KEGG   PATHWAY: amj04010
Entry
amj04010                    Pathway                                
Name
MAPK signaling pathway - Alligator mississippiensis (American alligator)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
amj04010  MAPK signaling pathway
amj04010

Other DBs
GO: 0000165
Organism
Alligator mississippiensis (American alligator) [GN:amj]
Gene
102564806  CACNA1A; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
102564626  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
102575519  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
102576817  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
102561875  CACNA1E; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
102563169  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
102566132  CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
102567624  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
102563699  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
102565821  CACNA2D1; calcium voltage-gated channel auxiliary subunit alpha2delta 1 [KO:K04858]
102558555  CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
102570532  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
106736655  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
102559323  CACNB1; calcium voltage-gated channel auxiliary subunit beta 1 [KO:K04862]
102559343  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
102559082  CACNB3; calcium voltage-gated channel auxiliary subunit beta 3 [KO:K04864]
106736635  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
102565332  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
102561501  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
102572864  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
102572607  CACNG4; calcium voltage-gated channel auxiliary subunit gamma 4 [KO:K04869]
102572375  CACNG5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
102570210  CACNG6; calcium voltage-gated channel auxiliary subunit gamma 6 [KO:K04871]
102569742  CACNG7; calcium voltage-gated channel auxiliary subunit gamma 7 [KO:K04872]
102569980  CACNG8; calcium voltage-gated channel auxiliary subunit gamma 8 [KO:K04873]
102572143  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106737076  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102572836  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102572486  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102574559  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102559993  GNA12; G protein subunit alpha 12 [KO:K04346]
102574789  GNG12; G protein subunit gamma 12 [KO:K04347]
102576759  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102576061  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102573328  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
106737480  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102564103  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
102560996  RASGRF2; Ras protein specific guanine nucleotide releasing factor 2 [KO:K12326]
106736825  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
102566493  RASGRP2; RAS guanyl releasing protein 2 [KO:K12361]
102577025  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
102563879  RAPGEF2; Rap guanine nucleotide exchange factor 2 [KO:K08018]
102564932  NF1; neurofibromin 1 [KO:K08052]
102577063  RASA1; RAS p21 protein activator 1 [KO:K04352]
102559499  RASA2; RAS p21 protein activator 2 [KO:K08053]
102571106  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
102561548  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
102560233  EGF; epidermal growth factor [KO:K04357]
102570675  TGFA; transforming growth factor alpha [KO:K08774]
102567241  EREG; epiregulin [KO:K09784]
102570896  AREG; amphiregulin [KO:K09782]
102570160  FGF1; fibroblast growth factor 1 [KO:K18496]
102567370  FGF2; fibroblast growth factor 2 [KO:K18497]
102571915  FGF20; fibroblast growth factor 20 [KO:K04358]
102572653  FGF22; fibroblast growth factor 22 [KO:K04358]
102577004  FGF9; fibroblast growth factor 9 [KO:K04358]
102564109  FGF6; fibroblast growth factor 6 [KO:K04358]
102564190  FGF18; fibroblast growth factor 18 [KO:K04358]
102573090  FGF16; fibroblast growth factor 16 [KO:K04358]
106737014  FGF8; fibroblast growth factor 8 [KO:K04358]
102568685  FGF10; fibroblast growth factor 10 [KO:K04358]
102572183  FGF5; fibroblast growth factor 5 [KO:K04358]
102570596  FGF17; fibroblast growth factor 17 [KO:K04358]
102563948  FGF3; fibroblast growth factor 3 [KO:K04358]
102563000  FGF4; fibroblast growth factor 4 [KO:K04358]
109280173  FGF7; fibroblast growth factor 7 [KO:K04358]
102563235  FGF19; fibroblast growth factor 19 [KO:K22603]
102565552  FGF21; fibroblast growth factor 21 [KO:K22429]
102564803  FGF23; fibroblast growth factor 23 [KO:K22428]
102568830  NGF; nerve growth factor [KO:K02582]
102568446  BDNF; brain derived neurotrophic factor [KO:K04355]
102573443  NTF3; neurotrophin 3 [KO:K04356]
102565762  INS; insulin [KO:K04526]
102559209  IGF1; insulin like growth factor 1 [KO:K05459]
102565996  IGF2; insulin like growth factor 2 [KO:K13769]
102568490  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102562234  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102572032  PDGFD; platelet derived growth factor D [KO:K05450]
102569106  PDGFC; platelet derived growth factor C [KO:K05450]
102560814  CSF1; colony stimulating factor 1 [KO:K05453]
102568076  KITLG; KIT ligand [KO:K05461]
102576555  VEGFA; vascular endothelial growth factor A [KO:K05448]
102567693  PGF; placental growth factor [KO:K16859]
102571219  VEGFC; vascular endothelial growth factor C [KO:K05449]
102569065  VEGFD; vascular endothelial growth factor D [KO:K05449]
102564574  HGF; hepatocyte growth factor [KO:K05460]
102569108  ANGPT1; angiopoietin 1 [KO:K05465]
102562725  angiopoietin-2 [KO:K05466]
102572586  ANGPT2; angiopoietin 2 [KO:K05466]
102567404  ANGPT4; angiopoietin 4 [KO:K05467]
109283968  EFNA2; ephrin A2 [KO:K05462]
102574357  EFNA5; ephrin A5 [KO:K05462]
102566292  EFNA1; ephrin A1 [KO:K05462]
102566528  EFNA3; ephrin A3 [KO:K05462]
102566764  EFNA4; ephrin-A4 [KO:K05462]
102566602  GDNF; glial cell derived neurotrophic factor [KO:K05452]
102559789  NRTN; neurturin [KO:K25414]
102558400  ARTN; artemin [KO:K25415]
102565209  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102561352  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
102577159  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
102559834  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
102574117  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102564591  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
106736800  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102567148  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
102574002  NGFR; nerve growth factor receptor [KO:K02583]
102568202  tumor necrosis factor receptor superfamily member 16-like [KO:K02583]
102568424  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
102559730  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
102558884  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
106736787  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102575338  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102566175  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102565932  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102573437  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
102566323  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
102566553  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
102561001  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
102567838  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102567818  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
102568767  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102559179  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
102558799  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102573157  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
102564907  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102576889  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102572638  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102562157  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102574430  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102575936  GTPase HRas [KO:K07827]
102566357  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102573349  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
102560726  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07830]
102573274  MRAS; muscle RAS oncogene homolog [KO:K07831]
106737102  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102576986  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102563228  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106736997  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102560921  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
106737342  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102561718  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109282845  mitogen-activated protein kinase 3-like [KO:K04371] [EC:2.7.11.24]
102568822  MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
102569927  MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
102563194  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
102574678  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
102561736  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
102571036  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
102564186  ATF4; activating transcription factor 4 [KO:K04374]
102563072  CFP; complement factor properdin [KO:K04375]
102569765  ELK4; ELK4, ETS transcription factor [KO:K04376]
102561083  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
106736977  SRF; serum response factor [KO:K04378]
102562416  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
102570040  MAPT; microtubule associated protein tau [KO:K04380]
102575487  STMN1; stathmin 1 [KO:K04381]
102571708  cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
102572619  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
102571930  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
102571167  cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
106736657  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
102572385  cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
102573324  PLA2G4F; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
102568256  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
102572848  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
102573092  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
102568705  PLA2G4F.1; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
102570036  PLA2G4C; phospholipase A2 group IVC [KO:K16342] [EC:3.1.1.4]
102564564  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
102569751  TNF; tumor necrosis factor [KO:K03156]
102570262  IL1B; interleukin-1 beta [KO:K04519]
102575353  uncharacterized LOC102575353 [KO:K04519]
102567067  TGFB1; transforming growth factor beta 1 [KO:K13375]
102562163  TGFB2; transforming growth factor beta 2 [KO:K13376]
102563668  TGFB3; transforming growth factor beta 3 [KO:K13377]
102560352  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102558564  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102567774  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
102568992  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
102567839  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
102573702  TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102564044  FASLG; Fas ligand [KO:K04389]
102562734  FAS; Fas cell surface death receptor [KO:K04390]
102576455  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102567702  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102563759  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102558748  CDC42; cell division cycle 42 [KO:K04393]
102573740  TRADD; TNFRSF1A associated via death domain [KO:K03171]
102572621  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102564363  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
102570112  DAXX; death domain associated protein [KO:K02308]
102560312  MYD88; myeloid differentiation primary response 88 [KO:K04729]
102575313  IRAK1; interleukin 1 receptor associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102560034  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102572036  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102575022  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
102570271  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
102560377  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
102563482  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
102567745  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
102558698  ECSIT; ECSIT signalling integrator [KO:K04405]
102576662  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
102559013  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
102563342  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
102576325  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102571099  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102569590  STK4; serine/threonine kinase 4 [KO:K04411]
102562825  STK3; serine/threonine kinase 3 [KO:K04412]
102569425  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
102566471  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102562794  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102570911  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
102574412  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102572648  mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
106736961  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
106736664  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102559099  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
102561424  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
102566049  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
102568383  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
102560853  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
102573024  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102569201  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102573918  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
102557819  TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
106736952  TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
102577347  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
102562496  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102566638  MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
106736984  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102575866  MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
102572345  MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
102571555  MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
102573539  FLNA; filamin A [KO:K04437]
102557881  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102559298  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
102562246  ARRB1; arrestin beta 1 [KO:K04439]
102577053  ARRB2; arrestin beta 2 [KO:K04439]
102566087  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102570366  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102570628  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102571419  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102571177  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
106736779  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102565670  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102573148  MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
102563674  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
106736633  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
102576860  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
102557866  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
102576728  CDC25B; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
102559296  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
102558779  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
102566064  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
102558421  JUND; JunD proto-oncogene, AP-1 transcription factor subunit [KO:K04449]
102572172  ATF2; activating transcription factor 2 [KO:K04450]
102570618  TP53; tumor protein p53 [KO:K04451]
102574043  DDIT3; DNA damage inducible transcript 3 [KO:K04452]
102574691  MAX; MYC associated factor X [KO:K04453]
102573957  MEF2C; myocyte enhancer factor 2C [KO:K04454]
102575596  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
102574794  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102558879  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102564996  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102572447  PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
106736712  PTPRR; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
102557921  PTPN5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
102560009  PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102559641  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102560060  DUSP4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102574381  DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102566065  DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102568234  DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102565247  DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102567008  DUSP6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102573928  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
102559914  DUSP10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102558037  DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102576572  PPP5C; protein phosphatase 5 catalytic subunit [KO:K04460] [EC:3.1.3.16]
102563048  PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
102558322  heat shock 70 kDa protein II [KO:K03283]
102569481  heat shock 70 kDa protein 1 [KO:K03283]
102568886  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
102561786  MECOM; MDS1 and EVI1 complex locus [KO:K04462] [EC:2.1.1.367]
102574038  MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
102577139  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
102572473  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102575720  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
106736873  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102561936  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102561500  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
102575019  NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
102558052  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102565688  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
102573364  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102571096  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
amj04070  Phosphatidylinositol signaling system
amj04110  Cell cycle
amj04115  p53 signaling pathway
amj04210  Apoptosis
amj04310  Wnt signaling pathway
KO pathway
ko04010   
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