KEGG   PATHWAY: one03013
Entry
one03013                    Pathway                                
Name
Nucleocytoplasmic transport - Oncorhynchus nerka (sockeye salmon)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
one03013  Nucleocytoplasmic transport
one03013

Other DBs
GO: 0050658
Organism
Oncorhynchus nerka (sockeye salmon) [GN:one]
Gene
115131931  aladin-like [KO:K14320]
115121918  nucleoporin-like protein 2 [KO:K14321]
115126323  nucleoporin-like protein 2 [KO:K14321]
115139901  gle1; nucleoporin GLE1 [KO:K18723]
115143528  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
115132426  ATP-dependent RNA helicase DDX19A-like isoform X1 [KO:K18655] [EC:5.6.2.7]
115102464  ATP-dependent RNA helicase DDX19A-like isoform X1 [KO:K18655] [EC:5.6.2.7]
115131942  mRNA export factor-like isoform X1 [KO:K14298]
115101639  mRNA export factor isoform X1 [KO:K14298]
115135864  nuclear pore complex protein Nup98-Nup96-like isoform X1 [KO:K14297]
115105594  nuclear pore complex protein Nup98-Nup96-like isoform X1 [KO:K14297]
115101190  nuclear pore complex protein Nup214-like isoform X1 [KO:K14317]
115117560  nuclear pore complex protein Nup214-like [KO:K14317]
115105467  nup88; nuclear pore complex protein Nup88 [KO:K14318]
115111817  E3 SUMO-protein ligase RanBP2-like isoform X1 [KO:K12172] [EC:2.3.2.-]
115108102  RANBP2-like and GRIP domain-containing protein 5/6 [KO:K12172] [EC:2.3.2.-]
115110412  ran GTPase-activating protein 1-like isoform X1 [KO:K14319]
115104269  ran GTPase-activating protein 1-like isoform X1 [KO:K14319]
115112922  ran GTPase-activating protein 1-like [KO:K14319]
115104018  SUMO-conjugating enzyme UBC9-like [KO:K10577]
115104196  SUMO-conjugating enzyme UBC9-B [KO:K10577]
115110339  SUMO-conjugating enzyme UBC9-B isoform X1 [KO:K10577]
115143874  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
115106551  ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
115110121  SUMO-conjugating enzyme UBC9-like [KO:K10577]
115118033  small ubiquitin-related modifier 3-like [KO:K12160]
115111222  small ubiquitin-related modifier 3-like isoform X1 [KO:K12160]
115129704  small ubiquitin-related modifier 1 [KO:K12160]
115142451  small ubiquitin-related modifier 2 [KO:K12160]
115129784  small ubiquitin-related modifier 3 [KO:K12160]
115121171  small ubiquitin-related modifier 1 [KO:K12160]
115115349  small ubiquitin-related modifier 2-like [KO:K12160]
115126416  small ubiquitin-related modifier 3 [KO:K12160]
115133487  small ubiquitin-related modifier 1 [KO:K12160]
115116529  small ubiquitin-related modifier 2-like [KO:K12160]
115127916  small ubiquitin-related modifier 3-like [KO:K12160]
115103537  small ubiquitin-related modifier 2 [KO:K12160]
115109655  nup160; nuclear pore complex protein Nup160 isoform X1 [KO:K14303]
115124143  sec13; protein SEC13 homolog isoform X1 [KO:K14004]
115142475  nuclear pore complex protein Nup133-like [KO:K14300]
115142512  LOW QUALITY PROTEIN: nuclear pore complex protein Nup133-like [KO:K14300]
115125834  nucleoporin SEH1 [KO:K14299]
115107691  nucleoporin Nup43-like [KO:K14305]
115139484  nucleoporin Nup43-like [KO:K14305]
115133032  nup37; nucleoporin Nup37 [KO:K14302]
115138345  protein ELYS-like [KO:K25129]
115146511  ahctf1; protein ELYS [KO:K25129]
115135765  nuclear pore glycoprotein p62-like isoform X1 [KO:K14306]
115105716  nuclear pore glycoprotein p62-like isoform X1 [KO:K14306]
115105010  nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
115123072  nucleoporin p58/p45-like isoform X1 [KO:K14307]
115127921  nup54; nucleoporin p54 isoform X1 [KO:K14308]
115109590  nup205; nuclear pore complex protein Nup205 [KO:K14310]
115115535  nup188; nucleoporin NUP188 homolog [KO:K14311]
115125559  nuclear pore complex protein Nup155-like [KO:K14312]
115109365  nuclear pore complex protein Nup93-like isoform X1 [KO:K14309]
115134297  nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
115113687  nucleoporin NUP35-like [KO:K14313]
115124813  nucleoporin NUP35-like isoform X1 [KO:K14313]
115126031  ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]
115131875  nup210; nuclear pore membrane glycoprotein 210 [KO:K14314]
115104768  nuclear envelope pore membrane protein POM 121-like [KO:K14316]
115135981  nuclear envelope pore membrane protein POM 121-like [KO:K14316]
115129566  transmembrane protein 33-like [KO:K20724]
115130833  transmembrane protein 33-like [KO:K20724]
115145152  nucleoprotein TPR-like isoform X1 [KO:K09291]
115108547  nucleoprotein TPR-like isoform X1 [KO:K09291]
115103205  nucleoprotein TPR-like isoform X1 [KO:K09291]
115128690  nuclear pore complex protein Nup153-like isoform X1 [KO:K14296]
115131300  nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
115129787  sentrin-specific protease 2-like isoform X1 [KO:K03345] [EC:3.4.22.68]
115132539  sentrin-specific protease 2-like isoform X1 [KO:K03345] [EC:3.4.22.68]
115104289  importin subunit alpha-1-like [KO:K15043]
115110641  importin subunit alpha-1-like [KO:K15043]
115121191  importin subunit alpha-5-like isoform X1 [KO:K15043]
115103838  importin subunit alpha-1-like [KO:K15043]
115103881  importin subunit alpha-1-like [KO:K15043]
115141729  kpna4; importin subunit alpha-3 [KO:K23583]
115120223  importin subunit alpha-4-like isoform X1 [KO:K23583]
115136859  importin subunit alpha-3-like [KO:K23583]
115113003  importin subunit alpha-4-like isoform X1 [KO:K23583]
115122359  importin subunit alpha-4 [KO:K23583]
115132249  kpna3; importin subunit alpha-4 isoform X1 [KO:K23583]
115121702  importin subunit alpha-7-like [KO:K15042]
115102377  importin subunit alpha-6-like [KO:K15042]
115140918  importin subunit alpha-6 [KO:K15042]
115110221  importin subunit beta-1-like isoform X1 [KO:K14293]
115110197  importin subunit beta-1 isoform X1 [KO:K14293]
115101108  transportin-1 [KO:K18752]
115117200  transportin-1-like [KO:K18752]
115106894  transportin-3-like isoform X1 [KO:K15436]
115133222  transportin-3 [KO:K15436]
115104483  LOW QUALITY PROTEIN: importin-4-like [KO:K20221]
115130223  ipo4; importin-4 [KO:K20221]
115112457  importin-7 [KO:K20223]
115113739  importin-7-like [KO:K20223]
115107003  importin-8-like isoform X1 [KO:K18755]
115133120  LOW QUALITY PROTEIN: importin-8-like [KO:K18755]
115136087  importin-9-like isoform X1 [KO:K20224]
115143470  importin-9 [KO:K20224]
115111881  ipo11; importin-11 isoform X1 [KO:K25201]
115145059  importin-13-like isoform X1 [KO:K25202]
115108476  importin-13-like isoform X1 [KO:K25202]
115114617  importin-13-like [KO:K25202]
115134584  snupn; snurportin-1 [KO:K13151]
115103888  exportin-1 [KO:K14290]
115103845  exportin-1-like [KO:K14290]
115143120  exportin-2 [KO:K18423]
115140187  exportin-2-like [KO:K18423]
115128745  exportin-4 isoform X1 [KO:K25203]
115112137  xpo4; exportin-4 isoform X1 [KO:K25203]
115113055  exportin-5-like isoform X1 [KO:K14289]
115116314  exportin-5-like [KO:K14289]
115109957  xpo6; exportin-6 [KO:K25204]
115121364  exportin-7 isoform X1 [KO:K18460]
115126130  exportin-7-like isoform X1 [KO:K18460]
115129470  GTP-binding nuclear protein Ran-like [KO:K07936]
115130705  GTP-binding nuclear protein Ran [KO:K07936]
115137353  GTP-binding nuclear protein Ran-like [KO:K07936]
115145774  GTP-binding nuclear protein Ran-like [KO:K07936]
115135134  elongation factor 1-alpha, somatic form [KO:K03231]
115104397  putative elongation factor 1-alpha-like 3 [KO:K03231]
115142421  elongation factor 1-alpha, somatic form-like [KO:K03231]
115130350  elongation factor 1-alpha-like [KO:K03231]
115113235  elongation factor 1-alpha, somatic form-like [KO:K03231]
115131685  elongation factor 1-alpha-like [KO:K03231]
115131686  elongation factor 1-alpha, oocyte form-like [KO:K03231]
115128316  elongation factor 1-alpha [KO:K03231]
115128317  elongation factor 1-alpha, oocyte form [KO:K03231]
115118480  phax; phosphorylated adapter RNA export protein [KO:K14291]
115129506  nuclear cap-binding protein subunit 1-like isoform X1 [KO:K12882]
115130754  nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
115124158  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
115141728  60S ribosomal export protein NMD3-like [KO:K07562]
115136857  LOW QUALITY PROTEIN: 60S ribosomal export protein NMD3-like [KO:K07562]
115104237  RNA-binding protein 8A-like isoform X1 [KO:K12876]
115141104  RNA-binding protein 8A isoform X1 [KO:K12876]
115145367  protein mago nashi homolog [KO:K12877]
115108626  protein mago nashi homolog [KO:K12877]
115104070  LOW QUALITY PROTEIN: protein CASC3-like [KO:K14323]
115110185  protein CASC3-like isoform X1 [KO:K14323]
115103982  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
115142675  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
115137976  LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
115114677  acin1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
115133440  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
115102779  LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
115129842  histone deacetylase complex subunit SAP18-like [KO:K14324]
115123845  histone deacetylase complex subunit SAP18-like [KO:K14324]
115144391  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
115106430  rnps1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
115116443  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
115138666  pinin-like [KO:K13114]
115146044  pinin-like [KO:K13114]
115110661  THO complex subunit 4-like [KO:K12881]
115110685  THO complex subunit 4-like isoform X1 [KO:K12881]
115142578  THO complex subunit 4-like [KO:K12881]
115103789  THO complex subunit 4-like [KO:K12881]
115108174  regulator of nonsense transcripts 1-like isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
115114229  regulator of nonsense transcripts 1-like isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
115109140  regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
115103240  regulator of nonsense transcripts 1-like isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
115106890  regulator of nonsense transcripts 2-like isoform X1 [KO:K14327]
115133226  regulator of nonsense transcripts 2-like isoform X1 [KO:K14327]
115129587  regulator of nonsense transcripts 3B-like [KO:K14328]
115130853  upf3b; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
115107515  LOW QUALITY PROTEIN: regulator of nonsense transcripts 3A-like [KO:K14328]
115125452  regulator of nonsense transcripts 3A-like isoform X1 [KO:K14328]
115135610  nuclear RNA export factor 1-like [KO:K14284]
115130950  nuclear RNA export factor 1-like isoform X1 [KO:K14284]
115101329  nuclear RNA export factor 1-like [KO:K14284]
115118693  NTF2-related export protein 2-like [KO:K14285]
115128831  spliceosome RNA helicase DDX39B-like [KO:K12812] [EC:5.6.2.7]
115138416  serine/arginine repetitive matrix protein 1-like [KO:K13171]
115146304  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
115132384  partner of Y14 and mago A [KO:K14294]
115102413  partner of Y14 and mago B [KO:K14294]
115102937  thoc1; THO complex subunit 1 [KO:K12878]
115135806  THO complex subunit 2-like [KO:K12879]
115105656  THO complex subunit 2-like [KO:K12879]
115111682  THO complex subunit 5 homolog [KO:K13174]
115140147  THO complex subunit 5 homolog isoform X1 [KO:K13174]
115110010  thoc6; THO complex subunit 6 homolog [KO:K13175]
115138270  thoc7; THO complex subunit 7 homolog isoform X1 [KO:K13176]
115129183  THO complex subunit 3-like isoform X1 [KO:K12880]
115131213  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
one03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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