KEGG   PATHWAY: pleu05165
Entry
pleu05165                   Pathway                                
Name
Human papillomavirus infection - Peromyscus leucopus (white-footed mouse)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
pleu05165  Human papillomavirus infection
pleu05165

Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680676  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
114680749  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
114680760  Tsc2; tuberin isoform X1 [KO:K07207]
114680916  Itga10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
114681039  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
114681065  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
114681076  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
114681158  Heyl; LOW QUALITY PROTEIN: hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
114681270  Ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
114681319  Wnt7a; protein Wnt-7a [KO:K00572]
114681329  [KO:K14608]
114681337  [KO:K14608]
114681518  Maml1; LOW QUALITY PROTEIN: mastermind-like protein 1 [KO:K06061]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681584  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
114681591  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
114681621  Sos1; son of sevenless homolog 1 [KO:K03099]
114681739  Itga7; integrin alpha-7 isoform X9 [KO:K06583]
114681747  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
114681779  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
114681841  Rbl1; retinoblastoma-like protein 1 [KO:K04681]
114681843  [KO:K02151]
114681945  Ube3a; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
114682025  [KO:K04632]
114682029  [KO:K04632]
114682088  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
114682099  Rela; transcription factor p65 [KO:K04735]
114682147  [KO:K04659]
114682499  Itga9; integrin alpha-9 [KO:K06585]
114682541  [KO:K00873] [EC:2.7.1.40]
114682558  Llgl1; LOW QUALITY PROTEIN: lethal(2) giant larvae protein homolog 1 [KO:K06094]
114682605  Pxn; paxillin isoform X1 [KO:K05760]
114682640  [KO:K06751]
114682644  [KO:K06751]
114682645  [KO:K06751]
114682649  [KO:K06751]
114682653  [KO:K06751]
114682654  [KO:K06751]
114682655  [KO:K06751]
114682656  [KO:K06751]
114682666  [KO:K06751]
114682671  [KO:K06751]
114682672  [KO:K06751]
114682673  [KO:K06751]
114682677  [KO:K06751]
114682685  [KO:K06751]
114682688  [KO:K06751]
114682692  Egf; pro-epidermal growth factor [KO:K04357]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682789  [KO:K10389]
114682809  Tubg2; tubulin gamma-2 chain [KO:K10389]
114682831  Atp6v0a1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
114682847  [KO:K04659]
114682971  Wnt3a; protein Wnt-3a [KO:K00312]
114683006  Wnt9a; protein Wnt-9a [KO:K01064]
114683042  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
114683055  Tcf7; transcription factor 7 isoform X2 [KO:K02620]
114683075  [KO:K06067] [EC:3.5.1.98]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114683308  Dvl3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
114683665  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684081  Apc2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
114684152  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114684224  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
114684579  [KO:K03062]
114684640  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
114684737  Scrib; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
114685101  Ticam1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842]
114685127  [KO:K02833]
114685139  Ifnb1; interferon beta [KO:K05415]
114685140  [KO:K05414]
114685141  [KO:K05414]
114685144  [KO:K05414]
114685147  [KO:K05414]
114685149  [KO:K05414]
114685150  [KO:K05414]
114685151  [KO:K05414]
114685152  [KO:K05414]
114685154  [KO:K05414]
114685155  [KO:K05414]
114685662  [KO:K14754]
114685687  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
114685753  Fzd7; frizzled-7 [KO:K02432]
114685999  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
114686016  Fzd9; frizzled-9 [KO:K02842]
114686138  Notch3; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 3 [KO:K20995]
114686260  Notch2; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 2 [KO:K20994]
114686366  [KO:K06751]
114686858  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
114687018  [KO:K06751]
114687019  [KO:K06751]
114687020  [KO:K06751]
114687156  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
114687192  Ppp2r5a; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
114687912  Crb3; protein crumbs homolog 3 [KO:K06090]
114687933  [KO:K06751]
114687935  [KO:K06751]
114687963  Fzd1; frizzled-1 [KO:K02432]
114688121  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
114688126  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
114688249  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
114688364  [KO:K19719]
114688453  [KO:K05414]
114688454  [KO:K05414]
114688456  [KO:K05414]
114688459  [KO:K05414]
114688460  [KO:K05414]
114688461  [KO:K05414]
114688462  [KO:K05414]
114688463  [KO:K05414]
114688482  [KO:K06751]
114688488  [KO:K02833]
114688490  [KO:K06751]
114688492  [KO:K06751]
114688790  [KO:K06751]
114688816  [KO:K06751]
114688817  [KO:K06751]
114688889  [KO:K06236]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689064  [KO:K11583]
114689321  [KO:K05414]
114689322  [KO:K05414]
114689603  Tada3; transcriptional adapter 3 [KO:K11315]
114689636  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114689726  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
114689971  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
114690258  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
114690277  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
114690442  Axin2; axin-2 [KO:K04385]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114690907  Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
114690969  Atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
114691010  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
114691083  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
114691309  [KO:K04393]
114691326  [KO:K03120]
114691337  Thbs2; thrombospondin-2 [KO:K04659]
114691497  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
114691507  Vtn; vitronectin [KO:K06251]
114691660  Itga11; integrin alpha-11 [KO:K06587]
114691790  Spp1; osteopontin isoform X1 [KO:K06250]
114691862  [KO:K06253]
114692317  Col9a1; collagen alpha-1(IX) chain isoform X2 [KO:K08131]
114692435  Itgb6; integrin beta-6 isoform X1 [KO:K06589]
114692533  Hey2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
114692613  Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053]
114692673  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
114692728  Tbpl2; TATA box-binding protein-like 2 [KO:K03120]
114692821  Notch1; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1 [KO:K02599]
114692892  Chad; chondroadherin [KO:K06248]
114692897  Col1a1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
114692904  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
114693042  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
114693171  Tp53; cellular tumor antigen p53 [KO:K04451]
114693209  Dvl2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
114693237  Hes7; LOW QUALITY PROTEIN: transcription factor HES-7 [KO:K09087]
114693293  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
114693314  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
114693374  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
114693444  Col1a2; LOW QUALITY PROTEIN: collagen alpha-2(I) chain [KO:K06236]
114693493  [KO:K02833]
114693506  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
114693540  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693565  [KO:K06238]
114693566  Col6a6; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693605  Fn1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
114693690  Fzd10; frizzled-10 [KO:K02842]
114693732  Jak1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
114693748  Patj; LOW QUALITY PROTEIN: inaD-like protein [KO:K06092]
114693817  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
114693946  Itga8; LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
114694235  Mfng; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
114694299  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
114694438  Fadd; FAS-associated death domain protein [KO:K02373]
114694498  Ccnd1; G1/S-specific cyclin-D1 isoform X2 [KO:K04503]
114694542  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
114694576  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
114694630  Tcirg1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
114694717  Wnt2; protein Wnt-2 [KO:K00182]
114694904  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
114694973  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
114695104  Col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
114695105  Col4a1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
114695212  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
114695317  Prkci; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695609  Wnt16; protein Wnt-16 [KO:K01558]
114695681  Maml2; mastermind-like protein 2 [KO:K06061]
114695763  Fzd8; frizzled-8 [KO:K02375]
114695816  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
114695857  Maml3; mastermind-like protein 3 isoform X1 [KO:K06061]
114695858  Foxo1; LOW QUALITY PROTEIN: forkhead box protein O1 [KO:K07201]
114695883  Ccna1; cyclin-A1 [KO:K06627]
114695903  Dlg2; disks large homolog 2 isoform X3 [KO:K12075]
114696103  Tert; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
114696435  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
114696436  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
114696517  Col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
114696519  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
114696553  [KO:K02833]
114696602  Itga5; integrin alpha-5 [KO:K06484]
114696632  Itgb7; integrin beta-7 isoform X1 [KO:K06590]
114696775  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
114696875  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
114696878  Lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
114697060  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
114697169  Ubr4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
114697206  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114697207  Wnt4; protein Wnt-4 [KO:K00408]
114697342  Ptger4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
114697589  [KO:K03174]
114697632  [KO:K21098]
114697765  Mpp5; MAGUK p55 subfamily member 5 isoform X2 [KO:K06091]
114697767  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
114698057  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
114698155  Lama3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
114698264  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114698332  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
114698334  Col4a6; collagen alpha-6(IV) chain [KO:K06237]
114698435  Ifnar1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
114698437  Ifnar2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
114698444  Psen1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
114698498  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
114698582  Nras; GTPase NRas [KO:K07828]
114698613  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
114698691  Wnt11; protein Wnt-11 isoform X1 [KO:K01384]
114698792  Rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
114698843  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
114698889  Ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
114699199  Wnt7b; protein Wnt-7b isoform X1 [KO:K00572]
114699281  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
114699702  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
114699826  [KO:K06053]
114699908  Atp6v1c1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
114699911  Fzd6; frizzled-6 [KO:K02376]
114700070  Rheb; GTP-binding protein Rheb [KO:K07208]
114700111  Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153]
114700347  [KO:K14754]
114700681  Hes6; transcription cofactor HES-6 isoform X1 [KO:K09087]
114700691  Col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
114700740  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
114700757  Wnt5b; protein Wnt-5b [KO:K00444]
114701036  Itgb8; integrin beta-8 [KO:K06591]
114701168  Tlr3; toll-like receptor 3 isoform X2 [KO:K05401]
114701275  [KO:K04393]
114701440  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114701602  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3 [KO:K04354]
114702071  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
114702120  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
114702202  Wnt9b; protein Wnt-9b [KO:K01064]
114702233  Itga2b; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
114702239  Fzd2; frizzled-2 [KO:K02235]
114702271  Wnt3; proto-oncogene Wnt-3 [KO:K00312]
114702284  Itgb3; integrin beta-3 [KO:K06493]
114702393  Lamb3; laminin subunit beta-3 [KO:K06244]
114702600  Hes3; transcription factor HES-3 [KO:K09088]
114702601  Hes2; transcription factor HES-2 isoform X2 [KO:K09087]
114702777  Tsc1; hamartin isoform X1 [KO:K07206]
114702976  Jag1; protein jagged-1 [KO:K06052]
114703016  Itga2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703073  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
114703087  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
114703115  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
114703181  Dlg3; disks large homolog 3 isoform X1 [KO:K21098]
114703207  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
114703253  Nfx1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
114703598  Itgav; integrin alpha-V isoform X1 [KO:K06487]
114703673  Tbpl1; TATA box-binding protein-like 1 [KO:K03120]
114703730  Itga4; integrin alpha-4 [KO:K06483]
114703745  Itga1; integrin alpha-1 [KO:K06480]
114703788  Lamc3; laminin subunit gamma-3 [KO:K06247]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114703908  Rfng; LOW QUALITY PROTEIN: beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
114704074  Lama1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
114704111  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
114704195  Col9a3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
114704204  Lama5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704437  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
114704479  Itga6; LOW QUALITY PROTEIN: integrin alpha-6 [KO:K06485]
114704508  Atp6v0a2; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
114704659  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114704814  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
114704849  Itgb5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
114704920  Col9a2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
114705017  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
114705035  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
114705057  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
114705069  Fzd5; frizzled-5 [KO:K02375]
114705120  Apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
114705144  Wnt8a; protein Wnt-8a [KO:K00714]
114705208  Lamb2; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
114705300  Vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
114705315  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
114705331  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114705506  Lfng; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
114705532  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114705645  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114705775  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
114705780  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
114705807  Notch4; neurogenic locus notch homolog protein 4 [KO:K20996]
114705810  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
114705817  Tnf; tumor necrosis factor [KO:K03156]
114705846  [KO:K06751]
114705857  Tnxb; tenascin-X isoform X12 [KO:K06252]
114705915  Thbs1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
114706143  Bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
114706157  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
114706175  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114706188  Bcap31; B-cell receptor-associated protein 31 [KO:K14009]
114706206  Atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114706553  E2f1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
114706839  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707024  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
114707030  Slc9a3r1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
114707063  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
114707070  Llgl2; LLGL scribble cell polarity complex component 2 isoform X7 [KO:K06094]
114707180  Ccna2; cyclin-A2 [KO:K06627]
114707200  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
114707263  Wnt2b; protein Wnt-2b [KO:K00182]
114707293  Fzd3; frizzled-3 isoform X1 [KO:K02329]
114707321  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
114707351  Hes1; transcription factor HES-1 [KO:K06054]
114707365  Pdgfrb; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
114707394  Csnk1a1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
114707632  Hey1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
114707893  Thbs3; LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
114707907  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
114707992  Reln; reelin isoform X3 [KO:K06249] [EC:3.4.21.-]
114708149  Wnt8b; protein Wnt-8b [KO:K00714]
114708251  Dvl1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
114708255  Hes5; transcription factor HES-5 [KO:K06055]
114708271  Isg15; ubiquitin-like protein ISG15 [KO:K12159]
114708277  Prkcz; LOW QUALITY PROTEIN: protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
114708454  Lamb1; laminin subunit beta-1 [KO:K05636]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708534  Col2a1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
114708546  Wnt10b; protein Wnt-10b [KO:K01357]
114708572  Wnt1; proto-oncogene Wnt-1 [KO:K03209]
114708668  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
114708777  Vwf; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
114708799  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114708834  Chd4; LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
114708909  Pkm; pyruvate kinase PKM isoform X2 [KO:K00873] [EC:2.7.1.40]
114709027  Tnc; LOW QUALITY PROTEIN: tenascin [KO:K06252]
114709033  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
114709186  Thbs4; LOW QUALITY PROTEIN: thrombospondin-4 [KO:K04659]
114709307  Wnt10a; LOW QUALITY PROTEIN: protein Wnt-10a [KO:K01357]
114709311  Wnt6; protein Wnt-6 [KO:K00445]
114709373  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
114709466  Axin1; axin-1 isoform X1 [KO:K02157]
114709485  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
114709621  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
114709670  Mtor; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
114709688  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
114710020  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
114710338  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
114710523  [KO:K04371] [EC:2.7.11.24]
114710614  [KO:K04498] [EC:2.3.1.48]
114710708  Fzd4; frizzled-4 [KO:K02354]
119089216  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Moody CA, Laimins LA
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Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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PMID:25752815
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Chen J
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Signaling pathways in HPV-associated cancers and therapeutic implications.
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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PMID:26008697
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High-risk human papillomavirus targets crossroads in immune signaling.
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Viruses 7:2485-506 (2015)
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PMID:19684440
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Molecular mechanisms of human papillomavirus-induced carcinogenesis.
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Public Health Genomics 12:268-80 (2009)
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PMID:23164805
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Human papillomavirus proteins as prospective therapeutic targets.
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Microb Pathog 58:55-65 (2013)
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Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
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Reference
PMID:17645777
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Narisawa-Saito M, Kiyono T
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Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Cancer Sci 98:1505-11 (2007)
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PMID:11486705
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Wolf JK, Ramirez PT.
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The molecular biology of cervical cancer.
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Cancer Invest 19:621-9 (2001)
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Reference
PMID:10793105
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zur Hausen H
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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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J Natl Cancer Inst 92:690-8 (2000)
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Kim YT, Zhao M
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Aberrant cell cycle regulation in cervical carcinoma.
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Yonsei Med J 46:597-613 (2005)
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Reference
PMID:15956361
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McCance DJ
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Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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PMID:15342967
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Motoyama S, Ladines-Llave CA, Luis Villanueva S, Maruo T
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Kobe J Med Sci 50:9-19 (2004)
Reference
PMID:24316445
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Tommasino M
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The human papillomavirus family and its role in carcinogenesis.
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Semin Cancer Biol 26:13-21 (2014)
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PMID:26295406
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Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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PMID:26289783
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Shah M, Anwar MA, Park S, Jafri SS, Choi S
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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Reference
PMID:26797638
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James CD, Roberts S
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:8 (2016)
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Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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Reference
PMID:21954943
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Subbaiah VK, Kranjec C, Thomas M, Banks L
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PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Nat Rev Cancer 12:877-86 (2012)
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Thomas M, Narayan N, Pim D, Tomaic V, Massimi P, Nagasaka K, Kranjec C, Gammoh N, Banks L
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Human papillomaviruses, cervical cancer and cell polarity.
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Oncogene 27:7018-30 (2008)
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Reference
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Cell intrinsic & extrinsic factors in cervical carcinogenesis.
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Indian J Med Res 130:286-95 (2009)
Reference
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Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
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Reference
PMID:26022660
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Zhang L, Wu J, Ling MT, Zhao L, Zhao KN
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The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
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Mol Cancer 14:87 (2015)
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Reference
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Papillomavirus E5: the smallest oncoprotein with many functions.
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Mol Cancer 10:140 (2011)
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Mechanisms of cell transformation by papillomavirus E5 proteins.
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Oncogene 20:7866-73 (2001)
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Ganguly N
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Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value.
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Cell Oncol (Dordr) 35:67-76 (2012)
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The E5 proteins.
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Virology 445:99-114 (2013)
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Breaking the DNA damage response to improve cervical cancer treatment.
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Cancer Treat Rev 42:30-40 (2016)
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Reference
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Chung CH, Gillison ML
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Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications.
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Control of interferon signaling in human papillomavirus infection.
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Park JS, Kim EJ, Kwon HJ, Hwang ES, Namkoong SE, Um SJ
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Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis.
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PMID:22499770
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Sandberg A, Lindell G, Kallstrom BN, Branca RM, Danielsson KG, Dahlberg M, Larson B, Forshed J, Lehtio J
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Tumor proteomics by multivariate analysis on individual pathway data for characterization of vulvar cancer phenotypes.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
  Authors
Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Durr P
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Proc Natl Acad Sci U S A 96:1291-6 (1999)
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Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
DOI:10.1074/jbc.M403385200
Reference
PMID:18505829
  Authors
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
DOI:10.1128/MCB.01969-07
Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
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J Virol 87:6062-72 (2013)
DOI:10.1128/JVI.00330-13
Related
pathway
pleu04064  NF-kappa B signaling pathway
pleu04110  Cell cycle
pleu04115  p53 signaling pathway
pleu04150  mTOR signaling pathway
pleu04151  PI3K-Akt signaling pathway
pleu04210  Apoptosis
pleu04310  Wnt signaling pathway
pleu04330  Notch signaling pathway
pleu04510  Focal adhesion
pleu04520  Adherens junction
pleu04530  Tight junction
pleu04612  Antigen processing and presentation
pleu04620  Toll-like receptor signaling pathway
pleu04630  JAK-STAT signaling pathway
KO pathway
ko05165   

DBGET integrated database retrieval system