KEGG   PATHWAY: mfot05170
Entry
mfot05170                   Pathway                                
Name
Human immunodeficiency virus 1 infection - Microtus fortis (reed vole)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
mfot05170  Human immunodeficiency virus 1 infection
mfot05170

Organism
Microtus fortis (reed vole) [GN:mfot]
Gene
126514916  T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
126504817  F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
126491292  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
126503398  LOW QUALITY PROTEIN: S-phase kinase-associated protein 1-like [KO:K03094]
126510984  S-phase kinase-associated protein 1 [KO:K03094]
126515064  cullin-1 [KO:K03347]
126492120  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
126501446  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
126505129  C-X-C chemokine receptor type 4 [KO:K04189]
126501117  C-C chemokine receptor type 5-like [KO:K04180]
126512093  guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630]
126499907  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
126500134  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
126487932  guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630]
126502958  guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
126499173  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126499912  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126508229  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126491758  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
126512534  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126494148  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
126503359  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
126507587  protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
126511626  paxillin isoform X1 [KO:K05760]
126492419  adapter molecule crk isoform X1 [KO:K04438]
126488990  crk-like protein [KO:K04438]
126492538  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126502126  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126509082  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126508140  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
126486986  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
126498514  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
126502367  nuclear factor NF-kappa-B p105 subunit [KO:K02580]
126498562  transcription factor p65 isoform X1 [KO:K04735]
126515189  protein c-Fos [KO:K04379]
126497948  transcription factor Jun [KO:K04448]
126498361  bcl2-associated agonist of cell death isoform X1 [KO:K02158]
126498807  GTPase HRas [KO:K02833]
126515221  GTPase KRas isoform X1 [KO:K07827]
126510868  GTPase NRas [KO:K07828]
126505550  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
126507499  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
126489299  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
126489023  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
126515955  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
126510731  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
126489320  guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
126506998  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126502936  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
126490074  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
126515231  inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
126499493  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
126506775  calmodulin-like protein 3 [KO:K02183]
126506795  calmodulin-4-like isoform X1 [KO:K02183]
126507242  calmodulin-1 [KO:K02183]
126507402  calmodulin-like protein 4 isoform X1 [KO:K02183]
126494792  calmodulin-3 [KO:K02183]
126504141  calmodulin-2 [KO:K02183]
126491266  protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
126491367  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
126500819  calcineurin subunit B type 1 [KO:K06268]
126509907  calcineurin subunit B type 2 [KO:K06268]
126515387  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
126487431  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
126502736  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
126490896  nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
126514970  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
126502354  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126493096  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126493216  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
126493984  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
126514867  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
126499250  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
126491703  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
126507651  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
126515642  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2-like [KO:K07826]
126491401  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
126498502  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
126501666  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
126505515  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126499229  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126512384  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126487356  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126489684  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
126489890  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
126489349  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
126494797  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
126515228  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
126493569  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
126493349  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
126512992  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
126493570  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
126510518  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
126489822  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126515814  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126500329  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
126508969  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
126512192  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
126491493  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
126486767  serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
126496845  serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
126496696  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
126516009  LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
126500782  LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
126498868  cofilin-1 [KO:K05765]
126499601  cofilin-2 [KO:K05765]
126491380  cofilin-1-like [KO:K05765]
126494877  tumor necrosis factor [KO:K03156]
126508214  tumor necrosis factor receptor superfamily member 1B [KO:K05141]
126506891  bcl-2-like protein 1 isoform X1 [KO:K04570]
126511616  toll-like receptor 2 [KO:K10159]
126507954  toll-like receptor 4 [KO:K10160]
126501081  myeloid differentiation primary response protein MyD88 [KO:K04729]
126496436  myeloid differentiation primary response protein MyD88-like [KO:K04729]
126492812  interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
126490221  interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
126504640  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
126515732  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
126513299  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
126503643  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
126504083  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
126504411  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
126490256  NF-kappa-B essential modulator isoform X1 [KO:K07210]
126499590  NF-kappa-B inhibitor alpha [KO:K04734]
126510709  interferon alpha-12-like [KO:K05414]
126510710  interferon alpha-12-like [KO:K05414]
126510711  interferon alpha-12-like [KO:K05414]
126510712  interferon alpha-12-like [KO:K05414]
126510718  interferon alpha-12-like [KO:K05414]
126510725  interferon alpha-1-like [KO:K05414]
126510729  interferon alpha-1-like [KO:K05414]
126510739  interferon alpha-12-like [KO:K05414]
126510740  interferon alpha-12-like [KO:K05414]
126510741  interferon beta [KO:K05415]
126492719  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
126492755  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
126501977  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
126502008  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
126500615  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126509741  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126511413  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126491081  cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
126497042  stimulator of interferon genes protein-like [KO:K12654]
126497170  stimulator of interferon genes protein isoform X1 [KO:K12654]
126515694  serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
126488203  interferon regulatory factor 3 isoform X1 [KO:K05411]
126515734  DNA dC->dU-editing enzyme APOBEC-3-like isoform X1 [KO:K18750] [EC:3.5.4.-]
126507063  deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544] [EC:3.1.5.-]
126492635  tripartite motif-containing protein 30A-like [KO:K10648] [EC:2.3.2.27]
126492636  tripartite motif-containing protein 30A-like isoform X1 [KO:K10648] [EC:2.3.2.27]
126492638  tripartite motif-containing protein 30A-like [KO:K10648] [EC:2.3.2.27]
126492642  tripartite motif-containing protein 30A-like [KO:K10648] [EC:2.3.2.27]
126492678  tripartite motif-containing protein 30A-like [KO:K10648] [EC:2.3.2.27]
126514416  tripartite motif-containing protein 30A-like isoform X1 [KO:K10648] [EC:2.3.2.27]
126491847  bone marrow stromal antigen 2 isoform X1 [KO:K06731]
126514827  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
126501520  receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
126502907  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
126505400  TNF receptor-associated factor 5 isoform X1 [KO:K09849]
126509272  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
126514653  dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
126500469  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
126491615  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
126511310  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
126511231  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
126505976  LOW QUALITY PROTEIN: FAS-associated death domain protein-like [KO:K02373]
126498470  FAS-associated death domain protein [KO:K02373]
126511842  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
126514820  BH3-interacting domain death agonist [KO:K04726]
126488161  apoptosis regulator BAX [KO:K02159]
126499837  bcl-2 homologous antagonist/killer [KO:K14021]
126487103  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
126498317  cytochrome c, somatic-like [KO:K08738]
126498847  cytochrome c-like [KO:K08738]
126513229  cytochrome c, somatic-like [KO:K08738]
126487150  cytochrome c, testis-specific [KO:K08738]
126493669  cytochrome c, somatic-like [KO:K08738]
126509522  cytochrome c, somatic [KO:K08738]
126497931  cytochrome c, somatic-like [KO:K08738]
126509557  caspase-9 [KO:K04399] [EC:3.4.22.62]
126495899  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
126504830  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
126493857  uncharacterized protein LOC126493857 [KO:K10784]
126510033  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
126510036  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
126510037  T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
126511281  T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
126499463  antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
126499436  antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
126499708  tapasin [KO:K08058]
126496760  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
126487733  calreticulin [KO:K08057]
126497914  calreticulin-like isoform X1 [KO:K08057]
126499744  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
126494243  patr class I histocompatibility antigen, CH28 alpha chain-like [KO:K06751]
126494244  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
126494248  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
126494250  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
126494251  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
126494252  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
126494272  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
126494405  H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751]
126494874  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
126495552  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
126495553  H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751]
126495556  H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751]
126495655  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
126495669  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
126495676  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
126495678  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
126495861  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
126495862  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
126495896  H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751]
126495897  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
126496142  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
126496283  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
126500793  AP-1 complex subunit beta-1 [KO:K12392]
126502485  AP-1 complex subunit gamma-1 [KO:K12391]
126490880  AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
126492211  AP-1 complex subunit mu-1 [KO:K12393]
126490554  AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
126491917  AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
126512706  AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
126512967  AP-1 complex subunit sigma-3 [KO:K12395]
126496254  beta-2-microglobulin [KO:K08055]
126513547  elongin-B-like [KO:K03873]
126494140  elongin-B-like [KO:K03873]
126498192  elongin-B [KO:K03873]
126498927  elongin-C-like [KO:K03872]
126501407  elongin-C [KO:K03872]
126515004  elongin-C-like [KO:K03872]
126486912  cullin-5 [KO:K10612]
126510667  RING-box protein 2 isoform X1 [KO:K10611]
126500026  DDB1- and CUL4-associated factor 1 isoform X1 [KO:K11789] [EC:2.7.11.1]
126498120  DNA damage-binding protein 1 isoform X1 [KO:K10610]
126498637  cullin-4A [KO:K10609]
126494663  cullin-4B isoform X1 [KO:K10609]
126491104  cullin-4B-like [KO:K10609]
126486910  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
126510625  serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
126490587  serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
126497036  M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
126514440  wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
126515053  LOW QUALITY PROTEIN: wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
126505279  LOW QUALITY PROTEIN: wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
126512615  G2/mitotic-specific cyclin-B1 [KO:K05868]
126492506  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868]
126491618  G2/mitotic-specific cyclin-B2 [KO:K21770]
126512909  G2/mitotic-specific cyclin-B3 [KO:K21771]
126499965  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
DOI:10.1016/j.bbamem.2013.06.020
Reference
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
  Authors
Choi WT, Duggineni S, Xu Y, Huang Z, An J
  Title
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
  Journal
J Med Chem 55:977-94 (2012)
DOI:10.1021/jm200568c
Reference
  Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
  Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
  Journal
J Biol Chem 286:12554-64 (2011)
DOI:10.1074/jbc.M110.182238
Reference
  Authors
Das SR, Jameel S
  Title
Biology of the HIV Nef protein.
  Journal
Indian J Med Res 121:315-32 (2005)
Reference
  Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
  Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
  Journal
Front Microbiol 5:177 (2014)
DOI:10.3389/fmicb.2014.00177
Reference
  Authors
Magadan JG, Bonifacino JS
  Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
  Journal
J Virol 86:757-72 (2012)
DOI:10.1128/JVI.05933-11
Reference
  Authors
Kumar A, Herbein G
  Title
The macrophage: a therapeutic target in HIV-1 infection.
  Journal
Mol Cell Ther 2:10 (2014)
DOI:10.1186/2052-8426-2-10
Reference
  Authors
Yokota S, Okabayashi T, Fujii N
  Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
  Journal
Mediators Inflamm 2010:184328 (2010)
DOI:10.1155/2010/184328
Reference
  Authors
Sauter D, Kirchhoff F
  Title
HIV replication: a game of hide and sense.
  Journal
Curr Opin HIV AIDS 11:173-81 (2016)
DOI:10.1097/COH.0000000000000233
Reference
  Authors
Altfeld M, Gale M Jr
  Title
Innate immunity against HIV-1 infection.
  Journal
Nat Immunol 16:554-62 (2015)
DOI:10.1038/ni.3157
Reference
  Authors
Pasquereau S, Kumar A, Herbein G
  Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
  Journal
Viruses 9:E64 (2017)
DOI:10.3390/v9040064
Reference
  Authors
Herbein G, Khan KA
  Title
Is HIV infection a TNF receptor signalling-driven disease?
  Journal
Trends Immunol 29:61-7 (2008)
DOI:10.1016/j.it.2007.10.008
Reference
  Authors
Kumar A, Abbas W, Herbein G
  Title
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
  Journal
Mediators Inflamm 2013:484378 (2013)
DOI:10.1155/2013/484378
Reference
  Authors
Abbas W, Herbein G
  Title
T-Cell Signaling in HIV-1 Infection.
  Journal
Open Virol J 7:57-71 (2013)
DOI:10.2174/1874357920130621001
Reference
  Authors
Cummins NW, Badley AD
  Title
Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
  Journal
Cell Death Dis 1:e99 (2010)
DOI:10.1038/cddis.2010.77
Reference
  Authors
Gougeon ML
  Title
Apoptosis as an HIV strategy to escape immune attack.
  Journal
Nat Rev Immunol 3:392-404 (2003)
DOI:10.1038/nri1087
Reference
  Authors
Fevrier M, Dorgham K, Rebollo A
  Title
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.
  Journal
Viruses 3:586-612 (2011)
DOI:10.3390/v3050586
Reference
  Authors
Ross TM
  Title
Using death to one's advantage: HIV modulation of apoptosis.
  Journal
Leukemia 15:332-41 (2001)
DOI:10.1038/sj.leu.2402028
Reference
  Authors
Hurley JH, Bonifacino JS
  Title
Nef-arious goings-on at the Golgi.
  Journal
Nat Struct Mol Biol 19:661-2 (2012)
DOI:10.1038/nsmb.2304
Reference
  Authors
Wonderlich ER, Leonard JA, Collins KL
  Title
HIV immune evasion disruption of antigen presentation by the HIV Nef protein.
  Journal
Adv Virus Res 80:103-27 (2011)
DOI:10.1016/B978-0-12-385987-7.00005-1
Reference
  Authors
Laguette N, Bregnard C, Benichou S, Basmaciogullari S
  Title
Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.
  Journal
Mol Aspects Med 31:418-33 (2010)
DOI:10.1016/j.mam.2010.05.003
Reference
  Authors
Pereira EA, daSilva LL
  Title
HIV-1 Nef: Taking Control of Protein Trafficking.
  Journal
Traffic 17:976-96 (2016)
DOI:10.1111/tra.12412
Reference
  Authors
Sugden SM, Bego MG, Pham TN, Cohen EA
  Title
Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence.
  Journal
Viruses 8:67 (2016)
DOI:10.3390/v8030067
Reference
  Authors
Bagga S, Bouchard MJ
  Title
Cell cycle regulation during viral infection.
  Journal
Methods Mol Biol 1170:165-227 (2014)
DOI:10.1007/978-1-4939-0888-2_10
Reference
  Authors
Andersen JL, Planelles V
  Title
The role of Vpr in HIV-1 pathogenesis.
  Journal
Curr HIV Res 3:43-51 (2005)
DOI:10.2174/1570162052772988
Reference
  Authors
Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V
  Title
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
  Journal
PLoS Pathog 2:e127 (2006)
DOI:10.1371/journal.ppat.0020127
Reference
  Authors
Takaori-Kondo A, Shindo K
  Title
HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
  Journal
Front Microbiol 4:34 (2013)
DOI:10.3389/fmicb.2013.00034
Reference
  Authors
Malim MH
  Title
APOBEC proteins and intrinsic resistance to HIV-1 infection.
  Journal
Philos Trans R Soc Lond B Biol Sci 364:675-87 (2009)
DOI:10.1098/rstb.2008.0185
Reference
  Authors
Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS
  Title
Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.
  Journal
J Virol 85:11220-34 (2011)
DOI:10.1128/JVI.05238-11
Related
pathway
mfot03050  Proteasome
mfot04010  MAPK signaling pathway
mfot04020  Calcium signaling pathway
mfot04064  NF-kappa B signaling pathway
mfot04110  Cell cycle
mfot04141  Protein processing in endoplasmic reticulum
mfot04142  Lysosome
mfot04150  mTOR signaling pathway
mfot04151  PI3K-Akt signaling pathway
mfot04210  Apoptosis
mfot04612  Antigen processing and presentation
mfot04620  Toll-like receptor signaling pathway
mfot04623  Cytosolic DNA-sensing pathway
mfot04668  TNF signaling pathway
mfot04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
LinkDB

DBGET integrated database retrieval system