KEGG   PATHWAY: chx05417
Entry
chx05417                    Pathway                                
Name
Lipid and atherosclerosis - Capra hircus (goat)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
chx05417  Lipid and atherosclerosis
chx05417

Organism
Capra hircus (goat) [GN:chx]
Gene
102184161  APOB; apolipoprotein B-100 [KO:K14462]
102183707  APOA4; apolipoprotein A-IV [KO:K08760]
102179867  apolipoprotein A-I [KO:K08757]
102180141  APOA1; apolipoprotein A-I [KO:K08757]
102186579  LDLR; low-density lipoprotein receptor [KO:K12473]
102185442  OLR1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763]
102180150  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
102170620  MMP1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
102181169  RHOA; transforming protein RhoA [KO:K04513]
102181692  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
102185338  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
102185042  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102168391  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102177551  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102179343  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102170135  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102188710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100846984  BAX; apoptosis regulator BAX isoform X3 [KO:K02159]
102189930  BAD; bcl2-associated agonist of cell death [KO:K02158]
102180684  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102183607  bcl-2-like protein 1 [KO:K04570]
100861254  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100860856  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
102180890  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102189357  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
102186785  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
102178760  POU2F2; POU domain, class 2, transcription factor 2 isoform X4 [KO:K09364]
102183249  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
102172335  CD40LG; CD40 ligand [KO:K03161]
102170823  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
102184867  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
102190840  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
102191099  LOW QUALITY PROTEIN: cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
102190572  LOW QUALITY PROTEIN: cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
102168873  AGER; advanced glycosylation end product-specific receptor isoform X2 [KO:K19722]
102178048  NOX1; NADPH oxidase 1 [KO:K08008]
102175938  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
102176291  NCF1; neutrophil cytosol factor 1 [KO:K08011]
102188617  cytochrome b-245 light chain [KO:K08009]
102171728  NCF2; neutrophil cytosol factor 2 isoform X2 [KO:K08010]
102175930  NCF4; neutrophil cytosol factor 4 [KO:K08012]
102173438  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102182890  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102180670  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
102186154  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
102188638  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102175799  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102173178  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102171520  FOS; proto-oncogene c-Fos [KO:K04379]
102185423  JUN; transcription factor AP-1 [KO:K04448]
102175889  C-C motif chemokine 2 [KO:K14624]
102181113  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
102178438  CXCL8; interleukin-8 [KO:K10030]
102173967  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102169516  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
102180926  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100860996  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102189174  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102184510  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102187180  NRAS; GTPase NRas [KO:K07828]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102174096  RELA; transcription factor p65 [KO:K04735]
102175660  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102170997  SELE; E-selectin [KO:K06494]
102170076  SELP; P-selectin [KO:K06496]
102174895  vascular cell adhesion protein 1 isoform X1 [KO:K06527]
102175177  vascular cell adhesion protein 1 isoform X1 [KO:K06527]
102170893  MMP3; stromelysin-1 [KO:K01394] [EC:3.4.24.17]
102168469  MMP9; matrix metalloproteinase-9 precursor [KO:K01403] [EC:3.4.24.35]
102180451  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100860816  IL1B; interleukin-1 beta [KO:K04519]
100860785  IL6; interleukin-6 precursor [KO:K05405]
100861232  TNF; tumor necrosis factor [KO:K03156]
100861238  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
102177850  heat shock 70 kDa protein 1-like [KO:K03283]
102178315  heat shock 70 kDa protein 1B [KO:K03283]
102182240  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102185412  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
100860849  HSP70.1; heat shock protein 70.1 [KO:K03283]
102186695  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
102172434  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
100860851  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
100861006  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102179454  HSP90B1; endoplasmin [KO:K09487]
100860747  TLR2; toll-like receptor 2 precursor [KO:K10159]
102186029  LBP; lipopolysaccharide-binding protein [KO:K05399]
102186320  lipopolysaccharide-binding protein [KO:K05399]
102177056  CD14; monocyte differentiation antigen CD14 [KO:K04391]
102182808  LY96; lymphocyte antigen 96 [KO:K05400]
100860955  TLR4; toll-like receptor 4 precursor [KO:K10160]
102184789  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
102174883  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102171575  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102177432  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102172830  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
102185161  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102187405  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
102172719  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
102181262  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102177406  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102171591  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102169137  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108636847  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
102170774  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
102171742  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
102169639  MIB1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
102187514  MIB2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
102185959  TANK; TRAF family member-associated NF-kappa-B activator isoform X3 [KO:K12650]
102183809  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102181474  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
106503773  IRF7; interferon regulatory factor 7 [KO:K09447]
102171811  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
108635529  interferon alpha-H-like [KO:K05414]
108633160  interferon alpha-1-like [KO:K05414]
100860850  IFNA; interferon-alpha precursor [KO:K05414]
102174842  interferon alpha-1-like [KO:K05414]
102179943  interferon alpha-H-like [KO:K05414]
102180761  interferon alpha-H [KO:K05414]
102181299  interferon alpha-H-like [KO:K05414]
108636621  interferon alpha-H-like [KO:K05414]
108636627  interferon alpha-H-like [KO:K05414]
102181867  interferon beta-2 [KO:K05415]
102189208  LOW QUALITY PROTEIN: interferon beta-2 [KO:K05415]
102181595  interferon beta-2-like [KO:K05415]
108636544  interferon beta-2-like [KO:K05415]
108636629  interferon beta-2-like [KO:K05415]
108636632  interferon beta-2-like [KO:K05415]
108636634  interferon beta-2 [KO:K05415]
108633243  interferon beta-2-like [KO:K05415]
100860959  CD36-like protein [KO:K06259]
100860958  CD36; platelet glycoprotein 4 [KO:K06259]
108633303  platelet glycoprotein 4-like [KO:K06259]
100861309  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
108634606  retinoic acid receptor RXR-alpha [KO:K08524]
102189445  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
102170009  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
102184639  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
102177814  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102189645  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
102176802  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
102177428  VAV1; proto-oncogene vav [KO:K05730]
100860932  TLR6; toll-like receptor 6 [KO:K10169]
102176930  RAP1A; ras-related protein Rap-1A [KO:K04353]
102174543  RAP1B; ras-related protein Rap-1b [KO:K07836]
102171272  CCL5; C-C motif chemokine 5 [KO:K12499]
102179590  C-C motif chemokine 3 isoform X1 [KO:K05408]
108638246  C-C motif chemokine 3-like [KO:K05408]
102171053  C-C motif chemokine 18 [KO:K05408]
102181154  C-C motif chemokine 3 [KO:K05408]
102170772  regakine-1 [KO:K05408]
102182115  growth-regulated alpha protein [KO:K05505]
102182683  growth-regulated alpha protein-like [KO:K05505]
102182395  growth-regulated protein homolog gamma isoform X1 [KO:K05505]
100861293  IL12A; interleukin-12 subunit alpha precursor [KO:K05406]
100860845  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
102173382  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
100861190  IL18; interleukin-18 [KO:K05482]
102185663  HSPA5; endoplasmic reticulum chaperone BiP precursor [KO:K09490] [EC:3.6.4.10]
102184016  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
102175557  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
102190790  ERO1A; ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
102188092  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
102176762  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102185715  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
102185084  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102175934  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
102185575  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
100861133  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102185072  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102173038  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102184255  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102172156  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102184460  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
102179197  ABCA1; ATP-binding cassette sub-family A member 1 isoform X1 [KO:K05641]
102181242  ABCG1; ATP-binding cassette sub-family G member 1 isoform X1 [KO:K05679]
102176737  NFE2L2; nuclear factor erythroid 2-related factor 2 [KO:K05638]
100861338  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
102177522  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
102184966  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102176363  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102188180  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102180958  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102188148  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102180505  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102169966  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102189653  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102181878  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102185007  CALM1; calmodulin [KO:K02183]
102172164  CALM2; calmodulin isoform X1 [KO:K02183]
102175311  calmodulin [KO:K02183]
106502751  calmodulin-like protein 3 [KO:K02183]
102187248  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
102169697  CALM3; calmodulin [KO:K02183]
102171428  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102176770  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102179767  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102184033  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102177339  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102182602  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
102173335  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
108638455  uncharacterized protein LOC108638455 [KO:K04722]
102175959  tumor necrosis factor receptor superfamily member 10C isoform X1 [KO:K04722]
108635411  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
108635488  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
108638473  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
108634850  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
102190310  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102178753  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102169919  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102176106  BID; BH3-interacting domain death agonist [KO:K04726]
106501717  cytochrome c 2 [KO:K08738]
102173997  cytochrome c [KO:K08738]
102188830  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
102174681  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102184605  CASP6; caspase-6 [KO:K04396] [EC:3.4.22.59]
102177031  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100861343  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
102169621  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:E218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
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Reference
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Related
pathway
chx04020  Calcium signaling pathway
chx04115  p53 signaling pathway
chx04141  Protein processing in endoplasmic reticulum
chx04151  PI3K-Akt signaling pathway
chx04210  Apoptosis
chx04620  Toll-like receptor signaling pathway
chx04621  NOD-like receptor signaling pathway
chx04668  TNF signaling pathway
chx04670  Leukocyte transendothelial migration
chx04975  Fat digestion and absorption
chx04979  Cholesterol metabolism
chx05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   
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