KEGG   PATHWAY: bta05167
Entry
bta05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Bos taurus (cow)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
bta05167  Kaposi sarcoma-associated herpesvirus infection
bta05167

Disease
H00041  Kaposi sarcoma
Organism
Bos taurus (cow) [GN:bta]
Gene
100125276  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
100125591  IRF7; interferon regulatory factor 7 [KO:K09447]
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100139219  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100140945  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100297344  CALM2; calmodulin-2 [KO:K02183]
100297496  CLEC2B; C-type lectin domain family 2 member B isoform X1 [KO:K10071]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100329204  IFNAD; interferon alpha-D [KO:K05414]
100329206  IFNAG; interferon alpha-G precursor [KO:K05414]
100329207  IFNAH; interferon alpha-H precursor [KO:K05414]
100329210  INFAF; interferon alpha-F precursor [KO:K05414]
100335490  [KO:K05414]
100335828  CD200R1L; cell surface glycoprotein CD200 receptor 2 isoform X2 [KO:K21668]
100337091  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100847184  [KO:K02833]
100847304  [KO:K08738]
100847700  [KO:K08738]
100847722  BECN2; beclin-2 [KO:K08334]
100848709  [KO:K05415]
101905399  [KO:K04368] [EC:2.7.12.2]
104968964  [KO:K04542]
104973792  [KO:K02183]
112441471  [KO:K05415]
112441480  [KO:K05415]
112443864  [KO:K07985]
112446776  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
112447733  [KO:K08738]
112447877  [KO:K05415]
112447878  [KO:K05415]
112447879  [KO:K05415]
112447880  [KO:K05415]
132344841  [KO:K02977]
132345931  [KO:K05414]
280677  C3; complement C3 preproprotein [KO:K03990]
280730  BAX; apoptosis regulator BAX [KO:K02159]
280795  FOS; protein c-Fos [KO:K04379]
280814  HCK; tyrosine-protein kinase HCK isoform 2 [KO:K08893] [EC:2.7.10.2]
280826  IL6; interleukin-6 precursor [KO:K05405]
280828  CXCL8; interleukin-8 precursor [KO:K10030]
280831  JUN; transcription factor Jun [KO:K04448]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
281073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
281095  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
281161  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
281201  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
281202  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
281203  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
281204  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
281212  GRO1; growth-regulated protein homolog alpha precursor [KO:K05505]
281214  CXCL2; growth-regulated protein homolog gamma precursor [KO:K05505]
281236  IFNAC; interferon alpha-C precursor [KO:K05414]
281370  UBB; polyubiquitin-B [KO:K08770]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
281535  TLR3; toll-like receptor 3 precursor [KO:K05401]
281542  TP53; cellular tumor antigen p53 [KO:K04451]
281572  VEGFA; vascular endothelial growth factor A isoform 3 precursor [KO:K05448]
281713  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
281796  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
281797  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
281814  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
281839  ICAM1; intercellular adhesion molecule 1 precursor [KO:K06490]
281845  IFNB1; interferon beta precursor [KO:K05415]
281854  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
281855  IKBKG; NF-kappa-B essential modulator [KO:K07210]
281878  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
281879  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
281987  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
282023  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
282127  ZFP36; tristetraprolin [KO:K15308]
282141  ANGPT2; angiopoietin-2 precursor [KO:K05466]
282257  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
282258  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
282291  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
282306  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
282307  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
282308  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
282321  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
282488  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
282527  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
286839  RPS27A; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
286850  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
286852  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
286865  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
286883  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
287018  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
317697  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
326597  CALM; calmodulin [KO:K02183]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
347700  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
407173  JSP.1; MHC Class I JSP.1 precursor [KO:K06751]
407771  CCR1; C-C chemokine receptor type 1 [KO:K04176]
407772  CCR8; C-C chemokine receptor type 8 [KO:K04183]
408001  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
408016  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
408018  CCR3; C-C chemokine receptor type 3 [KO:K04178]
408019  CCR4; C-C chemokine receptor type 4 [KO:K04179]
414345  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
444874  UBC; polyubiquitin-C [KO:K08770]
493720  FADD; FAS-associated death domain protein [KO:K02373]
497017  CCR5; C-C chemokine receptor type 5 [KO:K04180]
504531  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
504707  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
505453  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
506182  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
506322  NRAS; GTPase NRas [KO:K07828]
507432  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
507481  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
507917  [KO:K06751]
508233  RELA; transcription factor p65 [KO:K04735]
508541  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
508571  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
508619  IFNGR1; interferon gamma receptor 1 precursor [KO:K05132]
509855  IRF9; interferon regulatory factor 9 [KO:K04693]
510373  BID; BH3-interacting domain death agonist [KO:K04726]
510417  BOLA-NC1; non-classical MHC class I antigen precursor [KO:K06751]
510427  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
510434  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
510618  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
510726  IFNA16; interferon alpha-H [KO:K05414]
510767  CYCS; cytochrome c [KO:K08738]
510814  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
511023  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
511077  MYC; myc proto-oncogene protein [KO:K04377]
511224  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
511754  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
511812  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
512355  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
512484  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
512672  [KO:K06751]
512943  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
513340  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
513497  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
514090  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
514547  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
515303  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
515515  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
515621  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
515712  BOLA; MHC class I heavy chain isoform 1 precursor [KO:K06751]
515951  IFNAA; interferon alpha-A precursor [KO:K05414]
516008  CD200R1L; cell surface glycoprotein CD200 receptor 1 precursor [KO:K21668]
516979  IRF3; interferon regulatory factor 3 [KO:K05411]
517006  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
517016  [KO:K05415]
517108  [KO:K05414]
517948  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
520277  CALM3; calmodulin-3 [KO:K02183]
520404  CALML5; calmodulin-like protein 5 [KO:K02183]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
522155  IL6ST; interleukin-6 receptor subunit beta isoform X2 [KO:K05060]
523244  [KO:K05414]
524530  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
525246  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
525550  [KO:K05415]
525962  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
526469  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
527278  BECN1; beclin-1 [KO:K08334]
527410  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein isoform X1 [KO:K12365]
529196  [KO:K04176]
529425  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
530001  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
530401  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
533050  BoLA; major histocompatibility complex, class I, A precursor [KO:K06751]
533051  MIC1; major histocompatibility class I related protein precursor [KO:K07985]
533141  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
533216  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
533527  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
534492  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
534712  RB1; retinoblastoma-associated protein [KO:K06618]
534815  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
534996  LYN; tyrosine-protein kinase Lyn [KO:K05854] [EC:2.7.10.2]
535327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
535365  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
535369  E2F1; transcription factor E2F1 [KO:K17454]
535399  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
535742  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
537201  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
538831  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
539003  CTNNB1; catenin beta-1 [KO:K02105]
539277  CALML4; calmodulin-like protein 4 [KO:K02183]
539640  RCAN1; calcipressin-1 [KO:K17901]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
540106  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
540481  TCF7L2; transcription factor 7-like 2 [KO:K04491]
541127  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
541140  KRAS; GTPase KRas [KO:K07827]
541184  E2F3; transcription factor E2F3 [KO:K06620]
613667  CXCL3; chemokine (C-X-C motif) ligand 3 precursor [KO:K05505]
613930  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
614838  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X3 [KO:K21290]
615199  UBA52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
616942  [KO:K06751]
616977  [KO:K05415]
617024  E2F2; transcription factor E2F2 isoform X2 [KO:K09389]
617095  CALM1; calmodulin-1 [KO:K02183]
617412  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
617556  [KO:K05414]
617585  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
618399  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
618470  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
618906  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
618946  IFNB3; interferon beta-3 precursor [KO:K05415]
618947  [KO:K05414]
767904  MGC126945; LOW QUALITY PROTEIN: uncharacterized protein LOC767904 [KO:K06751]
781996  CYCT; cytochrome c 2 [KO:K08738]
782690  TCF7; transcription factor 7 [KO:K02620]
783912  [KO:K05414]
784525  [KO:K05415]
784843  [KO:K02927]
787278  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
787343  [KO:K05414]
788091  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
788119  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
790867  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
790875  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
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J Virol 74:5300-9 (2000)
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Related
pathway
bta04010  MAPK signaling pathway
bta04064  NF-kappa B signaling pathway
bta04110  Cell cycle
bta04115  p53 signaling pathway
bta04140  Autophagy - animal
bta04144  Endocytosis
bta04151  PI3K-Akt signaling pathway
bta04210  Apoptosis
bta04310  Wnt signaling pathway
bta04610  Complement and coagulation cascades
bta04620  Toll-like receptor signaling pathway
bta04630  JAK-STAT signaling pathway
bta04650  Natural killer cell mediated cytotoxicity
bta04668  TNF signaling pathway
KO pathway
ko05167   

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