KEGG   PATHWAY: bom05022
Entry
bom05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Bos mutus (wild yak)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
bom05022  Pathways of neurodegeneration - multiple diseases
bom05022

Organism
Bos mutus (wild yak) [GN:bom]
Gene
102267321  APP; amyloid beta precursor protein [KO:K04520]
102270620  MAPT; microtubule associated protein tau [KO:K04380]
102269395  SNCA; synuclein alpha [KO:K04528]
102280144  TARDBP; TAR DNA binding protein [KO:K23600]
102271294  FUS; FUS RNA binding protein [KO:K13098]
102276261  ATXN2L; ataxin 2 like [KO:K23625]
102279571  ATXN2; ataxin 2 [KO:K23625]
102283586  HTT; huntingtin [KO:K04533]
102269167  ATXN1; ataxin 1 [KO:K23616]
102277488  ATXN1L; ataxin 1 like [KO:K23616]
102277662  ATXN3; ataxin 3 [KO:K11863] [EC:3.4.22.-]
102287274  ataxin-3 [KO:K11863] [EC:3.4.22.-]
102278930  PRNP; prion protein [KO:K05634]
102275926  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
102271803  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
102269437  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
102269667  SPTBN2; spectrin beta, non-erythrocytic 2 [KO:K23932]
102280395  GRM1; glutamate metabotropic receptor 1 [KO:K04603]
102287414  GNAQ; G protein subunit alpha q [KO:K04634]
102270304  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
102284805  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
102264989  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
102278948  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
102273347  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102276260  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
102265099  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102278724  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102274116  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102265831  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102273672  TRPC3; transient receptor potential cation channel subfamily C member 3 [KO:K04966]
102277139  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
102269088  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102269013  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102271039  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102275567  RYR1; ryanodine receptor 1 [KO:K04961]
102280999  RYR2; ryanodine receptor 2 [KO:K04962]
102270854  RYR3; ryanodine receptor 3 [KO:K04963]
102284537  PDYN; prodynorphin [KO:K15840]
102282219  DLG4; discs large MAGUK scaffold protein 4 [KO:K11828]
102276953  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
102283831  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
102273574  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
102272710  GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C [KO:K05211]
102266852  GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212]
102268808  GRIA1; glutamate ionotropic receptor AMPA type subunit 1 [KO:K05197]
102281980  GRIA2; glutamate ionotropic receptor AMPA type subunit 2 [KO:K05198]
102274060  GRIA3; glutamate ionotropic receptor AMPA type subunit 3 [KO:K05199]
102281705  GRIA4; glutamate ionotropic receptor AMPA type subunit 4 [KO:K05200]
102266839  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
102277590  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
102271623  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102286805  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
102272241  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
102287982  STX1A; syntaxin 1A [KO:K04560]
102272741  CHRNA7; cholinergic receptor nicotinic alpha 7 subunit [KO:K04809]
102278227  ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
102287572  ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
102281077  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
102282629  PSEN1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
102284134  PSEN2; presenilin 2 [KO:K04522] [EC:3.4.23.-]
102276819  DERL1; derlin 1 [KO:K11519]
102271636  VCP; valosin containing protein [KO:K13525]
102268434  UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1 [KO:K02927]
102283817  ubiquitin-like [KO:K02927]
102282792  RPS27A; ribosomal protein S27a [KO:K02977]
102266974  UBB; ubiquitin B [KO:K04551]
102286294  UBC; ubiquitin C [KO:K08770]
102268867  PSMA6; proteasome subunit alpha 6 [KO:K02730] [EC:3.4.25.1]
102280502  PSMA2; proteasome subunit alpha 2 [KO:K02726] [EC:3.4.25.1]
102281751  PSMA4; proteasome subunit alpha 4 [KO:K02728] [EC:3.4.25.1]
102267294  PSMA7; proteasome subunit alpha 7 [KO:K02731] [EC:3.4.25.1]
102267252  PSMA8; proteasome subunit alpha 8 [KO:K02731] [EC:3.4.25.1]
102286734  PSMA5; proteasome subunit alpha 5 [KO:K02729] [EC:3.4.25.1]
102282779  PSMA1; proteasome subunit alpha 1 [KO:K02725] [EC:3.4.25.1]
102278344  PSMA3; proteasome subunit alpha 3 [KO:K02727] [EC:3.4.25.1]
102288037  PSMB6; proteasome subunit beta 6 [KO:K02738] [EC:3.4.25.1]
102287415  PSMB7; proteasome subunit beta 7 [KO:K02739] [EC:3.4.25.1]
102285347  PSMB3; proteasome subunit beta 3 [KO:K02735] [EC:3.4.25.1]
102273312  PSMB2; proteasome subunit beta 2 [KO:K02734] [EC:3.4.25.1]
102277881  PSMB5; proteasome subunit beta 5 [KO:K02737] [EC:3.4.25.1]
102283073  PSMB1; proteasome subunit beta 1 [KO:K02732] [EC:3.4.25.1]
102273322  PSMB4; proteasome subunit beta 4 [KO:K02736] [EC:3.4.25.1]
102266173  PSMC2; proteasome 26S subunit, ATPase 2 [KO:K03061]
102284281  PSMC1; proteasome 26S subunit, ATPase 1 [KO:K03062]
102266918  PSMC4; proteasome 26S subunit, ATPase 4 [KO:K03063]
102285542  PSMC6; proteasome 26S subunit, ATPase 6 [KO:K03064]
102277499  PSMC3; proteasome 26S subunit, ATPase 3 [KO:K03065]
102273025  PSMC5; proteasome 26S subunit, ATPase 5 [KO:K03066]
102278209  PSMD2; proteasome 26S subunit, non-ATPase 2 [KO:K03028]
102271943  PSMD1; proteasome 26S subunit, non-ATPase 1 [KO:K03032]
102271911  PSMD3; proteasome 26S subunit, non-ATPase 3 [KO:K03033]
102272891  PSMD9; proteasome 26S subunit, non-ATPase 9 [KO:K06693]
102279603  PSMD12; proteasome 26S subunit, non-ATPase 12 [KO:K03035]
102266745  PSMD11; proteasome 26S subunit, non-ATPase 11 [KO:K03036]
102281977  PSMD6; proteasome 26S subunit, non-ATPase 6 [KO:K03037]
102280022  PSMD7; proteasome 26S subunit, non-ATPase 7 [KO:K03038]
102274269  PSMD13; proteasome 26S subunit, non-ATPase 13 [KO:K03039]
102270676  PSMD4; proteasome 26S subunit, non-ATPase 4 [KO:K03029]
102287909  PSMD14; proteasome 26S subunit, non-ATPase 14 [KO:K03030]
102265951  PSMD8; proteasome 26S subunit, non-ATPase 8 [KO:K03031]
102287800  ADRM1; adhesion regulating molecule 1 [KO:K06691]
102272412  SEM1; SEM1, 26S proteasome complex subunit [KO:K10881]
102268542  26S proteasome complex subunit DSS1 [KO:K10881]
102282378  UCHL1; ubiquitin C-terminal hydrolase L1 [KO:K05611] [EC:3.4.19.12]
102283600  UBA1; ubiquitin like modifier activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
102271225  UBA7; ubiquitin like modifier activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
102276728  UBE2L3; ubiquitin conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
102279716  UBE2L6; ubiquitin conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
102275186  UBE2J2; ubiquitin conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
102268112  UBE2J1; ubiquitin conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
102283493  UBE2G2; ubiquitin conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
102276957  UBE2G1; ubiquitin conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
102274782  GPR37; G protein-coupled receptor 37 [KO:K04243]
102277397  SNCAIP; synuclein alpha interacting protein [KO:K04558]
102283374  HSPA5; heat shock protein family A (Hsp70) member 5 [KO:K09490] [EC:3.6.4.10]
102275175  VAPB; VAMP associated protein B and C [KO:K10707]
102282065  vesicle-associated membrane protein-associated protein B-like [KO:K10707]
102274690  ATF6; activating transcription factor 6 [KO:K09054]
102284065  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
102267259  XBP1; X-box binding protein 1 [KO:K09027]
102275172  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102275265  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102276849  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102272638  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102277976  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102266960  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102272421  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102274152  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102270765  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
102267423  ATF4; activating transcription factor 4 [KO:K04374]
102268138  SLC6A3; solute carrier family 6 member 3 [KO:K05036]
102277915  PINK1; PTEN induced putative kinase 1 [KO:K05688] [EC:2.7.11.1]
22161779  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
22161767  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
22161773  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
22161775  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
22161774  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
22161776  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
22161777  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
102272484  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
102276453  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
102285119  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
102279499  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
102287341  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
102285927  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
102287118  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
102278208  NDUFA4; NDUFA4, mitochondrial complex associated [KO:K03948]
102286782  NDUFA4L2; NDUFA4, mitochondrial complex associated like 2 [KO:K03948]
102278402  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
102282910  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
102281197  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
102275104  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
102286379  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
102270113  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
102271415  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
102271332  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
102269545  acyl carrier protein, mitochondrial-like [KO:K03955]
102271827  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
102281227  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
102287792  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
102268230  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
102278125  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
102278908  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
102283359  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
102270846  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102274842  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
102277192  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
102277839  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
102279407  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
102285299  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
102270261  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
102287778  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
102282668  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
102282284  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
102269675  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
102274147  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
102281347  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
102275372  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
102282129  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5 [KO:K03938]
106700772  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
102277555  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
102286718  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
102278157  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
102277732  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
102278228  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
102274978  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
102277085  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
102281830  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
102283287  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
22161778  CYTB; cytochrome b [KO:K00412]
102270480  cytochrome c1, heme protein, mitochondrial [KO:K00413]
102272636  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
102281629  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
102282170  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
102283409  cytochrome b-c1 complex subunit 7 [KO:K00417]
102271679  cytochrome b-c1 complex subunit 8 [KO:K00418]
102270524  cytochrome b-c1 complex subunit 9 [KO:K00419]
102273579  cytochrome b-c1 complex subunit 10 [KO:K00420]
22161772  COX3; cytochrome c oxidase subunit III [KO:K02262]
102278784  cytochrome c oxidase subunit 1-like [KO:K02256] [EC:7.1.1.9]
102267288  cytochrome c oxidase subunit 1-like [KO:K02256] [EC:7.1.1.9]
22161768  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
22161769  COX2; cytochrome c oxidase subunit II [KO:K02261]
102278005  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
102273691  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
106701007  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
102279149  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
102274326  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
102264524  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
102286844  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
102269681  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
102266923  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
102270387  cytochrome c oxidase subunit 6B1 [KO:K02267]
102286900  cytochrome c oxidase subunit 6B2 [KO:K02267]
102275847  cytochrome c oxidase subunit 6B1 [KO:K02267]
102269295  cytochrome c oxidase subunit 6C [KO:K02268]
102273168  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102278351  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
102286307  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
102282043  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
102277731  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
102265796  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
102270649  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102266263  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102267680  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102284257  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102264900  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102282881  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102288051  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
102285770  uncharacterized LOC102285770 [KO:K02272]
102279352  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
102276545  ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
102281283  ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
102272177  ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
102278585  ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit [KO:K02134]
102283527  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
106701624  ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [KO:K02135]
22161771  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
102287079  ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
102272523  ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
102266899  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
102284908  ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
102265342  ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) [KO:K02128]
102283543  ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
102277102  ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
102276478  ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
22161770  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
102268592  BCL2; BCL2, apoptosis regulator [KO:K02161]
102266916  VDAC1; voltage dependent anion channel 1 [KO:K05862]
102274999  TOMM40L; translocase of outer mitochondrial membrane 40 like [KO:K11518]
102275725  TOMM40; translocase of outer mitochondrial membrane 40 [KO:K11518]
102264532  MCU; mitochondrial calcium uniporter [KO:K20858]
102280361  calmodulin-alpha [KO:K02183]
102285968  CALML6; calmodulin like 6 [KO:K02183]
102281667  CALM1; calmodulin 1 [KO:K02183]
102287375  calmodulin [KO:K02183]
102268061  CALM2; calmodulin 2 [KO:K02183]
102265605  calmodulin-alpha [KO:K02183]
102266295  calmodulin [KO:K02183]
102282476  CALM3; calmodulin 3 [KO:K02183]
102269657  CALML3; calmodulin-like protein 3 [KO:K02183]
102271961  calmodulin-2/4-like [KO:K02183]
102284406  CALML4; calmodulin like 4 [KO:K02183]
102275863  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102286752  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102266749  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102272271  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102277736  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102275975  BAD; BCL2 associated agonist of cell death [KO:K02158]
102281889  FASLG; Fas ligand [KO:K04389]
102273906  FAS; Fas cell surface death receptor [KO:K04390]
102271962  FADD; Fas associated via death domain [KO:K02373]
102272602  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
102279560  BID; BH3 interacting domain death agonist [KO:K04726]
102279740  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102266544  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
102267844  LRRK2; leucine rich repeat kinase 2 [KO:K08844] [EC:2.7.11.1]
102273081  serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
102285355  TRAP1; TNF receptor associated protein 1 [KO:K09488]
102281314  VDAC2; voltage dependent anion channel 2 [KO:K15040]
102280707  VDAC3; voltage dependent anion channel 3 [KO:K15041]
102275932  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
102286445  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
102280125  SLC25A6; solute carrier family 25 member 6 [KO:K05863]
102287077  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
102269922  PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
102276866  cytochrome c [KO:K08738]
102277261  cytochrome c [KO:K08738]
102277620  cytochrome c [KO:K08738]
106700494  cytochrome c 2 [KO:K08738]
102285660  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
102268660  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102287348  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102272170  HIP1; huntingtin interacting protein 1 [KO:K04559]
102265677  IFT57; intraflagellar transport 57 [KO:K04638]
102284367  HSD17B10; hydroxysteroid 17-beta dehydrogenase 10 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
102271597  PPID; peptidylprolyl isomerase D [KO:K05864] [EC:5.2.1.8]
102288078  PARK7; Parkinsonism associated deglycase [KO:K05687] [EC:3.5.1.124]
102277355  BCL2L1; BCL2 like 1 [KO:K04570]
102271380  bcl-2-like protein 1 [KO:K04570]
102275311  MFN1; mitofusin 1 [KO:K21356] [EC:3.6.5.-]
102264443  MFN2; mitofusin 2 [KO:K06030] [EC:3.6.5.-]
102269587  OPTN; optineurin [KO:K19946]
102279447  SQSTM1; sequestosome 1 [KO:K14381]
102272461  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
102266010  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha [KO:K10435]
102288385  MAP1LC3C; microtubule associated protein 1 light chain 3 gamma [KO:K10435]
102279479  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
102287432  TANK; TRAF family member associated NFKB activator [KO:K12650]
102267197  WDR41; WD repeat domain 41 [KO:K23610]
102274044  SMCR8; Smith-Magenis syndrome chromosome region, candidate 8 [KO:K23611]
102277717  chromosome unknown open reading frame, human C9orf72 [KO:K23609]
102287920  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
102280315  RAB39B; RAB39B, member RAS oncogene family [KO:K07925]
102267685  RAB1A; RAB1A, member RAS oncogene family [KO:K07874]
102281727  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102277562  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102268847  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102264526  ATG101; autophagy related 101 [KO:K19730]
102270193  ATG13; autophagy related 13 [KO:K08331]
102281518  RB1CC1; RB1 inducible coiled-coil 1 [KO:K17589]
102269275  AMBRA1; autophagy and beclin 1 regulator 1 [KO:K17985]
102274484  BECN1; beclin 1 [KO:K08334]
102266952  BECN2; beclin 2 [KO:K08334]
102271813  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
102268738  ATG14; autophagy related 14 [KO:K17889]
102272578  NRBF2; nuclear receptor binding factor 2 [KO:K21246]
102282920  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102272084  ATG2A; autophagy related 2A [KO:K17906]
102279865  ATG2B; autophagy related 2B [KO:K17906]
102285764  WIPI2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
102277604  WIPI1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
102283583  ZFYVE1; zinc finger FYVE-type containing 1 [KO:K17603]
102274317  ALS2; ALS2, alsin Rho guanine nucleotide exchange factor [KO:K04575]
102272703  RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
102273253  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102278613  CHMP2B; charged multivesicular body protein 2B [KO:K12192]
102265013  FIG4; FIG4 phosphoinositide 5-phosphatase [KO:K22913] [EC:3.1.3.-]
102283440  SPG11; spastic paraplegia 11 (autosomal recessive) [KO:K19026]
102277911  TNF; tumor necrosis factor [KO:K03156]
102285873  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102265200  TNFRSF1B; TNF receptor superfamily member 1B [KO:K05141]
102264458  DAXX; death domain associated protein [KO:K02308]
102267773  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102272962  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102271030  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102271320  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
106701244  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102285848  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102280537  NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
102282760  CCS; copper chaperone for superoxide dismutase [KO:K04569]
102277527  GPX8; glutathione peroxidase 8 (putative) [KO:K00432] [EC:1.11.1.9]
102287394  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
102280278  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
102282633  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
102286040  GPX5; epididymal secretory glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
102278717  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
102279109  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
102280369  CAT; catalase [KO:K03781] [EC:1.11.1.6]
102271529  PRPH; peripherin [KO:K07607]
102285454  NEFL; neurofilament light [KO:K04572]
102285188  NEFM; neurofilament medium [KO:K04573]
102275464  NEFH; neurofilament heavy [KO:K04574]
102282376  KIF5A; kinesin family member 5A [KO:K10396]
102286740  KIF5B; kinesin family member 5B [KO:K10396]
102285160  KIF5C; kinesin family member 5C [KO:K10396]
102272561  KLC2; kinesin light chain 2 [KO:K10407]
102270418  KLC1; kinesin light chain 1 [KO:K10407]
102284057  KLC4; kinesin light chain 4 [KO:K10407]
102288105  KLC3; kinesin light chain 3 [KO:K10407]
102280742  TUBA4A; tubulin alpha 4a [KO:K07374]
102281213  tubulin alpha-1D chain [KO:K07374]
102280120  TUBA8; tubulin alpha 8 [KO:K07374]
102270684  tubulin alpha-1A chain [KO:K07374]
102270959  tubulin alpha-1C chain [KO:K07374]
102269928  TUBAL3; tubulin alpha like 3 [KO:K07374]
102273697  uncharacterized LOC102273697 [KO:K07374]
102285043  tubulin beta chain [KO:K07375]
102283188  TUBB6; tubulin beta 6 class V [KO:K07375]
102277577  uncharacterized LOC102277577 [KO:K07375]
102287404  TUBB1; tubulin beta 1 class VI [KO:K07375]
102277135  TUBB4A; tubulin beta 4A class IVa [KO:K07375]
102278004  TUBB; tubulin beta class I [KO:K07375]
102269975  TUBB4B; tubulin beta 4B class IVb [KO:K07375]
102281195  tubulin beta-2B chain [KO:K07375]
106701394  tubulin beta-4B chain-like [KO:K07375]
102275260  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102281103  CSNK2A1; casein kinase 2 alpha 1 [KO:K03097] [EC:2.7.11.1]
102272104  CSNK2A2; casein kinase 2 alpha 2 [KO:K03097] [EC:2.7.11.1]
102281369  CSNK2B; casein kinase 2 beta [KO:K03115]
102279714  BDNF; brain derived neurotrophic factor [KO:K04355]
102266401  DCTN1; dynactin subunit 1 [KO:K04648]
102283130  DCTN2; dynactin subunit 2 [KO:K10424]
102276497  DCTN3; dynactin subunit 3 [KO:K10425]
102279570  DCTN4; dynactin subunit 4 [KO:K10426]
102271887  DCTN5; dynactin subunit 5 [KO:K10427]
102276418  DCTN6; dynactin subunit 6 [KO:K10428]
102271664  ACTR1A; ARP1 actin-related protein 1 homolog A, centractin alpha [KO:K16575]
102287122  ACTR1B; ARP1 actin-related protein 1 homolog B, centractin beta [KO:K16575]
102278815  ACTR10; actin-related protein 10 homolog [KO:K16576]
102267981  HAP1; huntingtin associated protein 1 [KO:K04647]
102277505  DNAH7; dynein axonemal heavy chain 7 [KO:K10408]
102281380  DNAH5; dynein axonemal heavy chain 5 [KO:K10408]
102278498  DNAH6; dynein axonemal heavy chain 6 [KO:K10408]
102286992  DNAH9; dynein axonemal heavy chain 9 [KO:K10408]
102286880  DNAH11; dynein axonemal heavy chain 11 [KO:K10408]
102266327  DNAH12; dynein axonemal heavy chain 12 [KO:K10408]
102285669  dynein heavy chain 8, axonemal [KO:K10408]
102285560  DNAH10; dynein axonemal heavy chain 10 [KO:K10408]
102274449  DNAH17; dynein axonemal heavy chain 17 [KO:K10408]
102275451  DNAH14; dynein axonemal heavy chain 14 [KO:K10408]
102272577  DNAH1; dynein axonemal heavy chain 1 [KO:K10408]
102273133  DNAH3; dynein axonemal heavy chain 3 [KO:K10408]
102273231  DNAH2; dynein axonemal heavy chain 2 [KO:K10408]
102270373  DNALI1; dynein axonemal light intermediate chain 1 [KO:K10410]
102275642  DNAI1; dynein axonemal intermediate chain 1 [KO:K10409]
102266910  DNAI2; dynein axonemal intermediate chain 2 [KO:K11143]
102280856  DNAL1; dynein axonemal light chain 1 [KO:K10411]
102281822  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
102271451  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
102279381  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
102280002  calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
102283099  CAPN1; calpain 1 [KO:K01367] [EC:3.4.22.52]
102276298  CAPN2; calpain 2 [KO:K03853] [EC:3.4.22.53]
102284508  CDK5R1; cyclin dependent kinase 5 regulatory subunit 1 [KO:K11716]
102265949  CDK5; cyclin dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
102271384  CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]
102279768  DKK1; dickkopf WNT signaling pathway inhibitor 1 [KO:K02165]
102280056  DKK2; dickkopf WNT signaling pathway inhibitor 2 [KO:K02165]
102283413  DKK4; dickkopf WNT signaling pathway inhibitor 4 [KO:K02165]
102268143  WNT1; Wnt family member 1 [KO:K03209]
102285570  WNT2B; Wnt family member 2B [KO:K00182]
102288008  WNT2; Wnt family member 2 [KO:K00182]
102275609  WNT3A; Wnt family member 3A [KO:K00312]
102281377  WNT3; Wnt family member 3 [KO:K00312]
102269858  WNT4; Wnt family member 4 [KO:K00408]
102269211  WNT5A; Wnt family member 5A [KO:K00444]
102276467  WNT5B; Wnt family member 5B [KO:K00444]
102286828  WNT6; Wnt family member 6 [KO:K00445]
102279575  WNT7A; Wnt family member 7A [KO:K00572]
102284700  protein Wnt-7b-like [KO:K00572]
102287042  protein Wnt-7b [KO:K00572]
102285959  WNT8B; Wnt family member 8B [KO:K00714]
102285045  WNT8A; Wnt family member 8A [KO:K00714]
102278321  WNT9A; Wnt family member 9A [KO:K01064]
102283149  WNT9B; Wnt family member 9B [KO:K01064]
102276805  WNT10A; Wnt family member 10A [KO:K01357]
102267865  WNT10B; Wnt family member 10B [KO:K01357]
102266913  WNT11; Wnt family member 11 [KO:K01384]
102274851  WNT16; Wnt family member 16 [KO:K01558]
102269934  FZD1; frizzled class receptor 1 [KO:K02432]
102275255  FZD7; frizzled class receptor 7 [KO:K02432]
102277539  FZD2; frizzled class receptor 2 [KO:K02235]
102273339  FZD3; frizzled class receptor 3 [KO:K02329]
102286685  FZD4; frizzled class receptor 4 [KO:K02354]
102282966  FZD5; frizzled class receptor 5 [KO:K02375]
102276331  FZD8; frizzled class receptor 8 [KO:K02375]
102265247  FZD6; frizzled class receptor 6 [KO:K02376]
102267470  FZD10; frizzled class receptor 10 [KO:K02842]
102272449  FZD9; frizzled class receptor 9 [KO:K02842]
102277840  LRP6; LDL receptor related protein 6 [KO:K03068]
102268590  LRP5; LDL receptor related protein 5 [KO:K03068]
102286770  CSNK1E; casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
102273776  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
102287954  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
102280462  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
102269752  FRAT1; proto-oncogene FRAT1 [KO:K03069]
102267637  AXIN1; axin 1 [KO:K02157]
102278168  AXIN2; axin 2 [KO:K04385]
102282143  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
102272116  APC; APC, WNT signaling pathway regulator [KO:K02085]
102275011  CTNNB1; catenin beta 1 [KO:K02105]
102283373  casein kinase I isoform beta [KO:K08957] [EC:2.7.11.1]
102272853  CSNK1A1; casein kinase 1 alpha 1 [KO:K08957] [EC:2.7.11.1]
102287257  casein kinase I isoform alpha [KO:K08957] [EC:2.7.11.1]
102269709  casein kinase I isoform beta [KO:K08957] [EC:2.7.11.1]
102266016  AGER; advanced glycosylation end-product specific receptor [KO:K19722]
102278591  GTPase HRas [KO:K02833]
102277011  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102286500  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102269203  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102285079  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
102278631  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102288216  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102280670  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102271710  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102272368  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102284931  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102282195  NOX1; NADPH oxidase 1 [KO:K08008]
102288244  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
102272283  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
102268417  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102286969  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102265893  NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
102271174  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
102287919  IL6; interleukin 6 [KO:K05405]
102282330  IL1A; interleukin 1 alpha [KO:K04383]
102282890  IL1B; interleukin 1 beta [KO:K04519]
102269710  CSF1; colony stimulating factor 1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
  Authors
Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
DOI:10.1038/s41593-018-0237-7
Reference
PMID:28062563
  Authors
Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
  Journal
J Cell Mol Med 14:457-87 (2010)
DOI:10.1111/j.1582-4934.2010.01010.x
Reference
PMID:19707851
  Authors
Jellinger KA
  Title
Recent advances in our understanding of neurodegeneration.
  Journal
J Neural Transm (Vienna) 116:1111-62 (2009)
DOI:10.1007/s00702-009-0240-y
Reference
PMID:30743990
  Authors
Van Bulck M, Sierra-Magro A, Alarcon-Gil J, Perez-Castillo A, Morales-Garcia JA
  Title
Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
  Journal
Int J Mol Sci 20:E719 (2019)
DOI:10.3390/ijms20030719
Reference
PMID:15272267
  Authors
Ross CA, Poirier MA
  Title
Protein aggregation and neurodegenerative disease.
  Journal
Nat Med 10 Suppl:S10-7 (2004)
DOI:10.1038/nm1066
Reference
PMID:30250260
  Authors
Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
  Journal
Nat Neurosci 21:1332-1340 (2018)
DOI:10.1038/s41593-018-0235-9
Reference
PMID:25132814
  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
  Journal
Front Mol Neurosci 7:70 (2014)
DOI:10.3389/fnmol.2014.00070
Reference
PMID:25413678
  Authors
Zheng C, Geetha T, Babu JR
  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
  Journal
Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
PMID:32397599
  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
  Journal
Int J Mol Sci 21:E3369 (2020)
DOI:10.3390/ijms21093369
Reference
PMID:31783880
  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
DOI:10.1186/s13041-019-0504-x
Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
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Cells 7:E37 (2018)
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Related
pathway
bom00190  Oxidative phosphorylation
bom03050  Proteasome
bom04020  Calcium signaling pathway
bom04120  Ubiquitin mediated proteolysis
bom04137  Mitophagy - animal
bom04140  Autophagy - animal
bom04141  Protein processing in endoplasmic reticulum
bom04142  Lysosome
bom04210  Apoptosis
bom04310  Wnt signaling pathway
bom04724  Glutamatergic synapse
bom04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
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