KEGG   PATHWAY: pgig05169
Entry
pgig05169                   Pathway                                
Name
Epstein-Barr virus infection - Pteropus giganteus (Indian flying fox)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
pgig05169  Epstein-Barr virus infection
pgig05169

Organism
Pteropus giganteus (Indian flying fox) [GN:pgig]
Gene
120589495  complement receptor type 2-like isoform X1 [KO:K04012]
120620142  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
120597570  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
120597603  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
120597605  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
120597654  HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752]
120597655  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
120597657  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
120597658  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
120597659  boLa class II histocompatibility antigen, DQB*0101 beta chain-like isoform X1 [KO:K06752]
120597661  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
120597662  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
120597678  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
120597680  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
120613273  TLR2; toll-like receptor 2 [KO:K10159]
120586750  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
120618259  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
120605933  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
120606104  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
120603000  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
120589386  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
120595002  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
120609204  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
120595665  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
120605919  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
120620765  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
120591230  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120584840  RELA; transcription factor p65 [KO:K04735]
120618944  TNF; tumor necrosis factor [KO:K03156]
120602335  IL6; interleukin-6 isoform X1 [KO:K05405]
120612927  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
120603434  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
120619723  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
120605013  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
120617936  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
120584660  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
120615538  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
120605312  interferon alpha-4-like [KO:K05414]
120617124  interferon alpha-1-like [KO:K05414]
120606426  interferon alpha-1-like [KO:K05414]
120589528  interferon alpha-1-like [KO:K05414]
120589531  interferon alpha-5-like [KO:K05414]
120605473  IFNB1; interferon beta [KO:K05415]
120598793  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
120598866  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
120583126  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
120610872  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
120587473  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
120604905  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
120608511  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
120621778  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
120606727  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
120606729  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
120606731  2'-5'-oligoadenylate synthase 1-like isoform X1 [KO:K14216] [EC:2.7.7.84]
120588224  C-X-C motif chemokine 10-like [KO:K12671]
120614075  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
120609345  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
120584707  FADD; FAS-associated death domain protein [KO:K02373]
120587528  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
120607361  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
120610288  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
120584396  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
120606950  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
120597665  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
120602359  cytochrome c [KO:K08738]
120597089  cytochrome c, testis-specific-like [KO:K08738]
120611595  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
120585783  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
120618435  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
120589132  uncharacterized protein LOC120589132 [KO:K10785]
120622048  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
120622052  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
120622049  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
120617704  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
120591506  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
120619604  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
120595865  PSMC4; 26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
120608146  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6B-like [KO:K03063]
120604417  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
120607312  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
120600289  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
120592898  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
120597146  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
120611182  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
120600023  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
120620915  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
120593970  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
120614162  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
120585233  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
120597178  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
120596357  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
120603906  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
120614997  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
120597635  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
120597640  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
120597649  tapasin isoform X1 [KO:K08058]
120622712  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
120618527  CALR; calreticulin [KO:K08057]
120613145  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
120592308  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
120592320  saoe class I histocompatibility antigen, C alpha chain-like [KO:K06751]
120592626  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
120615897  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
120616337  HLA class I histocompatibility antigen, B alpha chain-like isoform X1 [KO:K06751]
120616593  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
120606422  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
120618951  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
120599497  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
120589178  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
120589505  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
120622700  B2M; beta-2-microglobulin [KO:K08055]
120619558  SNW1; SNW domain-containing protein 1 [KO:K06063]
120597918  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
120581992  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
120608742  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
120616117  NCOR2; LOW QUALITY PROTEIN: nuclear receptor corepressor 2 [KO:K06065]
120581611  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
120613367  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
120597037  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
120591185  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
120603717  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
120592866  HES1; transcription factor HES-1 [KO:K06054]
120598924  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
120596036  RUNX3; runt-related transcription factor 3 [KO:K09279]
120595433  MYC; myc proto-oncogene protein [KO:K04377]
120620375  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
120605043  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
120589680  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120597553  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
120583203  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
120594128  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
120583737  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
120607230  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
120598501  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
120617505  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
120582132  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120596984  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120585845  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
120606549  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120608247  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120620206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
120613959  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120595669  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120619079  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120589252  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
120605283  RELB; transcription factor RelB isoform X1 [KO:K09253]
120609155  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
120623059  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
120596238  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
120596185  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
120589749  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
120598851  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
120616614  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120609636  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120588349  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120599784  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
120607712  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
120589895  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
120600014  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
120602825  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
120602826  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
120597571  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
120597692  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
120621837  JUN; transcription factor AP-1 [KO:K04448]
120582192  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
120609269  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
120599738  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
120603392  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
120605809  CD44; CD44 antigen isoform X1 [KO:K06256]
120620083  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
120585087  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
120610878  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
120614640  VIM; vimentin [KO:K07606]
120603700  tumor necrosis factor alpha-induced protein 3-like isoform X1 [KO:K11859] [EC:3.4.19.12]
120615771  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
120606540  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
120611101  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
120607236  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
120594126  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
120604608  NEDD4; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
120616613  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120611559  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
120609262  BLNK; B-cell linker protein [KO:K07371]
120622970  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
120586194  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
120613734  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
120584714  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
120607308  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
120596338  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
120604974  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
120615024  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
120616219  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
120610618  CCNA1; cyclin-A1 [KO:K06627]
120605475  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
120617212  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
120604889  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
120583848  RB1; retinoblastoma-associated protein [KO:K06618]
120603555  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
120596256  E2F2; LOW QUALITY PROTEIN: transcription factor E2F2 [KO:K09389]
120596257  transcription factor E2F2-like [KO:K09389]
120605571  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
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Dawson CW, Port RJ, Young LS
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The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
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Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
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  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
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Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
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Cell Mol Immunol 4:185-96 (2007)
Reference
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  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
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Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
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PMID:28835489
  Authors
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Epstein-Barr Virus LMP1-Mediated Oncogenicity.
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J Virol 91:e01718-16 (2017)
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PMID:12740915
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Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
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Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
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Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
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Nat Rev Immunol 1:75-82 (2001)
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Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
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J Biol Chem 278:47753-61 (2003)
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Nat Rev Clin Oncol 12:11-26 (2015)
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Cancers (Basel) 10:E213 (2018)
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PLoS Pathog 5:e1000530 (2009)
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Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
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Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
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J Virol 83:4652-69 (2009)
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Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
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Virology 388:236-47 (2009)
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Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
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Front Oncol 8:265 (2018)
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Epstein-Barr virus: induction and control of cell transformation.
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J Cell Physiol 196:207-18 (2003)
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PMID:21347341
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Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
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Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
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PLoS Pathog 7:e1001275 (2011)
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Related
pathway
pgig03050  Proteasome
pgig04010  MAPK signaling pathway
pgig04020  Calcium signaling pathway
pgig04064  NF-kappa B signaling pathway
pgig04110  Cell cycle
pgig04115  p53 signaling pathway
pgig04210  Apoptosis
pgig04612  Antigen processing and presentation
pgig04620  Toll-like receptor signaling pathway
pgig04622  RIG-I-like receptor signaling pathway
pgig04630  JAK-STAT signaling pathway
pgig04662  B cell receptor signaling pathway
KO pathway
ko05169   
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