Entry
Name
Human immunodeficiency virus 1 infection - Microtus fortis (reed vole)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
mfot05170 Human immunodeficiency virus 1 infection
Ortholog table
Organism
Microtus fortis (reed vole) [GN:
mfot ]
Gene
126503398 LOW QUALITY PROTEIN: S-phase kinase-associated protein 1-like [KO:K03094 ]
126512093 guanine nucleotide-binding protein G(i) subunit alpha-3-like [KO:K04630 ]
126499907 guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
126500134 guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
126487932 guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630 ]
126502958 guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
126499912 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
126508229 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
126491758 phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
126512534 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
126494148 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
126510731 guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
126491367 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
126515387 nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
126487431 nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
126502736 nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
126493216 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
126493984 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
126514867 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
126507651 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
126515642 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2-like [KO:K07826 ]
126491401 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
126498502 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540 ]
126501666 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
126505515 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542 ]
126499229 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542 ]
126512384 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
126487356 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542 ]
126489684 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
126489890 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542 ]
126489349 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
126494797 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
126515228 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
126493569 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
126493349 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
126512992 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
126493570 guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
126510518 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
126489822 ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
126500329 ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
126501081 myeloid differentiation primary response protein MyD88 [KO:K04729 ]
126496436 myeloid differentiation primary response protein MyD88-like [KO:K04729 ]
126515732 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403 ]
126513299 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
126515734 DNA dC->dU-editing enzyme APOBEC-3-like isoform X1 [KO:K18750 ] [EC:3.5.4.-]
126507063 deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [KO:K22544 ] [EC:3.1.5.-]
126502907 tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
126505976 LOW QUALITY PROTEIN: FAS-associated death domain protein-like [KO:K02373 ]
126510037 T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450 ]
126499744 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
126494243 patr class I histocompatibility antigen, CH28 alpha chain-like [KO:K06751 ]
126494244 class I histocompatibility antigen, B alpha chain-like [KO:K06751 ]
126494248 patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751 ]
126494250 class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751 ]
126494251 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
126494252 saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751 ]
126494272 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
126494405 H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751 ]
126494874 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
126495552 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
126495553 H-2 class I histocompatibility antigen, D-37 alpha chain-like [KO:K06751 ]
126495556 H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751 ]
126495655 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
126495669 patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751 ]
126495676 H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751 ]
126495678 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
126495861 RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751 ]
126495862 H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751 ]
126495896 H-2 class I histocompatibility antigen, alpha chain-like isoform X1 [KO:K06751 ]
126495897 H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751 ]
126496142 H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751 ]
126496283 H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751 ]
126492506 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
Title
HIV persistence: chemokines and their signalling pathways.
Journal
Reference
Authors
Abbas W, Herbein G
Title
Plasma membrane signaling in HIV-1 infection.
Journal
Reference
Authors
Wu Y, Yoder A
Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
Journal
Reference
Authors
Choi WT, Duggineni S, Xu Y, Huang Z, An J
Title
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
Journal
Reference
Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
Journal
Reference
Authors
Das SR, Jameel S
Title
Biology of the HIV Nef protein.
Journal
Indian J Med Res 121:315-32 (2005)
Reference
Authors
Roy N, Pacini G, Berlioz-Torrent C, Janvier K
Title
Mechanisms underlying HIV-1 Vpu-mediated viral egress.
Journal
Reference
Authors
Magadan JG, Bonifacino JS
Title
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
Journal
Reference
Authors
Kumar A, Herbein G
Title
The macrophage: a therapeutic target in HIV-1 infection.
Journal
Reference
Authors
Yokota S, Okabayashi T, Fujii N
Title
The battle between virus and host: modulation of Toll-like receptor signaling pathways by virus infection.
Journal
Reference
Authors
Sauter D, Kirchhoff F
Title
HIV replication: a game of hide and sense.
Journal
Reference
Authors
Altfeld M, Gale M Jr
Title
Innate immunity against HIV-1 infection.
Journal
Reference
Authors
Pasquereau S, Kumar A, Herbein G
Title
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.
Journal
Reference
Authors
Herbein G, Khan KA
Title
Is HIV infection a TNF receptor signalling-driven disease?
Journal
Reference
Authors
Kumar A, Abbas W, Herbein G
Title
TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?
Journal
Reference
Authors
Abbas W, Herbein G
Title
T-Cell Signaling in HIV-1 Infection.
Journal
Reference
Authors
Cummins NW, Badley AD
Title
Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
Journal
Reference
Authors
Gougeon ML
Title
Apoptosis as an HIV strategy to escape immune attack.
Journal
Reference
Authors
Fevrier M, Dorgham K, Rebollo A
Title
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.
Journal
Reference
Authors
Ross TM
Title
Using death to one's advantage: HIV modulation of apoptosis.
Journal
Reference
Authors
Hurley JH, Bonifacino JS
Title
Nef-arious goings-on at the Golgi.
Journal
Reference
Authors
Wonderlich ER, Leonard JA, Collins KL
Title
HIV immune evasion disruption of antigen presentation by the HIV Nef protein.
Journal
Reference
Authors
Laguette N, Bregnard C, Benichou S, Basmaciogullari S
Title
Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins.
Journal
Reference
Authors
Pereira EA, daSilva LL
Title
HIV-1 Nef: Taking Control of Protein Trafficking.
Journal
Reference
Authors
Sugden SM, Bego MG, Pham TN, Cohen EA
Title
Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence.
Journal
Reference
Authors
Bagga S, Bouchard MJ
Title
Cell cycle regulation during viral infection.
Journal
Reference
Authors
Andersen JL, Planelles V
Title
The role of Vpr in HIV-1 pathogenesis.
Journal
Reference
Authors
Andersen JL, DeHart JL, Zimmerman ES, Ardon O, Kim B, Jacquot G, Benichou S, Planelles V
Title
HIV-1 Vpr-induced apoptosis is cell cycle dependent and requires Bax but not ANT.
Journal
Reference
Authors
Takaori-Kondo A, Shindo K
Title
HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
Journal
Reference
Authors
Malim MH
Title
APOBEC proteins and intrinsic resistance to HIV-1 infection.
Journal
Reference
Authors
Hultquist JF, Lengyel JA, Refsland EW, LaRue RS, Lackey L, Brown WL, Harris RS
Title
Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.
Journal
Related pathway
mfot04141 Protein processing in endoplasmic reticulum
mfot04612 Antigen processing and presentation
mfot04620 Toll-like receptor signaling pathway
KO pathway
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