KEGG   PATHWAY: mcal05166
Entry
mcal05166                   Pathway                                
Name
Human T-cell leukemia virus 1 infection - Mus caroli (Ryukyu mouse)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
mcal05166  Human T-cell leukemia virus 1 infection
mcal05166

Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110292203  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
110299546  Nrp1; neuropilin-1 isoform X1 [KO:K06724]
110310583  Myc; myc proto-oncogene protein [KO:K04377]
110295072  Trrap; transformation/transcription domain-associated protein isoform X2 [KO:K08874]
110285313  Kat5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
110296334  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
110299482  Itgal; integrin alpha-L isoform X1 [KO:K05718]
110311769  integrin beta-2-like protein [KO:K06464]
110303281  Itgb2; integrin beta-2 [KO:K06464]
110301325  Icam1; intercellular adhesion molecule 1 [KO:K06490]
110297313  Hras; GTPase HRas isoform X2 [KO:K02833]
110296194  Kras; GTPase KRas isoform X1 [KO:K07827]
110290873  Nras; GTPase NRas [KO:K07828]
110301502  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110303196  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110297836  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110311382  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110296921  Cd4; T-cell surface glycoprotein CD4 [KO:K06454]
110302359  Tln2; talin-2 [KO:K06271]
110292364  Tln1; talin-1 isoform X4 [KO:K06271]
110283635  Ranbp3; ran-binding protein 3 isoform X1 [KO:K15304]
110294655  Ran; GTP-binding nuclear protein Ran [KO:K07936]
110288573  GTP-binding nuclear protein Ran-like [KO:K07936]
110292956  GTP-binding nuclear protein Ran-like [KO:K07936]
110304602  Xpo1; exportin-1 isoform X1 [KO:K14290]
110299733  Calr; calreticulin [KO:K08057]
110292958  calreticulin-like isoform X1 [KO:K08057]
110305075  Canx; calnexin [KO:K08054]
110309045  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110309273  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
110290686  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
110304839  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
110293037  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
110284760  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
110308382  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110299723  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110309052  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
110310694  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
110286942  Il2rg; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
110292243  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
110299617  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110304461  signal transducer and activator of transcription 5A [KO:K11223]
110306026  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
110291180  Il2; interleukin-2 [KO:K05429]
110287975  class I histocompatibility antigen, Gogo-A*0501 alpha chain-like isoform X1 [KO:K06751]
110312557  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
110283877  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110288427  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, K-B alpha chain-like [KO:K06751]
110288489  H-2 class I histocompatibility antigen, D-K alpha chain-like [KO:K06751]
110288539  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110312198  H-2 class I histocompatibility antigen, L-D alpha chain-like isoform X4 [KO:K06751]
110312199  H-2 class I histocompatibility antigen, D-B alpha chain-like isoform X1 [KO:K06751]
110312200  H-2 class I histocompatibility antigen, D-37 alpha chain [KO:K06751]
110312202  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
110312220  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110312221  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
110312222  H-2 class I histocompatibility antigen, TLA(B) alpha chain-like [KO:K06751]
110287620  H-2 class I histocompatibility antigen, D-B alpha chain isoform X1 [KO:K06751]
110287649  H-2 class I histocompatibility antigen, D-K alpha chain-like [KO:K06751]
110287664  HLA class I histocompatibility antigen, A-25 alpha chain-like isoform X1 [KO:K06751]
110289160  H-2 class I histocompatibility antigen, K-K alpha chain-like [KO:K06751]
110288607  HLA class I histocompatibility antigen, A-32 alpha chain-like [KO:K06751]
110288635  H-2 class I histocompatibility antigen, Q7 alpha chain-like isoform X1 [KO:K06751]
110283629  H-2 class I histocompatibility antigen, TLA(B) alpha chain isoform X1 [KO:K06751]
110283630  H-2 class I histocompatibility antigen, D-K alpha chain-like isoform X1 [KO:K06751]
110288692  H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
110283690  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X3 [KO:K06751]
110283724  H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
110283726  HLA class I histocompatibility antigen, A-25 alpha chain-like isoform X1 [KO:K06751]
110283727  HLA class I histocompatibility antigen, A-24 alpha chain-like isoform X1 [KO:K06751]
110283728  HLA class I histocompatibility antigen, B-15 alpha chain-like isoform X1 [KO:K06751]
110283729  HLA class I histocompatibility antigen, A-25 alpha chain-like isoform X1 [KO:K06751]
110283730  HLA class I histocompatibility antigen, A-24 alpha chain-like isoform X1 [KO:K06751]
110312399  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
110312424  H-2 class I histocompatibility antigen, D-B alpha chain-like isoform X2 [KO:K06751]
110288817  HLA class I histocompatibility antigen, A-25 alpha chain-like isoform X1 [KO:K06751]
110310704  B2m; beta-2-microglobulin [KO:K08055]
110291229  Fdps; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
110294695  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
110304481  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
110286753  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
110300115  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
110291352  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
110309560  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
110300156  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
110310496  Tspo; translocator protein [KO:K05770]
110299775  Vac14; protein VAC14 homolog [KO:K15305]
110311764  Ranbp1; ran-specific GTPase-activating protein [KO:K15306]
110294349  Mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
110296187  Mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
110284043  Bub1b; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
110297775  Bub3; mitotic checkpoint protein BUB3 [KO:K02180]
110309589  Anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
110285702  Anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
110304665  Cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
110294047  Anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
110293908  Anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
110299673  Cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
110294056  Anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
110284785  Cdc23; cell division cycle protein 23 homolog isoform X1 [KO:K03355]
110300318  Anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
110305356  Anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
110292252  Cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
110301529  Anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
110297469  Anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
110303423  Anapc16; anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
110293740  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
110305624  Pttg1; securin isoform X1 [KO:K06635]
110310439  Espl1; separin [KO:K02365] [EC:3.4.22.49]
110301402  Ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
110292822  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
110293174  cyclin-dependent kinase inhibitor 2A [KO:K06621]
110303132  Cdk4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
110298189  Ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
110312516  Ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
110283679  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
110291693  Ccna1; cyclin-A1 isoform X1 [KO:K06627]
110291472  Ccna2; cyclin-A2 [KO:K06627]
110292124  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
110298604  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
110303221  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
110309179  Rb1; retinoblastoma-associated protein [KO:K06618]
110289983  E2f1; transcription factor E2F1 [KO:K17454]
110293508  E2f2; transcription factor E2F2 isoform X1 [KO:K09389]
110308034  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
110301441  Atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
110302416  Atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
110301495  Chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
110294527  Chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
110305297  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
110308009  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110299855  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110292624  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110290798  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110292183  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110301355  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110297609  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110294471  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110307022  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110311707  Dlg1; disks large homolog 1 isoform X4 [KO:K12076]
110285202  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110284110  Tnf; tumor necrosis factor [KO:K03156]
110296205  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
110307741  Map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
110304803  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
110294148  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110308920  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110304169  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110292423  Jun; transcription factor AP-1 [KO:K04448]
110302310  Mmp7; matrilysin isoform X1 [KO:K01397] [EC:3.4.24.23]
110293878  Il1r1; interleukin-1 receptor type 1 isoform X2 [KO:K04386]
110302131  Il1r2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
110302262  Cd3d; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
110302127  Cd3e; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
110302182  Cd3g; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
110305762  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
110285285  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110300158  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
110287188  Ikbkg; NF-kappa-B essential modulator isoform X4 [KO:K07210]
110306864  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
110291231  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110285703  Rela; transcription factor p65 [KO:K04735]
110304338  Gps2; G protein pathway suppressor 2 isoform X1 [KO:K15307]
110296619  Ltbr; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
110289392  Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
110310955  Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
110304892  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
110297403  Relb; transcription factor RelB [KO:K09253]
110285291  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
110298302  Zfp36; mRNA decay activator protein ZFP36 [KO:K15308]
110289347  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
110300342  Il15; interleukin-15 isoform X1 [KO:K05433]
110312676  Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
110295330  Il6; interleukin-6 [KO:K05405]
110305989  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
110284314  Lta; lymphotoxin-alpha [KO:K05468]
110288823  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
110286671  Xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
110298438  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
110292955  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
110306834  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
110292408  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110301725  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110284497  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
110301346  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
110284933  Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
110305998  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110307661  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
110306494  Adcy3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
110309267  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
110311373  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110310126  Adcy6; adenylate cyclase type 6 isoform X5 [KO:K08046] [EC:4.6.1.1]
110299719  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110310371  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110311555  Adcy9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
110290795  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
110300173  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110303123  Nfyb; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
110312600  H-2 class II histocompatibility antigen, A-U alpha chain [KO:K06752]
110284034  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
110312138  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
110312714  class II histocompatibility antigen, M alpha chain [KO:K06752]
110284178  HLA class II histocompatibility antigen, DO alpha chain isoform X2 [KO:K06752]
110283646  H-2 class II histocompatibility antigen, E-D beta chain [KO:K06752]
110312394  class II histocompatibility antigen, M beta 1 chain isoform X1 [KO:K06752]
110283699  H-2 class II histocompatibility antigen, E-U alpha chain [KO:K06752]
110312454  H-2 class II histocompatibility antigen, A beta chain [KO:K06752]
110283753  H-2 class II histocompatibility antigen, I-E beta chain-like isoform X1 [KO:K06752]
110284129  Srf; serum response factor isoform X1 [KO:K04378]
110299027  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
110286681  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
110289690  Spi1; transcription factor PU.1 isoform X2 [KO:K09438]
110301829  Ets1; protein C-ets-1 isoform X2 [KO:K02678]
110311296  Ets2; protein C-ets-2 [KO:K21932]
110284117  Tbp; TATA-box-binding protein isoform X1 [KO:K03120]
110303300  Tbpl1; TATA box-binding protein-like protein 1 [KO:K03120]
110289978  Tbpl2; TATA box-binding protein-like protein 2 isoform X1 [KO:K03120]
110307063  Fos; proto-oncogene c-Fos [KO:K04379]
110284697  Egr1; early growth response protein 1 [KO:K09203]
110285830  Fosl1; fos-related antigen 1 isoform X1 [KO:K04502]
110303857  Egr2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
110285614  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
110291408  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
110303337  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
110292754  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
110289497  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
110296066  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
110286367  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110310868  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110296203  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
110312537  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
110300532  Crtc1; CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
110291453  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
110299051  Crtc3; CREB-regulated transcription coactivator 3 [KO:K16334]
110310313  Ep300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110311224  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
110304328  Kat2a; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
110312276  Kat2b; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
110302901  Tcf3; transcription factor E2-alpha isoform X1 [KO:K09063]
110300157  Polb; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
110292164  Lck; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
110297919  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
110292857  Cdkn2c; cyclin-dependent kinase 4 inhibitor C isoform X1 [KO:K06622]
110307847  Tert; telomerase reverse transcriptase isoform X2 [KO:K11126] [EC:2.7.7.49]
110299185  Ventx; homeobox protein VENTX isoform X1 [KO:K09341]
110295170  Msx1; homeobox protein MSX-1 [KO:K09341]
110308427  Msx2; homeobox protein MSX-2 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
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Oncogene 24:5976-85 (2005)
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The HTLV-1 Tax interactome.
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Retrovirology 5:76 (2008)
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Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
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Viruses 3:794-810 (2011)
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PMID:21114861
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Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
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Current concepts regarding the HTLV-1 receptor complex.
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Retrovirology 7:99 (2010)
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Sinet F.
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Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
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BioSciences Master Reviews, July 2013
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Sattentau Q
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Avoiding the void: cell-to-cell spread of human viruses.
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Nat Rev Microbiol 6:815-26 (2008)
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Role of the cytoskeleton during leukocyte responses.
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Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
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Dutartre H, Claviere M, Journo C, Mahieux R
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Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
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J Virol 90:7607-17 (2016)
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Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
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A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
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Mol Cell Biol 25:6178-98 (2005)
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Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
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Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
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Viruses 3:861-85 (2011)
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  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
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Viruses 8:58 (2016)
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Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
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Front Microbiol 3:179 (2012)
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Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
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Front Microbiol 3:400 (2012)
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HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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Apoptosis 13:733-47 (2008)
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The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
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Cell Death Differ 12 Suppl 1:905-15 (2005)
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PMID:20332002
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Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
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HTLV-1 p13, a small protein with a busy agenda.
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Mol Aspects Med 31:350-8 (2010)
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PMID:23741982
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The modulation of apoptosis by oncogenic viruses.
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Virol J 10:182 (2013)
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Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
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Viruses 3:714-49 (2011)
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PMID:21994767
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Saggioro D
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Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
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Viruses 3:1001-14 (2011)
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PMID:16036567
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Harhaj EW, Harhaj NS
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Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
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IUBMB Life 57:83-91 (2005)
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Sun SC, Yamaoka S
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Activation of NF-kappaB by HTLV-I and implications for cell transformation.
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Oncogene 24:5952-64 (2005)
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PMID:9710600
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Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
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Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
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Mol Cell Biol 18:5157-65 (1998)
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Reference
PMID:21315773
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Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
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Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
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Biochim Biophys Acta 1813:731-41 (2011)
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PMID:26797638
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James CD, Roberts S
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Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
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Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
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J Biol Chem 290:26270-81 (2015)
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PMID:11264182
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Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
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Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
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Azran I, Schavinsky-Khrapunsky Y, Aboud M
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Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
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Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
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Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
mcal03013  Nucleocytoplasmic transport
mcal04010  MAPK signaling pathway
mcal04064  NF-kappa B signaling pathway
mcal04110  Cell cycle
mcal04115  p53 signaling pathway
mcal04151  PI3K-Akt signaling pathway
mcal04210  Apoptosis
mcal04350  TGF-beta signaling pathway
mcal04612  Antigen processing and presentation
mcal04660  T cell receptor signaling pathway
mcal04668  TNF signaling pathway
KO pathway
ko05166   
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