KEGG   ORTHOLOGY: K01115
Entry
K01115                      KO                                     

Name
PLD1_2
Definition
phospholipase D1/2 [EC:3.1.4.4]
Pathway
map00564  Glycerophospholipid metabolism
map00565  Ether lipid metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04014  Ras signaling pathway
map04024  cAMP signaling pathway
map04071  Sphingolipid signaling pathway
map04072  Phospholipase D signaling pathway
map04144  Endocytosis
map04666  Fc gamma R-mediated phagocytosis
map04724  Glutamatergic synapse
map04912  GnRH signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map05200  Pathways in cancer
map05208  Chemical carcinogenesis - reactive oxygen species
map05212  Pancreatic cancer
map05231  Choline metabolism in cancer
Disease
H02375  Cardiac valvular defect, developmental
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    K01115  PLD1_2; phospholipase D1/2
   00565 Ether lipid metabolism
    K01115  PLD1_2; phospholipase D1/2
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K01115  PLD1_2; phospholipase D1/2
   04072 Phospholipase D signaling pathway
    K01115  PLD1_2; phospholipase D1/2
   04071 Sphingolipid signaling pathway
    K01115  PLD1_2; phospholipase D1/2
   04024 cAMP signaling pathway
    K01115  PLD1_2; phospholipase D1/2
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K01115  PLD1_2; phospholipase D1/2
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K01115  PLD1_2; phospholipase D1/2
  09152 Endocrine system
   04912 GnRH signaling pathway
    K01115  PLD1_2; phospholipase D1/2
   04928 Parathyroid hormone synthesis, secretion and action
    K01115  PLD1_2; phospholipase D1/2
  09156 Nervous system
   04724 Glutamatergic synapse
    K01115  PLD1_2; phospholipase D1/2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01115  PLD1_2; phospholipase D1/2
   05208 Chemical carcinogenesis - reactive oxygen species
    K01115  PLD1_2; phospholipase D1/2
   05231 Choline metabolism in cancer
    K01115  PLD1_2; phospholipase D1/2
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K01115  PLD1_2; phospholipase D1/2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K01115  PLD1_2; phospholipase D1/2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.4  phospholipase D
     K01115  PLD1_2; phospholipase D1/2
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K01115  PLD1_2; phospholipase D1/2
 Endosome - Golgi transport
  Others
   Others
    K01115  PLD1_2; phospholipase D1/2
Other DBs
RN: R01310 R02051 R07385
GO: 0004630
Genes
HSA: 5337(PLD1) 5338(PLD2)
PTR: 454454(PLD2) 470996(PLD1)
PPS: 100984892(PLD1) 100985373(PLD2)
GGO: 101135150(PLD1) 101135996(PLD2)
PON: 100439813(PLD1) 100457163(PLD2)
NLE: 100601695(PLD2) 100605600(PLD1)
MCC: 694963(PLD1) 721573(PLD2)
MCF: 102130012(PLD2) 102132109(PLD1)
CSAB: 103221251(PLD1) 103242204(PLD2)
CATY: 105583465(PLD2) 105586073(PLD1)
PANU: 101017925(PLD2) 101018997(PLD1)
RRO: 104663087(PLD2) 104666985(PLD1)
RBB: 108524801(PLD2) 108540404(PLD1)
TFN: 117067870(PLD2) 117083734(PLD1)
PTEH: 111521351(PLD2) 111543478(PLD1)
CJC: 100391217(PLD2) 100397093(PLD1)
SBQ: 101028583(PLD1) 101035480(PLD2)
MMUR: 105855425(PLD1) 105879268(PLD2)
MMU: 18805(Pld1) 18806(Pld2)
MCAL: 110290757(Pld1) 110304819(Pld2)
MPAH: 110320262(Pld1) 110331978(Pld2)
RNO: 25096(Pld1) 25097(Pld2)
MCOC: 116079039(Pld2) 116095022(Pld1)
MUN: 110553679(Pld1) 110557322(Pld2)
CGE: 100689404(Pld1) 100752582(Pld2)
PLEU: 114687550(Pld2) 114697539(Pld1)
NGI: 103731722(Pld1) 103752195(Pld2)
HGL: 101700438(Pld1) 101713528(Pld2)
CCAN: 109684749(Pld2) 109694743(Pld1)
OCU: 100339661(PLD1) 103351480
TUP: 102495205(PLD1) 102499889(PLD2)
CFA: 479473(PLD2) 488167(PLD1)
VVP: 112924795(PLD2) 112926674(PLD1)
VLG: 121477350(PLD1) 121500703(PLD2)
AML: 100477588(PLD2) 100484111(PLD1)
UMR: 103660447(PLD2) 103676145(PLD1)
UAH: 113255060(PLD1) 113271085(PLD2)
ORO: 101369263(PLD1) 101383564(PLD2)
MPUF: 101672904(PLD1) 101690285(PLD2)
EJU: 114206976(PLD1) 114225446(PLD2)
MLX: 117999965(PLD2) 118006301(PLD1)
FCA: 101084052(PLD1) 101092214(PLD2)
PTG: 102962016(PLD1) 102971823(PLD2)
PPAD: 109246097(PLD2) 109275130(PLD1)
AJU: 106972398(PLD2) 106990052(PLD1)
HHV: 120226705(PLD2) 120234597(PLD1)
BTA: 514554(PLD1) 522159(PLD2)
BOM: 102279771(PLD1) 102288325(PLD2)
BIU: 109558091(PLD1) 109574235(PLD2)
BBUB: 102392536(PLD2) 102414958(PLD1)
CHX: 102174434(PLD1) 102176556(PLD2)
OAS: 101110687(PLD2) 101114661(PLD1)
ODA: 120866109(PLD2) 120869461(PLD1)
SSC: 100519446(PLD1) 414900(PLD2)
CFR: 102505040(PLD1) 102520901(PLD2)
CDK: 105085948(PLD1) 105101475(PLD2)
BACU: 102999715(PLD1) 103008865(PLD2)
LVE: 103069742(PLD2) 103084538(PLD1)
OOR: 101278706(PLD2) 101284082(PLD1)
DLE: 111174011(PLD1) 111185941(PLD2)
PCAD: 102978946(PLD2) 102986218(PLD1)
ECB: 100057774(PLD1) 100072863(PLD2)
EPZ: 103546360(PLD1) 103560664(PLD2)
EAI: 106844149(PLD2) 106847524(PLD1)
MYB: 102239050(PLD1) 102264100(PLD2)
MYD: 102756028(PLD1) 102760085(PLD2)
MMYO: 118671949(PLD2) 118675412(PLD1)
MNA: 107528068(PLD2) 107529520(PLD1) 107533526
HAI: 109371666(PLD1) 109394696(PLD2)
DRO: 112307458(PLD1) 112308502(PLD2)
SHON: 118987399(PLD1) 119001060(PLD2)
AJM: 119039312 119043204(PLD2) 119043442(PLD1)
MMF: 118617100(PLD1) 118633939(PLD2)
PALE: 102884736(PLD1) 102894598(PLD2)
RAY: 107509491(PLD2) 107515926(PLD1)
MJV: 108403340(PLD2) 108404196(PLD1)
TOD: 119231104(PLD2) 119257286(PLD1)
LAV: 100658318(PLD2) 100660595(PLD1)
MDO: 100009769(PLD1) 100618309(PLD2)
SHR: 100914579(PLD2) 100926651(PLD1)
PCW: 110194332(PLD2) 110204050(PLD1)
OAA: 100083157(PLD1) 103169305(PLD2)
GGA: 424986(PLD1)
PCOC: 116243417(PLD1)
MGP: 100547741(PLD1)
CJO: 107318313(PLD1)
NMEL: 110397970(PLD1)
APLA: 101802558(PLD1)
ACYG: 106031996(PLD1)
TGU: 100224050(PLD1)
LSR: 110480373(PLD1)
SCAN: 103815294(PLD1)
PMOA: 120504234(PLD1)
GFR: 102038107(PLD1)
FAB: 101820022(PLD1)
PHI: 102101034(PLD1)
PMAJ: 107208899(PLD1)
CCAE: 111933332(PLD1)
CCW: 104688039(PLD1)
ETL: 114061178(PLD1)
FPG: 101923489(PLD1)
FCH: 102052716(PLD1)
CLV: 102090500(PLD1)
EGZ: 104132470(PLD1)
NNI: 104022057(PLD1)
ACUN: 113483342(PLD1)
PADL: 103924963(PLD1)
AAM: 106486569
ASN: 102371892(PLD1)
AMJ: 102573958(PLD1)
CPOO: 109308438(PLD1)
GGN: 109287984(PLD1)
PSS: 102453139(PLD1) 102453375(PLD2)
CMY: 102945664(PLD1)
CPIC: 101931414(PLD1)
TST: 117882516(PLD1)
CABI: 116822702(PLD2) 116826742(PLD1)
ACS: 100566734(pld1)
PVT: 110079069(PLD1) 110082332(PLD2)
PBI: 103048104(PLD2) 103062756(PLD1)
PMUR: 107285044(PLD2) 107286542(PLD1)
PGUT: 117673452(PLD2) 117678188(PLD1)
PMUA: 114582880(PLD2) 114597981(PLD1)
ZVI: 118094092(PLD1) 118094994(PLD2)
GJA: 107113860(PLD1) 107124417(PLD2)
XLA: 100191021(pld1.L) 108711785(pld2.L) 108718097(pld1.S)
XTR: 100216200(pld2) 100379682(pld1)
NPR: 108784828(PLD1) 108800202
DRE: 556641(pld1a) 565743(pld2) 572492(pld1b) 799278(si:ch211-168k14.2)
ELY: 117264819(pld1b) 117266952(pld1a) 117268540(pld2)
PLEP: 121952268(pld2) 121953347(pld1a)
SLUC: 116039990(pld1b) 116057457(pld1a) 116064856(pld2)
ECRA: 117936004(pld1a) 117938286 117955583(pld2)
GAT: 120812048 120821943(pld2) 120833442(pld1a)
MSAM: 119884573 119895767 119896596(pld1b) 119910183(pld1a)
CUD: 121518590(pld2) 121526084(pld1a) 121527253(pld1b)
OAU: 116318061(pld1a) 116327243(pld1b) 116330227(pld2)
OML: 112142405(pld2) 112146779(pld1a) 112152484(pld1b)
CTUL: 119788173(pld1a) 119789581(pld2) 119796062(pld1b)
XGL: 120790215(pld1b) 120795286(pld1a) 120802433(pld2)
LCM: 102353212(PLD2) 102359218(PLD1)
CMK: 103189334(pld1) 103190576(pld2)
RTP: 109920481 109936146(pld1)
BFO: 118406399
CIN: 100182057
APLC: 110987506
SKO: 100366642(PLD1)
DME: Dmel_CG12110(Pld)
DER: 6540960
DSE: 116800372
DSI: Dsimw501_GD10404(Dsim_GD10404)
DAN: 6493918
DSR: 110189471
DPE: 113565068
DWI: 6639777
DAZ: 108615652
DNV: 108654014
DHE: 111604343
DVI: 6625246
MDE: 101896559
LCQ: 111687296
ACOZ: 120957908
AARA: 120903478
CPII: 120415323
AME: 725119
ACER: 107996876
BIM: 100742072
BTER: 100652186
CCAL: 108628900
OBB: 114882078
MGEN: 117223851
NMEA: 116428607
CGIG: 122401340
SOC: 105201964
MPHA: 105830415
AEC: 105149246
ACEP: 105627094
PBAR: 105427752
VEM: 105561603
HST: 105192308
DQU: 106747092
CFO: 105254432
FEX: 115243143
LHU: 105672039
PGC: 109854134
OBO: 105281694
PCF: 106787677
NVI: 100123116
CSOL: 105363898
MDL: 103580130
TCA: 658196
DPA: 109544965
ATD: 109608890
AGB: 108912508
NVL: 108565175
APLN: 108741102
OTU: 111414533
BMOR: 101746390
MSEX: 115454408
BANY: 112044320
PMAC: 106715649
PPOT: 106105657
PXU: 106113480
ZCE: 119833569
HAW: 110370970
TNL: 113507031
BTAB: 109032109
CLEC: 106669710
ZNE: 110835596
CSEC: 111863755
FCD: 110858053
DSV: 119464572
RMP: 119165403
VDE: 111255302
VJA: 111266998
TUT: 107371515
DPTE: 113789380
PTEP: 107442038
CEL: CELE_C04G6.3(pld-1)
CBR: CBG02320(Cbr-pld-1)
BMY: BM_BM12216(Bma-pld-1)
TSP: Tsp_10708
PCAN: 112566038
BGT: 106073444
CRG: 105332889
MYI: 110454166
PMAX: 117327709
OBI: 106868096
NVE: 5515662
EPA: 110241295
ATEN: 116308139
ADF: 107352864
PDAM: 113681466
SPIS: 111322011
HMG: 100213342
ATH: AT1G52570(PLDALPHA2) AT1G55180(PLDEPSILON) AT2G42010(PLDBETA1) AT3G05630(PLDP2) AT3G15730(PLDALPHA1) AT3G16785(PLDP1) AT4G00240(PLDBETA2) AT4G11830(PLDGAMMA2) AT4G11840(PLDGAMMA3) AT4G11850(PLDGAMMA1) AT4G35790(PLDDELTA) AT5G25370(PLDALPHA3)
LJA: Lj0g3v0004479.1(Lj0g3v0004479.1) Lj0g3v0057229.1(Lj0g3v0057229.1) Lj0g3v0060819.1(Lj0g3v0060819.1) Lj0g3v0101819.1(Lj0g3v0101819.1) Lj0g3v0116389.1(Lj0g3v0116389.1) Lj0g3v0255459.1(Lj0g3v0255459.1) Lj0g3v0335969.1(Lj0g3v0335969.1) Lj1g3v1911660.1(Lj1g3v1911660.1) Lj1g3v1911690.1(Lj1g3v1911690.1) Lj2g3v1647880.1(Lj2g3v1647880.1) Lj2g3v1659550.1(Lj2g3v1659550.1) Lj2g3v2003100.1(Lj2g3v2003100.1) Lj3g3v0305820.1(Lj3g3v0305820.1) Lj5g3v1500430.1(Lj5g3v1500430.1) Lj6g3v1491480.1(Lj6g3v1491480.1)
VVI: 100232987(PLD) 100241982(PLDdelta2) 100250490(PLDbeta2) 100252422(PLDdelta) 100252995(PLDbeta1) 100256679(PLDepsilon) 100257647(PLDalpha3) 100259366(PLDalpha4) 100261019(PLDdelta1) 100261040(PLDalpha1) 100261987(PLDp)
DOSA: Os01t0172400-01(Os01g0172400) Os02t0120200-01(Os02g0120200) Os03t0119100-01(Os03g0119100) Os03t0391400-01(Os03g0391400) Os05t0171000-01(Os05g0171000) Os06t0604200-02(Os06g0604200) Os06t0604300-01(Os06g0604300) Os06t0604400-01(Os06g0604400) Os07t0260400-01(Os07g0260400) Os08t0401800-00(Os08g0401800) Os09t0421300-01(Os09g0421300) Os10t0524400-01(Os10g0524400)
MNG: MNEG_3611
SCE: YKR031C(SPO14)
ERC: Ecym_6364
KMX: KLMA_40231(SPO14)
NCS: NCAS_0B07800(NCAS0B07800)
NDI: NDAI_0B05150(NDAI0B05150)
TPF: TPHA_0I00790(TPHA0I00790)
TBL: TBLA_0H02990(TBLA0H02990)
TDL: TDEL_0D01270(TDEL0D01270)
KAF: KAFR_0A03420(KAFR0A03420)
PIC: PICST_81277(SPO14)
CAL: CAALFM_C111590WA(PLD1)
SLB: AWJ20_2932(SPO14)
NTE: NEUTE1DRAFT132041(NEUTE1DRAFT_132041) NEUTE1DRAFT145274(NEUTE1DRAFT_145274) NEUTE1DRAFT78227(NEUTE1DRAFT_78227)
ANG: ANI_1_1734134(An15g07040) ANI_1_2596094(An11g11010) ANI_1_282064(An07g02240)
SPO: SPAC2F7.16c(pld1)
ABP: AGABI1DRAFT132820(AGABI1DRAFT_132820) AGABI1DRAFT58967(AGABI1DRAFT_58967)
ABV: AGABI2DRAFT186563(AGABI2DRAFT_186563) AGABI2DRAFT188389(AGABI2DRAFT_188389)
MGL: MGL_0321
MRT: MRET_0982
DDI: DDB_G0277949(pldC) DDB_G0279483(pldB) DDB_G0281031(pldA)
DFA: DFA_08300(pldA) DFA_08480(pldB) DFA_10706(pldC)
EHI: EHI_082560(145.t00004) EHI_146550(350.t00005)
SMIN: v1.2.008765.t1(symbB.v1.2.008765.t1) v1.2.012415.t1(symbB.v1.2.012415.t1)
CTU: CTU_19640
AMAL: I607_15880
AMAE: I876_16175
AMAO: I634_16120
AMAI: I635_16820
AMAG: I533_15700
AAUS: EP12_16430
ASP: AOR13_146
ALG: AQULUS_09790(clsA_2)
MMAI: sS8_2624
MEJ: Q7A_425
MEC: Q7C_2072
NOC: Noc_1912
NHL: Nhal_1635
NWA: Nwat_1713
TEE: Tel_01060
THIP: N838_28085
SVA: SVA_2285
RSL: RPSI07_mp0694(pld)
REH: H16_B0932(h16_B0932)
CGD: CR3_4461
BPH: Bphy_5412
PPUL: RO07_21795
PSPU: NA29_15260
HSE: Hsero_2476(cls)
CARE: LT85_0735
TBD: Tbd_1474
MFA: Mfla_1421
MEP: MPQ_1409(cls)
URU: DSM104443_01783(clsB)
EBA: ebA6946
ABRE: pbN1_34510
AZO: azo1783
AOA: dqs_1932
AZA: AZKH_2641
GEO: Geob_0958
DEU: DBW_1976
PPRF: DPRO_1097
DOL: Dole_2521
CCX: COCOR_07344(cls4)
HOH: Hoch_3786
PLA: Plav_1139
RLE: pRL120739
RLG: Rleg_5129
BRAD: BF49_6978
VGO: GJW-30_1_04197(ydjZ)
SNO: Snov_3983
MEX: Mext_0106
MCH: Mchl_0043
MCG: GL4_0147
HDI: HDIA_2150(cls)
TSO: IZ6_26990
RSP: RSP_0113
AZL: AZL_d02250(pld)
RRU: Rru_A0202
RRF: F11_01010
NJA: NSJP_1157
 » show all
Reference
PMID:8530346
  Authors
Hammond SM, Altshuller YM, Sung TC, Rudge SA, Rose K, Engebrecht J, Morris AJ, Frohman MA
  Title
Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family.
  Journal
J Biol Chem 270:29640-3 (1995)
DOI:10.1074/jbc.270.50.29640
  Sequence
[hsa:5337]
Reference
  Authors
Speranza F, Mahankali M, Henkels KM, Gomez-Cambronero J
  Title
The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase D.
  Journal
J Biol Chem 289:28885-97 (2014)
DOI:10.1074/jbc.M114.597146
  Sequence
[mmu:18805 18806]
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