KEGG   PATHWAY: myd05022
Entry
myd05022                    Pathway                                
Name
Pathways of neurodegeneration - multiple diseases - Myotis davidii (David's myotis)
Description
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affect either the peripheral or central nervous system (CNS). Neurodegenerative diseases (NDs) include highly debilitating illnesses, such as Alzheimer (AD), Parkinson disease (PD), amyotrophic lateral sclerosis, Huntington disease, spinocerebellar ataxias, and prion diseases (PrD). The hallmark event, which is thought to be at the root of these diseases, is the progressive accumulation of misfolded protein aggregates. Major basic processes include abnormal protein dynamics due to deficiency of the ubiquitin-proteosome-autophagy system, oxidative stress and free radical formation, endoplasmic reticulum stress, mitochondrial dysfunction and (secondary) disruptions of axonal transport.
Class
Human Diseases; Neurodegenerative disease
Pathway map
myd05022  Pathways of neurodegeneration - multiple diseases
myd05022

Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102751339  VDAC2; voltage dependent anion channel 2 [KO:K15040]
102751403  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
102751460  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
102751479  PSMC5; proteasome 26S subunit, ATPase 5 [KO:K03066]
102751509  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102751511  CDK5R1; cyclin dependent kinase 5 regulatory subunit 1 [KO:K11716]
102751515  [KO:K05863]
102751578  OPTN; optineurin [KO:K19946]
102751589  APP; amyloid beta precursor protein [KO:K04520]
102751649  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
102751662  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102751672  HSD17B10; hydroxysteroid 17-beta dehydrogenase 10 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
102751685  PLCB1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
102751738  CCS; copper chaperone for superoxide dismutase [KO:K04569]
102751770  GRIN1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
102751916  BID; BH3 interacting domain death agonist [KO:K04726]
102751928  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
102751934  APC; APC, WNT signaling pathway regulator [KO:K02085]
102751959  PLCB4; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
102751972  PSMD6; proteasome 26S subunit, non-ATPase 6 [KO:K03037]
102752017  ATG2A; autophagy related 2A [KO:K17906]
102752108  ATP2A2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:7.2.2.10]
102752110  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
102752127  AGER; advanced glycosylation end-product specific receptor [KO:K19722]
102752168  DCTN1; dynactin subunit 1 [KO:K04648]
102752216  ATXN3; ataxin 3 [KO:K11863] [EC:3.4.22.-]
102752324  PSMD3; proteasome 26S subunit, non-ATPase 3 [KO:K03033]
102752342  PSMB5; proteasome subunit beta 5 [KO:K02737] [EC:3.4.25.1]
102752405  TUBA8; tubulin alpha 8 [KO:K07374]
102752458  [KO:K08738]
102752481  ACTR10; actin-related protein 10 homolog [KO:K16576]
102752829  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
102752857  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
102752980  WNT2; Wnt family member 2 [KO:K00182]
102753267  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
102753314  [KO:K02128]
102753514  [KO:K02263]
102753546  [KO:K23609]
102753580  ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
102753591  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
102753621  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
102753690  NEFM; neurofilament medium [KO:K04573]
102753722  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
102753757  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102753812  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
102753904  UBA1; ubiquitin like modifier activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
102753986  BCL2L1; BCL2 like 1 [KO:K04570]
102754038  TUBB4B; tubulin beta 4B class IVb [KO:K07375]
102754140  DNAL1; dynein axonemal light chain 1 [KO:K10411]
102754184  SOD1; superoxide dismutase 1 [KO:K04565] [EC:1.15.1.1]
102754253  GPR37; G protein-coupled receptor 37 [KO:K04243]
102754417  [KO:K03948]
102754439  RB1CC1; RB1 inducible coiled-coil 1 [KO:K17589]
102754443  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
102754499  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
102754500  GRIA3; glutamate ionotropic receptor AMPA type subunit 3 [KO:K05199]
102754543  NEFL; neurofilament light [KO:K04572]
102754623  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102754707  [KO:K02267]
102754756  CALM1; calmodulin 1 [KO:K02183]
102754848  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
102754863  KIF5B; kinesin family member 5B [KO:K10396] [EC:5.6.1.3]
102754946  BDNF; brain derived neurotrophic factor [KO:K04355]
102754952  FUS; FUS RNA binding protein [KO:K13098]
102755007  SEPT5; septin 5 [KO:K04557]
102755062  CALML4; calmodulin like 4 [KO:K02183]
102755118  RAB5A; RAB5A, member RAS oncogene family [KO:K07887]
102755123  PLCB3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
102755181  WNT11; Wnt family member 11 [KO:K01384]
102755231  PSMB1; proteasome subunit beta 1 [KO:K02732] [EC:3.4.25.1]
102755292  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102755379  [KO:K02267]
102755480  ATXN2; ataxin 2 [KO:K23625]
102755500  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102755508  PSMC1; proteasome 26S subunit, ATPase 1 [KO:K03062]
102755548  DNAH11; dynein axonemal heavy chain 11 [KO:K10408]
102755559  ATF6; activating transcription factor 6 [KO:K09054]
102755674  CDK5; cyclin dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
102755690  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
102755728  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102755774  WNT5B; protein Wnt-5b [KO:K00444]
102755855  ATG14; autophagy related 14 [KO:K17889]
102755889  ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
102756007  WNT4; Wnt family member 4 [KO:K00408]
102756012  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102756030  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102756281  CALM2; calmodulin 2 [KO:K02183]
102756290  SLC25A5; solute carrier family 25 member 5 [KO:K05863]
102756370  [KO:K08334]
102756475  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102756535  DNAH8; dynein axonemal heavy chain 8 [KO:K10408]
102756594  DAXX; death domain associated protein [KO:K02308]
102756704  FADD; Fas associated via death domain [KO:K02373]
102756708  [KO:K00417]
102756826  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
102757004  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102757009  BECN1; beclin 1 [KO:K08334]
102757032  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5 [KO:K03938]
102757282  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102757314  VAPB; VAMP associated protein B and C [KO:K10707]
102757318  KLC3; kinesin light chain 3 [KO:K10407]
102757348  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
102757448  [KO:K06693]
102757681  PDYN; prodynorphin [KO:K15840]
102757738  DNAH3; dynein axonemal heavy chain 3 [KO:K10408]
102757803  WNT6; Wnt family member 6 [KO:K00445]
102757836  MAPT; microtubule associated protein tau [KO:K04380]
102757859  [KO:K06691]
102757881  FIG4; FIG4 phosphoinositide 5-phosphatase [KO:K22913] [EC:3.1.3.-]
102757960  PARK2; parkin RBR E3 ubiquitin protein ligase [KO:K04556] [EC:2.3.2.31]
102757961  PINK1; PTEN induced putative kinase 1 [KO:K05688] [EC:2.7.11.1]
102758002  [KO:K00572]
102758153  CSNK2A1; casein kinase 2 alpha 1 [KO:K03097] [EC:2.7.11.1]
102758201  MFN1; mitofusin 1 [KO:K21356] [EC:3.6.5.-]
102758211  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
102758219  [KO:K02134]
102758221  FZD8; frizzled class receptor 8 [KO:K02375]
102758322  PSMB4; proteasome subunit beta 4 [KO:K02736] [EC:3.4.25.1]
102758435  WNT8B; Wnt family member 8B [KO:K00714]
102758455  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
102758467  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha [KO:K10435]
102758474  PSMA4; proteasome subunit alpha 4 [KO:K02728] [EC:3.4.25.1]
102758563  TRPC3; transient receptor potential cation channel subfamily C member 3 [KO:K04966]
102758613  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
102758626  TRAP1; TNF receptor associated protein 1 [KO:K09488]
102758655  TUBB6; tubulin beta 6 class V [KO:K07375]
102758773  VDAC1; voltage dependent anion channel 1 [KO:K05862]
102758774  TNF; tumor necrosis factor [KO:K03156]
102758820  FZD1; frizzled class receptor 1 [KO:K02432]
102758914  UBE2G1; ubiquitin conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
102759108  SNCAIP; synuclein alpha interacting protein [KO:K04558]
102759134  [KO:K02264]
102759159  ATP2A1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:7.2.2.10]
102759239  GRIN2B; glutamate ionotropic receptor NMDA type subunit 2B [KO:K05210]
102759247  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102759314  DERL1; derlin 1 [KO:K11519]
102759459  ATP2A3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:7.2.2.10]
102759477  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102759481  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
102759487  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
102759550  DKK1; dickkopf WNT signaling pathway inhibitor 1 [KO:K02165]
102759593  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
102759594  AXIN1; axin 1 [KO:K02157]
102759597  FASLG; Fas ligand [KO:K04389]
102759600  PSMA3; proteasome subunit alpha 3 [KO:K02727] [EC:3.4.25.1]
102759738  UBE2G2; ubiquitin conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
102759782  [KO:K07374]
102759877  [KO:K08738]
102759984  UBE2L6; ubiquitin conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
102760054  ATG2B; autophagy related 2B [KO:K17906]
102760149  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
102760190  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
102760211  AXIN2; axin 2 [KO:K04385]
102760302  FAS; Fas cell surface death receptor [KO:K04390]
102760336  IL6; interleukin 6 [KO:K05405]
102760374  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
102760376  LRP5L; LDL receptor related protein 5 like [KO:K03068]
102760378  PSMB6; proteasome subunit beta 6 [KO:K02738] [EC:3.4.25.1]
102760391  STX1A; syntaxin 1A [KO:K04560]
102760422  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102760520  PLCB2; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
102760641  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
102760665  CSNK1A1L; casein kinase 1 alpha 1 like [KO:K08957] [EC:2.7.11.1]
102760710  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
102760712  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102760722  TOMM40; translocase of outer mitochondrial membrane 40 [KO:K11518]
102760847  GNAQ; G protein subunit alpha q [KO:K04634]
102760877  TUBA1A; tubulin alpha-1A chain [KO:K07374]
102760882  [KO:K00413]
102760913  FZD6; frizzled class receptor 6 [KO:K02376]
102760917  PSMD8; proteasome 26S subunit, non-ATPase 8 [KO:K03031]
102760954  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102760961  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102761017  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
102761038  CSNK1A1; casein kinase 1 alpha 1 [KO:K08957] [EC:2.7.11.1]
102761101  ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
102761184  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
102761228  [KO:K07374]
102761295  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
102761396  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
102761441  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102761492  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102761527  UBE2J2; ubiquitin conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
102761550  CASP8; caspase 8 [KO:K04398] [EC:3.4.22.61]
102761581  [KO:K02268]
102761671  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
102761716  CSNK2B; casein kinase 2 beta [KO:K03115]
102761738  ATXN1L; ataxin 1 like [KO:K23616]
102761803  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
102761840  [KO:K02272]
102761920  FZD9; frizzled class receptor 9 [KO:K02842]
102762024  PSMC2; proteasome 26S subunit, ATPase 2 [KO:K03061]
102762036  KIF5A; kinesin family member 5A [KO:K10396] [EC:5.6.1.3]
102762038  DNALI1; dynein axonemal light intermediate chain 1 [KO:K10410]
102762058  GPX8; glutathione peroxidase 8 (putative) [KO:K00432] [EC:1.11.1.9]
102762080  TNFRSF1B; TNF receptor superfamily member 1B [KO:K05141]
102762155  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
102762164  WNT10A; Wnt family member 10A [KO:K01357]
102762174  TANK; TRAF family member associated NFKB activator [KO:K12650]
102762192  DNAH1; dynein axonemal heavy chain 1 [KO:K10408]
102762248  PSMD1; proteasome 26S subunit, non-ATPase 1 [KO:K03032]
102762284  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102762321  DCTN2; dynactin subunit 2 [KO:K10424]
102762322  CSNK1E; casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
102762460  [KO:K02133] [EC:7.1.2.2]
102762488  HIP1; huntingtin interacting protein 1 [KO:K04559]
102762537  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102762580  PSMA1; proteasome subunit alpha 1 [KO:K02725] [EC:3.4.25.1]
102762643  PSMD14; proteasome 26S subunit, non-ATPase 14 [KO:K03030]
102762646  [KO:K03967]
102762680  [KO:K00415]
102762695  FZD4; frizzled class receptor 4 [KO:K02354]
102762753  [KO:K00414]
102762771  PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
102762786  WIPI1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
102762834  DNAH10; dynein axonemal heavy chain 10 [KO:K10408]
102762868  PRPH; peripherin [KO:K07607]
102762932  UBE2L3; ubiquitin conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
102762935  [KO:K07901]
102763091  GRM5; glutamate metabotropic receptor 5 [KO:K04604]
102763160  [KO:K07374]
102763208  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
102763244  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
102763465  [KO:K03029]
102763482  IFT57; intraflagellar transport 57 [KO:K04638]
102763548  WNT8A; Wnt family member 8A [KO:K00714]
102763571  KLC4; kinesin light chain 4 [KO:K10407]
102763588  PSMD7; proteasome 26S subunit, non-ATPase 7 [KO:K03038]
102763591  RYR1; ryanodine receptor 1 [KO:K04961]
102763635  NOS1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
102763646  FZD3; frizzled class receptor 3 [KO:K02329]
102763654  ATF4; activating transcription factor 4 [KO:K04374]
102763666  [KO:K02132]
102763674  PSMA6; proteasome subunit alpha 6 [KO:K02730] [EC:3.4.25.1]
102763752  ATXN2L; ataxin 2 like [KO:K23625]
102763784  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
102763805  MFN2; mitofusin 2 [KO:K06030] [EC:3.6.5.-]
102763814  PSMD13; proteasome 26S subunit, non-ATPase 13 [KO:K03039]
102763829  PPID; peptidylprolyl isomerase D [KO:K05864] [EC:5.2.1.8]
102763997  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102764039  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
102764112  [KO:K21421] [EC:1.-.-.-]
102764222  ATG101; autophagy related 101 [KO:K19730]
102764249  MAP1LC3B; microtubule associated protein 1 light chain 3 beta [KO:K10435]
102764280  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
102764405  [KO:K02183]
102764416  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102764429  NRBF2; nuclear receptor binding factor 2 [KO:K21246]
102764475  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
102764508  ACTR1A; ARP1 actin-related protein 1 homolog A, centractin alpha [KO:K16575]
102764661  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102764718  [KO:K02270]
102764728  PSMA5; proteasome subunit alpha 5 [KO:K02729] [EC:3.4.25.1]
102764742  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
102764809  RYR3; ryanodine receptor 3 [KO:K04963]
102764816  UBB; ubiquitin B [KO:K04551]
102764844  HSPA5; heat shock protein family A (Hsp70) member 5 [KO:K09490] [EC:3.6.4.10]
102764877  WNT1; Wnt family member 1 [KO:K03209]
102764949  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
102764986  NDUFB3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
102765024  WNT2B; Wnt family member 2B [KO:K00182]
102765131  KLC1; kinesin light chain 1 [KO:K10407]
102765167  WNT10B; Wnt family member 10B [KO:K01357]
102765234  GRIN2D; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212]
102765313  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
102765493  RYR2; ryanodine receptor 2 [KO:K04962]
102765562  WNT9A; Wnt family member 9A [KO:K01064]
102765585  FZD5; frizzled class receptor 5 [KO:K02375]
102765602  ATXN1; ataxin 1 [KO:K23616]
102765661  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102765684  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
102765830  [KO:K02270]
102765845  [KO:K05863]
102765864  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
102765923  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102765925  PSMB3; proteasome subunit beta 3 [KO:K02735] [EC:3.4.25.1]
102765971  TUBA4A; tubulin alpha 4a [KO:K07374]
102766001  ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
102766016  TUBB; tubulin beta class I [KO:K07375]
102766068  NEFH; neurofilament heavy [KO:K04574]
102766070  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
102766105  SPTBN2; spectrin beta, non-erythrocytic 2 [KO:K23932]
102766119  TUBB3; tubulin beta 3 class III [KO:K07375]
102766253  [KO:K07374]
102766307  ATP5G2; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C2 (subunit 9) [KO:K02128]
102766353  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
102766542  [KO:K04552] [EC:2.3.2.23]
102766550  ADRM1; adhesion regulating molecule 1 [KO:K06691]
102766586  [KO:K02268]
102766597  [KO:K02267]
102766630  [KO:K02263]
102766761  DNAL4; dynein axonemal light chain 4 [KO:K10412]
102766818  CSF1; colony stimulating factor 1 [KO:K05453]
102766824  [KO:K02134]
102766843  [KO:K05863]
102766887  PSMD12; proteasome 26S subunit, non-ATPase 12 [KO:K03035]
102766933  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102766991  [KO:K03947]
102767032  [KO:K02270]
102767074  [KO:K08334]
102767111  [KO:K02134]
102767244  DNAH17; dynein axonemal heavy chain 17 [KO:K10408]
102767250  PSMD2; proteasome 26S subunit, non-ATPase 2 [KO:K03028]
102767329  WNT9B; Wnt family member 9B [KO:K01064]
102767331  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
102767458  FZD2; frizzled class receptor 2 [KO:K02235]
102767480  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
102767486  XBP1; X-box binding protein 1 [KO:K09027]
102767488  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
102767532  ACTR1B; ARP1 actin-related protein 1 homolog B, centractin beta [KO:K16575]
102767612  WNT3; Wnt family member 3 [KO:K00312]
102767688  TARDBP; TAR DNA binding protein [KO:K23600]
102767782  [KO:K07375]
102767813  [KO:K02265]
102767912  RAB39B; RAB39B, member RAS oncogene family [KO:K07925]
102767943  UBE2J1; ubiquitin conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
102767979  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102768087  NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
102768121  [KO:K00416]
102768246  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
102768253  TUBB1; tubulin beta 1 class VI [KO:K07375]
102768337  DNAH14; dynein axonemal heavy chain 14 [KO:K10408]
102768379  KLC2; kinesin light chain 2 [KO:K10407]
102768382  AMBRA1; autophagy and beclin 1 regulator 1 [KO:K17985]
102768407  NDUFA4L2; NDUFA4, mitochondrial complex associated like 2 [KO:K03948]
102768516  CASP7; caspase 7 [KO:K04397] [EC:3.4.22.60]
102768532  TUBB4A; tubulin beta 4A class IVa [KO:K07375]
102768540  ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [KO:K02135]
102768616  HTT; huntingtin [KO:K04533]
102768725  [KO:K02268]
102768741  [KO:K05863]
102768884  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102769037  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102769091  UCHL1; ubiquitin C-terminal hydrolase L1 [KO:K05611] [EC:3.4.19.12]
102769127  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
102769185  ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
102769227  DNAH7; dynein axonemal heavy chain 7 [KO:K10408]
102769306  MCU; mitochondrial calcium uniporter [KO:K20858]
102769375  PRNP; prion protein [KO:K05634]
102769411  DCTN4; dynactin subunit 4 [KO:K10426]
102769473  BCL2; BCL2, apoptosis regulator [KO:K02161]
102769509  DNAH6; dynein axonemal heavy chain 6 [KO:K10408]
102769533  PSMB7; proteasome subunit beta 7 [KO:K02739] [EC:3.4.25.1]
102769631  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
102769655  [KO:K02271]
102769660  CAT; catalase [KO:K03781] [EC:1.11.1.6]
102769688  [KO:K07374]
102769788  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
102769800  [KO:K00411] [EC:7.1.1.8]
102769803  IL1B; interleukin 1 beta [KO:K04519]
102769833  PSMC3; proteasome 26S subunit, ATPase 3 [KO:K03065]
102770006  LRRK2; leucine rich repeat kinase 2 [KO:K08844] [EC:2.7.11.1]
102770007  CHMP2B; charged multivesicular body protein 2B [KO:K12192]
102770021  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102770040  GRIA2; glutamate ionotropic receptor AMPA type subunit 2 [KO:K05198]
102770100  IL1A; interleukin 1 alpha [KO:K04383]
102770205  UBA7; ubiquitin like modifier activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
102770207  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
102770215  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
102770227  SMCR8; Smith-Magenis syndrome chromosome region, candidate 8 [KO:K23611]
102770309  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102770312  CAPN1; calpain 1 [KO:K01367] [EC:3.4.22.52]
102770316  CSNK2A2; casein kinase 2 alpha 2 [KO:K03097] [EC:2.7.11.1]
102770419  ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
102770529  FZD7; frizzled class receptor 7 [KO:K02432]
102770550  [KO:K02271]
102770667  SLC6A3; solute carrier family 6 member 3 [KO:K05036]
102770704  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102770715  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102770732  SQSTM1; sequestosome 1 [KO:K14381]
102770736  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
102770825  ALS2; ALS2, alsin Rho guanine nucleotide exchange factor [KO:K04575]
102770928  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
102770933  PSMB2; proteasome subunit beta 2 [KO:K02734] [EC:3.4.25.1]
102770935  VCP; valosin containing protein [KO:K13525]
102771010  WNT5A; Wnt family member 5A [KO:K00444]
102771027  [KO:K02927]
102771029  [KO:K08738]
102771221  [KO:K02256] [EC:7.1.1.9]
102771249  [KO:K00420]
102771250  PSMA8; proteasome subunit alpha 8 [KO:K02731] [EC:3.4.25.1]
102771257  [KO:K07375]
102771275  [KO:K02266]
102771292  DNAI2; dynein axonemal intermediate chain 2 [KO:K11143]
102771311  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102771313  GRIN2A; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
102771330  RAB1A; RAB1A, member RAS oncogene family [KO:K07874]
102771342  [KO:K02927]
102771361  DNAH5; dynein axonemal heavy chain 5 [KO:K10408]
102771385  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
102771414  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
102771621  [KO:K00235] [EC:1.3.5.1]
102771665  BAD; BCL2 associated agonist of cell death [KO:K02158]
102771698  [KO:K08334]
102771718  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
102771720  [KO:K00419]
102771729  TOMM40L; translocase of outer mitochondrial membrane 40 like [KO:K11518]
102771802  RPS27A; ribosomal protein S27a [KO:K02977]
102771881  WDR41; WD repeat domain 41 [KO:K23610]
102771906  NDUFA4; NDUFA4, mitochondrial complex associated [KO:K03948]
102772033  CALM3; calmodulin 3 [KO:K02183]
102772041  KIF5C; kinesin family member 5C [KO:K10396] [EC:5.6.1.3]
102772062  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102772094  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
102772100  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
102772272  ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
102772354  PSEN2; presenilin 2 [KO:K04522] [EC:3.4.23.-]
102772361  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102772477  LRP6; LDL receptor related protein 6 [KO:K03068]
102772521  CALML6; calmodulin like 6 [KO:K02183]
102772576  HTRA2; HtrA serine peptidase 2 [KO:K08669] [EC:3.4.21.108]
102772683  WIPI2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
102772721  PSMC6; proteasome 26S subunit, ATPase 6 [KO:K03064]
102772748  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102772769  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
102772770  GRIA4; glutamate ionotropic receptor AMPA type subunit 4 [KO:K05200]
102772812  CALML3; calmodulin like 3 [KO:K02183]
102772876  VDAC3; voltage dependent anion channel 3 [KO:K15041]
102772927  PSMA2; proteasome subunit alpha 2 [KO:K02726] [EC:3.4.25.1]
102772987  PSMD9; proteasome 26S subunit, non-ATPase 9 [KO:K06693]
102773049  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
102773102  CALML5; calmodulin like 5 [KO:K02183]
102773139  [KO:K00418]
102773153  ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
102773220  SPG11; spastic paraplegia 11 (autosomal recessive) [KO:K19026]
102773255  DCTN6; dynactin subunit 6 [KO:K10428]
102773298  DNAH12; dynein axonemal heavy chain 12 [KO:K10408]
102773344  DLG4; discs large MAGUK scaffold protein 4 [KO:K11828]
102773354  PSMC4; proteasome 26S subunit, ATPase 4 [KO:K03063]
102773363  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102773376  NOX1; NADPH oxidase 1 [KO:K08008]
102773494  WNT16; Wnt family member 16 [KO:K01558]
102773513  UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1 [KO:K02927]
102773658  CTNNB1; catenin beta 1 [KO:K02105]
102773855  TUBAL3; tubulin alpha like 3 [KO:K07374]
102773861  APAF1; apoptotic peptidase activating factor 1 [KO:K02084]
102773882  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102773904  PSEN1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
102773943  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
102773959  [KO:K04741] [EC:3.4.22.-]
102773996  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
102774271  WNT3A; Wnt family member 3A [KO:K00312]
102774289  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
102774319  ATG13; autophagy related 13 [KO:K08331]
102774359  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
102774402  GRIA1; glutamate ionotropic receptor AMPA type subunit 1 [KO:K05197]
102774469  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102774608  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
102774648  DCTN3; dynactin subunit 3 [KO:K10425]
102774693  PARK7; Parkinsonism associated deglycase [KO:K05687] [EC:3.5.1.124]
102774769  ZFYVE1; zinc finger FYVE-type containing 1 [KO:K17603]
102774808  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
102774832  [KO:K08738]
102774839  [KO:K02267]
102774846  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102775005  GRIN2C; glutamate ionotropic receptor NMDA type subunit 2C [KO:K05211]
102775014  SEM1; SEM1, 26S proteasome complex subunit [KO:K10881]
102775072  [KO:K02264]
102775134  DNAH2; dynein axonemal heavy chain 2 [KO:K10408]
102775195  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
102775211  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102775219  DNAI1; dynein axonemal intermediate chain 1 [KO:K10409]
102775234  [KO:K02135]
102775351  [KO:K04440] [EC:2.7.11.24]
102775358  PSMA7; proteasome subunit alpha 7 [KO:K02731] [EC:3.4.25.1]
102775375  DCTN5; dynactin subunit 5 [KO:K10427]
102775413  ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
102775535  PSMD11; proteasome 26S subunit, non-ATPase 11 [KO:K03036]
107181364  LRP5; LDL receptor related protein 5 [KO:K03068]
107181822  PSMD4; proteasome 26S subunit, non-ATPase 4 [KO:K03029]
107182784  [KO:K10408]
22203917  COX2; cytochrome c oxidase subunit II [KO:K02261]
22203918  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
22203919  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
22203920  COX3; cytochrome c oxidase subunit III [KO:K02262]
22203921  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
22203922  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
22203923  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
22203924  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
22203925  CYTB; cytochrome b [KO:K00412]
22203926  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
22203927  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
22203928  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
22203929  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
Compound
C00001  H2O
C00002  ATP
C00008  ADP
C00009  Orthophosphate
C00012  Peptide
C00013  Diphosphate
C00017  Protein
C00020  AMP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C01996  Acetylcholine
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C15231  Maneb
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16844  Hydroxyl radical
C16845  Peroxynitrite
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Int J Mol Sci 20:E6004 (2019)
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Reference
PMID:27873462
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Golpich M, Amini E, Mohamed Z, Azman Ali R, Mohamed Ibrahim N, Ahmadiani A
  Title
Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.
  Journal
CNS Neurosci Ther 23:5-22 (2017)
DOI:10.1111/cns.12655
Reference
PMID:19828789
  Authors
Morfini GA, Burns M, Binder LI, Kanaan NM, LaPointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST
  Title
Axonal transport defects in neurodegenerative diseases.
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J Neurosci 29:12776-86 (2009)
DOI:10.1523/JNEUROSCI.3463-09.2009
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:23361386
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Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Reference
PMID:31558780
  Authors
Sleigh JN, Rossor AM, Fellows AD, Tosolini AP, Schiavo G
  Title
Axonal transport and neurological disease.
  Journal
Nat Rev Neurol 15:691-703 (2019)
DOI:10.1038/s41582-019-0257-2
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PMID:20434225
  Authors
Perlson E, Maday S, Fu MM, Moughamian AJ, Holzbaur EL
  Title
Retrograde axonal transport: pathways to cell death?
  Journal
Trends Neurosci 33:335-44 (2010)
DOI:10.1016/j.tins.2010.03.006
Related
pathway
myd00190  Oxidative phosphorylation
myd03050  Proteasome
myd04020  Calcium signaling pathway
myd04120  Ubiquitin mediated proteolysis
myd04137  Mitophagy - animal
myd04140  Autophagy - animal
myd04141  Protein processing in endoplasmic reticulum
myd04142  Lysosome
myd04210  Apoptosis
myd04310  Wnt signaling pathway
myd04724  Glutamatergic synapse
myd04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05022   

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