KEGG   PATHWAY: panu05022
Entry
panu05022                   Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Papio anubis (olive baboon)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
panu05022  Pathways of neurodegeneration - multiple diseases
panu05022

Organism
Papio anubis (olive baboon) [GN:panu]
Gene
101003817  APP; amyloid-beta precursor protein isoform X4 [KO:K04520]
101018182  LOW QUALITY PROTEIN: microtubule-associated protein tau-like [KO:K04380]
101004302  MAPT; microtubule-associated protein tau isoform X7 [KO:K04380]
101026073  SNCA; alpha-synuclein isoform X3 [KO:K04528]
101012526  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
100999207  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
101009607  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
101001338  ATXN2; ataxin-2 isoform X1 [KO:K23625]
101001753  ATXN2L; ataxin-2-like protein isoform X6 [KO:K23625]
101000758  HTT; huntingtin [KO:K04533]
101012589  ATXN1; ataxin-1 [KO:K23616]
101023742  ATXN1L; ataxin-1-like [KO:K23616]
101021868  ataxin-3-like protein [KO:K11863] [EC:3.4.22.-]
101018946  ATXN3; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
101022217  ATXN3L; ataxin-3-like protein [KO:K11863] [EC:3.4.22.-]
101012637  PRNP; major prion protein [KO:K05634]
101002299  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101008907  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101014406  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101022878  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
101005483  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
101020156  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
101024177  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [KO:K04634]
101013061  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
101012903  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100998763  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100999120  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858] [EC:3.1.4.11]
101010000  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
101012165  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101016532  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
101009865  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100137333  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100999924  TRPC3; short transient receptor potential channel 3 isoform X3 [KO:K04966]
101003936  SIGMAR1; sigma non-opioid intracellular receptor 1 isoform X1 [KO:K20719]
101017317  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101023200  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101001272  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101026547  ryanodine receptor 1 [KO:K04961]
101014706  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
101014060  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
101015738  PDYN; proenkephalin-B [KO:K15840]
101018290  DLG4; disks large homolog 4 isoform X5 [KO:K11828]
101001959  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X3 [KO:K05208]
101002110  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101009230  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101018050  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X3 [KO:K05211]
101014632  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
101000382  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
101026424  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
101020351  GRIA3; glutamate receptor 3 isoform X2 [KO:K05199]
101012565  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
101026237  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X7 [KO:K04850]
101002070  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X6 [KO:K04851]
101019865  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101025213  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101012925  STX1A; syntaxin-1A [KO:K04560]
101006072  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
101021063  ATP2A2; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101009959  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
100999076  ATP2A1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
101000508  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
101005201  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
101011564  DERL1; derlin-1 [KO:K11519]
100998120  VCP; transitional endoplasmic reticulum ATPase isoform X1 [KO:K13525]
101022082  ubiquitin-like [KO:K02927]
101018915  UBA52; ubiquitin-60S ribosomal protein L40 isoform X2 [KO:K02927]
101020976  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
101021708  ubiquitin-like [KO:K02977]
101020037  UBC; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K04551]
101022470  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
101021214  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101000967  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
101014380  PSMA8; proteasome subunit alpha-type 8 isoform X2 [KO:K02731] [EC:3.4.25.1]
100999118  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
101007366  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
101020989  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
101013344  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
116275734  proteasome subunit alpha type-3-like [KO:K02727] [EC:3.4.25.1]
101018540  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
101009488  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
101024402  PSMB3; proteasome subunit beta type-3 isoform X1 [KO:K02735] [EC:3.4.25.1]
101002516  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
100997814  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
101007533  PSMB1; proteasome subunit beta type-1 isoform X2 [KO:K02732] [EC:3.4.25.1]
116272469  proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
100137420  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
101005223  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
101006552  PSMC1; 26S proteasome regulatory subunit 4 isoform X1 [KO:K03062]
101016782  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
101018096  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
100998789  26S proteasome regulatory subunit 10B [KO:K03064]
101022271  PSMC3; 26S proteasome regulatory subunit 6A isoform X2 [KO:K03065]
101002087  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
101005799  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101016848  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101013675  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
101025669  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
101018302  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
101002325  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
100997045  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
101014998  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 isoform X3 [KO:K03038]
101026980  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
100137416  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
101021787  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
101022085  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101024714  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X2 [KO:K06691]
101027004  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
101014623  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
101017972  UBA1; ubiquitin-like modifier-activating enzyme 1 isoform X1 [KO:K03178] [EC:6.2.1.45]
101016869  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
101009793  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
101020504  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
101004589  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
101005234  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
101017327  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
101011735  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X2 [KO:K10575] [EC:2.3.2.23]
101004759  GPR37; prosaposin receptor GPR37 [KO:K04243]
101020369  SEPTIN5; septin-5 isoform X3 [KO:K04557]
101011425  SNCAIP; synphilin-1 isoform X4 [KO:K04558]
101021099  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
101012391  VAPB; vesicle-associated membrane protein-associated protein B/C isoform X1 [KO:K10707]
101014227  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
101001462  DDIT3; DNA damage-inducible transcript 3 protein isoform X2 [KO:K04452]
101017284  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101001514  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101017914  TRAF2; LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101002917  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101011807  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101005010  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101022320  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101019884  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101005329  LOW QUALITY PROTEIN: caspase-12 [KO:K04741] [EC:3.4.22.-]
101023378  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101007255  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
101025391  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101013627  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101022805  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
101024255  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
14444642  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
14444630  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
14444636  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
14444638  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
14444637  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
14444639  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
116273132  LOW QUALITY PROTEIN: uncharacterized protein LOC116273132 [KO:K03884] [EC:7.1.1.2]
14444640  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
101006922  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
100998941  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
101009040  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
101007924  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
101013937  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
103885307  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
101025484  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
108580506  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101014495  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
108580495  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101026476  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
108586421  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101021591  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
100999652  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101013121  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101008045  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
101025936  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
101008424  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
101006233  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X3 [KO:K03954]
103876537  acyl carrier protein, mitochondrial [KO:K03955]
101024176  acyl carrier protein, mitochondrial-like [KO:K03955]
116272890  acyl carrier protein, mitochondrial [KO:K03955]
101007204  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101026186  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101002746  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101001064  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
101019309  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
101021838  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X2 [KO:K03958]
101005887  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
108587044  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
101004754  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101026496  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101002541  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
101015506  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
100997770  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101026190  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
101003419  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101022237  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101022093  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101014764  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101001230  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
101002291  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101020754  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101017486  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
116275293  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101026904  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101002763  NDUFS8; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
100998717  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101017439  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101025145  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
116273554  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
101000070  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101001260  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
101006239  succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
101002161  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
101011036  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
110741279  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
101026782  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
14444641  CYTB; cytochrome b [KO:K00412]
101021397  cytochrome c1, heme protein, mitochondrial [KO:K00413]
101009600  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
101026315  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
101006001  cytochrome b-c1 complex subunit 6, mitochondrial isoform X2 [KO:K00416]
100997829  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
101017841  cytochrome b-c1 complex subunit 8 [KO:K00418]
100997845  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
116273763  cytochrome b-c1 complex subunit 10 [KO:K00420]
14444635  COX3; cytochrome c oxidase subunit III [KO:K02262]
14444631  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
14444632  COX2; cytochrome c oxidase subunit II [KO:K02261]
101006909  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
101019045  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
101003461  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
101020469  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
101001315  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
101006649  COX5A; cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
103877721  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
101007148  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
103876119  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
101000271  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
101018921  cytochrome c oxidase subunit 6B2 [KO:K02267]
101010708  cytochrome c oxidase subunit 6B1 [KO:K02267]
108586074  cytochrome c oxidase subunit 6C-like [KO:K02268]
101013819  cytochrome c oxidase subunit 6C [KO:K02268]
101002878  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
101019499  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
116271663  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
116271667  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
101021606  cytochrome c oxidase subunit 7A1, mitochondrial isoform X2 [KO:K02270]
101013709  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
116269782  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
103884346  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
108581070  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108585455  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
101014053  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
108586679  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108587428  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108586288  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
116274896  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
116274898  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
108585269  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
101019295  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
101026809  cytochrome c oxidase subunit 8C, mitochondrial isoform X2 [KO:K02273]
100126727  COX8A; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273]
100997548  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
101017406  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101010257  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
100137597  ATP5C1; ATP synthase subunit gamma, mitochondrial [KO:K02136]
101005176  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
14444634  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
101000308  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X2 [KO:K02127]
101007596  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101021172  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
101011935  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101017933  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
101018964  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
101024769  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
101007673  ATP synthase subunit d, mitochondrial [KO:K02138]
101016617  ATP synthase subunit O, mitochondrial [KO:K02137]
100137250  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
101005105  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
14444633  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
101026183  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
101020566  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101003676  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
101023043  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
101002958  MCU; calcium uniporter protein, mitochondrial isoform X2 [KO:K20858]
101017532  CALML6; calmodulin-like protein 6 [KO:K02183]
100997835  CALML5; calmodulin-like protein 5 [KO:K02183]
100997036  CALM2; calmodulin-2 [KO:K02183]
101019754  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
101007101  CALM1; calmodulin-1 isoform X1 [KO:K02183]
101011767  CALM3; calmodulin-3 isoform X2 [KO:K02183]
100998530  CALML3; calmodulin-like protein 3 [KO:K02183]
101024785  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101026693  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101025310  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
103877032  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101004981  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
101012551  BAD; bcl2-associated agonist of cell death [KO:K02158]
101000210  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101017433  FADD; FAS-associated death domain protein [KO:K02373]
101009470  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101008656  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
101000115  BAK1; bcl-2 homologous antagonist/killer isoform X2 [KO:K14021]
100137384  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
100999628  HTRA2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
101001298  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
101009552  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101019427  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
100998956  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101009750  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
101025041  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
101000631  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100997257  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101025906  cytochrome c-like [KO:K08738]
101020480  cytochrome c-like [KO:K08738]
101021327  cytochrome c-like [KO:K08738]
101014039  cytochrome c-like [KO:K08738]
101008579  cytochrome c [KO:K08738]
100997529  cytochrome c [KO:K08738]
101021349  cytochrome c-like [KO:K08738]
100997503  cytochrome c-like [KO:K08738]
101019410  cytochrome c-like [KO:K08738]
103878393  cytochrome c-like [KO:K08738]
108582823  cytochrome c-like [KO:K08738]
101014473  cytochrome c-like [KO:K08738]
101023208  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
101009907  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
101023728  CASP3; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
101006933  HIP1; huntingtin-interacting protein 1 isoform X2 [KO:K04559]
101014946  IFT57; intraflagellar transport protein 57 homolog isoform X2 [KO:K04638]
101012016  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
101001746  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
116271990  peptidyl-prolyl cis-trans isomerase D-like [KO:K05864] [EC:5.2.1.8]
101019084  PARK7; protein/nucleic acid deglycase DJ-1 [KO:K05687] [EC:3.5.1.124]
101019436  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101006371  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
101024137  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
101025763  OPTN; optineurin [KO:K19946]
101018581  SQSTM1; sequestosome-1 [KO:K14381]
108582275  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
110740813  MAP1LC3B2; LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3 beta 2 [KO:K10435]
100999213  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
101019892  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A isoform X2 [KO:K10435]
100999024  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
100999858  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101020486  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
101016297  WDR41; WD repeat-containing protein 41 isoform X4 [KO:K23610]
101021465  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
101002313  C9orf72; guanine nucleotide exchange C9orf72 homolog isoform X1 [KO:K23609]
101014385  RAB8A; ras-related protein Rab-8A [KO:K07901]
101007325  RAB39B; ras-related protein Rab-39B [KO:K07925]
100999260  RAB1A; ras-related protein Rab-1A isoform X1 [KO:K07874]
101015041  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
101010161  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
101005224  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
101022496  ATG101; autophagy-related protein 101 [KO:K19730]
101005094  ATG13; autophagy-related protein 13 isoform X8 [KO:K08331]
101009883  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
101004741  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X2 [KO:K17985]
100999381  beclin-2 [KO:K08334]
101012227  BECN1; beclin-1 isoform X5 [KO:K08334]
116273742  BECN2; beclin-2 [KO:K08334]
116273743  beclin-2 [KO:K08334]
101011963  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
101001656  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101017200  nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
101019324  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
101022653  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
101015836  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
100137474  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
101000917  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X5 [KO:K17908]
101016439  WD repeat domain phosphoinositide-interacting protein 2-like isoform X2 [KO:K17908]
101024767  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
100997356  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
101013507  ALS2; alsin isoform X1 [KO:K04575]
100999279  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
101003935  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100999632  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
101013917  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
101025983  SPG11; spatacsin isoform X1 [KO:K19026]
101013835  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101024834  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X2 [KO:K05141]
101025952  DAXX; death domain-associated protein 6 isoform X3 [KO:K02308]
101012583  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
101001515  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X4 [KO:K04433] [EC:2.7.12.2]
101001103  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101002393  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101024189  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101024771  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101025542  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
101024502  CCS; copper chaperone for superoxide dismutase isoform X1 [KO:K04569]
101009135  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
101023235  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
101018549  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
101018890  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
101020922  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
101017505  GPX2; glutathione peroxidase 2 isoform X1 [KO:K00432] [EC:1.11.1.9]
103885101  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
101013655  CAT; LOW QUALITY PROTEIN: catalase [KO:K03781] [EC:1.11.1.6]
101016100  PRPH; peripherin isoform X2 [KO:K07607]
101012980  NEFL; neurofilament light polypeptide [KO:K04572]
101014904  NEFM; neurofilament medium polypeptide [KO:K04573]
101023307  NEFH; LOW QUALITY PROTEIN: neurofilament heavy polypeptide [KO:K04574]
101002273  KIF5A; kinesin heavy chain [KO:K10396]
101014566  KIF5C; kinesin heavy chain [KO:K10396]
101002261  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
101026784  KLC3; kinesin light chain 3 isoform X3 [KO:K10407]
101000901  KLC2; kinesin light chain 2 [KO:K10407]
101010092  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
101022226  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
101010758  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101018365  tubulin alpha-1C chain isoform X1 [KO:K07374]
101006121  tubulin alpha-4A chain isoform X2 [KO:K07374]
101001204  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
101017171  LOW QUALITY PROTEIN: tubulin alpha chain [KO:K07374]
101016030  LOW QUALITY PROTEIN: tubulin beta-2A chain [KO:K07375]
101003610  TUBB4A; tubulin beta-4A chain [KO:K07375]
101016760  tubulin beta-2B chain isoform X1 [KO:K07375]
100998701  TUBB; tubulin beta chain [KO:K07375]
101005103  TUBB4B; tubulin beta-4B chain [KO:K07375]
100999710  tubulin beta-8 chain-like [KO:K07375]
116273103  tubulin beta-8 chain-like [KO:K07375]
101018350  tubulin beta-8 chain [KO:K07375]
100137440  TUBB2A; tubulin beta-2A chain [KO:K07375]
101005758  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
101014512  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
110742076  TUBB3; tubulin beta-3 chain [KO:K07375]
100998800  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101013938  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
101002737  CSNK2A1; casein kinase II subunit alpha isoform X2 [KO:K03097] [EC:2.7.11.1]
101007866  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
101016241  DCTN1; dynactin subunit 1 isoform X6 [KO:K04648]
100999496  DCTN2; dynactin subunit 2 isoform X3 [KO:K10424]
101006034  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
101017720  DCTN4; dynactin subunit 4 isoform X2 [KO:K10426]
101015822  DCTN5; dynactin subunit 5 isoform X2 [KO:K10427]
101008288  DCTN6; dynactin subunit 6 [KO:K10428]
101007489  ACTR1B; beta-centractin isoform X1 [KO:K16575]
101023419  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
101016438  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
101021843  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
101013747  DNAH7; dynein heavy chain 7, axonemal isoform X1 [KO:K10408]
103876134  DNAH10; dynein heavy chain 10, axonemal isoform X1 [KO:K10408]
101017895  dynein heavy chain 14, axonemal [KO:K10408]
101013562  dynein heavy chain 17, axonemal [KO:K10408]
101014725  DNAH9; dynein heavy chain 9, axonemal isoform X1 [KO:K10408]
101016123  DNAH6; dynein heavy chain 6, axonemal isoform X1 [KO:K10408]
101023096  DNAH12; dynein heavy chain 12, axonemal isoform X1 [KO:K10408]
101026626  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
101013413  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
101019979  DNAH5; dynein heavy chain 5, axonemal [KO:K10408]
101013563  DNAH8; dynein heavy chain 8, axonemal isoform X1 [KO:K10408]
101009834  DNAH2; dynein heavy chain 2, axonemal isoform X3 [KO:K10408]
101002935  DNAH3; dynein heavy chain 3, axonemal isoform X1 [KO:K10408]
101016231  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
101007991  DNAI1; dynein intermediate chain 1, axonemal isoform X2 [KO:K10409]
101005389  DNAL1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
101006108  DNAL4; dynein light chain 4, axonemal [KO:K10412]
116269450  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
116269451  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
101008925  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X10 [KO:K04515] [EC:2.7.11.17]
101009984  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X37 [KO:K04515] [EC:2.7.11.17]
101011087  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101019885  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X18 [KO:K04515] [EC:2.7.11.17]
101025437  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
101022030  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
101002671  CDK5R1; cyclin-dependent kinase 5 activator 1 isoform X2 [KO:K11716]
100999052  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
100999117  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
101014746  DKK2; dickkopf-related protein 2 [KO:K02165]
101008417  DKK1; dickkopf-related protein 1 [KO:K02165]
101019062  DKK4; dickkopf-related protein 4 [KO:K02165]
101013629  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101008897  WNT2B; protein Wnt-2b [KO:K00182]
100126674  WNT2; protein Wnt-2 precursor [KO:K00182]
101001727  WNT3; proto-oncogene Wnt-3 isoform X2 [KO:K00312]
101005424  WNT4; protein Wnt-4 [KO:K00408]
100997755  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
101019776  WNT5B; protein Wnt-5b [KO:K00444]
100997506  WNT6; protein Wnt-6 [KO:K00445]
101009898  WNT7B; protein Wnt-7b [KO:K00572]
101002180  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
101014279  WNT8A; protein Wnt-8a [KO:K00714]
101002037  WNT8B; protein Wnt-8b [KO:K00714]
100999626  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
101007522  WNT9B; protein Wnt-9b [KO:K01064]
100997855  WNT10A; protein Wnt-10a [KO:K01357]
101013252  WNT10B; protein Wnt-10b [KO:K01357]
101005798  WNT11; protein Wnt-11 [KO:K01384]
101022538  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
101015632  FZD7; frizzled-7 [KO:K02432]
100137461  FZD1; frizzled-1 [KO:K02432]
101011059  FZD2; frizzled-2 [KO:K02235]
101000744  FZD3; frizzled-3 isoform X1 [KO:K02329]
101013533  FZD4; frizzled-4 isoform X1 [KO:K02354]
101013139  FZD5; frizzled-5 [KO:K02375]
101012990  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
100999712  FZD6; frizzled-6 [KO:K02376]
101004836  FZD10; frizzled-10 [KO:K02842]
101010325  FZD9; frizzled-9 [KO:K02842]
101026239  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
100189542  LRP5; low-density lipoprotein receptor-related protein 5 precursor [KO:K03068]
101001218  casein kinase I isoform X2 [KO:K08960] [EC:2.7.11.1]
101019485  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
101007736  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X6 [KO:K02353]
101007009  DVL1; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
101009787  FRAT1; proto-oncogene FRAT1 [KO:K03069]
101013482  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
101012942  AXIN2; axin-2 isoform X1 [KO:K04385]
101015820  APC; adenomatous polyposis coli protein isoform X7 [KO:K02085]
101014712  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101004678  CSNK1A1; casein kinase I isoform X6 [KO:K08957] [EC:2.7.11.1]
101008836  CSNK1A1L; casein kinase I [KO:K08957] [EC:2.7.11.1]
101002992  HRAS; GTPase HRas isoform X2 [KO:K02833]
101017528  KRAS; GTPase KRas isoform X2 [KO:K07827]
101026253  NRAS; GTPase NRas isoform X2 [KO:K07828]
101019640  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101022780  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101009029  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101008394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101004074  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
100999821  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
101006760  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101021562  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
101017078  RELA; transcription factor p65 isoform X1 [KO:K04735]
101026781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580]
101019718  nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101025796  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100381195  IL6; interleukin-6 precursor [KO:K05405]
101023088  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
101023446  IL1B; interleukin-1 beta [KO:K04519]
101016725  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:30258237
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Gan L, Cookson MR, Petrucelli L, La Spada AR
  Title
Converging pathways in neurodegeneration, from genetics to mechanisms.
  Journal
Nat Neurosci 21:1300-1309 (2018)
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Reference
PMID:28062563
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Dugger BN, Dickson DW
  Title
Pathology of Neurodegenerative Diseases.
  Journal
Cold Spring Harb Perspect Biol 9:a028035 (2017)
DOI:10.1101/cshperspect.a028035
Reference
PMID:20070435
  Authors
Jellinger KA
  Title
Basic mechanisms of neurodegeneration: a critical update.
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J Cell Mol Med 14:457-87 (2010)
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Reference
PMID:19707851
  Authors
Jellinger KA
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Recent advances in our understanding of neurodegeneration.
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J Neural Transm (Vienna) 116:1111-62 (2009)
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Reference
PMID:30743990
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Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.
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Int J Mol Sci 20:E719 (2019)
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Reference
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Ross CA, Poirier MA
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Protein aggregation and neurodegenerative disease.
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Nat Med 10 Suppl:S10-7 (2004)
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Reference
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Soto C, Pritzkow S
  Title
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.
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Nat Neurosci 21:1332-1340 (2018)
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Reference
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  Authors
Dantuma NP, Bott LC
  Title
The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution.
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Front Mol Neurosci 7:70 (2014)
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Reference
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  Authors
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  Title
Failure of ubiquitin proteasome system: risk for neurodegenerative diseases.
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Neurodegener Dis 14:161-75 (2014)
DOI:10.1159/000367694
Reference
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  Authors
Park H, Kang JH, Lee S
  Title
Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates.
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Int J Mol Sci 21:E3369 (2020)
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Reference
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  Authors
Malik BR, Maddison DC, Smith GA, Peters OM
  Title
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease.
  Journal
Mol Brain 12:100 (2019)
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Reference
PMID:29734735
  Authors
Metaxakis A, Ploumi C, Tavernarakis N
  Title
Autophagy in Age-Associated Neurodegeneration.
  Journal
Cells 7:E37 (2018)
DOI:10.3390/cells7050037
Reference
PMID:25270767
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
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  Authors
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  Title
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities.
  Journal
Neuron 93:1015-1034 (2017)
DOI:10.1016/j.neuron.2017.01.022
Reference
PMID:30030024
  Authors
Chu CT
  Title
Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases.
  Journal
Neurobiol Dis 122:23-34 (2019)
DOI:10.1016/j.nbd.2018.07.015
Reference
PMID:19043451
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
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Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
PMID:21722302
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J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
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J Neurochem 142:812-826 (2017)
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Reference
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Reference
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Reference
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Reference
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Reference
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Reference
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Axonal transport deficits and neurodegenerative diseases.
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Reference
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Retrograde axonal transport: pathways to cell death?
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Trends Neurosci 33:335-44 (2010)
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Related
pathway
panu00190  Oxidative phosphorylation
panu03050  Proteasome
panu04020  Calcium signaling pathway
panu04120  Ubiquitin mediated proteolysis
panu04137  Mitophagy - animal
panu04140  Autophagy - animal
panu04141  Protein processing in endoplasmic reticulum
panu04142  Lysosome
panu04210  Apoptosis
panu04310  Wnt signaling pathway
panu04724  Glutamatergic synapse
panu04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   
LinkDB

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