KEGG   PATHWAY: mcc04014
Entry
mcc04014                    Pathway                                
Name
Ras signaling pathway - Macaca mulatta (rhesus monkey)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
mcc04014  Ras signaling pathway
mcc04014

Other DBs
GO: 0032318
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
698619  EGF; pro-epidermal growth factor isoform X2 [KO:K04357]
613031  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
705970  FGF1; fibroblast growth factor 1 [KO:K18496]
574136  FGF2; fibroblast growth factor 2 [KO:K18497]
710739  FGF6; fibroblast growth factor 6 [KO:K04358]
574345  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
701584  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
705612  FGF16; fibroblast growth factor 16 [KO:K04358]
702727  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
701847  FGF20; fibroblast growth factor 20 [KO:K04358]
708918  FGF3; fibroblast growth factor 3 precursor [KO:K04358]
709016  FGF4; fibroblast growth factor 4 [KO:K04358]
706659  FGF17; fibroblast growth factor 17 precursor [KO:K04358]
721324  FGF9; fibroblast growth factor 9 [KO:K04358]
695896  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
702072  FGF18; fibroblast growth factor 18 [KO:K04358]
722394  FGF8; fibroblast growth factor 8 [KO:K04358]
709109  FGF19; fibroblast growth factor 19 [KO:K22603]
718288  FGF21; fibroblast growth factor 21 [KO:K22429]
710643  FGF23; fibroblast growth factor 23 precursor [KO:K22428]
711681  NGF; beta-nerve growth factor [KO:K02582]
701245  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
721988  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
718534  NTF4; neurotrophin-4 precursor [KO:K12457]
704534  INS; insulin [KO:K04526]
698444  IGF1; insulin-like growth factor I precursor [KO:K05459]
710802  IGF2; insulin-like growth factor II isoform X2 [KO:K13769]
707725  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
703173  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
704310  PDGFD; platelet-derived growth factor D isoform X2 [KO:K05450]
700236  PDGFC; platelet-derived growth factor C [KO:K05450]
702532  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
574254  KITLG; kit ligand isoform X1 [KO:K05461]
719239  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X2 [KO:K05454]
574209  VEGFA; vascular endothelial growth factor A isoform 1 precursor [KO:K05448]
722115  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
701219  PGF; placenta growth factor isoform X2 [KO:K16859]
712654  VEGFD; vascular endothelial growth factor D [KO:K05449]
699502  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
708316  HGF; hepatocyte growth factor isoform X3 [KO:K05460]
697017  ANGPT1; angiopoietin-1 precursor [KO:K05465]
716811  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
715213  ANGPT4; angiopoietin-4 [KO:K05467]
717399  EFNA1; ephrin-A1 [KO:K05462]
717373  EFNA3; ephrin-A3 precursor [KO:K05462]
704351  EFNA5; ephrin-A5 precursor [KO:K05462]
717315  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
721231  EFNA2; ephrin-A2 [KO:K05462]
613027  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
700126  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
715949  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
712829  FGFR3; fibroblast growth factor receptor 3 isoform X10 [KO:K05094] [EC:2.7.10.1]
698494  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
574304  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
719670  NTRK1; high affinity nerve growth factor receptor isoform X3 [KO:K03176] [EC:2.7.10.1]
709757  NTRK2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
706009  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
708227  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
697002  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
711353  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
711512  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
696759  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
721712  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
114669851  receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
574133  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
716412  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
698293  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
704562  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
707455  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
692343  EPHA2; ephrin type-A receptor 2 precursor [KO:K05103] [EC:2.7.10.1]
702041  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
700367  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
700197  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
718982  SHC1; SHC-transforming protein 1 [KO:K06279]
721021  SHC2; SHC-transforming protein 2 [KO:K17447]
574275  SHC3; SHC-transforming protein 3 [KO:K17448]
714611  SHC4; SHC-transforming protein 4 [KO:K17449]
712044  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
713777  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
705601  SOS2; son of sevenless homolog 2 [KO:K03099]
697069  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
714173  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
703838  RASGRP1; RAS guanyl-releasing protein 1 isoform X3 [KO:K04350]
722044  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
707225  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
719595  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
710149  uncharacterized protein LOC710149 [KO:K10784]
698785  LOW QUALITY PROTEIN: uncharacterized protein LOC698785 [KO:K10785]
696306  T cell receptor beta variable 3-1 [KO:K10785]
697904  uncharacterized protein LOC697904 [KO:K10785]
703029  immunoglobulin lambda-1 light chain-like [KO:K10785]
707555  tyrosine-protein kinase ZAP-70 isoform X1 [KO:K07360] [EC:2.7.10.2]
704656  LAT; linker for activation of T-cells family member 1 isoform X2 [KO:K07362]
696317  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
703399  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
719248  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
713913  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
709489  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
695441  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
710000  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
100169972  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
718223  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
703336  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
710548  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
711335  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
114673987  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
708193  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
700606  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
100424606  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
114673968  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
722398  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
700724  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
698840  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
709728  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
718632  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
700652  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
717161  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
711350  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
574380  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100429880  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
698571  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
717686  calmodulin [KO:K02183]
698552  CALM1; calmodulin-1 isoform X1 [KO:K02183]
715270  CALM2; calmodulin-2 [KO:K02183]
703514  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
712159  CALML5; calmodulin-like protein 5 [KO:K02183]
722513  CALML3; calmodulin-like protein 3 [KO:K02183]
716584  CALM3; calmodulin-3 isoform X1 [KO:K02183]
693753  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
706351  calmodulin-like [KO:K02183]
698830  HRAS; GTPase HRas [KO:K02833]
707977  KRAS; GTPase KRas [KO:K07827]
709089  NRAS; GTPase NRas [KO:K07828]
716352  MRAS; ras-related protein M-Ras [KO:K07831]
718939  RRAS; ras-related protein R-Ras [KO:K07829]
699700  RRAS2; ras-related protein R-Ras2 [KO:K07830]
712911  NF1; neurofibromin isoform X1 [KO:K08052]
694085  RASA1; ras GTPase-activating protein 1 [KO:K04352]
715074  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
698964  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
719871  RASA4B; ras GTPase-activating protein 4B isoform X1 [KO:K17630]
717858  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
714353  RASAL1; rasGAP-activating-like protein 1 isoform X3 [KO:K17632]
718958  RASAL2; ras GTPase-activating protein nGAP isoform X8 [KO:K17633]
719214  RASAL3; RAS protein activator like-3 [KO:K17634]
702385  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
695382  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
717730  STK4; serine/threonine-protein kinase 4 [KO:K04411]
702288  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
717755  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
696709  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
719305  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
698585  PAK1; serine/threonine-protein kinase PAK 1 isoform X5 [KO:K04409] [EC:2.7.11.1]
710314  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
706217  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
696676  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
719458  PAK5; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
701589  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
706455  RHOA; transforming protein RhoA [KO:K04513]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
714717  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
697747  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
700591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
701237  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
709511  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467] [EC:2.7.11.10]
704683  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
717740  BAD; bcl2-associated agonist of cell death [KO:K02158]
713035  BCL2L1; bcl-2-like protein 1 [KO:K04570]
698055  FOXO4; forkhead box protein O4 [KO:K12358]
574159  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
695674  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X9 [KO:K25768]
700311  RALGAPA2; ral GTPase-activating protein subunit alpha-2 [KO:K25768]
705742  RALGAPB; ral GTPase-activating protein subunit beta isoform X2 [KO:K25769]
714436  RALGDS; ral guanine nucleotide dissociation stimulator isoform X4 [KO:K08732]
710293  ral-GDS-related protein isoform X2 [KO:K08732]
711158  ral-GDS-related protein-like isoform X1 [KO:K08732]
114670406  ral-GDS-related protein-like isoform X1 [KO:K08732]
100426259  ral-GDS-related protein-like [KO:K08732]
106992479  ral-GDS-related protein-like [KO:K08732]
106995524  ral-GDS-related protein-like isoform X1 [KO:K08732]
710997  ral-GDS-related protein-like isoform X1 [KO:K08732]
106995478  ral-GDS-related protein-like isoform X1 [KO:K08732]
713249  ral-GDS-related protein-like isoform X1 [KO:K08732]
717554  RGL1; ral guanine nucleotide dissociation stimulator-like 1 [KO:K17635]
718198  RGL2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
703440  RALA; ras-related protein Ral-A [KO:K07834]
695852  RALB; ras-related protein Ral-B [KO:K07835]
721573  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
694963  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
706296  EXOC2; exocyst complex component 2 [KO:K17637]
717427  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
717804  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
699736  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
711115  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
715782  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
114673776  RALBP1; ralA-binding protein 1 isoform X1 [KO:K08773]
707637  CDC42; cell division control protein 42 homolog [KO:K04393]
693560  AFDN; afadin isoform X1 [KO:K05702]
695572  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
694725  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
710415  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
721821  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
708938  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
698569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
712705  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
718321  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
708031  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
704299  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
704520  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
704735  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
704629  PLA2G5; calcium-dependent phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
717517  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
717084  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
696712  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
697726  PLA2G12A; group XIIA secretory phospholipase A2 precursor [KO:K01047] [EC:3.1.1.4]
100430900  PLA2G2F; group IIF secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
716635  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
100533113  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
718510  cytosolic phospholipase A2 gamma isoform X3 [KO:K16342] [EC:3.1.1.4]
707592  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
707690  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
100424593  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
700184  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
722178  PLAAT3; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
722182  PLAAT2; HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
712610  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
114672301  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
714697  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
715887  ETS2; protein C-ets-2 [KO:K21932]
713386  BRAP; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
706388  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
694642  KSR2; kinase suppressor of Ras 2 isoform X4 [KO:K18529] [EC:2.7.11.1]
711698  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
704404  RAP1A; ras-related protein Rap-1A [KO:K04353]
718171  RAP1B; ras-related protein Rap-1b [KO:K07836]
693750  LOW QUALITY PROTEIN: ras-related protein Rap-1b [KO:K07836]
701758  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
714321  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
722449  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
717037  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
697712  RAB5A; ras-related protein Rab-5A [KO:K07887]
708347  RAB5B; ras-related protein Rab-5B [KO:K07888]
709308  RAB5C; ras-related protein Rab-5C [KO:K07889]
708170  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
mcc04010  MAPK signaling pathway
mcc04015  Rap1 signaling pathway
mcc04020  Calcium signaling pathway
mcc04144  Endocytosis
mcc04151  PI3K-Akt signaling pathway
mcc04660  T cell receptor signaling pathway
mcc04720  Long-term potentiation
mcc04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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