KEGG   PATHWAY: cdk05163
Entry
cdk05163                    Pathway                                
Name
Human cytomegalovirus infection - Camelus dromedarius (Arabian camel)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
cdk05163  Human cytomegalovirus infection
cdk05163

Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105103397  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105086305  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105107003  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105085928  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105084758  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105101867  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
105092913  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
105099264  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
105104845  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105093393  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105085191  TSC1; hamartin isoform X1 [KO:K07206]
105099714  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
105098696  RHEB; GTP-binding protein Rheb [KO:K07208]
105107024  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
105089940  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105097829  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105104425  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
105084316  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105086448  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105106603  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105089560  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105102595  RELA; transcription factor p65 isoform X1 [KO:K04735]
105105749  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105104642  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105091467  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
105103654  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105105427  HRAS; GTPase HRas isoform X1 [KO:K02833]
105100066  KRAS; GTPase KRas isoform X1 [KO:K07827]
105089630  NRAS; GTPase NRas [KO:K07828]
105093099  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105093267  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105105302  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105095214  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105102769  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105102861  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
105094564  SP1; transcription factor Sp1 [KO:K04684]
105098976  ITGAV; integrin alpha-V precursor [KO:K06487]
105090426  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105084996  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
105101582  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
105102215  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
105087723  RHOA; transforming protein RhoA [KO:K04513]
105099837  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
105098117  STING1; stimulator of interferon response cGAMP interactor 1 [KO:K12654]
105089261  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105100198  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
105105541  interferon alpha-1-like [KO:K05414]
105105457  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
105105461  LOW QUALITY PROTEIN: interferon alpha-14-like [KO:K05414]
105095932  interferon alpha-14-like [KO:K05414]
116152603  interferon alpha-14-like [KO:K05414]
116152604  interferon alpha-14-like [KO:K05414]
105095933  IFNB1; interferon beta [KO:K05415]
105087473  TNF; tumor necrosis factor [KO:K03156]
105098228  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
105087344  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
105088459  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105099319  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
105106196  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105093155  IL1B; interleukin-1 beta [KO:K04519]
105099109  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
105092140  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105088228  C-C motif chemokine 2 [KO:K14624]
105097869  CCL5; C-C motif chemokine 5 [KO:K12499]
105091344  CXCL8; interleukin-8 [KO:K10030]
105095065  IL6; interleukin-6 [KO:K05405]
105105557  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105088562  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105098202  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105085924  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105086620  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105091500  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105088827  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
116156024  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4-like [KO:K04541]
105095042  GNG5; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
116148370  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
105104028  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X5 [KO:K04544]
116152527  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
105088740  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105104066  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X3 [KO:K04347]
116156911  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105098452  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
105088741  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
116157907  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1 [KO:K04549]
105087414  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
105106041  GNA11; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
105101292  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
105101500  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105101545  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X4 [KO:K05858] [EC:3.1.4.11]
105096910  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105093156  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X2 [KO:K04958]
105102013  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105101373  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
105096001  CALM1; calmodulin-1 [KO:K02183]
105093281  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
105104026  CALM3; calmodulin-3 [KO:K02183]
105105602  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105092364  CALM2; calmodulin-2 [KO:K02183]
116147086  calmodulin-like [KO:K02183]
105102643  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105092463  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105089593  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116152568  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
116157512  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105103850  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105105081  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X4 [KO:K17332]
105088479  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105102434  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
105099289  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105087520  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105085647  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
105100375  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105096168  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
105095715  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105094039  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105100030  ADCY3; adenylate cyclase type 3 isoform X5 [KO:K08043] [EC:4.6.1.1]
105102432  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105090284  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105103816  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105097528  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105096450  ADCY8; adenylate cyclase type 8 isoform X2 [KO:K08048] [EC:4.6.1.1]
105099828  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105095035  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105100776  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105097864  C-C motif chemokine 3-like [KO:K05408]
116157883  LOW QUALITY PROTEIN: C-C motif chemokine 3-like [KO:K05408]
105097865  regakine-1 [KO:K05408]
105097863  C-C motif chemokine 4 [KO:K12964]
105093820  CX3CL1; fractalkine [KO:K05508]
105086681  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
105085708  GNA13; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
105090229  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
105105625  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
105090126  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
105085470  AKAP13; A-kinase anchor protein 13 isoform X1 [KO:K16529]
105086272  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
105091254  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
105084622  CTNNB1; catenin beta-1 [KO:K02105]
116148424  PTGER1; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP1 subtype [KO:K04258]
105091422  PTGER2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
105096638  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X3 [KO:K04260]
105106911  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
105095656  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
105095655  neuroendocrine secretory protein 55 [KO:K04632]
105090321  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105104393  CCND1; LOW QUALITY PROTEIN: G1/S-specific cyclin-D1 [KO:K04503]
105096445  MYC; myc proto-oncogene protein [KO:K04377]
105089663  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
105107124  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105090458  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105088633  VEGFA; vascular endothelial growth factor A [KO:K05448]
105085694  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105101337  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
105101338  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105090355  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105090356  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105093562  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
105097571  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105091928  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105089327  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
105106926  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105105303  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
105091622  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105102288  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105095833  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105090854  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
105084484  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
105092280  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105092299  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105094833  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105103265  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105102240  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
105095121  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
105085072  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
105088123  CRK; adapter molecule crk isoform X1 [KO:K04438]
105095221  CRKL; crk-like protein [KO:K04438]
105102004  PXN; paxillin isoform X1 [KO:K05760]
105090182  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
105089870  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
105096069  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
105103464  CCR3; C-C chemokine receptor type 3 [KO:K04178]
105103475  C-C chemokine receptor type 5 [KO:K04180]
105101403  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
105101406  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
105101385  TAPBP; tapasin [KO:K08058]
105101715  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105100758  CALR; calreticulin [KO:K08057]
105087509  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
105087478  patr class I histocompatibility antigen, B-1 alpha chain isoform X1 [KO:K06751]
105087511  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
116147754  LOW QUALITY PROTEIN: saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
105104206  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
116152169  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
105106736  beta-2-microglobulin [KO:K08055]
105101700  beta-2-microglobulin [KO:K08055]
105101697  beta-2-microglobulin-like [KO:K08055]
105092872  cyclin-dependent kinase inhibitor 2A-like isoform X1 [KO:K06621]
105101086  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
105103011  TP53; cellular tumor antigen p53 [KO:K04451]
105101330  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
105100330  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105088747  CDK6; cyclin-dependent kinase 6 isoform X2 [KO:K02091] [EC:2.7.11.22]
105101803  RB1; LOW QUALITY PROTEIN: retinoblastoma-associated protein [KO:K06618]
105092697  E2F1; LOW QUALITY PROTEIN: transcription factor E2F1 [KO:K17454]
105088895  E2F2; transcription factor E2F2 [KO:K09389]
105089193  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
105092770  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105102832  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105104389  FADD; LOW QUALITY PROTEIN: FAS-associated death domain protein [KO:K02373]
105099181  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105100737  BID; LOW QUALITY PROTEIN: BH3-interacting domain death agonist [KO:K04726]
105102890  BAX; apoptosis regulator BAX [KO:K02159]
105101376  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105098528  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
105095080  cytochrome c [KO:K08738]
105092650  cytochrome c [KO:K08738]
105107056  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
105084433  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:E30 (2018)
DOI:10.3390/pathogens7010030
Reference
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
  Journal
Biomol Ther (Seoul) 25:69-79 (2017)
DOI:10.4062/biomolther.2016.208
Reference
  Authors
Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ
  Title
Constitutive beta-catenin signaling by the viral chemokine receptor US28.
  Journal
PLoS One 7:e48935 (2012)
DOI:10.1371/journal.pone.0048935
Reference
  Authors
Couty JP, Gershengorn MC
  Title
G-protein-coupled receptors encoded by human herpesviruses.
  Journal
Trends Pharmacol Sci 26:405-11 (2005)
DOI:10.1016/j.tips.2005.06.004
Reference
  Authors
Fiallos E, Judkins J, Matlaf L, Prichard M, Dittmer D, Cobbs C, Soroceanu L
  Title
Human cytomegalovirus gene expression in long-term infected glioma stem cells.
  Journal
PLoS One 9:e116178 (2014)
DOI:10.1371/journal.pone.0116178
Reference
  Authors
Vischer HF, Siderius M, Leurs R, Smit MJ
  Title
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
  Journal
Nat Rev Drug Discov 13:123-39 (2014)
DOI:10.1038/nrd4189
Reference
  Authors
Slinger E, Langemeijer E, Siderius M, Vischer HF, Smit MJ
  Title
Herpesvirus-encoded GPCRs rewire cellular signaling.
  Journal
Mol Cell Endocrinol 331:179-84 (2011)
DOI:10.1016/j.mce.2010.04.007
Reference
  Authors
Murphy PM
  Title
Viral exploitation and subversion of the immune system through chemokine mimicry.
  Journal
Nat Immunol 2:116-22 (2001)
DOI:10.1038/84214
Reference
  Authors
Vischer HF, Leurs R, Smit MJ
  Title
HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks.
  Journal
Trends Pharmacol Sci 27:56-63 (2006)
DOI:10.1016/j.tips.2005.11.006
Reference
  Authors
de Munnik SM, Smit MJ, Leurs R, Vischer HF
  Title
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
  Journal
Front Pharmacol 6:40 (2015)
DOI:10.3389/fphar.2015.00040
Reference
  Authors
Michelson S
  Title
Consequences of human cytomegalovirus mimicry.
  Journal
Hum Immunol 65:465-75 (2004)
DOI:10.1016/j.humimm.2004.02.002
Reference
  Authors
Tu CC, Arnolds KL, O'Connor CM, Spencer JV
  Title
Human Cytomegalovirus UL111A and US27 Gene Products Enhance the CXCL12/CXCR4 Signaling Axis via Distinct Mechanisms.
  Journal
J Virol 92:e01981-17 (2018)
DOI:10.1128/JVI.01981-17
Reference
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
  Authors
Noriega V, Redmann V, Gardner T, Tortorella D
  Title
Diverse immune evasion strategies by human cytomegalovirus.
  Journal
Immunol Res 54:140-51 (2012)
DOI:10.1007/s12026-012-8304-8
Reference
  Authors
Loureiro J, Ploegh HL
  Title
Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions.
  Journal
Adv Immunol 92:225-305 (2006)
DOI:10.1016/S0065-2776(06)92006-9
Reference
  Authors
Fortunato EA, McElroy AK, Sanchez I, Spector DH
  Title
Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus.
  Journal
Trends Microbiol 8:111-9 (2000)
DOI:10.1016/S0966-842X(00)01699-1
Reference
  Authors
Cinatl J Jr, Scholz M, Doerr HW
  Title
Role of tumor cell immune escape mechanisms in cytomegalovirus-mediated oncomodulation.
  Journal
Med Res Rev 25:167-85 (2005)
DOI:10.1002/med.20018
Reference
  Authors
Cinatl J Jr, Vogel JU, Kotchetkov R, Wilhelm Doerr H
  Title
Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: a novel role for viral infection in tumor progression.
  Journal
FEMS Microbiol Rev 28:59-77 (2004)
DOI:10.1016/j.femsre.2003.07.005
Reference
  Authors
Castillo JP, Kowalik TF
  Title
Human cytomegalovirus immediate early proteins and cell growth control.
  Journal
Gene 290:19-34 (2002)
DOI:10.1016/S0378-1119(02)00566-8
Reference
  Authors
Kalejta RF
  Title
Human cytomegalovirus pp71: a new viral tool to probe the mechanisms of cell cycle progression and oncogenesis controlled by the retinoblastoma family of tumor suppressors.
  Journal
J Cell Biochem 93:37-45 (2004)
DOI:10.1002/jcb.20177
Reference
  Authors
Brune W
  Title
Inhibition of programmed cell death by cytomegaloviruses.
  Journal
Virus Res 157:144-50 (2011)
DOI:10.1016/j.virusres.2010.10.012
Reference
  Authors
Brune W, Andoniou CE
  Title
Die Another Day: Inhibition of Cell Death Pathways by Cytomegalovirus.
  Journal
Viruses 9:E249 (2017)
DOI:10.3390/v9090249
Reference
  Authors
Yamin R, Lecker LSM, Weisblum Y, Vitenshtein A, Le-Trilling VTK, Wolf DG, Mandelboim O
  Title
HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.
  Journal
Cell Rep 15:1542-1553 (2016)
DOI:10.1016/j.celrep.2016.04.042
Reference
  Authors
Wang X, Sanchez J, Stone MJ, Payne RJ
  Title
Sulfation of the Human Cytomegalovirus Protein UL22A Enhances Binding to the Chemokine RANTES.
  Journal
Angew Chem Int Ed Engl 56:8490-8494 (2017)
DOI:10.1002/anie.201703059
Related
pathway
cdk00590  Arachidonic acid metabolism
cdk03050  Proteasome
cdk04010  MAPK signaling pathway
cdk04064  NF-kappa B signaling pathway
cdk04110  Cell cycle
cdk04150  mTOR signaling pathway
cdk04151  PI3K-Akt signaling pathway
cdk04210  Apoptosis
cdk04612  Antigen processing and presentation
cdk04623  Cytosolic DNA-sensing pathway
cdk04630  JAK-STAT signaling pathway
cdk04668  TNF signaling pathway
cdk04810  Regulation of actin cytoskeleton
KO pathway
ko05163   
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