KEGG   PATHWAY: pcw05169
Entry
pcw05169                    Pathway                                
Name
Epstein-Barr virus infection - Phascolarctos cinereus (koala)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
pcw05169  Epstein-Barr virus infection
pcw05169

Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110219631  CR2; LOW QUALITY PROTEIN: complement receptor type 2 [KO:K04012]
110203606  LOW QUALITY PROTEIN: complement component receptor 1-like protein [KO:K04012]
110221859  CD19; B-lymphocyte antigen CD19 [KO:K06465]
110203296  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
110201282  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
110204537  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
110199338  rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752]
110199339  HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
110199388  H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752]
110199389  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
110199403  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
110199459  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
110199460  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
110213633  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
110197028  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
110199045  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
110201533  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
110192620  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
110205796  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
110208533  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
110192034  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
110213919  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110196387  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110200334  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
110211795  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
110209686  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
110195563  RELA; transcription factor p65 isoform X1 [KO:K04735]
110199397  TNF; tumor necrosis factor [KO:K03156]
110213115  IL6; interleukin-6 [KO:K05405]
110200846  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
110218357  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
110197337  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
110211020  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
110219596  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
110202995  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
110219913  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
110201183  interferon tau-2-like [KO:K05414]
110199230  interferon tau-2-like [KO:K05414]
110199240  interferon omega-1-like [KO:K05414]
110199247  interferon omega-1-like [KO:K05414]
110199249  interferon tau-2-like [KO:K05414]
110199250  interferon tau-2-like [KO:K05414]
110199251  interferon tau-2-like [KO:K05414]
110199253  interferon tau-2-like [KO:K05414]
110199254  interferon tau-2-like [KO:K05414]
110199255  interferon tau-2-like [KO:K05414]
110201199  interferon tau-2-like [KO:K05414]
110201202  interferon tau-2-like [KO:K05414]
110201203  interferon alpha-2-like [KO:K05414]
110199211  interferon beta-like [KO:K05415]
110199212  interferon beta-like [KO:K05415]
110199213  interferon beta-like [KO:K05415]
110199216  interferon beta-like [KO:K05415]
110199218  interferon beta-like [KO:K05415]
110214849  interferon alpha/beta receptor 1-like [KO:K05130]
110214853  IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
110212891  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
110214168  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
110213248  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
110210934  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
110195167  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
110212711  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
110202068  2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
110202070  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
110202095  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
110209772  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
110209774  C-X-C motif chemokine 10-like [KO:K12671]
110201233  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
110198951  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
110197147  FADD; FAS-associated death domain protein [KO:K02373]
110197193  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
110218747  BID; BH3-interacting domain death agonist [KO:K04726]
110209301  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
110214751  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
110219776  BAX; apoptosis regulator BAX [KO:K02159]
110217311  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
110218411  cytochrome c-like [KO:K08738]
110218003  cytochrome c-like [KO:K08738]
110203137  cytochrome c-like [KO:K08738]
110213139  cytochrome c [KO:K08738]
110221734  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
110198824  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
110222594  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
110207187  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
110207190  CD3G; T-cell surface glycoprotein CD3 gamma chain isoform X1 [KO:K06452]
110207189  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
110199767  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
110206983  PSMC2; LOW QUALITY PROTEIN: 26S protease regulatory subunit 7 [KO:K03061]
110217774  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
110201617  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
110199865  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
110224015  PSMC3; 26S protease regulatory subunit 6A isoform X1 [KO:K03065]
110215691  PSMC5; 26S protease regulatory subunit 8 isoform X1 [KO:K03066]
110221248  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
110198030  PSMD1; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
110215856  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
110218285  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
110192235  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
110202295  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
110210247  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
110203710  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
110220733  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
110202455  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
110205179  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
110217633  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
110199416  LOW QUALITY PROTEIN: antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
110199321  LOW QUALITY PROTEIN: antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
110199346  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
110199320  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
110199417  LOW QUALITY PROTEIN: antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
110217175  TAPBP; tapasin isoform X1 [KO:K08058]
110223618  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
110214405  CALR; calreticulin [KO:K08057]
110209460  calreticulin-like [KO:K08057]
110203128  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
110199325  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
110199390  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
110203695  HLA class I histocompatibility antigen, B-8 alpha chain-like [KO:K06751]
110223003  HLA class I histocompatibility antigen, B-40 alpha chain-like [KO:K06751]
110223021  HLA class I histocompatibility antigen, B-35 alpha chain-like isoform X1 [KO:K06751]
110223022  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
110202415  HLA class I histocompatibility antigen, A-69 alpha chain-like isoform X1 [KO:K06751]
110202416  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
110218416  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
110218421  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
110218435  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
110218436  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
110218438  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
110218444  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
110199312  H-2 class I histocompatibility antigen, D-D alpha chain-like isoform X1 [KO:K06751]
110218456  zinc-alpha-2-glycoprotein-like [KO:K06751]
110218463  zinc-alpha-2-glycoprotein-like isoform X1 [KO:K06751]
110218465  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
110199902  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
110223608  B2M; beta-2-microglobulin [KO:K08055]
110208272  SNW1; SNW domain-containing protein 1 [KO:K06063]
110213985  SIN3A; LOW QUALITY PROTEIN: paired amphipathic helix protein Sin3a [KO:K11644]
110206263  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
110222906  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
110196820  NCOR2; LOW QUALITY PROTEIN: nuclear receptor corepressor 2 [KO:K06065]
110202333  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
110216008  SAP30; LOW QUALITY PROTEIN: histone deacetylase complex subunit SAP30 [KO:K19202]
110211586  CIR1; LOW QUALITY PROTEIN: corepressor interacting with RBPJ 1 [KO:K06066]
110206703  RBPJL; LOW QUALITY PROTEIN: recombining binding protein suppressor of hairless-like protein [KO:K06053]
110212266  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
110193151  HES1; transcription factor HES-1 [KO:K06054]
110201244  HES4; transcription factor HES-4 isoform X1 [KO:K06054]
110202110  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
110206085  RUNX3; LOW QUALITY PROTEIN: runt-related transcription factor 3 [KO:K09279]
110216083  MYC; myc proto-oncogene protein [KO:K04377]
110198581  USP7; ubiquitin carboxyl-terminal hydrolase 7 [KO:K11838] [EC:3.4.19.12]
110211045  MDM2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
110194271  TP53; cellular tumor antigen p53 [KO:K04451]
110217257  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
110212964  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
110223449  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
110195907  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
110223919  DDB2; LOW QUALITY PROTEIN: DNA damage-binding protein 2 [KO:K10140]
110216585  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
110222706  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
110204454  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110208219  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110199476  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
110223395  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110216530  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110209293  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110205475  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110202713  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110203042  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110215732  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
110219736  RELB; transcription factor RelB [KO:K09253]
110194796  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
110210433  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
110202311  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
110213490  NFKBIE; LOW QUALITY PROTEIN: NF-kappa-B inhibitor epsilon [KO:K05872]
110193880  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
110202112  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
110216709  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110209710  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110215514  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110205309  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110201152  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
110223168  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
110219359  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
110217326  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110217327  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110205920  MAPK11; LOW QUALITY PROTEIN: mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
110205921  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110212948  JUN; transcription factor AP-1 [KO:K04448]
110205253  LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
110205289  ENTPD8; LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
110215401  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
110213157  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
110193707  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
110192604  CD44; CD44 antigen isoform X1 [KO:K06256]
110223126  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
110219366  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
110214227  intercellular adhesion molecule 1-like isoform X1 [KO:K06490]
110194491  VIM; LOW QUALITY PROTEIN: vimentin [KO:K07606]
110199059  TNFAIP3; LOW QUALITY PROTEIN: tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
110223345  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110198372  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
110221373  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
110203252  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
110205050  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
110193513  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110214297  immunoglobulin alpha-2 heavy chain-like isoform X1 [KO:K06856]
110214304  Ig heavy chain Mem5-like [KO:K06856]
110192312  BTK; tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
110215508  BLNK; B-cell linker protein isoform X1 [KO:K07371]
110212621  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
110214774  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
110218707  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
110197171  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110218698  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110203289  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110210989  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110209152  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
110222963  CCNA2; cyclin-A2 [KO:K06627]
110195227  CCNA1; LOW QUALITY PROTEIN: cyclin-A1 [KO:K06627]
110220000  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
110207433  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
110195790  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
110210908  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
110213446  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
110216806  E2F1; transcription factor E2F1 [KO:K17454]
110206051  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
110208713  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
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Semin Cancer Biol 18:397-408 (2008)
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PLoS Pathog 5:e1000530 (2009)
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Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
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J Virol 83:4652-69 (2009)
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Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
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Future Virol 4:79-91 (2009)
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Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
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Front Oncol 8:265 (2018)
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Epstein-Barr virus: induction and control of cell transformation.
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J Cell Physiol 196:207-18 (2003)
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Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
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PLoS Pathog 7:e1001275 (2011)
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Related
pathway
pcw03050  Proteasome
pcw04010  MAPK signaling pathway
pcw04020  Calcium signaling pathway
pcw04064  NF-kappa B signaling pathway
pcw04110  Cell cycle
pcw04115  p53 signaling pathway
pcw04210  Apoptosis
pcw04612  Antigen processing and presentation
pcw04620  Toll-like receptor signaling pathway
pcw04622  RIG-I-like receptor signaling pathway
pcw04630  JAK-STAT signaling pathway
pcw04662  B cell receptor signaling pathway
KO pathway
ko05169   
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