KEGG   PATHWAY: ggo05417
Entry
ggo05417                    Pathway                                
Name
Lipid and atherosclerosis - Gorilla gorilla gorilla (western lowland gorilla)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
ggo05417  Lipid and atherosclerosis
ggo05417

Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101132618  APOB; apolipoprotein B-100 [KO:K14462]
101136927  APOA4; apolipoprotein A-IV [KO:K08760]
101137897  APOA1; apolipoprotein A-I [KO:K08757]
101124590  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
101126233  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
101131951  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
101131051  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
101134778  RHOA; transforming protein RhoA [KO:K04513]
101134988  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
101128007  NOS3; nitric oxide synthase 3 isoform X1 [KO:K13242] [EC:1.14.13.39]
101143811  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101146434  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101152123  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101130978  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101135298  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101129336  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101137723  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101138019  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
129526696  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101152769  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
101151128  BAD; bcl2-associated agonist of cell death [KO:K02158]
101142025  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101136123  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101152026  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
101124033  MAPK8; mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101133141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101146178  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
101124828  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101139434  POU2F2; POU domain, class 2, transcription factor 2 isoform X20 [KO:K09364]
101134981  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
101147181  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
101126651  CD40; tumor necrosis factor receptor superfamily member 5 isoform X2 [KO:K03160]
101152672  CD40LG; CD40 ligand [KO:K03161]
101129522  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
101146638  cytochrome P450 2A6 [KO:K17683] [EC:1.14.14.-]
101151678  cytochrome P450 2B6 [KO:K17709] [EC:1.14.14.-]
101127173  cytochrome P450 2C8 [KO:K17718] [EC:1.14.14.1]
101126456  cytochrome P450 2C9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
101148349  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
101150956  AGER; advanced glycosylation end product-specific receptor isoform X2 [KO:K19722]
101129463  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
101144859  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101154464  NCF1; neutrophil cytosol factor 1 [KO:K08011]
101141497  cytochrome b-245 light chain [KO:K08009]
101133476  NCF2; neutrophil cytosol factor 2 [KO:K08010]
101135662  NCF4; neutrophil cytosol factor 4 isoform X2 [KO:K08012]
101135430  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101153251  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101149427  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101135038  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101124029  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101128843  cell division control protein 42 homolog [KO:K04393]
101154090  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101143954  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101124339  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X4 [KO:K04431] [EC:2.7.12.2]
101127590  FOS; protein C-Fos [KO:K04379]
101145729  JUN; transcription factor Jun [KO:K04448]
101127502  ICAM1; intercellular adhesion molecule 1 precursor [KO:K06490]
101130732  CXCL8; interleukin-8 [KO:K10030]
101145420  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
101142374  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X3 [KO:K04433] [EC:2.7.12.2]
101134492  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101134843  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101148438  MAPK13; mitogen-activated protein kinase 13 isoform X3 [KO:K04441] [EC:2.7.11.24]
101152640  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
101136425  HRAS; GTPase HRas isoform X1 [KO:K02833]
101144039  KRAS; GTPase KRas isoform X2 [KO:K07827]
101146562  NRAS; GTPase NRas [KO:K07828]
101140164  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101135988  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101150285  RELA; transcription factor p65 isoform X1 [KO:K04735]
101153465  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101148956  SELE; E-selectin [KO:K06494]
101148237  SELP; P-selectin isoform X3 [KO:K06496]
101152201  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
101131989  MMP3; stromelysin-1 [KO:K01394] [EC:3.4.24.17]
101138361  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
101152441  FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390]
101130571  IL1B; interleukin-1 beta [KO:K04519]
101151687  IL6; interleukin-6 isoform X1 [KO:K05405]
129534132  TNF; tumor necrosis factor [KO:K03156]
101147788  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
101150049  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
115931220  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
101134225  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
101135640  HSPA1L; heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
101128042  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101131586  heat shock 70 kDa protein 1A [KO:K03283]
115932977  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
101147203  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
101148292  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
101143849  HSP90AB1; heat shock protein HSP 90-beta isoform X2 [KO:K04079]
109025530  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
115936257  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
109029337  heat shock protein HSP 90-beta-like [KO:K04079]
101127820  HSP90B1; endoplasmin [KO:K09487]
101143886  endoplasmin-like [KO:K09487]
101128447  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
101124968  LBP; lipopolysaccharide-binding protein isoform X1 [KO:K05399]
101147111  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101129198  LY96; lymphocyte antigen 96 precursor [KO:K05400]
101148715  TLR4; toll-like receptor 4 precursor [KO:K10160]
101139748  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
101141837  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101141826  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101140803  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
101152087  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101138846  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
101126531  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101144707  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
101137405  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101141659  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101145841  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
115932121  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
101128204  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101149137  TICAM2; TIR domain-containing adapter molecule 2 isoform X1 [KO:K05409]
101143359  TICAM1; TIR domain-containing adapter molecule 1 isoform X1 [KO:K05842]
101136595  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101150372  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X8 [KO:K10645] [EC:2.3.2.27]
101124947  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
101135715  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
101125384  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101138038  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101138881  IRF7; interferon regulatory factor 7 isoform X2 [KO:K09447]
101144709  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
101139336  interferon alpha-16 [KO:K05414]
101140412  interferon alpha-5 [KO:K05414]
101142673  interferon alpha-1/13 [KO:K05414]
101142301  IFNA8; interferon alpha-8 [KO:K05414]
101141176  IFNA6; interferon alpha-6 [KO:K05414]
101141543  interferon alpha-1/13 [KO:K05414]
101141916  IFNA2; interferon alpha-2 [KO:K05414]
101137870  IFNA21; interferon alpha-21 [KO:K05414]
101138981  interferon alpha-17 [KO:K05414]
101139713  interferon alpha-14 [KO:K05414]
115935827  interferon alpha-4 [KO:K05414]
115935829  interferon alpha-17 [KO:K05414]
115935831  interferon alpha-10-like [KO:K05414]
115935832  interferon alpha-7 [KO:K05414]
115935833  interferon alpha-7 [KO:K05414]
115935834  interferon alpha-7 [KO:K05414]
134756937  interferon alpha-17-like [KO:K05414]
101137136  IFNB1; interferon beta [KO:K05415]
101124855  CD36; platelet glycoprotein 4 [KO:K06259]
101134077  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101128749  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
101143109  RXRB; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
101152695  RXRG; retinoic acid receptor RXR-gamma isoform X2 [KO:K08526]
101145340  LYN; tyrosine-protein kinase Lyn isoform X3 [KO:K05854] [EC:2.7.10.2]
101128620  PTK2; focal adhesion kinase 1 isoform X14 [KO:K05725] [EC:2.7.10.2]
101124128  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101142265  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101139851  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101128798  TLR6; toll-like receptor 6 isoform X1 [KO:K10169]
101125618  RAP1A; ras-related protein Rap-1A isoform X2 [KO:K04353]
101125880  RAP1B; ras-related protein Rap-1b [KO:K07836]
101125807  CCL5; C-C motif chemokine 5 isoform X2 [KO:K12499]
101139671  uncharacterized protein LOC101139671 [KO:K05408]
101153934  CCL3; C-C motif chemokine 3 [KO:K05408]
129533794  C-C motif chemokine 3-like 1 [KO:K05408]
101134092  C-X-C motif chemokine 2 [KO:K05505]
101131798  CXCL1; growth-regulated alpha protein [KO:K05505]
101133388  C-X-C motif chemokine 3 [KO:K05505]
101150677  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
101141274  IL12B; interleukin-12 subunit beta [KO:K05425]
101125506  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
101138403  IL18; interleukin-18 isoform X3 [KO:K05482]
101125975  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
101144626  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X3 [KO:K09054]
101140706  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101124686  ERO1A; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
101151145  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101134676  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X28 [KO:K04515] [EC:2.7.11.17]
101153594  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101148194  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8 [KO:K04515] [EC:2.7.11.17]
101136547  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101147776  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
101129388  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101139584  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101153927  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
101133025  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101144745  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
101147354  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
101152414  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101151472  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X2 [KO:K05641]
101138600  ABCG1; ATP-binding cassette sub-family G member 1 isoform X8 [KO:K05679]
101145508  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
101128578  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
101136563  caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
101139335  VLDLR; very low-density lipoprotein receptor isoform X2 [KO:K20053]
101147096  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101147811  LOW QUALITY PROTEIN: putative 3-phosphoinositide-dependent protein kinase 2 [KO:K06276] [EC:2.7.11.1]
101125534  GSK3B; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101147593  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101131247  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101142854  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101140350  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
101153613  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101129357  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101154323  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
101135199  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
101151475  CALML3; calmodulin-like protein 3 [KO:K02183]
101151113  CALML5; calmodulin-like protein 5 [KO:K02183]
101139397  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101140627  calmodulin-2-like [KO:K02183]
101139013  CALM2; calmodulin-2 isoform X1 [KO:K02183]
101149474  CALM1; calmodulin-1 isoform X1 [KO:K02183]
129528583  CALM3; calmodulin-3 [KO:K02183]
129532589  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101144930  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
101146305  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101132713  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101144871  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
115933538  PPP3R1; calcineurin subunit B type 1 isoform X3 [KO:K06268]
101130096  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
101146659  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
101141415  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B [KO:K04722]
101149216  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101137781  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101138898  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101142032  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
101135431  cytochrome c [KO:K08738]
101152462  cytochrome c-like [KO:K08738]
101129170  cytochrome c-like [KO:K08738]
109025909  cytochrome c [KO:K08738]
109027916  cytochrome c-like [KO:K08738]
115932158  cytochrome c-like [KO:K08738]
101146129  cytochrome c, somatic-like [KO:K08738]
129524120  cytochrome c-like [KO:K08738]
129527250  cytochrome c-like [KO:K08738]
129526436  cytochrome c-like [KO:K08738]
129526136  cytochrome c-like [KO:K08738]
115933428  cytochrome c-like [KO:K08738]
109023149  cytochrome c, somatic-like [KO:K08738]
101135722  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
101130414  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101149243  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
101126742  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101147760  CASP7; LOW QUALITY PROTEIN: caspase-7 [KO:K04397] [EC:3.4.22.60]
101133524  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
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Related
pathway
ggo04020  Calcium signaling pathway
ggo04115  p53 signaling pathway
ggo04141  Protein processing in endoplasmic reticulum
ggo04151  PI3K-Akt signaling pathway
ggo04210  Apoptosis
ggo04620  Toll-like receptor signaling pathway
ggo04621  NOD-like receptor signaling pathway
ggo04668  TNF signaling pathway
ggo04670  Leukocyte transendothelial migration
ggo04975  Fat digestion and absorption
ggo04979  Cholesterol metabolism
ggo05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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