1.4]
123806391  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
123806504  RASA4B; ras GTPase-activating protein 4B [KO:K17630]
123806569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123806644  [KO:K07834]
123806785  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123806862  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123806865  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123806902  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123807193  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123807317  HRAS; GTPase HRas isoform X1 [KO:K02833]
123807352  IGF2; insulin-like growth factor II [KO:K13769]
123807354  INS; insulin isoform X1 [KO:K04526]
123807471  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123807479  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123807508  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
123807517  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123807522  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123807596  RASA3; ras GTPase-activating protein 3 [KO:K12380]
123807646  FGF20; fibroblast growth factor 20 [KO:K04358]
123807983  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
123808002  CALM1; calmodulin-1 [KO:K02183]
123808019  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
123808036  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
123808048  ARF6; ADP-ribosylation factor 6 [KO:K07941]
123808057  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
123808069  FGF7; fibroblast growth factor 7 [KO:K04358]
123808110  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123808220  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
123808460  PGF; placenta growth factor isoform X1 [KO:K16859]
123808510  [KO:K05735] [EC:2.7.11.1]
123808570  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
123808571  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
123808572  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
123808608  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123808639  SHC4; SHC-transforming protein 4 [KO:K17449]
123808681  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
123809425  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
123809769  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123809804  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
123810054  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
123810187  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
123810291  RALB; ras-related protein Ral-B [KO:K07835]
123810462  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123810596  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123810635  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
123810671  NTF3; neurotrophin-3 [KO:K04356]
123810721  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123810790  FGF1; fibroblast growth factor 1 [KO:K18496]
123810931  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
123810976  FGF18; fibroblast growth factor 18 [KO:K04358]
123811087  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
123811120  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123811124  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123811159  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123811181  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
123811430  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123811479  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
123811490  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123811574  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
123811727  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
123811734  [KO:K07360] [EC:2.7.10.2]
123811737  CALM2; calmodulin-2 [KO:K02183]
123811921  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
123811931  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
123811958  RALA; ras-related protein Ral-A [KO:K07834]
123812121  [KO:K04545]
123812406  KRAS; GTPase KRas isoform X1 [KO:K07827]
123812719  RAP1B; ras-related protein Rap-1b [KO:K07836]
123812867  RAB5B; ras-related protein Rab-5B [KO:K07888]
123812878  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
123813112  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
123813249  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
123813509  FGF23; fibroblast growth factor 23 [KO:K22428]
123813510  FGF6; fibroblast growth factor 6 [KO:K04358]
123813523  KITLG; kit ligand isoform X1 [KO:K05461]
123813640  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123813667  FGF2; fibroblast growth factor 2 [KO:K18497]
123813731  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123813767  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
123813838  SHC2; SHC-transforming protein 2 [KO:K17447]
123813920  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
123814141  PDGFC; platelet-derived growth factor C [KO:K05450]
123814206  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
123814364  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123814395  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
123814659  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
123814723  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
123814793  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
123814838  STK4; serine/threonine-protein kinase 4 [KO:K04411]
123814855  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
123815314  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
123815356  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
123815475  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
123815479  [KO:K07887]
123815569  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
123815579  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
123815667  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123815784  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
123815790  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
123815841  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
123816071  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
123816209  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
123816229  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
123816243  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
123816440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123816445  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123816473  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123816777  RAB5C; ras-related protein Rab-5C [KO:K07889]
123816833  [KO:K10784]
123816854  NF1; neurofibromin isoform X1 [KO:K08052]
123816993  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
123817087  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
123817259  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
123817350  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123817374  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123817558  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
123818097  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
123818357  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
123818378  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
123818381  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
123818449  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123818549  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
123819554  FGF10; fibroblast growth factor 10 [KO:K04358]
123819929  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
123820012  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
123820257  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
123820624  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
123820781  EXOC2; exocyst complex component 2 [KO:K17637]
123820887  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123820995  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
123821009  [KO:K02183]
123821116  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
123821417  VEGFA; vascular endothelial growth factor A [KO:K05448]
123821470  [KO:K04545]
123821836  [KO:K10632] [EC:2.3.2.27]
123821913  AFDN; afadin isoform X1 [KO:K05702]
123821983  [KO:K04542]
123822036  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
123822119  [KO:K04542]
123822352  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123822657  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
123822727  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
123822789  FGF9; fibroblast growth factor 9 [KO:K04358]
123823025  CALM3; calmodulin-3 [KO:K02183]
123823052  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
123823081  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
123823352  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
123823364  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
123823378  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
123823464  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
123823743  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123823849  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
123823859  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
123824140  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123824352  FGF16; fibroblast growth factor 16 [KO:K04358]
123824358  FOXO4; forkhead box protein O4 [KO:K12358]
123824375  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123824520  [KO:K04513]
123824527  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123824628  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
123824870  RASA1; ras GTPase-activating protein 1 [KO:K04352]
123825087  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
123825297  [KO:K04542]
123825394  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
123825413  [KO:K04542]
123825494  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123825523  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123825544  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
123825630  [KO:K04409] [EC:2.7.11.1]
123826086  RALBP1; ralA-binding protein 1 [KO:K08773]
123826542  [KO:K04542]
123826750  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123826776  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
123826853  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123826858  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
123827153  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
123827960  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
123828039  ETS2; protein C-ets-2 [KO:K21932]
123828245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123828291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123828441  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123828459  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
123828462  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
123828668  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
123828714  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
123828777  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
123828974  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123829098  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
123829150  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
123829212  FGF3; fibroblast growth factor 3 [KO:K04358]
123829213  FGF19; fibroblast growth factor 19 [KO:K22603]
123829227  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123829277  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
123829336  BAD; bcl2-associated agonist of cell death [KO:K02158]
123829356  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123829410  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123829444  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
123829488  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
123829518  RELA; transcription factor p65 [KO:K04735]
123829593  FGF4; fibroblast growth factor 4 [KO:K04358]
123829604  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
123830134  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123830210  FGF21; fibroblast growth factor 21 isoform X1 [KO:K22429]
123830294  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
123830304  RRAS; ras-related protein R-Ras [KO:K07829]
123830318  NTF4; neurotrophin-4 [KO:K12457]
123830380  RHOA; transforming protein RhoA [KO:K04513]
123830565  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123830614  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
123830616  RAB5A; ras-related protein Rab-5A [KO:K07887]
123830760  MRAS; ras-related protein M-Ras [KO:K07831]
123831226  CALML3; calmodulin-like protein 3 [KO:K02183]
123831240  [KO:K02183]
123831289  FGF5; fibroblast growth factor 5 [KO:K04358]
123831548  [KO:K01047] [EC:3.1.1.4]
123831625  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
123831835  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123831845  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
123831922  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123832005  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123832016  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
123832120  [KO:K01047] [EC:3.1.1.4]
123832149  [KO:K01047] [EC:3.1.1.4]
123832151  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
123832250  PLA2G2F; group IIF secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
123832251  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
123832297  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123832298  [KO:K02649]
123832310  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123832500  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
123832645  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
123833335  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
phas04010  MAPK signaling pathway
phas04015  Rap1 signaling pathway
phas04020  Calcium signaling pathway
phas04144  Endocytosis
phas04151  PI3K-Akt signaling pathway
phas04660  T cell receptor signaling pathway
phas04720  Long-term potentiation
phas04810  Regulation of actin cytoskeleton
KO pathway
ko04014   

DBGET integrated database retrieval system