KEGG   PATHWAY: mjv04014
Entry
mjv04014                    Pathway                                
Name
Ras signaling pathway - Manis javanica (Malayan pangolin)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
mjv04014  Ras signaling pathway
mjv04014

Other DBs
GO: 0032318
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108408073  EGF; pro-epidermal growth factor [KO:K04357]
108388206  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
108405921  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
108393279  FGF20; fibroblast growth factor 20 [KO:K04358]
108402439  FGF16; fibroblast growth factor 16 [KO:K04358]
108397295  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108397792  FGF10; fibroblast growth factor 10 [KO:K04358]
108383974  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
108391342  fibroblast growth factor 6 [KO:K04358]
108393043  FGF9; fibroblast growth factor 9 [KO:K04358]
108396343  FGF5; fibroblast growth factor 5 [KO:K04358]
118970663  FGF6; fibroblast growth factor 6 [KO:K04358]
108389506  FGF4; fibroblast growth factor 4 [KO:K04358]
108394626  FGF3; fibroblast growth factor 3 [KO:K04358]
118973114  FGF7; fibroblast growth factor 7 [KO:K04358]
118971119  FGF19; fibroblast growth factor 19 [KO:K22603]
108400332  FGF21; fibroblast growth factor 21 isoform X2 [KO:K22429]
108391341  FGF23; fibroblast growth factor 23 isoform X2 [KO:K22428]
108386081  NGF; beta-nerve growth factor [KO:K02582]
108401589  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
108395105  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
108400338  NTF4; neurotrophin-4 [KO:K12457]
108402614  INS; insulin [KO:K04526]
108410340  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
108402612  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
118970652  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
108397360  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
108393368  PDGFC; platelet-derived growth factor C isoform X4 [KO:K05450]
108390154  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
108400987  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
108396268  KITLG; kit ligand isoform X1 [KO:K05461]
108400302  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
108407135  VEGFA; vascular endothelial growth factor A [KO:K05448]
108407564  VEGFB; vascular endothelial growth factor B isoform X3 [KO:K16858]
108399226  PGF; placenta growth factor isoform X1 [KO:K16859]
108391501  VEGFC; vascular endothelial growth factor C [KO:K05449]
108384371  VEGFD; vascular endothelial growth factor D [KO:K05449]
108399212  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
108392444  ANGPT1; angiopoietin-1 [KO:K05465]
108410138  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
108386709  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
108405281  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
108407285  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
108397962  EGFR; epidermal growth factor receptor isoform X5 [KO:K04361] [EC:2.7.10.1]
108403050  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108395520  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108383914  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
108398432  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
108391063  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
108383338  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
108400418  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
108404652  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
108403280  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
108385741  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108385397  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
108385396  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
108391899  KIT; mast/stem cell growth factor receptor Kit isoform X5 [KO:K05091] [EC:2.7.10.1]
108407453  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
108385338  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108408755  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108400781  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
108399322  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
108399089  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
108393890  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
108400653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108409341  GAB1; GRB2-associated-binding protein 1 isoform X6 [KO:K09593]
108393407  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
108407280  SHC-transforming protein 1 isoform X1 [KO:K06279]
118972101  SHC-transforming protein 1-like isoform X1 [KO:K06279]
108391745  SHC2; SHC-transforming protein 2 isoform X2 [KO:K17447]
108394387  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
108402352  SHC4; SHC-transforming protein 4 [KO:K17449]
108405695  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
108391894  SOS2; son of sevenless homolog 2 [KO:K03099]
108385648  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
108407248  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
108400464  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
108397030  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
108396371  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
108387321  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
108388253  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
108391417  tyrosine-protein kinase ZAP-70 isoform X1 [KO:K07360] [EC:2.7.10.2]
108407644  LAT; LOW QUALITY PROTEIN: linker for activation of T-cells family member 1 [KO:K07362]
108399555  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
108398173  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
108409379  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
108403551  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
108409661  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
108395258  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
108386548  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
108393633  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
108394280  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
108386580  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
108393262  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
108406129  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
108398401  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
108404891  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108399649  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
108386122  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X5 [KO:K04547]
108398403  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
108391050  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X2 [KO:K04549]
108408343  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108389020  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
108387895  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
108388298  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
108405840  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
108406616  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
108406654  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
108386142  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
108383704  calmodulin-A-like [KO:K02183]
108406136  CALM3; calmodulin-3 [KO:K02183]
108391461  CALM2; calmodulin-2 [KO:K02183]
108389026  CALM1; calmodulin-1 [KO:K02183]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
118967667  GTPase HRas-like isoform X1 [KO:K02833]
108395842  KRAS; GTPase KRas isoform X1 [KO:K07827]
108398047  NRAS; GTPase NRas [KO:K07828]
108406677  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
108400295  RRAS; ras-related protein R-Ras [KO:K07829]
108393784  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
108397806  NF1; neurofibromin isoform X1 [KO:K08052]
108394495  RASA1; ras GTPase-activating protein 1 [KO:K04352]
108410200  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
108399967  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
108383785  RASA4B; ras GTPase-activating protein 4B isoform X1 [KO:K17630]
108393935  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
108386932  RASAL1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
108397737  ras GTPase-activating protein nGAP-like [KO:K17633]
108400959  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
108408742  RASAL3; RAS protein activator like-3 [KO:K17634]
108402875  RASSF1; ras association domain-containing protein 1 isoform X3 [KO:K09850]
108390201  RASSF5; ras association domain-containing protein 5 isoform X2 [KO:K08015]
108398293  STK4; serine/threonine-protein kinase 4 [KO:K04411]
108387898  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
108407595  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
108392664  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
108384279  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
108391169  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
108409892  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
108395451  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
108394258  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
118966805  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
108383250  transforming protein RhoA [KO:K04513]
108406544  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108400388  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108395975  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108400819  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
108409586  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
108399795  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108391706  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108397005  RELA; transcription factor p65 isoform X1 [KO:K04735]
108407571  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
108393091  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
108403323  FOXO4; forkhead box protein O4 isoform X1 [KO:K12358]
108401438  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108398222  RALGAPA2; ral GTPase-activating protein subunit alpha-2 [KO:K25768]
108405677  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
108407892  RALGAPB; ral GTPase-activating protein subunit beta [KO:K25769]
108388220  RALGDS; ral guanine nucleotide dissociation stimulator isoform X2 [KO:K08732]
108409175  RGL1; ral guanine nucleotide dissociation stimulator-like 1 [KO:K17635]
108396176  ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
118969924  ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
108393225  RALA; ras-related protein Ral-A [KO:K07834]
108400050  RALB; ras-related protein Ral-B [KO:K07835]
108403340  PLD2; phospholipase D2 isoform X4 [KO:K01115] [EC:3.1.4.4]
108404196  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
108409930  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
108399262  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108389971  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
108396943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108384893  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108385635  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108404591  RALBP1; ralA-binding protein 1 [KO:K08773]
108391531  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108386819  AFDN; afadin isoform X1 [KO:K05702]
108404149  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108392139  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108385046  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108400663  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108392241  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
108397534  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
108397693  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
108394929  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X2 [KO:K01047] [EC:3.1.1.4]
108398626  PLA2G2F; group IIF secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
108398628  PLA2G2D; group IID secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
108398634  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
108386410  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
108387961  group XIIA secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
108406034  PLA2G2E; group IIE secretory phospholipase A2 isoform X2 [KO:K01047] [EC:3.1.1.4]
108410188  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
108402518  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
108385404  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
108385409  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
108385414  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
108392650  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
108393922  PLAAT3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
108401876  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
108408853  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
108387001  ETS2; protein C-ets-2 isoform X1 [KO:K21932]
108400553  BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
108402048  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
108401965  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
108403513  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
108395546  RAP1A; ras-related protein Rap-1A [KO:K04353]
108407356  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
108392641  LOW QUALITY PROTEIN: ras-related protein Rap-1b-like [KO:K07836]
108393532  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
108387768  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
108385666  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108395733  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
108394838  RIN1; ras and Rab interactor 1 [KO:K17638]
108408195  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
108393116  ABL2; tyrosine-protein kinase ABL2 isoform X2 [KO:K08887] [EC:2.7.10.2]
108409860  RAB5A; ras-related protein Rab-5A [KO:K07887]
108389601  RAB5B; ras-related protein Rab-5B [KO:K07888]
108388342  ras-related protein Rab-5C [KO:K07889]
118972640  ras-related protein Rab-5C [KO:K07889]
108388018  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
mjv04010  MAPK signaling pathway
mjv04015  Rap1 signaling pathway
mjv04020  Calcium signaling pathway
mjv04144  Endocytosis
mjv04151  PI3K-Akt signaling pathway
mjv04660  T cell receptor signaling pathway
mjv04720  Long-term potentiation
mjv04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
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