KEGG   PATHWAY: hhv04014
Entry
hhv04014                    Pathway                                
Name
Ras signaling pathway - Hyaena hyaena (striped hyena)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
hhv04014  Ras signaling pathway
hhv04014

Other DBs
GO: 0032318
Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120236138  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
120236624  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
120234333  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
120238033  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
120224487  FGF16; fibroblast growth factor 16 [KO:K04358]
120243219  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
120233064  FGF10; fibroblast growth factor 10 [KO:K04358]
120233875  FGF4; fibroblast growth factor 4 [KO:K04358]
120233886  FGF3; fibroblast growth factor 3 [KO:K04358]
120234087  FGF18; fibroblast growth factor 18 [KO:K04358]
120239484  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
120235046  FGF7; fibroblast growth factor 7 [KO:K04358]
120222265  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
120242355  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
120247465  FGF9; fibroblast growth factor 9 [KO:K04358]
120247728  FGF6; fibroblast growth factor 6 [KO:K04358]
120248082  FGF20; fibroblast growth factor 20 [KO:K04358]
120233885  FGF19; fibroblast growth factor 19 [KO:K22603]
120243454  FGF21; fibroblast growth factor 21 [KO:K22429]
120247734  FGF23; fibroblast growth factor 23 [KO:K22428]
120238779  NGF; beta-nerve growth factor [KO:K02582]
120220096  BDNF; brain-derived neurotrophic factor [KO:K04355]
120221154  NTF3; neurotrophin-3 [KO:K04356]
120240806  NTF4; neurotrophin-4 [KO:K12457]
120226896  INS; insulin [KO:K04526]
120245431  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
120225512  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
120226895  insulin-like growth factor II isoform X1 [KO:K13769]
120227991  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
120233377  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
120223081  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
120246757  PDGFD; platelet-derived growth factor D [KO:K05450]
120244521  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
120237065  KITLG; kit ligand isoform X1 [KO:K05461]
120244135  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
120231199  VEGFA; vascular endothelial growth factor A [KO:K05448]
120240107  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
120232932  VEGFD; vascular endothelial growth factor D [KO:K05449]
120222108  VEGFC; vascular endothelial growth factor C [KO:K05449]
120221164  hepatocyte growth factor-like [KO:K05460]
120245413  HGF; hepatocyte growth factor [KO:K05460]
120222328  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
120221654  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
120235433  ANGPT4; angiopoietin-4 [KO:K05467]
120240773  EFNA5; ephrin-A5 [KO:K05462]
120242369  EFNA2; ephrin-A2 [KO:K05462]
120244682  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
120244722  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
120244725  EFNA1; ephrin-A1 [KO:K05462]
120238884  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
120238662  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
120244115  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120231844  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120236775  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
120228984  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
120244665  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
120224500  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
120244875  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
120233674  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
120222584  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120236611  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
120236560  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
120222581  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
120247007  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
120247154  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
120225370  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
120243048  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
120223826  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
120223605  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
120229831  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
120228194  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
120242435  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
120229624  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
120244661  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
120242345  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
120237954  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
120220858  SHC4; SHC-transforming protein 4 [KO:K17449]
120236974  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
120242567  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
120220282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
120244628  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120228585  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
120228197  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
120224815  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
120240123  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
120244026  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
120220621  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
120232052  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
120242177  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
120219859  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
120242569  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
120223690  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
120220432  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
120246690  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
120235024  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
120247989  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
120249175  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
120241831  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
120241642  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
120244574  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
120242329  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
120237008  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
120234397  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
120220331  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
120245305  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
120241598  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
120234413  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
120229112  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
120241649  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
120245321  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
120219964  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
120222317  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
120222782  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
120239836  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
120236891  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
120232098  CALM1; calmodulin-1 [KO:K02183]
120237182  calmodulin-like [KO:K02183]
120237195  calmodulin-like protein 3 [KO:K02183]
120241014  CALM2; calmodulin-2 [KO:K02183]
120221982  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
120241987  CALM3; calmodulin-3 isoform X1 [KO:K02183]
120242524  CALML6; calmodulin-like protein 6 [KO:K02183]
120223392  HRAS; GTPase HRas isoform X1 [KO:K02833]
120223531  KRAS; GTPase KRas [KO:K07827]
120243068  NRAS; GTPase NRas [KO:K07828]
120222404  MRAS; ras-related protein M-Ras [KO:K07831]
120244187  RRAS; ras-related protein R-Ras [KO:K07829]
120244997  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
120245671  NF1; neurofibromin isoform X1 [KO:K08052]
120224108  RASA1; ras GTPase-activating protein 1 [KO:K04352]
120242649  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
120223463  RASA3; ras GTPase-activating protein 3 [KO:K12380]
120239342  RASA4B; ras GTPase-activating protein 4B [KO:K17630]
120238208  SYNGAP1; ras/Rap GTPase-activating protein SynGAP [KO:K17631]
120247265  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
120247464  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
120239137  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
120229298  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
120228927  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
120242604  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
120229789  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
120227958  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120241186  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120228188  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
120229608  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
120244384  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
120241977  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
120242769  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
120226240  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
120232303  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
120229394  RHOA; transforming protein RhoA [KO:K04513]
120249159  transforming protein RhoA-like [KO:K04513]
120233608  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120220979  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
120246696  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120219997  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120239233  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120247089  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
120235277  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120244696  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120247774  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120226622  IKBKG; NF-kappa-B essential modulator [KO:K07210]
120243217  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
120233999  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
120222817  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120240185  RELA; transcription factor p65 [KO:K04735]
120240137  BAD; bcl2-associated agonist of cell death [KO:K02158]
120235381  BCL2L1; bcl-2-like protein 1 [KO:K04570]
120246045  FOXO4; forkhead box protein O4 [KO:K12358]
120224200  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120248605  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
120219749  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
120228578  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
120230137  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
120245838  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
120238206  RGL2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
120235587  RALA; ras-related protein Ral-A [KO:K07834]
120233552  RALB; ras-related protein Ral-B [KO:K07835]
120226705  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
120234597  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
120223853  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
120233179  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
120237156  REL; proto-oncogene c-Rel [KO:K09254]
120244180  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120232781  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120245677  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120221596  RALBP1; ralA-binding protein 1 [KO:K08773]
120233626  cell division control protein 42 homolog [KO:K04393]
120231260  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120248697  AFDN; afadin isoform X1 [KO:K05702]
120244293  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
120231327  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120221655  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120242086  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120238830  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120242212  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
120242898  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
120232702  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
120244250  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120233754  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
120227896  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120229741  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120229754  group IIE secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
120229818  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
120229820  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120229829  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120236132  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
120232221  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
120232262  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
120232263  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
120232300  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
120248736  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
120241143  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
120249171  phospholipase A and acyltransferase 3-like isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
120219889  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
120237105  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
120229546  ETS2; protein C-ets-2 [KO:K21932]
120230499  BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
120245555  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
120234520  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
120236212  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
120247125  RAP1A; ras-related protein Rap-1A [KO:K04353]
120240794  RAP1B; ras-related protein Rap-1b [KO:K07836]
120230566  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
120234190  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120233260  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120239766  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
120240098  RIN1; ras and Rab interactor 1 [KO:K17638]
120230153  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
120247462  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
120222031  RAB5A; ras-related protein Rab-5A [KO:K07887]
120219965  RAB5B; ras-related protein Rab-5B [KO:K07888]
120239005  LOW QUALITY PROTEIN: ras-related protein Rab-5C-like [KO:K07889]
120248450  RAB5C; ras-related protein Rab-5C [KO:K07889]
120220270  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
hhv04010  MAPK signaling pathway
hhv04015  Rap1 signaling pathway
hhv04020  Calcium signaling pathway
hhv04144  Endocytosis
hhv04151  PI3K-Akt signaling pathway
hhv04660  T cell receptor signaling pathway
hhv04720  Long-term potentiation
hhv04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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