Entry
Name
Salmonella infection - Equus caballus (horse)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
BRITE hierarchy
Pathway map
Ortholog table
Organism
Equus caballus (horse) [GN:
ecb ]
Gene
100050008 PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282 ]
100063269 VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X2 [KO:K20179 ]
100052817 VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
100057119 VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
100058750 VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182 ]
100062843 VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184 ]
100061459 DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
100052139 DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
100053015 DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X5 [KO:K10415 ]
100065490 DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416 ]
100056767 DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
100069106 DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417 ]
100069352 DYNLRB1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419 ]
100054468 FYCO1; FYVE and coiled-coil domain-containing protein 1 [KO:K21954 ]
100054085 PLEKHM2; pleckstrin homology domain-containing family M member 2 [KO:K15348 ]
100061081 GCC2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282 ]
100063459 AHNAK; neuroblast differentiation-associated protein AHNAK isoform X6 [KO:K23934 ]
100054189 ARHGEF26; rho guanine nucleotide exchange factor 26 isoform X1 [KO:K13744 ]
100055551 ELMO1; engulfment and cell motility protein 1 isoform X6 [KO:K12366 ]
100056774 ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985 ]
100147688 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
100065012 MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754 ]
100065683 MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758 ]
100053166 FHOD1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938 ]
100061732 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
100071224 CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749 ]
100063100 CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749 ]
100050895 WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083 ]
100059292 ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757 ]
100058358 actin-related protein 2/3 complex subunit 4 isoform X14 [KO:K05755 ]
100067289 ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754 ]
100051623 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100058141 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100051753 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100050532 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289 ] [EC:2.7.1.153 ]
100064130 PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
100056431 PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923 ] [EC:2.7.1.154 ]
100054391 PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X4 [KO:K00923 ] [EC:2.7.1.154 ]
100064503 TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403 ]
100053940 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
100630219 CD14; monocyte differentiation antigen CD14 precursor [KO:K04391 ]
100070300 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
100060433 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404 ]
100051087 TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
100067894 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X4 [KO:K02580 ]
100069844 NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727 ]
100059548 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
100065824 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
100064377 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
100057812 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
102149226 tumor necrosis factor receptor superfamily member 10A [KO:K04722 ]
102150834 tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K04722 ]
100073322 NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800 ]
100073304 NAIP; baculoviral IAP repeat-containing protein 1 isoform X1 [KO:K12807 ]
100070605 NLRC4; NLR family CARD domain-containing protein 4 isoform X2 [KO:K12805 ]
100063252 apoptosis-associated speck-like protein containing a CARD isoform X2 [KO:K12799 ]
Compound
C01194 1-Phosphatidyl-D-myo-inositol
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C11554 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
Authors
Bernal-Bayard J, Ramos-Morales F
Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
Journal
Reference
Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
Journal
Reference
Authors
Wemyss MA, Pearson JS
Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
Journal
Reference
Authors
Bierschenk D, Boucher D, Schroder K
Title
Salmonella-induced inflammasome activation in humans.
Journal
Reference
Authors
Pinaud L, Sansonetti PJ, Phalipon A
Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
Journal
Reference
Authors
LaRock DL, Chaudhary A, Miller SI
Title
Salmonellae interactions with host processes.
Journal
Reference
Authors
Ramsden AE, Holden DW, Mota LJ
Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
Journal
Reference
Authors
van der Heijden J, Finlay BB
Title
Type III effector-mediated processes in Salmonella infection.
Journal
Reference
Authors
Galan JE
Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
Journal
Reference
Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
Title
Salmonella takes control: effector-driven manipulation of the host.
Journal
Reference
Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
Journal
Reference
Authors
Patel JC, Galan JE
Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
Journal
Reference
Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Journal
Reference
Authors
Fu Y, Galan JE
Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
Journal
Related pathway
ecb04621 NOD-like receptor signaling pathway
KO pathway
LinkDB
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