KEGG PATHWAY: one03013

KEGG

PATHWAY: one03013

Entry

one03013                    Pathway

Name

Nucleocytoplasmic transport - Oncorhynchus nerka (sockeye salmon)

Description

The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.

Class

Genetic Information Processing; Translation

Pathway map

Nucleocytoplasmic transport

Other DBs

GO:

Organism

Oncorhynchus nerka (sockeye salmon) [GN:one]

Gene

[KO:K18655] [EC:5.6.2.7]

thoc1; THO complex subunit 1 [KO:K12878]

[KO:K14326] [EC:5.6.2.5 5.6.2.3]

[KO:K13025] [EC:5.6.2.7]

nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]

nup88; nuclear pore complex protein Nup88 [KO:K14318]

rnps1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]

ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]

[KO:K12172] [EC:2.3.2.-]

[KO:K14326] [EC:5.6.2.5 5.6.2.3]

[KO:K14326] [EC:5.6.2.5 5.6.2.3]

nup205; nuclear pore complex protein Nup205 [KO:K14310]

nup160; nuclear pore complex protein Nup160 isoform X1 [KO:K14303]

xpo6; exportin-6 [KO:K25204]

thoc6; THO complex subunit 6 homolog [KO:K13175]

[KO:K12172] [EC:2.3.2.-]

ipo11; importin-11 isoform X1 [KO:K25201]

xpo4; exportin-4 isoform X1 [KO:K25203]

[KO:K14326] [EC:5.6.2.5 5.6.2.3]

acin1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]

nup188; nucleoporin NUP188 homolog [KO:K14311]

phax; phosphorylated adapter RNA export protein [KO:K14291]

sec13; protein SEC13 homolog isoform X1 [KO:K14004]

ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]

ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]

nup54; nucleoporin p54 isoform X1 [KO:K14308]

[KO:K12812] [EC:5.6.2.7]

[KO:K03345] [EC:3.4.22.68]

ipo4; importin-4 [KO:K20221]

upf3b; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]

nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]

nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]

kpna3; importin subunit alpha-4 isoform X1 [KO:K23583]

[KO:K18655] [EC:5.6.2.7]

[KO:K03345] [EC:3.4.22.68]

nup37; nucleoporin Nup37 [KO:K14302]

snupn; snurportin-1 [KO:K13151]

thoc7; THO complex subunit 7 homolog isoform X1 [KO:K13176]

gle1; nucleoporin GLE1 [KO:K18723]

kpna4; importin subunit alpha-3 [KO:K23583]

[KO:K13025] [EC:5.6.2.7]

[KO:K18655] [EC:5.6.2.7]

ahctf1; protein ELYS [KO:K25129]

Reference

Authors

Tran EJ, Wente SR

Title

Dynamic nuclear pore complexes: life on the edge.

Journal

Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027

Reference

Authors

Rodriguez MS, Dargemont C, Stutz F

Title

Nuclear export of RNA.

Journal

Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014

Reference

Authors

Palancade B, Doye V

Title

Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?

Journal

Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001

Reference

Authors

Reed R, Cheng H

Title

TREX, SR proteins and export of mRNA.

Journal

Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011

Reference

Authors

Tange TO, Shibuya T, Jurica MS, Moore MJ

Title

Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.

Journal

RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905

Reference

Authors

Beck M, Schirmacher P, Singer S

Title

Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.

Journal

J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021

Related
pathway

mRNA surveillance pathway

KO pathway

DBGET integrated database retrieval system