KEGG   PATHWAY: ocu04024
Entry
ocu04024                    Pathway                                
Name
cAMP signaling pathway - Oryctolagus cuniculus (rabbit)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
ocu04024  cAMP signaling pathway
ocu04024

Other DBs
GO: 0019933
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100352512  VIP peptides [KO:K05264]
100301553  CRH; corticoliberin precursor [KO:K05256]
100009481  CGA; glycoprotein hormones alpha chain precursor [KO:K08522]
100009427  LHB; lutropin subunit beta precursor [KO:K08521]
127487006  glycoprotein hormone alpha-2 isoform X1 [KO:K25483]
100351194  glycoprotein hormone beta-5 [KO:K25484]
100302414  TSHB; thyrotropin subunit beta precursor [KO:K05251]
100344462  pro-opiomelanocortin [KO:K05228]
100341777  glucagon isoform X2 [KO:K05259]
100350350  gastric inhibitory polypeptide [KO:K05258]
100008946  FSHB; follitropin subunit beta precursor [KO:K05250]
100009087  NPPA; natriuretic peptides A precursor [KO:K12334]
100009031  pituitary adenylate cyclase-activating polypeptide [KO:K05262]
100338084  beta-1 adrenergic receptor [KO:K04141]
100340821  beta-2 adrenergic receptor [KO:K04142]
100008915  DRD1; D(1A) dopamine receptor [KO:K04144]
100342687  D(1B) dopamine receptor [KO:K05840]
100339944  adenosine receptor A2a [KO:K04266]
100338471  5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
100345437  5-hydroxytryptamine receptor 6 [KO:K04162]
100009369  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100009032  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X3 [KO:K04587]
100009382  vasoactive intestinal polypeptide receptor 2 [KO:K04590]
100302436  CRHR1; corticotropin-releasing factor receptor 1 precursor [KO:K04578]
100345681  corticotropin-releasing factor receptor 2 isoform X7 [KO:K04579]
100349903  lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
100353965  thyrotropin receptor isoform X1 [KO:K04249]
100347821  adrenocorticotropic hormone receptor [KO:K04200]
100356720  glucagon-like peptide 1 receptor [KO:K04581]
100350463  gastric inhibitory polypeptide receptor [KO:K04580]
100348687  glucose-dependent insulinotropic receptor [KO:K08424]
100343287  follicle-stimulating hormone receptor isoform X1 [KO:K04247]
100343663  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
100008904  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
100346323  neuroendocrine secretory protein 55 [KO:K04632]
100009270  EDN1; endothelin-1 precursor [KO:K16366]
100008634  EDN2; endothelin-2 precursor [KO:K16367]
100348609  endothelin-3 isoform X1 [KO:K05227]
100353697  somatostatin [KO:K05237]
100301542  NPY; neuropeptide Y precursor [KO:K05232]
100349547  appetite-regulating hormone isoform X3 [KO:K05254]
100343798  oxytocin [KO:K05243]
100358620  5-hydroxytryptamine receptor 1E [KO:K04153]
100008780  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
100328964  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
100345520  5-hydroxytryptamine receptor 1F [KO:K04153]
100009594  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
100346573  muscarinic acetylcholine receptor M1 [KO:K04129]
100342878  muscarinic acetylcholine receptor M2 [KO:K04130]
100347371  D(2) dopamine receptor isoform X1 [KO:K04145]
100346845  gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
100353026  gamma-aminobutyric acid type B receptor subunit 1 isoform X4 [KO:K04615]
100328615  ADORA1; adenosine receptor A1 [KO:K04265]
100126073  EDNRA; endothelin-1 receptor precursor [KO:K04197]
100008936  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
100359158  somatostatin receptor type 1 [KO:K04217]
100356395  somatostatin receptor type 2 [KO:K04218]
127485509  somatostatin receptor type 5 [KO:K04221]
100345808  hydroxycarboxylic acid receptor 1 [KO:K08401]
100346068  hydroxycarboxylic acid receptor 2 [KO:K08402]
100345896  free fatty acid receptor 2 [KO:K04328]
100341188  succinate receptor 1 [KO:K10042]
100009389  PTGER3; prostaglandin E2 receptor EP3 subtype isoform 1 [KO:K04260]
100008670  OXTR; oxytocin receptor [KO:K04229]
100101582  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
100338391  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100359147  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100339066  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
103347035  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100009201  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100343958  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100346742  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100009315  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100354934  adenylate cyclase type 6 isoform X8 [KO:K08046] [EC:4.6.1.1]
100357357  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100337882  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100340877  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100008902  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
100348238  adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
100009524  cGMP-gated cation channel alpha-1 [KO:K04948]
100009269  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
100349478  cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
100358494  cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
100359123  cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
100350985  cyclic nucleotide-gated cation channel beta-3 isoform X1 [KO:K04953]
103345165  LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
100347856  calmodulin-like protein 3 [KO:K02183]
100354905  calmodulin-3 [KO:K02183]
100352392  CALM2; calmodulin [KO:K02183]
100350107  calmodulin-1 [KO:K02183]
100345526  calmodulin-like protein 4 isoform X1 [KO:K02183]
100342451  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100341507  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100101557  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
100101556  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
103345118  calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
100346465  blood vessel epicardial substance [KO:K21108]
100353039  popeye domain-containing protein 2 isoform X2 [KO:K26206]
100350012  popeye domain-containing protein 3 isoform X1 [KO:K26207]
100356478  potassium channel subfamily K member 2 isoform X1 [KO:K04913]
108176286  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
100009452  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
100354688  ATP-binding cassette sub-family C member 4 isoform X1 [KO:K05673]
100356363  rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
100348394  rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
127489362  ras-related protein R-Ras [KO:K07829]
100355920  ras-related protein R-Ras2 [KO:K07830]
100339661  phospholipase D1 [KO:K01115] [EC:3.1.4.4]
103351479  phospholipase D2 [KO:K01115] [EC:3.1.4.4]
100344504  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100346929  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100342664  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100337999  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100351588  ras-related protein Rap-1A [KO:K04353]
100339891  ras-related protein Rap-1b [KO:K07836]
100338333  rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100341627  guanine nucleotide exchange factor VAV3 [KO:K05730]
100339873  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100356520  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100352056  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100354264  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
100356250  transforming protein RhoA [KO:K04513]
100348967  transforming protein RhoA-like [KO:K04513]
100340661  transforming protein RhoA [KO:K04513]
100346856  LOW QUALITY PROTEIN: transforming protein RhoA [KO:K04513]
100343368  transforming protein RhoA-like [KO:K04513]
100343680  transforming protein RhoA-like [KO:K04513]
127489660  transforming protein RhoA-like [KO:K04513]
100346256  afadin isoform X1 [KO:K05702]
100348663  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100345181  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100337822  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100357841  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100345250  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100342852  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100353706  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127486116  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100351964  serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100347407  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127489461  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
100347345  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100348561  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100008815  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100342212  cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
100355399  protein phosphatase 1 regulatory subunit 1B [KO:K15494]
100009587  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100009298  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100353054  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100351999  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100358175  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100343130  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
100345475  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100357876  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100357483  cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
100354135  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100340619  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100356949  LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
100338345  protein c-Fos [KO:K04379]
100008856  JUN; transcription factor Jun [KO:K04448]
100355047  transcriptional activator GLI3 isoform X2 [KO:K06230]
100358990  zinc finger protein GLI1 isoform X4 [KO:K16797]
100345046  protein patched homolog 1 isoform X1 [KO:K06225]
100344588  hedgehog-interacting protein isoform X1 [KO:K06231]
100357341  NF-kappa-B inhibitor alpha [KO:K04734]
100349426  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
127485184  transcription factor p65 isoform X1 [KO:K04735]
100008944  transcription factor SOX-9 [KO:K18435]
100356422  peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
100338450  peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
100352378  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
100351711  proteinase-activated receptor 1 [KO:K03914]
100358587  bcl2-associated agonist of cell death [KO:K02158]
100339941  hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
100009220  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100346837  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100350558  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100343384  myosin regulatory light polypeptide 9 [KO:K12755]
100009299  PLN; cardiac phospholamban [KO:K05852]
100037716  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
100354976  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
100038308  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100009536  RYR2; ryanodine receptor 2 [KO:K04962]
127486893  glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100337889  glutamate receptor ionotropic, NMDA 2A [KO:K05209]
100353266  glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
100356338  glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
103346363  LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100343526  glutamate receptor ionotropic, NMDA 3A [KO:K05213]
127489904  glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
100348217  glutamate receptor 1 isoform X1 [KO:K05197]
100357153  glutamate receptor 2 isoform X1 [KO:K05198]
100341980  glutamate receptor 3 isoform X2 [KO:K05199]
100338204  glutamate receptor 4 isoform X1 [KO:K05200]
100009471  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
100349382  sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
100358269  sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
100008756  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
100302415  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
100009577  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
100008749  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
100008788  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
100350113  protein ATP1B4 isoform X2 [KO:K01540]
103349229  sodium/potassium-transporting ATPase subunit gamma isoform X2 [KO:K01538]
127482585  sodium/potassium-transporting ATPase subunit gamma-like isoform X1 [KO:K01538]
103345420  phospholemman isoform X1 [KO:K13360]
100009586  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100349347  calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
127484746  calcium release-activated calcium channel protein 1 [KO:K16056]
100356760  plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
100355180  plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
103351031  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4-like [KO:K05850] [EC:7.2.2.10]
100339414  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4-like [KO:K05850] [EC:7.2.2.10]
100356734  plasma membrane calcium-transporting ATPase 4 isoform X3 [KO:K05850] [EC:7.2.2.10]
100353865  plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
103351001  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
100009543  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
100101555  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100327259  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100357261  voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100009585  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100009330  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
100352820  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
100351753  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2 [KO:K13293] [EC:3.1.4.53]
100355058  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2 [KO:K13293] [EC:3.1.4.53]
100009247  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
100340245  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
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Related
pathway
ocu00071  Fatty acid degradation
ocu04015  Rap1 signaling pathway
ocu04020  Calcium signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04210  Apoptosis
ocu04260  Cardiac muscle contraction
ocu04340  Hedgehog signaling pathway
ocu04720  Long-term potentiation
ocu04740  Olfactory transduction
ocu04972  Pancreatic secretion
ocu04976  Bile secretion
KO pathway
ko04024   
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