KEGG   PATHWAY: pee04010
Entry
pee04010                    Pathway                                
Name
MAPK signaling pathway - Phycodurus eques (leafy seadragon)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pee04010  MAPK signaling pathway
pee04010

Other DBs
GO: 0000165
Organism
Phycodurus eques (leafy seadragon) [GN:pee]
Gene
133414507  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
133404583  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
133414234  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
133397145  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
133408965  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
133399393  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
133406774  voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
133411137  voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
133407340  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
133401401  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04853]
133417578  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
133414436  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04855]
133414365  LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
133403676  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
133402394  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
133408910  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
133403146  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
133396938  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1 [KO:K04858]
133408985  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
133409304  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
133413220  voltage-dependent calcium channel subunit alpha-2/delta-3-like isoform X1 [KO:K04860]
133408811  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
133402790  voltage-dependent calcium channel subunit alpha-2/delta-4-like isoform X1 [KO:K04861]
133397146  cacna2d4a; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
133415116  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
133396207  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
133414197  voltage-dependent L-type calcium channel subunit beta-3-like [KO:K04864]
133409517  cacnb3a; voltage-dependent L-type calcium channel subunit beta-3a [KO:K04864]
133411085  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a isoform X1 [KO:K04865]
133411109  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
133415243  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
133404083  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
133415276  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a isoform X1 [KO:K04867]
133404490  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
133414803  cacng3b; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
133404094  voltage-dependent calcium channel gamma-3 subunit-like [KO:K04868]
133414873  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
133404082  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
133404627  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
133402088  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
133396131  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
133401471  cacng7b; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
133395871  voltage-dependent calcium channel gamma-7 subunit-like isoform X1 [KO:K04872]
133401469  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
133395870  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04873]
133414665  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
133404060  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
133405975  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
133411404  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
133414406  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
133404595  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
133414687  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
133403675  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
133401470  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
133403577  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
133411979  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
133415335  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
133400332  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
133407807  protein phosphatase 3 catalytic subunit alpha-like isoform X1 [KO:K04348] [EC:3.1.3.16]
133413450  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
133415821  protein phosphatase 3 catalytic subunit alpha-like isoform X1 [KO:K04348] [EC:3.1.3.16]
133398066  protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
133403799  ppp3r1b; calcineurin subunit B type 1b isoform X1 [KO:K06268]
133409619  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
133403312  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
133415497  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
133399945  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
133413417  rasgrf2a; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
133412567  RAS guanyl-releasing protein 1-like isoform X1 [KO:K04350]
133405070  rasgrp4; RAS guanyl-releasing protein 4 [KO:K04350]
133397865  RAS guanyl-releasing protein 2-like isoform X1 [KO:K12361]
133409782  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
133407343  rapgef2b; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
133405294  nf1a; neurofibromin isoform X1 [KO:K08052]
133400067  ras GTPase-activating protein 1-like isoform X1 [KO:K04352]
133401618  ras-related protein Rap-1A isoform X1 [KO:K04353]
133408301  ras-related protein Rap-1A-like [KO:K04353]
133397067  ras-related protein Rap-1b-like isoform X1 [KO:K07836]
133407368  egf; pro-epidermal growth factor [KO:K04357]
133408919  tgfa; protransforming growth factor alpha [KO:K08774]
133400609  proepiregulin-like [KO:K09784]
133407634  fgf1a; putative fibroblast growth factor 1 isoform X1 [KO:K18496]
133415954  fibroblast growth factor 1-like [KO:K18496]
133408191  fgf2; fibroblast growth factor 2 [KO:K18497]
133400272  fgf5; fibroblast growth factor 5 [KO:K04358]
133406425  fgf22; fibroblast growth factor 22 [KO:K04358]
133400607  fibroblast growth factor 10-like [KO:K04358]
133407540  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
133407566  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
133407813  fgf16; fibroblast growth factor 16 [KO:K04358]
133408092  fibroblast growth factor 20-like [KO:K04358]
133402501  fgf6a; fibroblast growth factor 6a [KO:K04358]
133413830  fgf10a; fibroblast growth factor 10a [KO:K04358]
133396922  fibroblast growth factor 6-like [KO:K04358]
133409765  fgf8a; fibroblast growth factor 8 [KO:K04358]
133404302  fgf20a; fibroblast growth factor 20a [KO:K04358]
133404536  fgf8b; fibroblast growth factor 8b [KO:K04358]
133399351  fgf7; LOW QUALITY PROTEIN: fibroblast growth factor 7 [KO:K04358]
133399222  fgf19; fibroblast growth factor 19 [KO:K22603]
133418131  fgf21; fibroblast growth factor 21 [KO:K22429]
133397488  fgf23; fibroblast growth factor 23 [KO:K22428]
133409141  ngfb; nerve growth factor [KO:K02582]
133398716  ngfa; neurotrophin-7 [KO:K02582]
133416319  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
133397418  ntf3; neurotrophin-3 [KO:K04356]
133407894  LOW QUALITY PROTEIN: insulin-like [KO:K04526]
133416067  LOW QUALITY PROTEIN: insulin-like [KO:K04526]
133416094  insulin-like [KO:K04526]
133415074  igf3; insulin-like growth factor 3 [KO:K05459]
133397194  igf1; insulin-like growth factor I [KO:K05459]
133402663  igf2b; insulin-like growth factor 2b isoform X1 [KO:K13769]
133415223  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
133404330  platelet-derived growth factor subunit A-like [KO:K04359]
133404446  pdgfba; platelet-derived growth factor beta polypeptide a [KO:K17386]
133407885  pdgfc; platelet-derived growth factor C [KO:K05450]
133404990  pdgfd; platelet-derived growth factor D [KO:K05450]
133402324  kitlga; kit ligand a isoform X1 [KO:K05461]
133397423  uncharacterized protein LOC133397423 [KO:K05461]
133401100  vegfaa; vascular endothelial growth factor A-A [KO:K05448]
133407348  vegfba; vascular endothelial growth factor A [KO:K05448]
133416936  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
133412927  pgfb; vascular endothelial growth factor A [KO:K16859]
133399149  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
133399308  vegfd; vascular endothelial growth factor D [KO:K05449]
133403145  hgfb; hepatocyte growth factor isoform X1 [KO:K05460]
133397395  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
133395538  angpt1; angiopoietin-1 [KO:K05465]
133396180  angpt2b; angiopoietin-2b [KO:K05466]
133409937  angpt2a; angiopoietin-2a [KO:K05466]
133399918  efna5b; ephrin-A5b isoform X1 [KO:K05462]
133401240  efna1b; ephrin-A1b [KO:K05462]
133413166  efna2a; ephrin-A2 [KO:K05462]
133395552  efna3a; ephrin-A3 [KO:K05462]
133395623  efna1a; ephrin-A1a isoform X1 [KO:K05462]
133402027  efna3b; ephrin-A3b [KO:K05462]
133402028  si:dkey-246i14.3; ephrin-A4 isoform X1 [KO:K05462]
133413730  ephrin-A5b-like [KO:K05462]
133414184  gdnfa; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
133399863  glial cell line-derived neurotrophic factor-like [KO:K05452]
133411881  neurturin isoform X1 [KO:K25414]
133411781  glial cell line-derived neurotrophic factor [KO:K25415]
133406557  LOW QUALITY PROTEIN: artemin [KO:K25415]
133396747  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
133411354  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
133417636  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
133402191  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
133408295  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
133410327  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
133405123  receptor tyrosine-protein kinase erbB-4-like isoform X1 [KO:K05085] [EC:2.7.10.1]
133400419  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
133413432  fibroblast growth factor receptor 1-A-like isoform X1 [KO:K04362] [EC:2.7.10.1]
133410174  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
133412419  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
133415690  fgfr4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
133418175  ngfrb; nerve growth factor receptor b [KO:K02583]
133401666  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
133415456  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
133401853  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
133413559  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b [KO:K04360] [EC:2.7.10.1]
133399870  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
133406145  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
133411346  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
133403348  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
133398212  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
133406249  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
133407552  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
133415885  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
133407406  csf1ra; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
133415884  csf1rb; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 receptor 2 [KO:K05090] [EC:2.7.10.1]
133404064  kitb; KIT proto-oncogene, receptor tyrosine kinase b isoform X1 [KO:K05091] [EC:2.7.10.1]
133405986  kita; mast/stem cell growth factor receptor kita isoform X1 [KO:K05091] [EC:2.7.10.1]
133396489  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
133407770  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
133396297  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
133407933  flt4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
133406030  kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
133403286  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
133412881  epha2b; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
133409273  ephrin type-A receptor 2-like isoform X1 [KO:K05103] [EC:2.7.10.1]
133409412  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
133415512  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
133412669  sos2; son of sevenless homolog 2 [KO:K03099]
133403931  son of sevenless homolog 1-like isoform X1 [KO:K03099]
133403096  GTPase HRas [KO:K02833]
133403059  kras; GTPase KRas isoform X1 [KO:K07827]
133414337  zgc:55558; GTPase KRas isoform X1 [KO:K07827]
133415207  rras; ras-related protein R-Ras [KO:K07830]
133399364  rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
133410351  ras-related protein M-Ras [KO:K07831]
133400428  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
133396939  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
133409227  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
133402354  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
133406476  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
133412350  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
133400250  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
133414520  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
133406157  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
133405999  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b isoform X1 [KO:K04372] [EC:2.7.11.1]
133412492  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
133408037  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
133396523  rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
133396672  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
133415417  atf4b; activating transcription factor 4b [KO:K04374]
133404514  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
133407245  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
133396416  myca; transcriptional regulator Myc-A [KO:K04377]
133409655  srfb; serum response factor b isoform X1 [KO:K04378]
133403926  serum response factor-like isoform X1 [KO:K04378]
133412738  fosaa; protein c-Fos [KO:K04379]
133417283  fosab; v-fos FBJ murine osteosarcoma viral oncogene homolog Ab [KO:K04379]
133417284  protein c-Fos-like [KO:K04379]
133417744  microtubule-associated protein tau-like [KO:K04380]
133395575  stmn1a; stathmin 1a [KO:K04381]
133402181  stathmin-like [KO:K04381]
133402182  stathmin-like [KO:K04381]
133406764  cytosolic phospholipase A2-like isoform X1 [KO:K16342] [EC:3.1.1.4]
133410117  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
133410200  pla2g4f.1; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
133395629  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
133400081  il1b; interleukin-1 beta [KO:K04519]
133405086  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
133401102  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
133407580  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
133417328  transforming growth factor beta-3 proprotein-like isoform X1 [KO:K13377]
133413080  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
133401422  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
133410457  interleukin-1 receptor type 1 isoform X1 [KO:K04386]
133405583  interleukin-1 receptor accessory protein-like isoform X1 [KO:K04723]
133396341  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
133395494  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
133410599  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
133406663  faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
133408162  cd40lg; CD40 ligand isoform X1 [KO:K04389]
133408478  LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
133409656  tumor necrosis factor receptor superfamily member 6-like isoform X1 [KO:K04390]
133417648  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
133414370  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
133404601  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
133395307  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
133401428  cdc42l; cell division cycle 42, like [KO:K04393]
133401807  cell division control protein 42 homolog isoform X1 [KO:K04393]
133395482  cell division control protein 42 homolog [KO:K04393]
133408361  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
133415157  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
133407620  casp3b; caspase-3b isoform X1 [KO:K02187] [EC:3.4.22.56]
133403901  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
133400426  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
133413579  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
133413736  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
133395993  daxx; death domain-associated protein 6 [KO:K02308]
133396375  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
133411351  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
133403261  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
133399116  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
133400567  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
133413261  gadd45bb; growth arrest and DNA-damage-inducible, beta b isoform X1 [KO:K04402]
133413772  gadd45gb.1; growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1 [KO:K04402]
133413831  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
133411405  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
133403519  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
133416740  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
133398043  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
133409933  mitogen-activated protein kinase kinase kinase kinase 3-like isoform X1 [KO:K04406] [EC:2.7.11.1]
133408040  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 4-like [KO:K04407] [EC:2.7.11.1]
133410701  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
133410816  mitogen-activated protein kinase kinase kinase kinase 4-like isoform X1 [KO:K04407] [EC:2.7.11.1]
133405131  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
133406396  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
133413099  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
133408430  serine/threonine-protein kinase 4-like isoform X1 [KO:K04411]
133396079  stk3; serine/threonine-protein kinase 3 [KO:K04412]
133397667  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 2-like [KO:K04414] [EC:2.7.11.1]
133396444  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
133397778  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
133402519  map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
133396365  map3k22; mitogen-activated protein kinase kinase kinase 22 [KO:K04421] [EC:2.7.11.25]
133415214  map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
133412991  map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
133405456  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
133410049  map3k21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
133409086  mitogen-activated protein kinase kinase kinase 12-like isoform X1 [KO:K04423] [EC:2.7.11.25]
133417098  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
133410451  si:ch211-45c16.2; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
133411730  mitogen-activated protein kinase kinase kinase 20-like [KO:K04424] [EC:2.7.11.25]
133410866  map3k20a; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
133401281  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
133416918  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
133416795  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
133409822  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
133418195  taok2b; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
133413461  taok3b; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
133414559  taok2a; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
133404700  taok1a; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
133399622  taok3a; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
133417708  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
133414890  dual specificity mitogen-activated protein kinase kinase 4-like isoform X1 [KO:K04430] [EC:2.7.12.2]
133403602  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
133414425  map2k6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
133402667  C-Jun-amino-terminal kinase-interacting protein 1-like isoform X1 [KO:K04434]
133399109  C-Jun-amino-terminal kinase-interacting protein 1-like [KO:K04434]
133403117  mapk8ip2; LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
133414925  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
133408579  flna; filamin-A isoform X1 [KO:K04437]
133413836  crkl; crk-like protein [KO:K04438]
133416205  adapter molecule crk-like [KO:K04438]
133405417  crk; adapter molecule crk [KO:K04438]
133415668  arrestin red cell [KO:K04439]
133405061  arrb1; beta-arrestin-1 [KO:K04439]
133417593  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
133407378  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
133413369  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
133409637  mapk8a; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
133407143  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
133402715  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
133408660  mapk14b; LOW QUALITY PROTEIN: mitogen-activated protein kinase 14B [KO:K04441] [EC:2.7.11.24]
133397036  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
133397038  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
133404768  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
133399854  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
133399930  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
133408756  mapkapk2a; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
133408814  MAP kinase-activated protein kinase 2-like [KO:K04444] [EC:2.7.11.1]
133409166  mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
133412721  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
133415608  rps6ka4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
133412664  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
133395438  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
133401997  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
133397202  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
133406080  jun; transcription factor AP-1 [KO:K04448]
133413725  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
133411290  transcription factor Jun-like [KO:K04448]
133406627  transcription factor JunD-like isoform X1 [KO:K04449]
133412030  transcription factor JunD-like [KO:K04449]
133410969  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
133397665  tp53; cellular tumor antigen p53 [KO:K04451]
133416941  cellular tumor antigen p53-like isoform X1 [KO:K04451]
133408654  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
133412405  protein max-like isoform X1 [KO:K04453]
133416723  max; protein max isoform X1 [KO:K04453]
133400062  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
133413467  myocyte-specific enhancer factor 2C-like [KO:K04454]
133415615  hspb1; heat shock protein beta-1 [KO:K04455]
133412376  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
133409516  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
133404039  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
133404960  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
133412422  ppm1aa; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
133415875  ppm1nb; protein phosphatase, Mg2+/Mn2+ dependent, 1Nb (putative) [KO:K04457] [EC:3.1.3.16]
133405439  ppm1na; protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative) [KO:K04457] [EC:3.1.3.16]
133397405  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
133403064  tyrosine-protein phosphatase non-receptor type 5-like [KO:K18018] [EC:3.1.3.48]
133411463  tyrosine-protein phosphatase non-receptor type 7-like [KO:K18019] [EC:3.1.3.48]
133408031  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
133399949  dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133403011  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133414172  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133409114  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133409272  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133397056  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133403584  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133415161  si:ch211-195b15.8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133402326  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
133417255  dusp10; dual specificity protein phosphatase 10 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
133395185  dusp3a; uncharacterized protein dusp3a isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
133415048  LOW QUALITY PROTEIN: dual specificity protein phosphatase 3-like [KO:K17614] [EC:3.1.3.16 3.1.3.48]
133404958  ppp5c; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
133418125  ppm1bb; protein phosphatase 1bb isoform X1 [KO:K04461] [EC:3.1.3.16]
133409778  ppm1ba; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
133407388  heat shock 70 kDa protein 1-like [KO:K03283]
133401742  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
133405022  hspa8b; LOW QUALITY PROTEIN: heat shock protein family A (Hsp70) member 8b [KO:K03283]
133416449  hspa8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
133416713  heat shock 70 kDa protein 1 [KO:K03283]
133405387  mecom; LOW QUALITY PROTEIN: MDS1 and EVI1 complex locus protein EVI1-A [KO:K04462] [EC:2.1.1.367]
133399164  map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
133417997  mapk7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
133409188  probable nuclear hormone receptor HR38 isoform X1 [KO:K04465]
133399799  probable nuclear hormone receptor HR38 [KO:K04465]
133418292  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
133414492  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
133417719  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
133410156  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
133399974  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
133408750  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
133415295  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
133404857  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
133408020  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
133409491  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
133397822  rela; LOW QUALITY PROTEIN: transcription factor p65 [KO:K04735]
133405450  relb; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pee04070  Phosphatidylinositol signaling system
pee04110  Cell cycle
pee04115  p53 signaling pathway
pee04210  Apoptosis
pee04310  Wnt signaling pathway
KO pathway
ko04010   
LinkDB

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