KEGG   PATHWAY: phas04151
Entry
phas04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Phyllostomus hastatus (greater spear-nosed bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
phas04151  PI3K-Akt signaling pathway
phas04151

Other DBs
GO: 0043491
Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123806865  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123811931  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
123831167  EREG; proepiregulin [KO:K09784]
123831258  AREG; amphiregulin [KO:K09782]
123810790  FGF1; fibroblast growth factor 1 [KO:K18496]
123813667  FGF2; fibroblast growth factor 2 [KO:K18497]
123819554  FGF10; fibroblast growth factor 10 [KO:K04358]
123813510  FGF6; fibroblast growth factor 6 [KO:K04358]
123828462  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
123813920  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
123828974  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123829212  FGF3; fibroblast growth factor 3 [KO:K04358]
123807646  FGF20; fibroblast growth factor 20 [KO:K04358]
123829593  FGF4; fibroblast growth factor 4 [KO:K04358]
123808069  FGF7; fibroblast growth factor 7 [KO:K04358]
123822789  FGF9; fibroblast growth factor 9 [KO:K04358]
123831289  FGF5; fibroblast growth factor 5 [KO:K04358]
123824352  FGF16; fibroblast growth factor 16 [KO:K04358]
123810976  FGF18; fibroblast growth factor 18 [KO:K04358]
123829213  FGF19; fibroblast growth factor 19 [KO:K22603]
123830210  FGF21; fibroblast growth factor 21 isoform X1 [KO:K22429]
123813509  FGF23; fibroblast growth factor 23 [KO:K22428]
123804625  NGF; beta-nerve growth factor [KO:K02582]
123810054  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
123810671  NTF3; neurotrophin-3 [KO:K04356]
123830318  NTF4; neurotrophin-4 [KO:K12457]
123807354  INS; insulin isoform X1 [KO:K04526]
123810596  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123807352  IGF2; insulin-like growth factor II [KO:K13769]
123810721  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123816209  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
123805628  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123814141  PDGFC; platelet-derived growth factor C [KO:K05450]
123804682  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
123813523  KITLG; kit ligand isoform X1 [KO:K05461]
123830294  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
123821417  VEGFA; vascular endothelial growth factor A [KO:K05448]
123829410  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123808460  PGF; placenta growth factor isoform X1 [KO:K16859]
123807508  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
123830134  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123811490  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123833335  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
123807479  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123814659  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
123804470  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
123804521  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
123804847  EFNA1; ephrin-A1 [KO:K05462]
123814206  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
123818097  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
123824736  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
123814187  NRTN; neurturin [KO:K25414]
123832146  ARTN; artemin [KO:K25415]
123814197  PSPN; persephin [KO:K25416]
123811124  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123816974  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
123812915  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
123828079  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
123807471  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123828714  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
123815667  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123811430  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123817259  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
123804735  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123820257  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
123811181  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
123809769  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123815579  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
123807517  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123813249  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
123815790  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
123822727  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
123822657  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
123811159  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123815784  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
123824375  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123820012  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
123831625  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
123821068  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
123817350  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123811120  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123807983  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
123807317  HRAS; GTPase HRas isoform X1 [KO:K02833]
123812406  KRAS; GTPase KRas isoform X1 [KO:K07827]
123804414  NRAS; GTPase NRas [KO:K07828]
123814364  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123808110  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123813640  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123806569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123825523  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123828676  IRS1; insulin receptor substrate 1 [KO:K16172]
123813727  TLR2; toll-like receptor 2 [KO:K10159]
123820226  TLR4; toll-like receptor 4 [KO:K10160]
123810462  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123815559  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
123825555  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
123829016  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
123816860  somatotropin-like [KO:K05438]
123824055  PRL; prolactin isoform X1 [KO:K05439]
123810979  OSM; oncostatin-M [KO:K05418]
123814106  IL2; interleukin-2 [KO:K05429]
123811876  IL6; interleukin-6 isoform X1 [KO:K05405]
123812938  IL4; interleukin-4 [KO:K05430]
123825829  IL7; interleukin-7 [KO:K05431]
123819865  interferon alpha-4-like [KO:K05414]
123819961  interferon alpha-4-like [KO:K05414]
123819962  interferon alpha-4-like [KO:K05414]
123820149  interferon beta-like [KO:K05415]
123820232  IFNB1; interferon beta [KO:K05415]
123806463  EPO; erythropoietin [KO:K05437]
123817183  CSF3; granulocyte colony-stimulating factor [KO:K05423]
123824618  GHR; growth hormone receptor isoform X1 [KO:K05080]
123824704  PRLR; prolactin receptor [KO:K05081]
123824734  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
123831329  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
123816246  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
123824325  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
123830027  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
123804359  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
123825528  interleukin-4 receptor subunit alpha-like [KO:K05071]
123825621  interleukin-4 receptor subunit alpha-like [KO:K05071]
123824890  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
123828062  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
123827993  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
123828310  EPOR; erythropoietin receptor [KO:K05079]
123831933  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
123816436  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
123819931  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
123828481  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
123811431  COL1A2; collagen alpha-2(I) chain [KO:K06236]
123817007  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
123813041  COL2A1; collagen alpha-1(II) chain [KO:K19719]
123805086  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
123828626  collagen alpha-4(IV) chain-like isoform X1 [KO:K06237]
123828663  collagen alpha-3(IV) chain-like isoform X1 [KO:K06237]
123807417  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
123807418  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
123827979  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
123828101  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
123823182  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
123830557  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
123830774  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
123830851  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
123821491  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
123815252  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
123832314  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
123826329  LAMA1; laminin subunit alpha-1 [KO:K05637]
123821337  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
123826058  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
123814754  LAMA5; laminin subunit alpha-5 [KO:K06240]
123821757  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
123811425  LAMB1; laminin subunit beta-1 [KO:K05636]
123830578  laminin subunit beta-2 [KO:K06243]
123830721  laminin subunit beta-2-like [KO:K06243]
123818499  LAMB3; laminin subunit beta-3 [KO:K06244]
123811550  LAMB4; laminin subunit beta-4 [KO:K06245]
123818340  LAMC1; laminin subunit gamma-1 [KO:K05635]
123818501  LAMC2; laminin subunit gamma-2 [KO:K06246]
123823475  LAMC3; laminin subunit gamma-3 [KO:K06247]
123817271  CHAD; chondroadherin [KO:K06248]
123811428  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
123808233  THBS1; thrombospondin-1 [KO:K16857]
123804394  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
123828346  cartilage oligomeric matrix protein [KO:K04659]
123822087  THBS2; thrombospondin-2 [KO:K04659]
123824624  THBS4; thrombospondin-4 [KO:K04659]
123829917  FN1; fibronectin isoform X1 [KO:K05717]
123806841  SPP1; osteopontin [KO:K06250]
123817279  VTN; vitronectin [KO:K06251]
123818429  TNR; tenascin-R [KO:K06252]
123818484  TNN; tenascin-N [KO:K06252]
123820005  TNC; tenascin isoform X1 [KO:K06252]
123810279  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
123810560  VWF; von Willebrand factor [KO:K03900]
123806889  bone sialoprotein 2 [KO:K06253]
123819526  ITGA1; integrin alpha-1 [KO:K06480]
123819523  ITGA2; integrin alpha-2 [KO:K06481]
123817155  ITGA2B; integrin alpha-IIb [KO:K06476]
123816998  ITGA3; integrin alpha-3 [KO:K06482]
123820586  ITGA4; integrin alpha-4 [KO:K06483]
123812834  ITGA5; integrin alpha-5 [KO:K06484]
123824106  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
123812759  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
123831184  ITGA8; integrin alpha-8 [KO:K06584]
123830492  ITGA9; integrin alpha-9 [KO:K06585]
123804746  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
123808275  ITGA11; integrin alpha-11 [KO:K06587]
123820205  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
123806803  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123817163  ITGB3; integrin beta-3 [KO:K06493]
123816849  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
123827040  ITGB5; integrin beta-5 [KO:K06588]
123828273  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
123812639  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
123811434  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
123833261  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
123826750  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
123830565  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123831922  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
123828291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
123824527  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
123832298  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
123824873  F2R; proteinase-activated receptor 1 [KO:K03914]
123829436  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
123829775  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
123820165  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
123828624  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
123816484  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
123824324  lysophosphatidic acid receptor 4 [KO:K04275]
123810728  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
123818742  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
123832310  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123806391  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
123810635  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
123827153  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
123808220  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
123808681  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
123829444  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
123804859  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
123821983  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
123822119  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
123816473  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
123825297  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
123825413  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
123826542  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
123813731  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123823052  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
123812121  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
123819929  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
123821470  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
123811727  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
123828441  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123816445  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123825394  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
123811087  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
123817087  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
123811696  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
123809306  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
123809423  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
123807097  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
123813698  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
123830412  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
123824594  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
123820937  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
123823356  TSC1; hamartin isoform X1 [KO:K07206]
123807207  TSC2; tuberin isoform X1 [KO:K07207]
123818003  RHEB; GTP-binding protein Rheb [KO:K07208]
123807134  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
123831556  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123816937  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
123807542  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
123812804  eukaryotic translation initiation factor 4E-like [KO:K03259]
123813039  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
123806860  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
123823219  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
123829298  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
123817599  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
123812396  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
123819683  RPS6; 40S ribosomal protein S6 [KO:K02991]
123805431  40S ribosomal protein S6-like [KO:K02991]
123820789  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
123828526  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
123829778  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
123808751  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
123817558  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
123828255  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
123816444  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
123823436  PKN3; LOW QUALITY PROTEIN: serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
123821687  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
123815277  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
123833270  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
123808608  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123823743  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123832297  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123814354  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
123811435  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
123829008  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
123804296  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
123807483  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123809960  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
123824185  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
123818226  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
123828358  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
123813225  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
123828790  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
123815904  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
123830018  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
123830444  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
123825185  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
123818512  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
123821502  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
123829552  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
123808039  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
123808140  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
123821362  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
123808632  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
123810694  HSP90B1; endoplasmin [KO:K09487]
123828483  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
123804750  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
123826182  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
123806175  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
123807919  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
123804958  MTCP1; protein p13 MTCP-1 [KO:K16837]
123817951  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
123817357  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
123827255  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
123812688  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
123830251  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
123820444  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
123815008  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
123821322  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
123817295  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
123817418  G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
123833339  MYC; myc proto-oncogene protein [KO:K04377]
123829562  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
123822234  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
123812935  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
123813020  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
123812897  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
123811100  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
123813418  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
123821479  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
123833091  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
123805874  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
123821950  FOXO3; forkhead box protein O3 [KO:K09408]
123805724  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
123818449  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123812072  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
123833064  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
123814839  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
123822462  YWHAQ; 14-3-3 protein theta [KO:K16197]
123808515  LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha-like [KO:K16197]
123816661  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
123811001  YWHAH; 14-3-3 protein eta [KO:K16198]
123806362  YWHAG; 14-3-3 protein gamma [KO:K16198]
123829336  BAD; bcl2-associated agonist of cell death [KO:K02158]
123814855  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
123826047  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
123832288  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
123828120  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123808666  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123816126  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123804840  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
123819667  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
123813639  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
123829665  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
123810038  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
123811809  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
123810486  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
123804387  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
123823408  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
123812630  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
123823081  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
123828668  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
123807522  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123829518  RELA; transcription factor p65 [KO:K04735]
123806785  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123821648  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
123813040  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
123809443  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
phas00010  Glycolysis / Gluconeogenesis
phas04010  MAPK signaling pathway
phas04012  ErbB signaling pathway
phas04062  Chemokine signaling pathway
phas04064  NF-kappa B signaling pathway
phas04068  FoxO signaling pathway
phas04110  Cell cycle
phas04115  p53 signaling pathway
phas04150  mTOR signaling pathway
phas04210  Apoptosis
phas04370  VEGF signaling pathway
phas04510  Focal adhesion
phas04620  Toll-like receptor signaling pathway
phas04630  JAK-STAT signaling pathway
phas04662  B cell receptor signaling pathway
phas04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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