KEGG   PATHWAY: pgig05010
Entry
pgig05010                   Pathway                                
Name
Alzheimer disease - Pteropus giganteus (Indian flying fox)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
pgig05010  Alzheimer disease
pgig05010

Organism
Pteropus giganteus (Indian flying fox) [GN:pgig]
Gene
120604587  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
120622059  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
120598931  amyloid-beta precursor protein isoform X1 [KO:K04520]
120623032  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
120590240  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
120615795  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
120596623  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
120597822  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
120611646  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
120601718  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
120622031  BACE1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
120598839  BACE2; beta-secretase 2 isoform X1 [KO:K07747] [EC:3.4.23.45]
120600808  RTN3; reticulon-3 isoform X1 [KO:K20723]
120621642  RTN4; reticulon-4 isoform X1 [KO:K20720]
120592455  PSENEN; gamma-secretase subunit PEN-2 isoform X1 [KO:K06170]
120619472  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
120619111  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
120584281  NCSTN; nicastrin isoform X1 [KO:K06171]
120604549  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
120585194  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
120609305  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
120598567  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
120589267  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
120584746  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
120588577  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
120598742  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
120613848  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial-like [KO:K03944]
120581414  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
120616482  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
120602254  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
120604950  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
120601258  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
120602938  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
120602939  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6-like [KO:K03950]
120598765  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
120605755  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
120607301  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1 [KO:K03953]
120592183  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
120584540  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
120615433  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
120611623  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
120606599  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
120619622  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
120601134  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
120587522  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
120586679  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
120597142  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
120612925  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
120618472  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
120609201  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
120595681  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
120620248  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
120605511  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
120587568  NDUFS1; LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
120584202  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
120607415  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
120608171  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
120593298  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
120586301  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
120583687  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
120584743  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
120613219  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
120590396  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
120586318  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
120585752  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
120584198  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
120621994  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
120617223  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
120588814  cytochrome c1, heme protein, mitochondrial [KO:K00413]
120582316  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
120584555  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
120620319  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
120605463  cytochrome b-c1 complex subunit 7 [KO:K00417]
120616506  cytochrome b-c1 complex subunit 8 [KO:K00418]
120610685  cytochrome b-c1 complex subunit 8-like [KO:K00418]
120601887  cytochrome b-c1 complex subunit 9 [KO:K00419]
120603514  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
120622928  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
120597795  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
120610239  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
120606788  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
120620534  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
120592433  cytochrome c oxidase subunit 6B1 [KO:K02267]
120598319  cytochrome c oxidase subunit 6B2 [KO:K02267]
120595634  cytochrome c oxidase subunit 6C isoform X1 [KO:K02268]
120592495  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
120594945  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
120609699  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
120621725  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
120591688  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
120588028  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
120588365  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
120586049  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
120604925  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
120609017  ATP5F1C; ATP synthase subunit gamma, mitochondrial [KO:K02136]
120583693  ATP5F1D; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
120585021  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
120602187  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
120596836  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
120611266  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
120600221  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
120598636  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
120598886  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
120593567  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
120613451  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
120581285  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
120609565  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
120595502  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
120591624  ADP/ATP translocase 3-like [KO:K05863]
120616243  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
120618453  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
120586046  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
120589516  ADP/ATP translocase 3 [KO:K05863]
120609581  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
120606606  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
120605275  APOE; apolipoprotein E [KO:K04524]
120604943  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
120609345  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
120611633  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
120584707  FADD; FAS-associated death domain protein [KO:K02373]
120587528  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
120607361  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
120604475  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
120617886  CALM3; calmodulin-3 [KO:K02183]
120619605  CALM1; calmodulin-1 [KO:K02183]
120608993  calmodulin-alpha-like isoform X1 [KO:K02183]
120621675  CALM2; calmodulin-2 isoform X1 [KO:K02183]
120591098  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120606631  PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
120609542  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
120594548  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
120596960  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
120600645  BAD; bcl2-associated agonist of cell death [KO:K02158]
120602359  cytochrome c [KO:K08738]
120597089  cytochrome c, testis-specific-like [KO:K08738]
120611595  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
120585783  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
120618435  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
120600782  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
120592559  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
120587228  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
120590530  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
120588271  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
120587190  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
120600630  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
120611916  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
120611973  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
120599777  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
120620377  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
120613742  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
120600167  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
120606995  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
120607351  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
120606299  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
120587067  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
120619319  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
120595320  LOW QUALITY PROTEIN: neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
120609520  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
120606851  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120620121  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120587230  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
120582429  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120618337  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
120597599  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
120616088  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
120620145  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
120621089  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
120584186  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
120601994  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
120604962  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
120600114  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120594611  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
120599784  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
120615779  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
120598851  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
120616614  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120609636  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120588349  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120612759  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
120602997  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
120620763  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
120591738  PSMA2; proteasome subunit alpha type-2 isoform X1 [KO:K02726] [EC:3.4.25.1]
120599350  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
120603909  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
120587318  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
120584985  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
120603239  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
120603477  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
120607873  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
120601686  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
120608950  sperm motility kinase-like [KO:K02735] [EC:3.4.25.1]
120611217  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
120581927  LOW QUALITY PROTEIN: proteasome subunit beta type-2-like [KO:K02734] [EC:3.4.25.1]
120593235  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
120593764  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
120618217  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
120585246  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
120591506  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
120619604  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
120595865  PSMC4; 26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
120608146  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6B-like [KO:K03063]
120604417  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
120607312  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
120600289  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
120592898  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
120597146  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
120611182  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
120616070  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
120600023  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
120620915  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
120593970  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
120614162  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
120585233  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
120597178  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
120596357  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
120603906  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
120614997  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
120599677  LOW QUALITY PROTEIN: caspase-12-like [KO:K04741] [EC:3.4.22.-]
120606760  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
120584867  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
120619310  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
120620914  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
120592161  SLC39A1; zinc transporter ZIP1 [KO:K14709]
120583742  SLC39A3; zinc transporter ZIP3 [KO:K14709]
120608074  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
120608543  zinc transporter ZIP2-like isoform X1 [KO:K14709]
120588830  SLC39A4; zinc transporter ZIP4 [KO:K14710]
120604908  SLC39A5; LOW QUALITY PROTEIN: zinc transporter ZIP5 [KO:K14711]
120586605  SLC39A6; zinc transporter ZIP6 [KO:K14712]
120597647  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
120591104  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
120612791  SLC39A9; zinc transporter ZIP9 [KO:K14715]
120587486  SLC39A10; zinc transporter ZIP10 [KO:K14716]
120600304  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
120614652  SLC39A12; zinc transporter ZIP12 [KO:K14718]
120607271  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
120606629  SLC39A14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
120602147  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
120601504  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
120586669  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120609077  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
120591136  DKK2; dickkopf-related protein 2 [KO:K02165]
120609374  DKK1; dickkopf-related protein 1 isoform X1 [KO:K02165]
120595503  DKK4; dickkopf-related protein 4 [KO:K02165]
120618559  WNT1; proto-oncogene Wnt-1 [KO:K03209]
120585033  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
120601108  WNT2; protein Wnt-2 [KO:K00182]
120616644  WNT3A; protein Wnt-3a [KO:K00312]
120589261  WNT3; proto-oncogene Wnt-3 [KO:K00312]
120596198  WNT4; protein Wnt-4 [KO:K00408]
120606289  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
120607346  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
120587668  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
120602874  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
120613810  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
120581156  WNT8A; protein Wnt-8a isoform X1 [KO:K00714]
120608938  WNT8B; protein Wnt-8b [KO:K00714]
120616643  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
120589260  WNT9B; protein Wnt-9b [KO:K01064]
120618208  WNT10B; protein Wnt-10b [KO:K01357]
120587739  WNT10A; protein Wnt-10a [KO:K01357]
120590369  WNT11; protein Wnt-11 [KO:K01384]
120601159  WNT16; protein Wnt-16 [KO:K01558]
120615046  FZD1; frizzled-1 [KO:K02432]
120587540  FZD7; frizzled-7 [KO:K02432]
120589224  FZD2; frizzled-2 [KO:K02235]
120613253  FZD3; frizzled-3 isoform X1 [KO:K02329]
120590461  FZD4; frizzled-4 [KO:K02354]
120593264  FZD8; frizzled-8 [KO:K02375]
120587587  FZD5; frizzled-5 [KO:K02375]
120595684  FZD6; frizzled-6 [KO:K02376]
120591641  FZD9; frizzled-9 [KO:K02842]
120615989  FZD10; frizzled-10 [KO:K02842]
120613720  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
120584733  LRP5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5 [KO:K03068]
120614818  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
120614091  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
120593039  DVL3; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
120589630  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
120609253  FRAT1; proto-oncogene FRAT1 [KO:K03069]
120609254  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
120603501  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
120617345  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
120618929  CSNK2B; casein kinase II subunit beta [KO:K03115]
120620161  AXIN1; axin-1 isoform X1 [KO:K02157]
120600021  AXIN2; LOW QUALITY PROTEIN: axin-2 [KO:K04385]
120590819  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
120583698  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
120582202  CTNNB1; catenin beta-1 [KO:K02105]
120581532  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
120604954  kinesin heavy chain isoform X1 [KO:K10396]
120584120  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
120597184  KIF5C; kinesin heavy chain [KO:K10396]
120613941  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
120605294  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
120584814  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
120596144  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
120606832  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
120618200  tubulin alpha-1A chain [KO:K07374]
120618201  TUBA1C; tubulin alpha-1C chain [KO:K07374]
120618203  tubulin alpha-1A chain-like [KO:K07374]
120607368  TUBA8; tubulin alpha-8 chain [KO:K07374]
120587682  tubulin alpha-1B chain-like [KO:K07374]
120587683  tubulin alpha-4A chain [KO:K07374]
120593379  TUBB; tubulin beta chain [KO:K07375]
120603889  TUBB1; tubulin beta-1 chain [KO:K07375]
120615448  TUBB4A; LOW QUALITY PROTEIN: tubulin beta-4A chain [KO:K07375]
120607707  tubulin beta-2A chain [KO:K07375]
120607710  tubulin beta-2A chain-like [KO:K07375]
120599744  TUBB4B; tubulin beta-4B chain isoform X1 [KO:K07375]
120588919  TUBB6; tubulin beta-6 chain [KO:K07375]
120589166  tubulin beta-3 chain [KO:K07375]
120618880  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
120584662  HRAS; GTPase HRas isoform X1 [KO:K02833]
120618351  KRAS; GTPase KRas isoform X1 [KO:K07827]
120585069  NRAS; GTPase NRas isoform X1 [KO:K07828]
120605533  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
120601203  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120621476  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120604492  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
120615382  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
120611567  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
120622444  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
120590536  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
120584840  RELA; transcription factor p65 [KO:K04735]
120591230  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120620943  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
120617547  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
120618944  TNF; tumor necrosis factor [KO:K03156]
120602335  IL6; interleukin-6 isoform X1 [KO:K05405]
120593734  interleukin-1 alpha-like [KO:K04383]
120610305  IL1A; interleukin-1 alpha [KO:K04383]
120593744  IL1B; interleukin-1 beta [KO:K04519]
120584998  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
120588322  SNCA; alpha-synuclein [KO:K04528]
120621778  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
120609204  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
120595665  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
120605919  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
120584612  INS; insulin [KO:K04526]
120599285  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
120597107  IRS1; insulin receptor substrate 1 [KO:K16172]
120605338  IRS2; insulin receptor substrate 2 isoform X1 [KO:K07187]
120616378  IRS4; insulin receptor substrate 4 isoform X1 [KO:K17446]
120606549  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120608247  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120620206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
120582132  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120596984  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120585845  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
120613959  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120595669  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120619079  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120585826  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
120615974  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
120589825  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
120602133  ATG101; autophagy-related protein 101 [KO:K19730]
120606859  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
120607252  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
120606809  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
120619070  BECN2; beclin-2 [KO:K08334]
120611068  BECN1; beclin-1 isoform X1 [KO:K08334]
120582068  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
120605604  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
120609419  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
120586191  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
120619671  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
120600867  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
120615611  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
120599998  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
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J Clin Invest 114:23-7 (2004)
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Related
pathway
pgig00190  Oxidative phosphorylation
pgig03050  Proteasome
pgig04020  Calcium signaling pathway
pgig04140  Autophagy - animal
pgig04141  Protein processing in endoplasmic reticulum
pgig04210  Apoptosis
pgig04310  Wnt signaling pathway
pgig04910  Insulin signaling pathway
pgig04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
LinkDB

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