KEGG   PATHWAY: npo05417
Entry
npo05417                    Pathway                                
Name
Lipid and atherosclerosis - Nyctereutes procyonoides (raccoon dog)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
npo05417  Lipid and atherosclerosis
npo05417

Organism
Nyctereutes procyonoides (raccoon dog) [GN:npo]
Gene
129510997  APOB; apolipoprotein B-100 [KO:K14462]
129497618  APOA4; apolipoprotein A-IV [KO:K08760]
129497380  APOA1; apolipoprotein A-I [KO:K08757]
129521725  LDLR; low-density lipoprotein receptor [KO:K12473]
129517092  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
129500320  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
129497337  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
129521354  RHOA; transforming protein RhoA [KO:K04513]
129510900  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
129515953  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
129496789  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129498637  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
129507069  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129513452  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129520803  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129522073  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129508823  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129495892  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129499851  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129517633  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129514778  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129501028  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
129503119  BAD; bcl2-associated agonist of cell death [KO:K02158]
129496481  BCL2L1; bcl-2-like protein 1 [KO:K04570]
129495480  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129514527  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129494670  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129501796  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129522825  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129500563  SOD2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
129494612  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
129508751  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
129497199  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
129500391  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
129521609  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
129518821  CD40LG; CD40 ligand [KO:K03161]
129506483  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
129497114  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
129512915  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
129518564  NOX1; NADPH oxidase 1 [KO:K08008]
129517451  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
129519543  NCF1; neutrophil cytosol factor 1 [KO:K08011]
129497305  cytochrome b-245 light chain [KO:K08009]
129505958  NCF2; neutrophil cytosol factor 2 [KO:K08010]
129511803  NCF4; neutrophil cytosol factor 4 [KO:K08012]
129519689  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129494438  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129499911  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
129506479  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
129520729  cell division control protein 42 homolog [KO:K04393]
129514007  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
129497178  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
129521885  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
129496401  FOS; protein c-Fos [KO:K04379]
129497811  JUN; transcription factor Jun [KO:K04448]
129511180  C-C motif chemokine 2 [KO:K14624]
129522410  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
129520383  CXCL8; interleukin-8 [KO:K10030]
129497110  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
129508745  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
129511619  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
129511620  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
129512956  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
129512957  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
129494224  HRAS; GTPase HRas isoform X1 [KO:K02833]
129505561  KRAS; GTPase KRas isoform X1 [KO:K07827]
129501466  NRAS; GTPase NRas [KO:K07828]
129502349  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
129507918  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129519082  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129503049  RELA; transcription factor p65 isoform X1 [KO:K04735]
129521190  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129509155  SELE; E-selectin [KO:K06494]
129508998  SELP; P-selectin [KO:K06496]
129519078  VCAM1; vascular cell adhesion protein 1 isoform X1 [KO:K06527]
129497419  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
129496726  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
129508172  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
129510730  IL1B; interleukin-1 beta [KO:K04519]
129502880  IL6; interleukin-6 [KO:K05405]
129512779  TNF; tumor necrosis factor [KO:K03156]
129498420  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
129506733  LOW QUALITY PROTEIN: 60 kDa heat shock protein, mitochondrial-like [KO:K04077] [EC:5.6.1.7]
129522728  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
129503012  heat shock cognate 71 kDa protein [KO:K03283]
129496819  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
129512479  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
129512480  heat shock 70 kDa protein 1 [KO:K03283]
129512788  heat shock 70 kDa protein 1 [KO:K03283]
129514743  heat shock cognate 71 kDa protein-like [KO:K03283]
129496359  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
129494758  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
129494639  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
129496348  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
129513069  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
129516837  HSP90B1; endoplasmin [KO:K09487]
129516767  TLR2; toll-like receptor 2 [KO:K10159]
129496793  lipopolysaccharide-binding protein-like [KO:K05399]
129497956  lipopolysaccharide-binding protein-like [KO:K05399]
129513753  CD14; monocyte differentiation antigen CD14 [KO:K04391]
129505396  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
129494517  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
129496815  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
129506934  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
129505651  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
129518585  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
129494142  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
129511324  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
129499952  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
129512811  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
129493669  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129515857  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
129517602  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129499457  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
129522440  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
129496135  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
129508734  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
129497714  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
129498574  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
129515179  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
129511757  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
129494159  IRF7; interferon regulatory factor 7 [KO:K09447]
129499930  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
129494481  interferon alpha-1/2-like [KO:K05414]
129494482  interferon alpha-1/2-like [KO:K05414]
129494483  interferon alpha-1/2-like [KO:K05414]
129494485  interferon alpha-1/2-like [KO:K05414]
129494486  interferon alpha-1/2-like [KO:K05414]
129494487  interferon alpha-1/2 [KO:K05414]
129494488  interferon alpha-1/2 [KO:K05414]
129494489  interferon alpha-1/2 [KO:K05414]
129494490  interferon alpha-1/2 [KO:K05414]
129494491  interferon alpha-1/2 [KO:K05414]
129494492  interferon alpha-1/2 [KO:K05414]
129494493  interferon alpha-1/2 [KO:K05414]
129494495  interferon alpha-1/2 [KO:K05414]
129494496  interferon alpha-1/2 [KO:K05414]
129494497  interferon alpha-1/2 [KO:K05414]
129494498  interferon alpha-1/2 [KO:K05414]
129494499  interferon alpha-1/2 [KO:K05414]
129494500  interferon alpha-1/2 [KO:K05414]
129494696  interferon alpha-1/2-like [KO:K05414]
129494819  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
129495209  interferon alpha-3-like [KO:K05414]
129495280  LOW QUALITY PROTEIN: interferon alpha-1/2-like [KO:K05414]
129495282  interferon alpha-1/2 [KO:K05414]
129494739  IFNB1; interferon beta [KO:K05415]
129494196  CD36; platelet glycoprotein 4 [KO:K06259]
129521806  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
129510105  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
129512540  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
129515284  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
129505366  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
129502645  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
129506552  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
129519437  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
129521483  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
129510635  TLR6; toll-like receptor 6 [KO:K10169]
129501387  RAP1A; ras-related protein Rap-1A [KO:K04353]
129511430  RAP1B; ras-related protein Rap-1b [KO:K07836]
129516189  CCL5; C-C motif chemokine 5 isoform X1 [KO:K12499]
129509929  regakine-1-like [KO:K05408]
129513937  C-C motif chemokine 3 [KO:K05408]
129519109  growth-regulated protein homolog gamma-like [KO:K05505]
129520159  permeability factor 2-like [KO:K05505]
129520255  permeability factor 2-like [KO:K05505]
129498700  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
129509743  IL12B; interleukin-12 subunit beta [KO:K05425]
129521666  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
129497319  IL18; interleukin-18 [KO:K05482]
129505834  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
129515280  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
129511473  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
129496224  ERO1A; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
129521608  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
129515997  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
129509461  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129509507  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
129521159  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
129511084  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
129496206  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
129511576  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129506702  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
129515072  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
129509222  MAP3K5; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129508383  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
129494709  ABCA1; LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA1 [KO:K05641]
129502050  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
129498775  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
129519951  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
129500168  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
129519211  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
129503652  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
129495445  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
129514485  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
129496345  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
129497947  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
129496894  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
129504276  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
129497646  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
129500550  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
129493567  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
129495972  CALM1; calmodulin-1 [KO:K02183]
129497741  CALML6; calmodulin-like protein 6 [KO:K02183]
129506414  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
129500769  CALM3; calmodulin-3 [KO:K02183]
129511712  CALM2; calmodulin-2 isoform X1 [KO:K02183]
129513685  calmodulin-like protein 3 [KO:K02183]
129513765  CALML5; calmodulin-like protein 5 [KO:K02183]
129523448  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129509604  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
129521210  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
129495049  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
129511439  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
129498619  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
129501496  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
129503428  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
129506047  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129523021  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
129503380  BID; BH3-interacting domain death agonist [KO:K04726]
129502969  cytochrome c [KO:K08738]
129506647  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
129515281  cytochrome c-like [KO:K08738]
129518214  cytochrome c-like [KO:K08738]
129516890  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
129513406  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129521236  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
129503548  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
129493702  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
129497070  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
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Related
pathway
npo04020  Calcium signaling pathway
npo04115  p53 signaling pathway
npo04141  Protein processing in endoplasmic reticulum
npo04151  PI3K-Akt signaling pathway
npo04210  Apoptosis
npo04620  Toll-like receptor signaling pathway
npo04621  NOD-like receptor signaling pathway
npo04668  TNF signaling pathway
npo04670  Leukocyte transendothelial migration
npo04975  Fat digestion and absorption
npo04979  Cholesterol metabolism
npo05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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