KEGG   PATHWAY: aamp04010
Entry
aamp04010                   Pathway                                
Name
MAPK signaling pathway - Arvicola amphibius (Eurasian water vole)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
aamp04010  MAPK signaling pathway
aamp04010

Other DBs
GO: 0000165
Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119801772  Cacna1a; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
119818472  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
119806908  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
119828004  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
119827366  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
119804579  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
119811216  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
119811778  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
119822616  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
119827234  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
119803844  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
119809135  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
119828041  Cacna2d3; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
119807657  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
119811413  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
119816251  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
119822706  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
119818715  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
119811062  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
119823550  Cacng2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
119801197  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
119813331  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
119813480  Cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
119822029  Cacng6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
119821623  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
119821396  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
119800975  Prkacb; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
119802004  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
119812144  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119822917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
119820784  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
119825531  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
119801689  Gng14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
119807698  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
119800939  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
119800012  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119800123  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119823004  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
119826596  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
119810089  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
119810287  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
119814508  Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
119802087  Rasgrp2; LOW QUALITY PROTEIN: RAS guanyl-releasing protein 2 [KO:K12361]
119806793  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
119821876  Rasgrp4; RAS guanyl-releasing protein 4 [KO:K12363]
119826540  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
119811264  Nf1; neurofibromin isoform X1 [KO:K08052]
119809233  Rasa1; LOW QUALITY PROTEIN: ras GTPase-activating protein 1 [KO:K04352]
119810331  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
119800929  Rap1a; ras-related protein Rap-1A [KO:K04353]
119803252  Rap1b; ras-related protein Rap-1b [KO:K07836]
119800992  Egf; pro-epidermal growth factor [KO:K04357]
119807169  Tgfa; protransforming growth factor alpha [KO:K08774]
119814097  Areg; amphiregulin [KO:K09782]
119814061  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
119826229  Fgf2; fibroblast growth factor 2 [KO:K18497]
119800369  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
119800397  Fgf9; fibroblast growth factor 9 [KO:K04358]
119814352  Fgf7; fibroblast growth factor 7 [KO:K04358]
119808412  Fgf6; fibroblast growth factor 6 [KO:K04358]
119808698  Fgf10; fibroblast growth factor 10 [KO:K04358]
119802892  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
119812198  Fgf3; fibroblast growth factor 3 [KO:K04358]
119805412  Fgf16; fibroblast growth factor 16 [KO:K04358]
119825456  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
119805928  Fgf5; fibroblast growth factor 5 [KO:K04358]
119805944  Fgf4; fibroblast growth factor 4 [KO:K04358]
119813362  Fgf20; fibroblast growth factor 20 [KO:K04358]
119806542  Fgf19; fibroblast growth factor 19 [KO:K22603]
119802871  Fgf21; fibroblast growth factor 21 [KO:K22429]
119807114  Fgf23; fibroblast growth factor 23 [KO:K22428]
119801207  Ngf; beta-nerve growth factor [KO:K02582]
119815449  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
119807825  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
119802440  Ntf4; neurotrophin-4 [KO:K12457]
119805421  Ins; insulin [KO:K04526]
119803277  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
119802040  Igf2; insulin-like growth factor II [KO:K13769]
119825753  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119823283  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
119810057  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
119826417  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
119801389  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
119803565  Kitlg; kit ligand isoform X1 [KO:K05461]
119803021  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
119822340  vascular endothelial growth factor A-like [KO:K05448]
119822341  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
119801722  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
119819672  Pgf; placenta growth factor isoform X1 [KO:K16859]
119812191  Vegfc; vascular endothelial growth factor C [KO:K05449]
119805399  Vegfd; LOW QUALITY PROTEIN: vascular endothelial growth factor D [KO:K05449]
119803884  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
119823684  Angpt1; angiopoietin-1 [KO:K05465]
119813161  Angpt2; angiopoietin-2 [KO:K05466]
119815725  Angpt4; angiopoietin-4 [KO:K05467]
119801198  Efna4; ephrin-A4 [KO:K05462]
119801284  Efna1; ephrin-A1 isoform X1 [KO:K05462]
119801318  Efna3; ephrin-A3 [KO:K05462]
119817904  Efna2; ephrin-A2 [KO:K05462]
119820458  Efna5; ephrin-A5 isoform X1 [KO:K05462]
119810480  Gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
119825112  Nrtn; neurturin [KO:K25414]
119817983  Artn; artemin isoform X1 [KO:K25415]
119811184  Pspn; persephin [KO:K25416]
119812357  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119811725  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
119803504  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
119821978  Erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
119811944  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
119827742  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
119805838  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119805848  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119811014  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
119811259  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119812129  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
119805744  fibroblast growth factor receptor 3-like isoform X1 [KO:K05094] [EC:2.7.10.1]
119805841  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119805908  fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
119816377  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
119812353  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
119800869  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
119816678  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
119825604  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
119802616  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
119807129  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
119815474  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
119814133  Csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
119799770  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
119824393  Flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
119824995  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
119813056  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
119813736  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
119806540  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119817629  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
119816636  Epha2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
119807136  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
119813014  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
119818434  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
119806329  Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
119800249  Hras; GTPase HRas isoform X1 [KO:K02833]
119804230  GTPase KRas-like [KO:K07827]
119806318  Kras; GTPase KRas isoform X1 [KO:K07827]
119801497  Nras; GTPase NRas [KO:K07828]
119802651  Rras; ras-related protein R-Ras [KO:K07829]
119800706  Rras2; ras-related protein R-Ras2 [KO:K07830]
119810543  Mras; ras-related protein M-Ras [KO:K07831]
119805132  Araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
119806667  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
119808272  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119805902  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
119809903  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119827491  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119801293  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
119824680  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119813356  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119816390  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
119817893  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
119816400  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
119804739  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
119804854  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
119820494  Rps6ka2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
119822546  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
119804537  Elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
119827372  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
119822940  Myc; myc proto-oncogene protein [KO:K04377]
119823601  Srf; serum response factor isoform X1 [KO:K04378]
119819161  Fos; proto-oncogene c-Fos [KO:K04379]
119812136  Mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
119822452  stathmin-like [KO:K04381]
119816895  Stmn1; stathmin isoform X1 [KO:K04381]
119827616  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
119815214  Pla2g4f; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
119815600  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
119815216  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
119820365  cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
119814209  cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
119822506  Tnf; tumor necrosis factor [KO:K03156]
119813991  Il1a; interleukin-1 alpha [KO:K04383]
119814887  Il1b; interleukin-1 beta [KO:K04519]
119821456  Tgfb1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
119827432  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
119819138  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
119808154  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119822271  Il1r1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
119825053  interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
119826264  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
119810460  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
119827881  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119804936  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119814846  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
119814535  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
119824999  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
119822752  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
119812100  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
119806427  cell division control protein 42 homolog [KO:K04393]
119816496  Cdc42; cell division control protein 42 homolog [KO:K04393]
119801899  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
119812861  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119818726  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119822854  Daxx; death domain-associated protein 6 [KO:K02308]
119809015  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
119805097  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
119822715  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
119814858  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119822349  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
119816942  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma isoform X1 [KO:K04402]
119807493  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
119822536  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
119820349  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
119810684  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
119806389  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
119822393  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
119821336  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
119802636  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
119824822  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
119815394  Stk4; serine/threonine-protein kinase 4 [KO:K04411]
119822913  Stk3; serine/threonine-protein kinase 3 [KO:K04412]
119814420  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
119817321  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
119809929  Map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
119814316  Map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
119814348  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
119812909  Map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
119819048  Map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
119820456  Map3k10; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
119802045  Map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
119822282  Map3k12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
119825626  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
119818413  Map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
119816611  Map3k6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
119820587  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
119826355  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119820823  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
119810634  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
119811271  Taok1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
119824725  Taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
119813036  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
119824883  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119813155  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
119812035  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
119814580  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
119823125  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
119811915  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
119804645  Flna; filamin-A isoform X1 [KO:K04437]
119811835  Crk; adapter molecule crk isoform X1 [KO:K04438]
119824768  Crkl; crk-like protein [KO:K04438]
119802788  Arrb1; beta-arrestin-1 [KO:K04439]
119812847  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
119811270  Mapk9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
119813574  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119827427  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119822988  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119823276  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119823839  Mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
119823840  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119824856  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
119827858  Mapkapk2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
119825282  LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
119810646  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
119819333  Rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
119812480  Rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
119815611  Cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
119814795  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
119801672  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
119816694  Jun; transcription factor AP-1 [KO:K04448]
119812518  Jund; transcription factor jun-D [KO:K04449]
119819075  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
119818608  cellular tumor antigen p53-like [KO:K04451]
119813419  Tp53; cellular tumor antigen p53 [KO:K04451]
119803285  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
119825996  protein max-like [KO:K04453]
119805389  LOW QUALITY PROTEIN: protein max-like [KO:K04453]
119820001  Max; protein max isoform X1 [KO:K04453]
119810346  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
119825268  Hspb1; heat shock protein beta-1 [KO:K04455]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119818456  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
119803463  Ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
119802794  Ptpn5; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
119827621  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
119812340  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
119821528  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119815479  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119810710  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119805373  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119812581  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119806773  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
119803535  Dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
119805349  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
119827583  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
119812869  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
119821207  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
119808428  Ppm1b; LOW QUALITY PROTEIN: protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
119808171  heat shock cognate 71 kDa protein-like [KO:K03283]
119827066  Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
119809148  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
119822472  heat shock 70 kDa protein 1A [KO:K03283]
119822473  heat shock 70 kDa protein 1-like [KO:K03283]
119822478  heat shock 70 kDa protein 1A [KO:K03283]
119816023  heat shock cognate 71 kDa protein-like [KO:K03283]
119822758  heat shock cognate 71 kDa protein-like [KO:K03283]
119826334  heat shock cognate 71 kDa protein-like [KO:K03283]
119826790  Mecom; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
119808775  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
119812382  Mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
119823130  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
119813599  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
119816335  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
119812324  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119804668  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119812516  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119814408  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119820792  Relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Pharmacol Ther 93:193-202 (2002)
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PMID:12947395
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Oncogene 22:5885-96 (2003)
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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PMID:12390245
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Skaper SD
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Methods Mol Biol 846:1-12 (2012)
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
PMID:19483709
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Ajibade AA, Wang HY, Wang RF
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Trends Immunol 34:307-16 (2013)
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
aamp04070  Phosphatidylinositol signaling system
aamp04110  Cell cycle
aamp04115  p53 signaling pathway
aamp04210  Apoptosis
aamp04310  Wnt signaling pathway
aamp04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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