KEGG   PATHWAY: bbis04062
Entry
bbis04062                   Pathway                                
Name
Chemokine signaling pathway - Bison bison bison (American bison)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
bbis04062  Chemokine signaling pathway
bbis04062

Other DBs
GO: 0070098
Organism
Bison bison bison (American bison) [GN:bbis]
Gene
104979739  VAV1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
104979758  CCL25; C-C motif chemokine 25 [KO:K13072]
104980049  PXN; paxillin isoform X1 [KO:K05760]
104980103  ADRBK2; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
104980280  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
104980414  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
104980465  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
104980493  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
104981087  CDC42; cell division control protein 42 homolog [KO:K04393]
104981176  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
104981377  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
104981582  NRAS; GTPase NRas [KO:K07828]
104981626  RAP1A; ras-related protein Rap-1A [KO:K04353]
104981671  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
104981704  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
104981904  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
104982045  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
104982198  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
104982909  CRKL; crk-like protein [KO:K04438]
104983330  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
104983352  CCL28; C-C motif chemokine 28 isoform X1 [KO:K05513]
104984484  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
104984486  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
104984593  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
104984678  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
104984862  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104985110  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
104985138  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
104985237  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
104985349  CCR8; C-C chemokine receptor type 8 [KO:K04183]
104985357  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
104985394  CCR4; C-C chemokine receptor type 4 isoform X1 [KO:K04179]
104986217  [KO:K05507]
104986245  [KO:K04456] [EC:2.7.11.1]
104986263  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
104986444  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
104986704  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
104986737  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104986748  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
104987029  RELA; transcription factor p65 [KO:K04735]
104987070  ADRBK1; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
104987131  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
104987189  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
104987190  BAD; LOW QUALITY PROTEIN: bcl2-associated agonist of cell death [KO:K02158]
104987195  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
104987292  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
104987293  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
104987295  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
104987311  [KO:K05505]
104987314  [KO:K10030]
104987316  [KO:K05407]
104987317  PPBP; platelet basic protein [KO:K10029]
104987318  CXCL5; C-X-C motif chemokine 5 [KO:K05506]
104987320  [KO:K10030]
104987339  [KO:K05505]
104987398  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
104987424  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
104987876  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
104988072  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
104988263  SHC4; SHC-transforming protein 4 [KO:K17449]
104988445  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
104988446  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
104988679  CCL21; C-C motif chemokine 21 [KO:K16062]
104988681  CCL19; C-C motif chemokine 19 isoform X1 [KO:K05512]
104988684  CCL27; C-C motif chemokine 27 [KO:K16598]
104988719  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
104988909  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
104989034  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
104989637  [KO:K04456] [EC:2.7.11.1]
104989700  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
104989774  RAP1B; ras-related protein Rap-1b [KO:K07836]
104989906  HCK; tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
104990266  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
104990277  SOS2; son of sevenless homolog 2 [KO:K03099]
104990431  CCR10; C-C chemokine receptor type 10 [KO:K04185]
104990441  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
104990505  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
104990595  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
104990727  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
104990788  [KO:K11224]
104990883  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
104991180  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
104991251  CCR6; C-C chemokine receptor type 6 [KO:K04181]
104991731  ADCY8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
104991843  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
104991966  SHC2; SHC-transforming protein 2 [KO:K17447]
104992086  SHC3; SHC-transforming protein 3 [KO:K17448]
104992176  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
104992475  [KO:K04176]
104992483  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104992684  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
104992716  [KO:K02649]
104992794  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104992893  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
104993223  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
104993333  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
104993955  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
104994107  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
104994333  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104994417  GRK4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
104994462  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
104994506  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
104994637  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
104995325  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
104995356  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104995620  [KO:K04371] [EC:2.7.11.24]
104995923  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
104995929  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
104996058  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104996170  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104996481  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
104996518  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
104996774  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
104997117  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
104997186  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
104997209  RHOA; transforming protein RhoA [KO:K04513]
104997365  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
104997725  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
104998177  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104998445  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104998489  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104998683  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
104998917  CCL26; C-C motif chemokine 26 [KO:K21096]
104998918  CCL24; C-C motif chemokine 24 [KO:K21097]
104998946  NCF1; neutrophil cytosol factor 1 [KO:K08011]
104999066  CXCL12; stromal cell-derived factor 1 [KO:K10031]
104999107  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
104999381  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
104999563  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
104999721  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
104999859  [KO:K04347]
104999887  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
104999941  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
104999978  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104999981  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
105000225  KRAS; GTPase KRas isoform X1 [KO:K07827]
105000345  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105000595  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105000706  FOXO3; forkhead box protein O3 [KO:K09408]
105001032  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105001683  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105001778  GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
105001799  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105002565  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
105002719  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105002984  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
105003123  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105003252  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105003360  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105003447  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105003509  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105003595  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
105003597  [KO:K04456] [EC:2.7.11.1]
105003692  HRAS; GTPase HRas [KO:K02833]
105003756  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
105003757  [KO:K04175]
105003906  CRK; adapter molecule crk [KO:K04438]
105003994  [KO:K14624]
105003995  [KO:K16597]
105003997  [KO:K16596]
105004018  CCL5; C-C motif chemokine 5 [KO:K12499]
105004019  CCL16; C-C motif chemokine 16 [KO:K21093]
105004020  CCL14; C-C motif chemokine 14 [KO:K21092]
105004022  [KO:K05511]
105004026  [KO:K05408]
105004028  [KO:K05408]
105004029  [KO:K12964]
105004031  [KO:K05408]
105004304  CCL17; C-C motif chemokine 17 [KO:K21083]
105004306  CX3CL1; fractalkine isoform X1 [KO:K05508]
105004307  CCL22; C-C motif chemokine 22 [KO:K21095]
105004638  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
105004701  CCR3; C-C chemokine receptor type 3 [KO:K04178]
105004703  CCR2; C-C chemokine receptor type 2 [KO:K04177]
105004704  CCR5; C-C chemokine receptor type 5 [KO:K04180]
105004705  CCR1; C-C chemokine receptor type 1 [KO:K04176]
105004706  XCR1; chemokine XC receptor 1 [KO:K04193]
105004708  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
105004710  CCR9; C-C chemokine receptor type 9 [KO:K04184]
105004742  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
105005375  [KO:K04542]
105005584  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
bbis04010  MAPK signaling pathway
bbis04060  Cytokine-cytokine receptor interaction
bbis04120  Ubiquitin mediated proteolysis
bbis04630  JAK-STAT signaling pathway
bbis04670  Leukocyte transendothelial migration
bbis04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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