Entry
Name
Epstein-Barr virus infection - Cavia porcellus (domestic guinea pig)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases. EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Ortholog table
Organism
Cavia porcellus (domestic guinea pig) [GN:
cpoc ]
Gene
100718695 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
100720632 HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752 ]
100717851 HLA class II histocompatibility antigen, DO beta chain [KO:K06752 ]
100718133 HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752 ]
100713671 HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752 ]
100714501 HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752 ]
100714780 HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
100715615 HLA class II histocompatibility antigen, DP alpha 1 chain-like isoform X1 [KO:K06752 ]
100716183 HLA class II histocompatibility antigen, DM alpha chain [KO:K06752 ]
100716469 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
100719246 HLA class II histocompatibility antigen, DRB1-16 beta chain [KO:K06752 ]
100735392 HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752 ]
100735670 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
100735949 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
100720894 HLA class II histocompatibility antigen, DRB1-1 beta chain-like [KO:K06752 ]
100719800 HLA class II histocompatibility antigen, DRB1-1 beta chain-like [KO:K06752 ]
100733381 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
100735373 Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
100717911 Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
100730075 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
100724910 Irf3; LOW QUALITY PROTEIN: interferon regulatory factor 3 [KO:K05411 ]
100724708 Stat1; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
100719719 Stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
100726403 Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
100727781 Cd3e; T-cell surface glycoprotein CD3 epsilon chain isoform X2 [KO:K06451 ]
100717173 Psmc5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066 ]
100725505 Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028 ]
100736234 Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032 ]
100725725 Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033 ]
100719676 Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035 ]
100718311 Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036 ]
100715202 Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037 ]
100720798 Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038 ]
100714436 Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039 ]
101788278 Psmd4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029 ]
100721655 Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030 ]
100731823 Psmd8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031 ]
100736167 Adrm1; proteasomal ubiquitin receptor ADRM1 isoform X2 [KO:K06691 ]
100724396 HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751 ]
100723126 patr class I histocompatibility antigen, alpha chain E-like isoform X2 [KO:K06751 ]
100733898 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
100733617 LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-18 alpha chain-like [KO:K06751 ]
100723401 HLA class I histocompatibility antigen, B-46 alpha chain-like isoform X2 [KO:K06751 ]
100723960 class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751 ]
100712777 LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751 ]
100713317 HLA class I histocompatibility antigen, A-11 alpha chain-like isoform X2 [KO:K06751 ]
100716535 Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053 ]
100717262 Rbpjl; recombining binding protein suppressor of hairless-like protein [KO:K06053 ]
100715029 Fcer2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468 ]
100719739 Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
100730773 Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
100720622 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100727986 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100735084 Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100734206 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100730242 Pik3r1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
100734044 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100715820 Nfkb2; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit [KO:K04469 ]
100732953 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
100728791 Cd40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
100717967 Icam1; LOW QUALITY PROTEIN: intercellular adhesion molecule 1 [KO:K06490 ]
100717084 Stat3; signal transducer and activator of transcription 3 isoform X3 [KO:K04692 ]
100727219 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392 ]
100726796 Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859 ] [EC:3.1.4.11 ]
100716297 Rb1; LOW QUALITY PROTEIN: retinoblastoma-associated protein [KO:K06618 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Young LS, Rickinson AB.
Title
Epstein-Barr virus: 40 years on.
Journal
Reference
Authors
Saha A, Robertson ES
Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
Journal
Reference
Authors
Ning S
Title
Innate immune modulation in EBV infection.
Journal
Reference
Authors
Stanfield BA, Luftig MA
Title
Recent advances in understanding Epstein-Barr virus.
Journal
Reference
Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
Journal
Reference
Authors
Rajsbaum R, Garcia-Sastre A
Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
Journal
Reference
Authors
Hoffmann HH, Schneider WM, Rice CM
Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
Journal
Reference
Authors
Spender LC, Inman GJ
Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
Journal
Reference
Authors
Fu Q, He C, Mao ZR
Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
Journal
Reference
Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
Journal
Reference
Authors
Melchjorsen J
Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
Journal
Reference
Authors
Hansen TH, Bouvier M
Title
MHC class I antigen presentation: learning from viral evasion strategies.
Journal
Reference
Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
Journal
Reference
Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
Journal
Reference
Authors
Ghosh Roy S, Robertson ES, Saha A
Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
Journal
Reference
Authors
Dawson CW, Port RJ, Young LS
Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
Journal
Reference
Authors
Cai Q, Chen K, Young KH
Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
Journal
Reference
Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
Authors
Ersing I, Bernhardt K, Gewurz BE
Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
Journal
Reference
Authors
Wang LW, Jiang S, Gewurz BE
Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
Journal
Reference
Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
Journal
Reference
Authors
Edwards RH, Marquitz AR, Raab-Traub N
Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
Journal
Reference
Authors
Thorley-Lawson DA
Title
Epstein-Barr virus: exploiting the immune system.
Journal
Reference
Authors
Eliopoulos AG, Young LS
Title
LMP1 structure and signal transduction.
Journal
Reference
Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
Journal
Reference
Authors
Kang H, Kiess A, Chung CH
Title
Emerging biomarkers in head and neck cancer in the era of genomics.
Journal
Reference
Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
Journal
Reference
Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
Journal
Reference
Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
Journal
Reference
Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
Journal
Reference
Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
Journal
Reference
Authors
Longnecker R
Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
Journal
Reference
Authors
El-Sharkawy A, Al Zaidan L, Malki A
Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
Journal
Reference
Authors
Dolcetti R, Masucci MG
Title
Epstein-Barr virus: induction and control of cell transformation.
Journal
Reference
Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
Journal
Related pathway
cpoc04612 Antigen processing and presentation
cpoc04620 Toll-like receptor signaling pathway
cpoc04622 RIG-I-like receptor signaling pathway
KO pathway
LinkDB
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