KEGG   PATHWAY: pleu05417
Entry
pleu05417                   Pathway                                
Name
Lipid and atherosclerosis - Peromyscus leucopus (white-footed mouse)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
pleu05417  Lipid and atherosclerosis
pleu05417

Disease
H02505  Atherosclerosis
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680674  Plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
114680676  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
114680796  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
114681035  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
114681418  Calm3; calmodulin-3 [KO:K02183]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681524  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114681835  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
114681932  Hspa4; heat shock 70 kDa protein 4 [KO:K09489]
114681971  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
114681974  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
114681989  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
114681994  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
114682099  Rela; transcription factor p65 [KO:K04735]
114682227  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
114682503  Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682740  Casp6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
114682786  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
114683009  Nlrp3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
114683205  Nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114683255  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114683276  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
114683448  Abca1; phospholipid-transporting ATPase ABCA1 [KO:K05641]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684216  Vav2; guanine nucleotide exchange factor VAV2 isoform X4 [KO:K05730]
114684433  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
114684640  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
114684877  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
114685101  Ticam1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842]
114685127  [KO:K02833]
114685139  Ifnb1; interferon beta [KO:K05415]
114685140  [KO:K05414]
114685141  [KO:K05414]
114685144  [KO:K05414]
114685147  [KO:K05414]
114685149  [KO:K05414]
114685150  [KO:K05414]
114685151  [KO:K05414]
114685152  [KO:K05414]
114685154  [KO:K05414]
114685155  [KO:K05414]
114685358  Pou2f2; POU domain, class 2, transcription factor 2 isoform X5 [KO:K09364]
114686066  Map2k7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
114686218  [KO:K04079]
114686359  Rxrb; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
114686371  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
114686543  Vav1; proto-oncogene vav [KO:K05730]
114686570  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
114686813  Arhgef1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
114686853  Casp1; caspase-1 [KO:K01370] [EC:3.4.22.36]
114686934  [KO:K03283]
114687049  Apob; apolipoprotein B-100 [KO:K14462]
114687156  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
114687991  [KO:K04374]
114688453  [KO:K05414]
114688454  [KO:K05414]
114688456  [KO:K05414]
114688459  [KO:K05414]
114688460  [KO:K05414]
114688461  [KO:K05414]
114688462  [KO:K05414]
114688463  [KO:K05414]
114688488  [KO:K02833]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689321  [KO:K05414]
114689322  [KO:K05414]
114689366  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
114689632  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
114689745  [KO:K08738]
114689756  Il6; interleukin-6 [KO:K05405]
114689882  Il12b; interleukin-12 subunit beta [KO:K05425]
114689894  Atf6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
114689910  Rxrg; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
114689924  Pou2f1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
114689971  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
114690001  [KO:K06496]
114690023  Sele; LOW QUALITY PROTEIN: E-selectin [KO:K06494]
114690029  Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
114690125  Ly96; lymphocyte antigen 96 [KO:K05400]
114690242  Il18; interleukin-18 [KO:K05482]
114690337  [KO:K07408] [EC:1.14.14.1]
114690416  Ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
114690439  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114690458  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
114690660  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114691135  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
114691212  Apoa1; apolipoprotein A-I [KO:K08757]
114691236  Apoa4; apolipoprotein A-IV [KO:K08760]
114691286  Pou2f3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
114691309  [KO:K04393]
114691380  Sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
114691550  [KO:K14624]
114691605  [KO:K14624]
114691640  Calml4; calmodulin-like protein 4 isoform X2 [KO:K02183]
114691668  Tank; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
114691694  [KO:K04079]
114691738  Il12a; interleukin-12 subunit alpha [KO:K05406]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114691978  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114692579  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
114692635  Mmp9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
114692638  Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
114692795  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
114693019  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114693020  Mapk11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
114693067  Irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
114693118  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
114693171  Tp53; cellular tumor antigen p53 [KO:K04451]
114693293  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
114693311  Rap1b; ras-related protein Rap-1b [KO:K07836]
114693378  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
114693493  [KO:K02833]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693595  Hras; GTPase HRas isoform X1 [KO:K02833]
114693632  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
114693708  Ncf1; neutrophil cytosol factor 1 [KO:K08011]
114693759  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
114693760  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
114693761  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
114693762  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
114693764  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
114693768  Jun; transcription factor AP-1 [KO:K04448]
114693817  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
114693819  [KO:K08738]
114693978  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7 [KO:K04515] [EC:2.7.11.17]
114693991  Xbp1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
114694222  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
114694280  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2 [KO:K04403]
114694285  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
114694913  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114695207  Icam1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
114695236  Ldlr; low-density lipoprotein receptor [KO:K12473]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695408  [KO:K08738]
114695419  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114695777  [KO:K09487]
114696054  Ero1a; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
114696553  [KO:K02833]
114697006  Nox1; NADPH oxidase 1 [KO:K08008]
114697063  Casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
114697206  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
114697551  Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
114697589  [KO:K03174]
114697745  Hspa2; heat shock-related 70 kDa protein 2 [KO:K26598]
114697766  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
114697848  [KO:K09489]
114697928  [KO:K08738]
114698038  Fos; proto-oncogene c-Fos [KO:K04379]
114698057  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
114698166  Mib1; E3 ubiquitin-protein ligase MIB1 [KO:K10645] [EC:2.3.2.27]
114698582  Nras; GTPase NRas [KO:K07828]
114698768  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
114698806  [KO:K04348] [EC:3.1.3.16]
114698838  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114699694  [KO:K20053]
114699775  [KO:K05403]
114699802  [KO:K04077] [EC:5.6.1.7]
114699957  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
114700088  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
114700198  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114700207  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
114700550  Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
114700616  Hsp90b1; endoplasmin [KO:K09487]
114700736  Bid; BH3-interacting domain death agonist [KO:K04726]
114700813  [KO:K08738]
114700818  Nfe2l2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
114700859  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
114700910  [KO:K04513]
114700968  [KO:K08009]
114701275  [KO:K04393]
114701319  [KO:K21421] [EC:1.-.-.-]
114701414  Olr1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114701719  [KO:K05505]
114701735  [KO:K05505]
114701736  [KO:K05505]
114702008  Tlr6; toll-like receptor 6 isoform X1 [KO:K10169]
114702690  [KO:K04722]
114702794  Rxra; retinoic acid receptor RXR-alpha [KO:K08524]
114702810  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
114703046  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114703073  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
114703084  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
114703574  [KO:K08738]
114703666  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
114703672  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114703993  Abcg1; ATP-binding cassette sub-family G member 1 isoform X2 [KO:K05679]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704433  [KO:K12799]
114704437  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
114704659  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114704693  Hspa5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
114704797  Hspd1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
114704800  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
114705020  Calm1; calmodulin-1 [KO:K02183]
114705140  Cd14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
114705216  Rhoa; transforming protein RhoA [KO:K04513]
114705519  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
114705602  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
114705738  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114705782  Tlr4; toll-like receptor 4 isoform X2 [KO:K10160]
114705813  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
114705817  Tnf; tumor necrosis factor [KO:K03156]
114705867  Hspa1a; heat shock 70 kDa protein 1A [KO:K03283]
114705868  [KO:K03283]
114705870  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
114705921  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114706162  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114706165  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114706175  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114706205  Irak1; interleukin-1 receptor-associated kinase 1 isoform X3 [KO:K04730] [EC:2.7.11.1]
114706431  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
114706753  [KO:K05399]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707230  Cd40lg; CD40 ligand [KO:K03161]
114707256  Rap1a; ras-related protein Rap-1A [KO:K04353]
114707396  Camk2a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
114707430  Vcam1; vascular cell adhesion protein 1 [KO:K06527]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114707732  [KO:K05408]
114707747  Ccl5; C-C motif chemokine 5 [KO:K12499]
114707842  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
114708012  Mmp1; interstitial collagenase [KO:K01388] [EC:3.4.24.7]
114708015  [KO:K01394] [EC:3.4.24.17]
114708224  Cd36; platelet glycoprotein 4 [KO:K06259]
114708232  Mib2; E3 ubiquitin-protein ligase MIB2 isoform X1 [KO:K10645] [EC:2.3.2.27]
114708260  Calml6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
114708477  Kras; GTPase KRas isoform X2 [KO:K07827]
114708768  [KO:K02183]
114708779  Calml3; calmodulin-like protein 3 [KO:K02183]
114708799  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114709020  [KO:K08738]
114709209  Calm2; calmodulin-2 [KO:K02183]
114709520  Il1b; interleukin-1 beta [KO:K04519]
114710187  Vldlr; very low-density lipoprotein receptor isoform X1 [KO:K20053]
114710188  Tlr2; toll-like receptor 2 [KO:K10159]
114710233  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
114710287  [KO:K08738]
114710385  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
114710523  [KO:K04371] [EC:2.7.11.24]
114710754  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119086152  [KO:K12799]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
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Related
pathway
pleu04020  Calcium signaling pathway
pleu04115  p53 signaling pathway
pleu04141  Protein processing in endoplasmic reticulum
pleu04151  PI3K-Akt signaling pathway
pleu04210  Apoptosis
pleu04620  Toll-like receptor signaling pathway
pleu04621  NOD-like receptor signaling pathway
pleu04668  TNF signaling pathway
pleu04670  Leukocyte transendothelial migration
pleu04975  Fat digestion and absorption
pleu04979  Cholesterol metabolism
pleu05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   

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