KEGG   PATHWAY: tod05169
Entry
tod05169                    Pathway                                
Name
Epstein-Barr virus infection - Talpa occidentalis (Iberian mole)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
tod05169  Epstein-Barr virus infection
tod05169

Organism
Talpa occidentalis (Iberian mole) [GN:tod]
Gene
119234695  complement receptor type 1-like [KO:K04012]
119241794  CD19; B-lymphocyte antigen CD19 [KO:K06465]
119251395  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
119252077  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
119252079  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
119252300  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
119252301  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119252303  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119252305  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
119252306  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
119252307  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
119252309  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
119252310  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119252317  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119252318  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
119252320  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
119252323  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
119252326  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
119253063  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119253072  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
119253280  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
119253282  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
119233466  TLR2; toll-like receptor 2 [KO:K10159]
119258024  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
119247577  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
119245797  IRAK1; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
119255354  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119247246  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
119252963  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
119252700  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119233588  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2 [KO:K04467] [EC:2.7.11.10]
119257853  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
119245781  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119239019  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
119243680  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119248814  RELA; transcription factor p65 isoform X1 [KO:K04735]
119253235  TNF; tumor necrosis factor isoform X1 [KO:K03156]
119243289  IL6; interleukin-6 [KO:K05405]
119235264  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
119250785  LOW QUALITY PROTEIN: TNF receptor-associated factor 3-like [KO:K03174]
119239469  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
119248120  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
119234149  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
119248779  IRF7; interferon regulatory factor 7 [KO:K09447]
119249593  IRF3; interferon regulatory factor 3 [KO:K05411]
119232539  interferon alpha-6-like [KO:K05414]
119231101  IFNB1; interferon beta [KO:K05415]
119257231  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
119257233  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
119235485  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119240943  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
119256041  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
119248061  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
119238075  IRF9; interferon regulatory factor 9 [KO:K04693]
119259396  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
119244963  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
119245323  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
119245324  OAS1; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
119260769  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
119236212  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
119233895  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
119250504  FADD; FAS-associated death domain protein [KO:K02373]
119256101  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
119247866  BID; BH3-interacting domain death agonist [KO:K04726]
119259202  BCL2L11; bcl-2-like protein 11 isoform X2 [KO:K16341]
119243742  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
119248671  apoptosis regulator BAX-like [KO:K02159]
119248674  apoptosis regulator BAX-like [KO:K02159]
119249544  apoptosis regulator BAX-like isoform X1 [KO:K02159]
119249545  apoptosis regulator BAX-like [KO:K02159]
119249546  apoptosis regulator BAX-like [KO:K02159]
119249548  apoptosis regulator BAX-like [KO:K02159]
119249549  apoptosis regulator BAX-like [KO:K02159]
119249551  apoptosis regulator BAX-like isoform X1 [KO:K02159]
119249552  apoptosis regulator BAX-like [KO:K02159]
119249553  apoptosis regulator BAX-like isoform X1 [KO:K02159]
119249555  apoptosis regulator BAX isoform X1 [KO:K02159]
119249569  apoptosis regulator BAX-like [KO:K02159]
119252348  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
119235620  cytochrome c-like [KO:K08738]
119243508  cytochrome c [KO:K08738]
119255974  cytochrome c 2 [KO:K08738]
119248206  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
119235667  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
119257947  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119238019  uncharacterized protein LOC119238019 [KO:K10784]
119239887  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
119242080  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
119239888  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
119242275  CD247; T-cell surface glycoprotein CD3 zeta chain [KO:K06453]
119245005  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
119239288  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
119249308  26S proteasome regulatory subunit 6B [KO:K03063]
119249318  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
119259796  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 10B-like [KO:K03064]
119239095  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
119255297  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
119232639  PSMC5; 26S proteasome regulatory subunit 8 [KO:K03066]
119257348  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
119256293  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
119231146  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
119231647  26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
119231681  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
119230665  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
119230764  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
119249015  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
119249818  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
119237103  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
119255870  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
119250210  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
119237110  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
119242544  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
119246774  26S proteasome complex subunit SEM1-like [KO:K10881]
119239966  26S proteasome complex subunit SEM1-like [KO:K10881]
119252321  TAP1; antigen peptide transporter 1 isoform X2 [KO:K05653] [EC:7.4.2.14]
119251393  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
119251981  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
119252147  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
119252341  TAPBP; tapasin isoform X1 [KO:K08058]
119238557  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
119241009  CALR; calreticulin [KO:K08057]
119233314  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119258418  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
119258434  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X2 [KO:K06751]
119258435  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119242843  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X2 [KO:K06751]
119242845  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119243231  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251067  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119251071  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251072  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
119251075  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251077  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251117  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X2 [KO:K06751]
119251138  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251165  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251167  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251183  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251189  HLA class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119251196  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251199  patr class I histocompatibility antigen, A-108 alpha chain-like isoform X1 [KO:K06751]
119251208  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251212  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
119251215  patr class I histocompatibility antigen, B-1 alpha chain-like isoform X1 [KO:K06751]
119251229  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119251240  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251268  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119251270  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119251277  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119251278  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119251289  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251297  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119251301  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119251308  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
119251309  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251319  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251322  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251332  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119251343  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119243833  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251946  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251966  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251970  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119251974  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
119251982  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
119251983  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
119251986  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
119251987  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251994  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119251995  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119251996  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251998  HLA class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
119252000  patr class I histocompatibility antigen, A-108 alpha chain-like isoform X4 [KO:K06751]
119252001  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119252003  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X2 [KO:K06751]
119252004  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119252005  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119252018  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252020  HLA class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
119252022  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X2 [KO:K06751]
119252031  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252033  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
119252034  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X3 [KO:K06751]
119252037  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
119252039  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119252040  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119252045  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119252048  patr class I histocompatibility antigen, A-108 alpha chain-like isoform X3 [KO:K06751]
119252056  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119252057  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like isoform X2 [KO:K06751]
119252059  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
119252060  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119252067  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
119252069  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
119252072  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252075  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
119252076  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119252098  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119252138  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
119252140  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119252145  HLA class I histocompatibility antigen, B alpha chain-like isoform X2 [KO:K06751]
119252149  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252151  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252154  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
119252156  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119252157  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119252159  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
119252162  patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
119252164  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
119252165  HLA class I histocompatibility antigen, alpha chain G-like isoform X2 [KO:K06751]
119252167  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119252170  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119252172  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like isoform X5 [KO:K06751]
119252178  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252180  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119252182  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252186  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119252187  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252189  uncharacterized protein LOC119252189 isoform X3 [KO:K06751]
119252191  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119236634  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119252311  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119253123  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119253126  patr class I histocompatibility antigen, A-108 alpha chain-like isoform X1 [KO:K06751]
119253172  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119253179  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119253184  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119253185  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119253190  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119253192  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119253199  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
119253215  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119253216  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119253231  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119253263  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
119253903  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
119253926  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119248584  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119238571  B2M; beta-2-microglobulin [KO:K08055]
119239323  SNW1; SNW domain-containing protein 1 [KO:K06063]
119238403  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
119237269  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
119252801  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
119245066  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
119257978  SAP30; LOW QUALITY PROTEIN: histone deacetylase complex subunit SAP30 [KO:K19202]
119236277  SAP30L; histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
119255944  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
119261214  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
119254438  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
119256797  HES1; transcription factor HES-1 [KO:K06054]
119240349  FCER2; low affinity immunoglobulin epsilon Fc receptor [KO:K06468]
119235487  RUNX3; runt-related transcription factor 3 isoform X1 [KO:K09279]
119238040  MYC; LOW QUALITY PROTEIN: myc proto-oncogene protein [KO:K04377]
119241943  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
119247528  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
119230677  TP53; cellular tumor antigen p53 [KO:K04451]
119252397  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
119230627  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
119235315  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
119240543  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
119255301  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
119260894  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
119234414  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
119257726  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119236721  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
119257304  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119237093  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119260810  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119241117  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119244519  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
119239481  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119249321  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119230450  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
119248659  RELB; transcription factor RelB [KO:K09253]
119233568  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
119248933  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
119249286  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
119252518  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
119232588  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
119240438  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119234816  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119236621  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
119261431  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
119256545  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119230651  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
119251060  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
119230399  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
119231622  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
119252387  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119252388  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
119247132  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119247133  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
119235421  JUN; transcription factor Jun [KO:K04448]
119234573  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
119232986  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
119258357  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
119236102  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
119255365  CD44; CD44 antigen isoform X3 [KO:K06256]
119233334  LOW QUALITY PROTEIN: integrin alpha-L-like [KO:K05718]
119241739  ITGAL; integrin alpha-L [KO:K05718]
119236336  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
119240938  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
119244724  VIM; vimentin [KO:K07606]
119240827  vimentin [KO:K07606]
119251021  LOW QUALITY PROTEIN: tumor necrosis factor alpha-induced protein 3-like [KO:K11859] [EC:3.4.19.12]
119252914  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
119241109  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
119232887  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
119241288  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
119232025  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
119238654  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
119241672  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
119246027  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
119233559  BLNK; B-cell linker protein isoform X1 [KO:K07371]
119249121  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
119261442  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
119247697  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
119249876  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
119246910  LOW QUALITY PROTEIN: G1/S-specific cyclin-D1-like [KO:K04503]
119247816  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
119252455  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119248102  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119242143  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119234789  CCNA2; cyclin-A2 [KO:K06627]
119258844  CCNA1; cyclin-A1 [KO:K06627]
119239439  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
119249194  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
119248037  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
119258908  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
119234016  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
119235422  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
119251678  E2F3; transcription factor E2F3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
tod03050  Proteasome
tod04010  MAPK signaling pathway
tod04020  Calcium signaling pathway
tod04064  NF-kappa B signaling pathway
tod04110  Cell cycle
tod04115  p53 signaling pathway
tod04210  Apoptosis
tod04612  Antigen processing and presentation
tod04620  Toll-like receptor signaling pathway
tod04622  RIG-I-like receptor signaling pathway
tod04630  JAK-STAT signaling pathway
tod04662  B cell receptor signaling pathway
KO pathway
ko05169   
LinkDB

DBGET integrated database retrieval system