KEGG   PATHWAY: mcc05162
Entry
mcc05162                    Pathway                                
Name
Measles - Macaca mulatta (rhesus monkey)
Description
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. MV infection is characterized by virus-induced immune suppression that can lead to increased susceptibility to secondary bacterial and viral infections. The P, V and C proteins act as virulence factors to suppress innate immune response in host by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. Moreover,  H protein expressed on viral particles and binding to SLAM or CD46,  as well as N protein liberated from infected cells and interacting with Fc-gamma R, causes an inhibition of IL-12 synthesis in dendritic cells. IL-12 is a key cytokine inducing cellular immune responses to protect host from the harm caused by pathogenic infections.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcc05162  Measles
mcc05162

Disease
H00394  Measles
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100425223  CYCS; cytochrome c [KO:K08738]
100426724  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
100428309  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
106992322  [KO:K05414]
106995399  [KO:K08738]
106995851  IFNA6; interferon alpha-6 [KO:K05414]
114669853  [KO:K11218] [EC:2.7.10.2]
114669856  [KO:K03283]
114672663  [KO:K05414]
114672664  [KO:K05414]
114675515  [KO:K14021]
574128  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
574129  STAT5A; signal transducer and activator of transcription 5A isoform 2 [KO:K11223]
574130  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
574159  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
574211  CD209; CD209 antigen isoform 1 [KO:K06563]
574290  TLR2; toll-like receptor 2 precursor [KO:K10159]
574291  TLR7; toll-like receptor 7 [KO:K05404]
574300  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
574320  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
574332  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
574360  TLR4; toll-like receptor 4 precursor [KO:K10160]
574373  CD209L2; CD209 antigen-like protein 2 [KO:K06563]
574395  TLR9; toll-like receptor 9 precursor [KO:K10161]
641338  IL2RG; cytokine receptor common subunit gamma precursor [KO:K05070]
677689  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
693650  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
693961  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
694164  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
694544  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
694631  [KO:K05414]
694747  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
694844  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
695164  TP73; tumor protein p73 isoform X1 [KO:K10148]
695215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
695335  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
695607  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
696306  [KO:K10785]
696331  IL2RB; interleukin-2 receptor subunit beta precursor [KO:K05069]
696494  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
696875  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
697188  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697904  [KO:K10785]
698014  RAB9B; ras-related protein Rab-9B [KO:K07900]
698160  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
698225  [KO:K08738]
698785  [KO:K10785]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
699467  CD3E; T-cell surface glycoprotein CD3 epsilon chain isoform X1 [KO:K06451]
699575  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
699578  IRF7; interferon regulatory factor 7 [KO:K09447]
699582  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
699604  IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130]
699726  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
699736  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
699919  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
699951  [KO:K08738]
700193  IL1A; interleukin-1 alpha precursor [KO:K04383]
700382  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
700517  EIF3H; eukaryotic translation initiation factor 3 subunit H isoform X1 [KO:K03247]
700568  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
700589  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
701246  [KO:K08738]
701580  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
701822  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
702024  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:3.6.4.13]
702077  FOS; proto-oncogene c-Fos [KO:K04379]
702488  [KO:K08738]
702781  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
703029  [KO:K10785]
703101  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
703205  IL12A; interleukin-12 subunit alpha [KO:K05406]
703325  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
703879  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
704130  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
704638  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:3.6.4.13]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
704701  IL1B; interleukin-1 beta precursor [KO:K04519]
705270  CD3G; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452]
705313  CD28; T-cell-specific surface glycoprotein CD28 precursor [KO:K06470]
705449  [KO:K08738]
705819  IL6; interleukin-6 precursor [KO:K05405]
706534  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707407  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
707989  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
708017  IL2; interleukin-2 precursor [KO:K05429]
708526  RACK1; receptor of activated protein C kinase 1 [KO:K14753]
708606  FADD; FAS-associated death domain protein [KO:K02373]
708912  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
709412  [KO:K03283]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
709559  IFNA13; interferon alpha-1/13 precursor [KO:K05414]
709755  IFNA8; interferon alpha-8 [KO:K05414]
709760  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
709948  IFNA2; interferon alpha-2 precursor [KO:K05414]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710149  [KO:K10784]
710150  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
710487  [KO:K05414]
710528  [KO:K05414]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710568  [KO:K05414]
710654  IFNA10; interferon alpha-4 precursor [KO:K05414]
710751  [KO:K05414]
710848  [KO:K05414]
711002  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
711088  [KO:K05414]
711115  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
711252  IFNA21; interferon alpha-21 [KO:K05414]
711309  [KO:K08738]
711414  IFNB1; interferon beta precursor [KO:K05415]
711712  MSN; moesin [KO:K05763]
712148  [KO:K08738]
712265  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
712342  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
712401  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
712455  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
712694  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
713035  BCL2L1; bcl-2-like protein 1 [KO:K04570]
713114  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
714082  CD46; membrane cofactor protein precursor [KO:K04007]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
714841  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
715186  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
715335  IRF9; interferon regulatory factor 9 [KO:K04693]
715650  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
715782  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
715807  CSNK2B; casein kinase II subunit beta [KO:K03115]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
716056  [KO:K08738]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
716452  JUN; transcription factor AP-1 [KO:K04448]
716633  [KO:K03283]
716907  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
717427  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
717616  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
717740  BAD; bcl2-associated agonist of cell death [KO:K02158]
717955  BBC3; bcl-2-binding component 3 [KO:K10132]
718759  ADAR; double-stranded RNA-specific adenosine deaminase isoform X5 [KO:K12968] [EC:3.5.4.37]
718948  BAX; apoptosis regulator BAX [KO:K02159]
718970  IRF3; interferon regulatory factor 3 [KO:K05411]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
719747  SLAMF1; signaling lymphocytic activation molecule [KO:K06536]
720001  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
720009  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor [KO:K12560]
720040  JAK3; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
720054  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
720906  RAB9A; ras-related protein Rab-9A [KO:K07899]
780935  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:19203113
  Authors
Schneider-Schaulies S, Schneider-Schaulies J
  Title
Measles virus-induced immunosuppression.
  Journal
Curr Top Microbiol Immunol 330:243-69 (2009)
DOI:10.1007/978-3-540-70617-5_12
Reference
PMID:19203114
  Authors
Hahm B
  Title
Hostile communication of measles virus with host innate immunity and dendritic cells.
  Journal
Curr Top Microbiol Immunol 330:271-87 (2009)
DOI:10.1007/978-3-540-70617-5_13
Reference
PMID:19198566
  Authors
Gerlier D, Valentin H
  Title
Measles virus interaction with host cells and impact on innate immunity.
  Journal
Curr Top Microbiol Immunol 329:163-91 (2009)
DOI:10.1007/978-3-540-70523-9_8
Reference
PMID:16690907
  Authors
Schneider-Schaulies S, Dittmer U
  Title
Silencing T cells or T-cell silencing: concepts in virus-induced immunosuppression.
  Journal
J Gen Virol 87:1423-38 (2006)
DOI:10.1099/vir.0.81713-0
Reference
PMID:22049305
  Authors
Avota E, Gassert E, Schneider-Schaulies S
  Title
Cytoskeletal dynamics: concepts in measles virus replication and immunomodulation.
  Journal
Viruses 3:102-17 (2011)
DOI:10.3390/v3020102
Reference
PMID:27854326
  Authors
Jiang Y, Qin Y, Chen M
  Title
Host-Pathogen Interactions in Measles Virus Replication and Anti-Viral Immunity.
  Journal
Viruses 8:E308 (2016)
DOI:10.3390/v8110308
Reference
PMID:18922877
  Authors
Pfaller CK, Conzelmann KK
  Title
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
  Journal
J Virol 82:12365-73 (2008)
DOI:10.1128/JVI.01321-08
Reference
PMID:17720800
  Authors
Yokota S, Okabayashi T, Yokosawa N, Fujii N
  Title
Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20.
  Journal
FASEB J 22:74-83 (2008)
DOI:10.1096/fj.07-8976com
Reference
PMID:23146309
  Authors
Delpeut S, Noyce RS, Siu RW, Richardson CD
  Title
Host factors and measles virus replication.
  Journal
Curr Opin Virol 2:773-83 (2012)
DOI:10.1016/j.coviro.2012.10.008
Reference
PMID:26878224
  Authors
Shah M, Anwar MA, Kim JH, Choi S
  Title
Advances in Antiviral Therapies Targeting Toll-like Receptors.
  Journal
Expert Opin Investig Drugs 25:437-53 (2016)
DOI:10.1517/13543784.2016.1154040
Reference
PMID:12620806
  Authors
Yokota S, Saito H, Kubota T, Yokosawa N, Amano K, Fujii N
  Title
Measles virus suppresses interferon-alpha signaling pathway: suppression of Jak1 phosphorylation and association of viral accessory proteins, C and V, with interferon-alpha receptor complex.
  Journal
Virology 306:135-46 (2003)
DOI:10.1016/S0042-6822(02)00026-0
Reference
PMID:12804771
  Authors
Takeuchi K, Kadota SI, Takeda M, Miyajima N, Nagata K
  Title
Measles virus V protein blocks interferon (IFN)-alpha/beta but not IFN-gamma signaling by inhibiting STAT1 and STAT2 phosphorylation.
  Journal
FEBS Lett 545:177-82 (2003)
DOI:10.1016/S0014-5793(03)00528-3
Reference
PMID:12805463
  Authors
Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM
  Title
STAT protein interference and suppression of cytokine signal transduction by measles virus V protein.
  Journal
J Virol 77:7635-44 (2003)
DOI:10.1128/JVI.77.13.7635-7644.2003
Reference
PMID:14585342
  Authors
Shaffer JA, Bellini WJ, Rota PA
  Title
The C protein of measles virus inhibits the type I interferon response.
  Journal
Virology 315:389-97 (2003)
DOI:10.1016/S0042-6822(03)00537-3
Reference
PMID:16971451
  Authors
Carsillo T, Traylor Z, Choi C, Niewiesk S, Oglesbee M
  Title
hsp72, a host determinant of measles virus neurovirulence.
  Journal
J Virol 80:11031-9 (2006)
DOI:10.1128/JVI.01438-06
Reference
PMID:15914229
  Authors
Zhang X, Bourhis JM, Longhi S, Carsillo T, Buccellato M, Morin B, Canard B, Oglesbee M
  Title
Hsp72 recognizes a P binding motif in the measles virus N protein C-terminus.
  Journal
Virology 337:162-74 (2005)
DOI:10.1016/j.virol.2005.03.035
Reference
PMID:29712906
  Authors
Ke Z, Strauss JD, Hampton CM, Brindley MA, Dillard RS, Leon F, Lamb KM, Plemper RK, Wright ER
  Title
Promotion of virus assembly and organization by the measles virus matrix protein.
  Journal
Nat Commun 9:1736 (2018)
DOI:10.1038/s41467-018-04058-2
Reference
PMID:24155404
  Authors
Pfaller CK, Radeke MJ, Cattaneo R, Samuel CE
  Title
Measles virus C protein impairs production of defective copyback double-stranded viral RNA and activation of protein kinase R.
  Journal
J Virol 88:456-68 (2014)
DOI:10.1128/JVI.02572-13
Reference
PMID:17686838
  Authors
Sato H, Masuda M, Kanai M, Tsukiyama-Kohara K, Yoneda M, Kai C
  Title
Measles virus N protein inhibits host translation by binding to eIF3-p40.
  Journal
J Virol 81:11569-76 (2007)
DOI:10.1128/JVI.00570-07
Reference
PMID:19895323
  Authors
Sion-Vardy N, Lasarov I, Delgado B, Gopas J, Benharroch D, Ariad S
  Title
Measles virus: evidence for association with lung cancer.
  Journal
Exp Lung Res 35:701-12 (2009)
DOI:10.3109/01902140902853176
Reference
PMID:16140759
  Authors
Chen M, Cortay JC, Logan IR, Sapountzi V, Robson CN, Gerlier D
  Title
Inhibition of ubiquitination and stabilization of human ubiquitin E3 ligase PIRH2 by measles virus phosphoprotein.
  Journal
J Virol 79:11824-36 (2005)
DOI:10.1128/JVI.79.18.11824-11836.2005
Reference
PMID:16699046
  Authors
Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM
  Title
Measles virus V protein inhibits p53 family member p73.
  Journal
J Virol 80:5644-50 (2006)
DOI:10.1128/JVI.02400-05
Reference
PMID:10756053
  Authors
Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C
  Title
Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.
  Journal
J Virol 74:4387-93 (2000)
DOI:10.1128/JVI.74.9.4387-4393.2000
Reference
PMID:20601611
  Authors
Kushwah R, Hu J
  Title
Dendritic cell apoptosis: regulation of tolerance versus immunity.
  Journal
J Immunol 185:795-802 (2010)
DOI:10.4049/jimmunol.1000325
Reference
PMID:10590149
  Authors
Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C
  Title
Measles virus induces functional TRAIL production by human dendritic cells.
  Journal
J Virol 74:556-9 (2000)
DOI:10.1128/JVI.74.1.556-559.2000
Reference
PMID:11846228
  Authors
Vidalain PO, Azocar O, Rabourdin-Combe C, Servet-Delprat C
  Title
Measle virus-infected dendritic cells develop immunosuppressive and cytotoxic activities.
  Journal
Immunobiology 204:629-38 (2001)
DOI:10.1078/0171-2985-00102
Reference
PMID:10423127
  Authors
Engelking O, Fedorov LM, Lilischkis R, ter Meulen V, Schneider-Schaulies S
  Title
Measles virus-induced immunosuppression in vitro is associated with deregulation of G1 cell cycle control proteins.
  Journal
J Gen Virol 80 ( Pt 7):1599-608 (1999)
DOI:10.1099/0022-1317-80-7-1599
Reference
PMID:30510918
  Authors
Fan Y, Sanyal S, Bruzzone R
  Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
  Journal
Front Cell Infect Microbiol 8:396 (2018)
DOI:10.3389/fcimb.2018.00396
Reference
PMID:20636817
  Authors
Griffin DE
  Title
Measles virus-induced suppression of immune responses.
  Journal
Immunol Rev 236:176-89 (2010)
DOI:10.1111/j.1600-065X.2010.00925.x
Reference
PMID:11385511
  Authors
Avota E, Avots A, Niewiesk S, Kane LP, Bommhardt U, ter Meulen V, Schneider-Schaulies S
  Title
Disruption of Akt kinase activation is important for immunosuppression induced by measles virus.
  Journal
Nat Med 7:725-31 (2001)
DOI:10.1038/89106
Reference
PMID:15308747
  Authors
Avota E, Muller N, Klett M, Schneider-Schaulies S
  Title
Measles virus interacts with and alters signal transduction in T-cell lipid rafts.
  Journal
J Virol 78:9552-9 (2004)
DOI:10.1128/JVI.78.17.9552-9559.2004
Reference
PMID:16963735
  Authors
Yanagi Y, Takeda M, Ohno S
  Title
Measles virus: cellular receptors, tropism and pathogenesis.
  Journal
J Gen Virol 87:2767-79 (2006)
DOI:10.1099/vir.0.82221-0
Reference
PMID:16237742
  Authors
Kerdiles YM, Sellin CI, Druelle J, Horvat B
  Title
Immunosuppression caused by measles virus: role of viral proteins.
  Journal
Rev Med Virol 16:49-63 (2006)
DOI:10.1002/rmv.486
Related
pathway
mcc04110  Cell cycle
mcc04115  p53 signaling pathway
mcc04120  Ubiquitin mediated proteolysis
mcc04210  Apoptosis
mcc04620  Toll-like receptor signaling pathway
mcc04622  RIG-I-like receptor signaling pathway
mcc04630  JAK-STAT signaling pathway
mcc04658  Th1 and Th2 cell differentiation
mcc04660  T cell receptor signaling pathway
KO pathway
ko05162   

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