KEGG   PATHWAY: dle05022
Entry
dle05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Delphinapterus leucas (beluga whale)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
dle05022  Pathways of neurodegeneration - multiple diseases
dle05022

Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
111162636  [KO:K02266]
111162721  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
111162788  NEFH; neurofilament heavy polypeptide [KO:K04574]
111162798  [KO:K00419]
111162874  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
111162905  UBE2L3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
111162930  [KO:K02272]
111162959  [KO:K07374]
111162961  SEPTIN5; septin-5 isoform X1 [KO:K04557]
111163019  TUBB6; tubulin beta-6 chain [KO:K07375]
111163022  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
111163074  [KO:K07374]
111163102  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
111163109  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
111163115  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
111163116  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
111163140  C9orf72; guanine nucleotide exchange C9orf72 homolog isoform X1 [KO:K23609]
111163197  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
111163319  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
111163436  PINK1; serine/threonine-protein kinase PINK1, mitochondrial isoform X1 [KO:K05688] [EC:2.7.11.1]
111163530  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
111163688  UBE2J1; ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
111163814  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
111163853  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
111163908  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
111163910  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
111164113  [KO:K03957]
111164181  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
111164367  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
111164373  DERL1; derlin-1 [KO:K11519]
111164526  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
111164612  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
111164777  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
111164871  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
111164902  HTT; huntingtin isoform X2 [KO:K04533]
111165123  [KO:K00413]
111165265  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
111165308  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
111165456  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
111165539  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
111165552  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
111165554  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
111165617  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111165622  PRNP; major prion protein [KO:K05634]
111165653  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
111165862  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
111165889  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
111165994  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
111166011  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111166070  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
111166115  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
111166133  [KO:K00420]
111166137  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
111166150  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
111166314  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
111166341  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
111166353  BECN1; beclin-1 isoform X1 [KO:K08334]
111166412  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
111166424  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
111166580  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
111166597  RAB8A; ras-related protein Rab-8A [KO:K07901]
111166602  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
111166656  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
111166689  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
111166859  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
111166971  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
111166990  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
111167070  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
111167564  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
111167604  NRBF2; nuclear receptor-binding factor 2 [KO:K21246]
111167700  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
111167760  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
111167764  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
111168040  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111168047  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
111168108  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111168155  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
111168206  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
111168252  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
111168263  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
111168340  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
111168438  [KO:K00432] [EC:1.11.1.9]
111168440  GPX6; LOW QUALITY PROTEIN: glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
111168498  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1 [KO:K04556] [EC:2.3.2.31]
111168714  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
111168811  WNT7A; protein Wnt-7a [KO:K00572]
111168836  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
111168878  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
111168973  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111169035  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111169056  [KO:K05864] [EC:5.2.1.8]
111169059  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
111169079  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
111169129  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
111169258  SQSTM1; sequestosome-1 [KO:K14381]
111169265  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111169279  WNT9A; protein Wnt-9a [KO:K01064]
111169289  WNT3A; protein Wnt-3a [KO:K00312]
111169438  CTNNB1; catenin beta-1 [KO:K02105]
111169490  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
111169718  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
111169730  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
111169895  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111170121  [KO:K07374]
111170127  [KO:K02183]
111170218  FZD2; frizzled-2 [KO:K02235]
111170265  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111170282  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
111170285  [KO:K02273]
111170307  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
111170340  HRAS; GTPase HRas isoform X1 [KO:K02833]
111170348  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
111170425  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
111170450  [KO:K21421] [EC:1.-.-.-]
111170487  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
111170519  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
111170529  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
111170657  TNF; tumor necrosis factor [KO:K03156]
111170669  TUBB; tubulin beta chain [KO:K07375]
111170713  [KO:K03115]
111170751  RAB39B; ras-related protein Rab-39B [KO:K07925]
111170779  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
111170925  [KO:K17603]
111170949  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
111171485  DKK2; dickkopf-related protein 2 [KO:K02165]
111171524  [KO:K02271]
111171679  DNAH7; dynein heavy chain 7, axonemal [KO:K10408]
111171723  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
111171726  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
111171735  ALS2; alsin isoform X1 [KO:K04575]
111171737  FZD7; frizzled-7 [KO:K02432]
111171760  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
111171775  FZD5; frizzled-5 [KO:K02375]
111171848  [KO:K07374]
111171851  [KO:K07374]
111171923  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
111171993  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
111172029  [KO:K02273]
111172090  WNT6; protein Wnt-6 [KO:K00445]
111172091  WNT10A; protein Wnt-10a [KO:K01357]
111172168  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
111172296  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
111172361  ACTR1A; alpha-centractin [KO:K16575]
111172389  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
111172443  FRAT1; proto-oncogene FRAT1 [KO:K03069]
111172445  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
111172449  [KO:K03943] [EC:7.1.1.2]
111172519  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
111172540  DKK1; dickkopf-related protein 1 [KO:K02165]
111172662  WNT8B; protein Wnt-8b [KO:K00714]
111172744  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
111172792  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
111172793  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
111172892  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
111172911  [KO:K08738]
111173047  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
111173062  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
111173114  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
111173116  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
111173130  ATG14; beclin 1-associated autophagy-related key regulator isoform X2 [KO:K17889]
111173152  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
111173226  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
111173238  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
111173388  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
111173401  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
111173410  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
111173475  DCTN6; dynactin subunit 6 [KO:K10428]
111173555  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
111173590  DKK4; dickkopf-related protein 4 [KO:K02165]
111173600  [KO:K00237]
111173776  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
111173795  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
111173809  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
111173834  KIF5A; kinesin heavy chain isoform X2 [KO:K10396] [EC:5.6.1.3]
111173835  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
111173840  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
111173848  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
111173862  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
111173931  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
111173965  [KO:K02268]
111173978  ATG101; autophagy-related protein 101 [KO:K19730]
111174031  [KO:K08738]
111174048  PRPH; peripherin isoform X1 [KO:K07607]
111174050  [KO:K07374]
111174051  [KO:K07374]
111174052  [KO:K07374]
111174054  WNT10B; protein Wnt-10b [KO:K01357]
111174055  WNT1; proto-oncogene Wnt-1 [KO:K03209]
111174109  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 [KO:K08844] [EC:2.7.11.1]
111174169  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111174197  [KO:K08738]
111174220  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
111174254  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
111174269  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
111174277  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
111174313  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
111174382  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
111174397  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
111174428  [KO:K00414]
111174571  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
111174575  [KO:K08738]
111174611  APP; amyloid-beta precursor protein isoform X1 [KO:K04520]
111174794  CALM2; calmodulin-2 [KO:K02183]
111174833  [KO:K02270]
111174841  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
111175110  [KO:K21246]
111175568  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
111175599  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
111175620  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
111175766  [KO:K00416]
111175818  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
111175930  [KO:K08738]
111175937  [KO:K03960]
111175981  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
111176031  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
111176104  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
111176151  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
111176162  CALM1; calmodulin-1 [KO:K02183]
111176166  PSMC1; 26S proteasome regulatory subunit 4 isoform X1 [KO:K03062]
111176274  DNAL1; dynein light chain 1, axonemal [KO:K10411]
111176287  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
111176290  ZFYVE1; zinc finger FYVE domain-containing protein 1 [KO:K17603]
111176582  TUBA8; tubulin alpha-8 chain isoform X2 [KO:K07374]
111176583  [KO:K07374]
111176587  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
111176594  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
111176602  WNT5B; protein Wnt-5b [KO:K00444]
111176645  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
111176656  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111176773  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
111176787  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
111176821  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
111176851  KRAS; GTPase KRas [KO:K07827]
111176861  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111176963  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
111176980  TUBB4B; tubulin beta-4B chain [KO:K07375]
111176991  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
111177009  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
111177217  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
111177231  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
111177253  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
111177424  BECN2; beclin-2 [KO:K08334]
111177426  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
111177507  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
111177533  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
111177653  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111177666  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
111177745  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111177758  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
111177826  [KO:K02264]
111177869  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
111177885  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
111177938  FZD8; frizzled-8 [KO:K02375]
111177953  [KO:K02268]
111177988  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
111178019  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
111178074  OPTN; optineurin isoform X1 [KO:K19946]
111178120  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
111178244  NOX1; LOW QUALITY PROTEIN: NADPH oxidase 1 [KO:K08008]
111178277  [KO:K02271]
111178333  [KO:K02135]
111178524  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
111178539  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
111178547  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
111178574  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
111178680  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
111178690  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
111178692  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
111178736  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111178738  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
111178771  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
111178841  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
111178896  GPR37; prosaposin receptor GPR37 [KO:K04243]
111178932  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
111179014  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
111179019  PPID; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
111179065  SNCA; alpha-synuclein [KO:K04528]
111179093  WNT16; protein Wnt-16 [KO:K01558]
111179107  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111179110  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111179238  WNT2; protein Wnt-2 [KO:K00182]
111179417  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
111179428  [KO:K02263]
111179556  ATXN1L; ataxin-1-like [KO:K23616]
111179575  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
111179686  [KO:K07375]
111179785  CAT; catalase [KO:K03781] [EC:1.11.1.6]
111179820  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
111179996  NRAS; GTPase NRas [KO:K07828]
111180026  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
111180038  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
111180064  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
111180078  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
111180199  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
111180361  FZD6; frizzled-6 [KO:K02376]
111180389  [KO:K02268]
111180406  [KO:K00417]
111180543  [KO:K08738]
111180640  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
111180666  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
111180711  CALM3; calmodulin-3 [KO:K02183]
111180740  FZD1; frizzled-1 [KO:K02432]
111180743  KLC3; kinesin light chain 3 [KO:K10407]
111180759  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
111180858  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
111180860  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
111180892  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
111180900  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
111180964  [KO:K00411] [EC:7.1.1.8]
111180981  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
111180991  [KO:K02267]
111181038  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
111181212  [KO:K02270]
111181221  [KO:K03958]
111181225  [KO:K02267]
111181308  TUBB2A; tubulin beta-2A chain [KO:K07375]
111181312  [KO:K07375]
111181329  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
111181386  ATXN1; ataxin-1 [KO:K23616]
111181484  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
111181538  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
111181590  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
111181649  SPG11; spatacsin isoform X1 [KO:K19026]
111181753  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
111181786  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
111181886  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111181978  IL6; interleukin-6 [KO:K05405]
111182027  HIP1; huntingtin-interacting protein 1 isoform X1 [KO:K04559]
111182042  STX1A; syntaxin-1A isoform X1 [KO:K04560]
111182105  [KO:K02266]
111182109  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
111182181  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111182193  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
111182199  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
111182232  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111182238  DCTN5; dynactin subunit 5 [KO:K10427]
111182239  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
111182267  [KO:K00415]
111182272  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
111182319  FZD9; frizzled-9 [KO:K02842]
111182360  SNCAIP; synphilin-1 isoform X1 [KO:K04558]
111182430  [KO:K00418]
111182441  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
111182541  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
111182565  WNT8A; protein Wnt-8a [KO:K00714]
111182576  WNT3; proto-oncogene Wnt-3 [KO:K00312]
111182582  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
111182584  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
111182616  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
111182623  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
111182644  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
111182750  [KO:K10408]
111182751  [KO:K10408]
111182847  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
111182859  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
111182897  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111182905  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
111182912  AXIN2; axin-2 isoform X1 [KO:K04385]
111182917  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111182925  WNT9B; protein Wnt-9b [KO:K01064]
111182969  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
111183077  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
111183091  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
111183100  DCTN4; dynactin subunit 4 [KO:K10426]
111183108  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
111183125  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
111183230  [KO:K02270]
111183499  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
111183521  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111183530  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
111183542  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
111183554  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
111183629  FADD; FAS-associated death domain protein [KO:K02373]
111183639  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
111183646  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
111183653  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
111183658  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
111183696  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
111183700  CCS; copper chaperone for superoxide dismutase [KO:K04569]
111183714  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
111183745  RELA; transcription factor p65 isoform X1 [KO:K04735]
111183768  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
111183789  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
111183810  BAD; bcl2-associated agonist of cell death [KO:K02158]
111183812  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
111183826  [KO:K02273]
111183839  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
111183938  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
111183956  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
111183961  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
111183977  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
111183981  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
111184170  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
111184255  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
111184326  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
111184329  [KO:K02263]
111184343  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
111184364  PDYN; proenkephalin-B [KO:K15840]
111184500  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
111184516  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
111184673  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
111184814  WNT11; protein Wnt-11 [KO:K01384]
111184910  [KO:K03968]
111184951  FZD4; frizzled-4 [KO:K02354]
111184956  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
111184959  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
111185093  AXIN1; axin-1 isoform X1 [KO:K02157]
111185160  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
111185164  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
111185246  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
111185390  FZD3; frizzled-3 [KO:K02329]
111185425  NEFL; neurofilament light polypeptide [KO:K04572]
111185426  NEFM; neurofilament medium polypeptide [KO:K04573]
111185661  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
111185662  DLG4; disks large homolog 4 isoform X1 [KO:K11828]
111185664  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X4 [KO:K02353]
111185761  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
111185796  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
111185804  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
111185881  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
111185895  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
111185965  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
111185989  [KO:K13241] [EC:1.14.13.39]
111186068  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
111186116  TRPC3; short transient receptor potential channel 3 isoform X2 [KO:K04966]
111186169  IFT57; intraflagellar transport protein 57 homolog isoform X1 [KO:K04638]
111186212  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
111186230  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
111186244  [KO:K08960] [EC:2.7.11.1]
111186252  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
111186361  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
111186364  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111186395  DNAL4; dynein light chain 4, axonemal isoform X1 [KO:K10412]
111186418  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
111186557  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
111186598  RAB1A; ras-related protein Rab-1A [KO:K07874]
111186607  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
111186656  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
111186724  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
111186725  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
111186772  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
111186806  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
111186817  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
111186827  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
111186839  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
111186871  ATXN2; ataxin-2 isoform X2 [KO:K23625]
111186887  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
111186914  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
111186930  UBC; polyubiquitin-C [KO:K04551]
111186931  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
111186950  FZD10; frizzled-10 [KO:K02842]
111187038  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
111187099  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
111187104  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
111187116  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
111187117  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
111187122  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
111187123  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
111187180  PARK7; protein/nucleic acid deglycase DJ-1 [KO:K05687] [EC:3.5.1.124]
111187200  CALML6; calmodulin-like protein 6 [KO:K02183]
111187265  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
111187362  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
111187469  ACTR1B; beta-centractin [KO:K16575]
111187492  IL1B; interleukin-1 beta [KO:K04519]
111187501  IL1A; interleukin-1 alpha [KO:K04383]
111187511  [KO:K02265]
111187821  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
111187864  [KO:K15041]
111188117  VCP; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
111188120  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
31412977  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
31412980  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
31412985  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
31412987  COX2; cytochrome c oxidase subunit II [KO:K02261]
31412988  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
31412989  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
31412990  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
31412993  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
31412994  CYTB; cytochrome b [KO:K00412]
31413000  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
31413001  COX3; cytochrome c oxidase subunit III [KO:K02262]
31413004  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
31413006  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Converging pathways in neurodegeneration, from genetics to mechanisms.
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Reference
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Front Mol Neurosci 7:70 (2014)
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Mol Brain 12:100 (2019)
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Reference
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Metaxakis A, Ploumi C, Tavernarakis N
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Autophagy in Age-Associated Neurodegeneration.
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Cells 7:E37 (2018)
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Targeting autophagy in neurodegenerative diseases.
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Trends Pharmacol Sci 35:583-91 (2014)
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Chu CT
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Related
pathway
dle00190  Oxidative phosphorylation
dle03050  Proteasome
dle04020  Calcium signaling pathway
dle04120  Ubiquitin mediated proteolysis
dle04137  Mitophagy - animal
dle04140  Autophagy - animal
dle04141  Protein processing in endoplasmic reticulum
dle04142  Lysosome
dle04210  Apoptosis
dle04310  Wnt signaling pathway
dle04724  Glutamatergic synapse
dle04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   

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