KEGG   PATHWAY: efus05169
Entry
efus05169                   Pathway                                
Name
Epstein-Barr virus infection - Eptesicus fuscus (big brown bat)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
efus05169  Epstein-Barr virus infection
efus05169

Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103304232  complement receptor type 2-like isoform X1 [KO:K04012]
114229928  LOW QUALITY PROTEIN: complement receptor type 2-like [KO:K04012]
103300826  CD19; B-lymphocyte antigen CD19 [KO:K06465]
103303049  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
103303050  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
103304353  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X2 [KO:K06752]
103304486  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
103304511  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
103300442  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
103295592  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
103303036  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
103304919  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
103303047  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
103304352  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
129150533  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
103303048  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
103303037  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
103304354  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
103304514  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752]
103288450  TLR2; toll-like receptor 2 [KO:K10159]
103298161  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103285212  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X2 [KO:K04733] [EC:2.7.11.1]
103302249  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
103290874  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103288851  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103302357  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
103293777  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
103288473  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
103288179  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103302255  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103301979  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103299786  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103291087  RELA; transcription factor p65 isoform X1 [KO:K04735]
103300478  TNF; tumor necrosis factor isoform X1 [KO:K03156]
103292051  IL6; interleukin-6 [KO:K05405]
103286489  RIGI; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
103285642  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
103301807  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
103292497  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103297481  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103302547  IRF7; interferon regulatory factor 7 [KO:K09447]
103297623  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
103289195  IFNB1; interferon beta [KO:K05415]
103289928  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103289837  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
103284092  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103301133  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
103290572  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
103292429  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
103301487  IRF9; interferon regulatory factor 9 [KO:K04693]
103305673  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
103293910  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
103287239  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
129148092  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
103287240  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
103304839  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
103295348  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
103296397  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103291049  FADD; FAS-associated death domain protein [KO:K02373]
103290541  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103303807  BID; BH3-interacting domain death agonist isoform X3 [KO:K04726]
103302915  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
103303728  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
103297647  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103303014  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103292869  cytochrome c-like [KO:K08738]
103291881  cytochrome c [KO:K08738]
103305670  cytochrome c-like [KO:K08738]
103303075  cytochrome c-like [KO:K08738]
129150288  cytochrome c-like [KO:K08738]
103300565  cytochrome c-like [KO:K08738]
103289111  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
103292032  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103295435  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103293819  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
103293740  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
103293741  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
103296565  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
103293448  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
103304940  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
103284315  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
103283740  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
103290830  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
103293143  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
103300648  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
103303194  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
103297147  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
103293125  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
103291678  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
103290378  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
103284630  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 isoform X1 [KO:K03038]
103302549  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
103298998  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [KO:K03029]
103283375  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
103284353  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
103300233  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
114234657  LOW QUALITY PROTEIN: 26S proteasome complex subunit SEM1 [KO:K10881]
114234249  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
129150467  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
114229614  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103303044  TAPBP; tapasin [KO:K08058]
103287370  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103301007  CALR; calreticulin [KO:K08057]
103301649  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
103300539  patr class I histocompatibility antigen, B-1 alpha chain-like isoform X1 [KO:K06751]
103283920  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
129147051  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
129147596  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
129147597  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
103304883  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
103304180  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
114229892  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
129147115  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
129147758  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
103304812  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
103304966  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
103304787  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
114229502  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
114229990  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X1 [KO:K06751]
103304222  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
103287538  B2M; beta-2-microglobulin isoform X2 [KO:K08055]
103283531  SNW1; SNW domain-containing protein 1 [KO:K06063]
103300180  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
103300141  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
103303280  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
103293384  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
103300391  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
103295779  SAP30L; histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
103298476  SAP30; histone deacetylase complex subunit SAP30 [KO:K19202]
103283490  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
103301758  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
103285017  RBPJ; recombining binding protein suppressor of hairless isoform X3 [KO:K06053]
103295178  HES1; transcription factor HES-1 [KO:K06054]
103295090  FCER2; LOW QUALITY PROTEIN: low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
103292069  RUNX3; runt-related transcription factor 3 [KO:K09279]
103292358  MYC; myc proto-oncogene protein [KO:K04377]
103286121  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
103292522  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
103296897  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
103295571  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103284106  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
103294264  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103299999  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103291020  DDB2; DNA damage-binding protein 2 [KO:K10140]
103305339  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
103290060  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
103286747  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103296140  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103295411  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103299551  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103305161  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103294784  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103284312  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
103301793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103293483  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103293009  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103301400  RELB; transcription factor RelB [KO:K09253]
103288512  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
103284564  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
103284340  NFKBIB; NF-kappa-B inhibitor beta isoform X2 [KO:K02581]
103296618  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
103296845  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103295027  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X7 [KO:K04431] [EC:2.7.12.2]
103301660  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
103292821  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103287875  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103295968  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103302882  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
103303990  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
103299424  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
103295508  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
103298650  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103298707  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
103295577  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103284067  JUN; transcription factor Jun [KO:K04448]
103297979  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
103288631  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X2 [KO:K01510] [EC:3.6.1.5]
103296114  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
103301981  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
103290879  CD44; CD44 antigen [KO:K06256]
103296258  ITGAL; integrin alpha-L [KO:K05718]
103291352  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
103301176  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
103292588  VIM; vimentin [KO:K07606]
103305243  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
103299558  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
103293093  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
103287627  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
103300004  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
103287450  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
103299146  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
129148251  uncharacterized protein LOC129148251 [KO:K06856]
103299705  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
103288634  BLNK; B-cell linker protein [KO:K07371]
103284403  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
103298086  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
103285100  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
103290903  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
103288032  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103301919  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
103292479  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
103292850  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
103301644  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
103303305  CCNA1; cyclin-A1 [KO:K06627]
103292334  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
103284864  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
103292405  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
103289677  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
103293372  E2F1; transcription factor E2F1 [KO:K17454]
103292075  E2F2; transcription factor E2F2 [KO:K09389]
103290149  E2F3; transcription factor E2F3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
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Nat Rev Cancer 4:757-68 (2004)
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Reference
PMID:21372216
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Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
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Clin Cancer Res 17:3056-63 (2011)
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Reference
PMID:21429244
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Ning S
  Title
Innate immune modulation in EBV infection.
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Herpesviridae 2:1 (2011)
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Reference
PMID:28408983
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Stanfield BA, Luftig MA
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Recent advances in understanding Epstein-Barr virus.
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F1000Res 6:386 (2017)
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Reference
PMID:24586164
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van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
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Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
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Trends Immunol 36:124-38 (2015)
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Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
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Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
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Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
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Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
efus03050  Proteasome
efus04010  MAPK signaling pathway
efus04020  Calcium signaling pathway
efus04064  NF-kappa B signaling pathway
efus04110  Cell cycle
efus04115  p53 signaling pathway
efus04210  Apoptosis
efus04612  Antigen processing and presentation
efus04620  Toll-like receptor signaling pathway
efus04622  RIG-I-like receptor signaling pathway
efus04630  JAK-STAT signaling pathway
efus04662  B cell receptor signaling pathway
KO pathway
ko05169   
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