KEGG   PATHWAY: tge04014
Entry
tge04014                    Pathway                                
Name
Ras signaling pathway - Theropithecus gelada (gelada)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
tge04014  Ras signaling pathway
tge04014

Other DBs
GO: 0032318
Organism
Theropithecus gelada (gelada) [GN:tge]
Gene
112624610  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112604653  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
112626218  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
112624619  FGF2; fibroblast growth factor 2 [KO:K18497]
112628041  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
112635323  FGF6; fibroblast growth factor 6 [KO:K04358]
112606831  FGF4; fibroblast growth factor 4 [KO:K04358]
112607217  FGF3; fibroblast growth factor 3 [KO:K04358]
112630377  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112630484  FGF20; fibroblast growth factor 20 [KO:K04358]
112616411  FGF16; fibroblast growth factor 16 [KO:K04358]
112631781  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
112624795  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
112610592  FGF9; fibroblast growth factor 9 [KO:K04358]
112626373  FGF18; fibroblast growth factor 18 [KO:K04358]
112626403  FGF10; fibroblast growth factor 10 [KO:K04358]
112612323  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
112606810  FGF19; fibroblast growth factor 19 [KO:K22603]
112613542  FGF21; fibroblast growth factor 21 [KO:K22429]
112635291  FGF23; fibroblast growth factor 23 [KO:K22428]
112608614  NGF; beta-nerve growth factor [KO:K02582]
112607193  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
112634735  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
112613253  NTF4; neurotrophin-4 [KO:K12457]
112635504  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112605601  IGF2; insulin-like growth factor II [KO:K13769]
112620011  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
112633086  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112606868  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
112625330  PDGFC; platelet-derived growth factor C [KO:K05450]
112605466  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
112635307  KITLG; kit ligand isoform X1 [KO:K05461]
112611838  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
112622794  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
112607256  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
112629345  PGF; placenta growth factor isoform X1 [KO:K16859]
112615683  VEGFD; vascular endothelial growth factor D [KO:K05449]
112625469  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
112620515  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112630669  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
112629962  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
112633366  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
112624372  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
112610717  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
112611866  EFNA2; ephrin-A2 [KO:K05462]
112626705  EFNA5; ephrin-A5 [KO:K05462]
112612330  EFNA4; LOW QUALITY PROTEIN: ephrin-A4 [KO:K05462]
112620091  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
112629744  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112631500  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
112625207  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
112625972  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
112609431  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
112607006  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
112607806  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
112613164  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
112628505  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
112625154  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112626117  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112625968  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
112624589  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
112610848  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
112610885  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
112626121  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
112624522  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
112620574  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
112608598  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
112604695  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
112608918  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
112625008  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
112606981  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
112628791  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
112612298  SHC2; SHC-transforming protein 2 [KO:K17447]
112608168  SHC3; SHC-transforming protein 3 [KO:K17448]
112627393  SHC4; SHC-transforming protein 4 [KO:K17449]
112635452  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
112628758  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
112604731  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112632711  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
112614034  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
112627599  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
112606964  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
112604574  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
112613560  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
112621713  uncharacterized protein LOC112621713 [KO:K10785]
112621718  uncharacterized protein LOC112621718 [KO:K10785]
112620195  immunoglobulin delta heavy chain-like [KO:K10785]
112620205  uncharacterized protein LOC112620205 [KO:K10785]
112604729  tyrosine-protein kinase ZAP-70 isoform X1 [KO:K07360] [EC:2.7.10.2]
112614229  LAT; linker for activation of T-cells family member 1 [KO:K07362]
112631715  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
112632175  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
112620636  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
112634141  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
112619070  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
112627568  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
112629356  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
112606716  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
112627501  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
112623092  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
112613438  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
112612425  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
112608393  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
112608663  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
112621764  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
112624588  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112614614  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
112621057  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
112609503  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
112608183  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
112618864  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112612552  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
112628060  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
112625910  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
112608539  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
112614685  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
112634692  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
112628492  CALM1; calmodulin-1 isoform X1 [KO:K02183]
112636897  CALM2; calmodulin-2 isoform X1 [KO:K02183]
112609174  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
112631384  calmodulin-like [KO:K02183]
112631589  CALML3; calmodulin-like protein 3 [KO:K02183]
112631867  CALML5; calmodulin-like protein 5 [KO:K02183]
112627411  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
112612423  CALM3; calmodulin-3 isoform X1 [KO:K02183]
112607359  HRAS; GTPase HRas isoform X1 [KO:K02833]
112634105  KRAS; GTPase KRas isoform X1 [KO:K07827]
112619416  NRAS; GTPase NRas isoform X1 [KO:K07828]
112618821  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
112612574  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
112606963  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
112610227  NF1; neurofibromin isoform X1 [KO:K08052]
112625711  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
112619290  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
112610932  RASA3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
112620426  RASA4B; ras GTPase-activating protein 4B isoform X1 [KO:K17630]
112623419  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
112634376  RASAL1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
112633657  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
112612696  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
112619231  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
112607851  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
112633320  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
112620958  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
112620191  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
112633210  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112609500  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
112606386  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
112618517  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
112616281  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
112612922  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
112632986  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
112627537  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
112622050  transforming protein RhoA-like isoform X1 [KO:K04513]
112608311  RHOC; rho-related GTP-binding protein RhoC isoform X1 [KO:K04513]
112618614  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
112618874  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112634042  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112619294  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112614522  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112625914  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112612001  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
112629473  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112609286  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112612288  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112616513  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112616847  NF-kappa-B essential modulator-like [KO:K07210]
112632013  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112629970  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112624752  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112605794  RELA; transcription factor p65 isoform X1 [KO:K04735]
112606473  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
112632856  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
112616637  FOXO4; forkhead box protein O4 isoform X1 [KO:K12358]
112636918  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
112628879  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
112633221  RALGAPA2; ral GTPase-activating protein subunit alpha-2 [KO:K25768]
112632970  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
112607916  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
112632401  ral-GDS-related protein-like [KO:K08732]
112632635  ral-GDS-related protein-like [KO:K08732]
112632636  ral-GDS-related protein-like [KO:K08732]
112632868  LOW QUALITY PROTEIN: ral-GDS-related protein-like [KO:K08732]
112632869  ral-GDS-related protein-like [KO:K08732]
112613161  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
112623228  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
112620933  RALA; ras-related protein Ral-A [KO:K07834]
112617110  ras-related protein Ral-B [KO:K07835]
112617149  ras-related protein Ral-B isoform X1 [KO:K07835]
112610028  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
112619557  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
112623323  EXOC2; exocyst complex component 2 [KO:K17637]
112635245  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
112604661  REL; proto-oncogene c-Rel [KO:K09254]
112624632  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112631631  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112626308  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112611499  RALBP1; ralA-binding protein 1 [KO:K08773]
112627433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112622839  AFDN; afadin isoform X1 [KO:K05702]
112632083  SHOC2; leucine-rich repeat protein SHOC-2 [KO:K19613]
112619721  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112627624  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
112612394  MAP2K2; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112614214  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
112632792  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
112618618  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
112607074  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
112613704  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112613910  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112614127  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112631491  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
112624576  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112633626  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112633953  PLA2G5; calcium-dependent phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
112612212  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112634572  PLA2G2D; group IID secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
112634699  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
112627871  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
112627983  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
112614273  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
112611901  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
112627440  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
112627837  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
112632360  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
112606894  PLA2G16; HRAS-like suppressor 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
112606816  HRASLS2; HRAS-like suppressor 2 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
112607111  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
112616509  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
112606658  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
112620338  ETS2; protein C-ets-2 [KO:K21932]
112635315  BRAP; BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
112609949  KSR1; kinase suppressor of Ras 1 [KO:K14958]
112635047  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
112621139  RAPGEF5; rap guanine nucleotide exchange factor 5 [KO:K08019]
112626061  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
112635460  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
112631367  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
112609643  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112614190  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112613317  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
112607404  RIN1; ras and Rab interactor 1 isoform X1 [KO:K17638]
112607912  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
112612953  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
112619083  RAB5A; ras-related protein Rab-5A [KO:K07887]
112634219  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
112610415  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
112628676  ARF6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
tge04010  MAPK signaling pathway
tge04015  Rap1 signaling pathway
tge04020  Calcium signaling pathway
tge04144  Endocytosis
tge04151  PI3K-Akt signaling pathway
tge04660  T cell receptor signaling pathway
tge04720  Long-term potentiation
tge04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
LinkDB

DBGET integrated database retrieval system