KEGG   PATHWAY: pvp05166
Entry
pvp05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Pteropus vampyrus (large flying fox)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
pvp05166  Human T-cell leukemia virus 1 infection
pvp05166

Disease
H00009  Adult T-cell leukemia
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288252  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
105288383  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105288413  TSPO2; translocator protein 2 [KO:K05770]
105288434  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
105288466  SRF; serum response factor isoform X1 [KO:K04378]
105288623  KAT2B; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
105288626  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
105288712  B2M; beta-2-microglobulin isoform X2 [KO:K08055]
105288830  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
105288850  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105288852  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105288878  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
105288933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105289063  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105289203  ANAPC5; anaphase-promoting complex subunit 5 isoform X2 [KO:K03352]
105289208  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105289485  TBPL1; TATA box-binding protein-like protein 1 [KO:K03120]
105289628  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
105289813  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105289893  PTTG1; securin isoform X1 [KO:K06635]
105290035  SPI1; transcription factor PU.1 [KO:K09438]
105290070  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
105290195  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105290449  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
105290574  LCK; tyrosine-protein kinase Lck isoform X1 [KO:K05856] [EC:2.7.10.2]
105291202  GPS2; G protein pathway suppressor 2 [KO:K15307]
105291226  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105291271  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X4 [KO:K04430] [EC:2.7.12.2]
105291562  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
105291624  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105292087  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105292297  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
105292451  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105292561  MYC; myc proto-oncogene protein [KO:K04377]
105292626  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
105292640  SMAD2; mothers against decapentaplegic homolog 2 isoform X3 [KO:K04500]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105293031  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105293112  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105293152  IL6; interleukin-6 isoform X2 [KO:K05405]
105293217  [KO:K09047]
105293261  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105293290  CCNA1; cyclin-A1 [KO:K06627]
105293469  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105293481  [KO:K06751]
105293539  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
105293597  [KO:K07936]
105293611  CDC23; cell division cycle protein 23 homolog [KO:K03355]
105293621  EGR1; early growth response protein 1 [KO:K09203]
105293636  TRRAP; transformation/transcription domain-associated protein [KO:K08874]
105293648  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
105293923  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105294273  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
105294314  TLN2; talin-2 [KO:K06271]
105294634  [KO:K14290]
105294703  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105294975  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
105295516  [KO:K05863]
105295611  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
105295681  BUB3; mitotic checkpoint protein BUB3 [KO:K02180]
105295781  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105295953  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
105295976  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X3 [KO:K03159]
105295979  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105296040  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105296163  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105296245  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
105296266  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105296361  FDPS; farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
105296392  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
105296460  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105296533  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105296583  CRTC1; CREB-regulated transcription coactivator 1 isoform X5 [KO:K15309]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105296612  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
105296813  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
105296840  RANBP1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
105296858  ETS1; protein C-ets-1 [KO:K02678]
105297086  CDC20; cell division cycle protein 20 homolog [KO:K03363]
105297140  [KO:K02649]
105297173  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
105297418  RELB; transcription factor RelB [KO:K09253]
105297463  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
105297518  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105297731  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X3 [KO:K04421] [EC:2.7.11.25]
105297910  KAT5; histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
105297999  RELA; transcription factor p65 [KO:K04735]
105298000  FOSL1; fos-related antigen 1 [KO:K04502]
105298014  TSPO; translocator protein isoform X1 [KO:K05770]
105298032  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
105298051  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
105298070  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105298191  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
105298360  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
105298404  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105298440  CDKN2B; cyclin-dependent kinase 4 inhibitor B isoform X4 [KO:K04685]
105298601  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105298726  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
105298727  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
105298813  EGR2; E3 SUMO-protein ligase EGR2 isoform X1 [KO:K12496]
105298947  [KO:K03358]
105299169  [KO:K02537]
105299206  TGFB3; transforming growth factor beta-3 [KO:K13377]
105299213  FOS; proto-oncogene c-Fos [KO:K04379]
105299360  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105299564  RAN; GTP-binding nuclear protein Ran [KO:K07936]
105299581  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105299605  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
105299968  CANX; calnexin [KO:K08054]
105299978  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105300023  RB1; retinoblastoma-associated protein [KO:K06618]
105300159  [KO:K04456] [EC:2.7.11.1]
105300168  ZFP36; mRNA decay activator protein ZFP36 [KO:K15308]
105300389  VENTX; homeobox protein VENTX [KO:K09341]
105300524  POLB; DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
105300538  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105300663  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
105300942  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
105300960  [KO:K06752]
105300961  [KO:K06752]
105300962  [KO:K06752]
105300964  [KO:K06752]
105300969  [KO:K06752]
105300971  [KO:K06752]
105300973  [KO:K06752]
105301004  [KO:K06752]
105301022  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105301039  [KO:K06752]
105301101  RANBP3; ran-binding protein 3 [KO:K15304]
105301205  IL15; interleukin-15 isoform X1 [KO:K05433]
105301250  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
105301762  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105301830  MSX1; homeobox protein MSX-1 [KO:K09341]
105302208  IL2; interleukin-2 [KO:K05429]
105302217  CCNA2; cyclin-A2 [KO:K06627]
105302256  TCF3; transcription factor E2-alpha [KO:K09063]
105302532  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105302600  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105302660  ESPL1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
105302895  CRTC3; CREB-regulated transcription coactivator 3 isoform X1 [KO:K16334]
105303009  NRP1; neuropilin-1 isoform X1 [KO:K06724]
105303020  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105303028  ITGB2; integrin beta-2 [KO:K06464]
105303095  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105303098  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
105303182  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105303436  JUN; transcription factor AP-1 [KO:K04448]
105303447  CDC27; cell division cycle protein 27 homolog isoform X5 [KO:K03350]
105303461  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
105303659  ANAPC15; anaphase-promoting complex subunit 15 isoform X2 [KO:K25228]
105303723  TBP; TATA-box-binding protein [KO:K03120]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105303965  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
105304017  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
105304241  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
105304277  E2F1; transcription factor E2F1 [KO:K17454]
105304456  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform X2 [KO:K06679]
105304532  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105304619  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105305089  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
105305274  [KO:K06752]
105305286  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105305325  TNF; tumor necrosis factor [KO:K03156]
105305326  LTA; lymphotoxin-alpha isoform X1 [KO:K05468]
105305333  [KO:K06752]
105305341  [KO:K06751]
105305461  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105305503  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105305546  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105305590  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
105305747  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105305833  VAC14; protein VAC14 homolog isoform X1 [KO:K15305]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105306273  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
105306301  KAT2A; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
105306335  [KO:K11223]
105306336  [KO:K11224]
105306466  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
105306467  TLN1; talin-1 [KO:K06271]
105306744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105306745  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105307128  [KO:K04503]
105307175  CALR; calreticulin [KO:K08057]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307393  CDK4; cyclin-dependent kinase 4 isoform X2 [KO:K02089] [EC:2.7.11.22]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105307737  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
105307744  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
105307874  [KO:K03357]
105307881  MSX2; homeobox protein MSX-2 [KO:K09341]
105307945  TGFB1; transforming growth factor beta-1 [KO:K13375]
105308002  [KO:K05863]
105308299  [KO:K08041] [EC:4.6.1.1]
105308400  [KO:K14290]
105308501  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105308799  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105309020  ETS2; protein C-ets-2 [KO:K21932]
105309091  TBPL2; TATA box-binding protein-like protein 2 [KO:K03120]
105309227  [KO:K06752]
105309263  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
105309400  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105309403  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
105309601  [KO:K06751]
105309663  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
105309746  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105309848  [KO:K06751]
105309856  [KO:K01397] [EC:3.4.24.23]
105309864  [KO:K06751]
105310129  [KO:K06751]
105310192  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
105310193  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
105310204  [KO:K06752]
105310338  [KO:K06752]
105310778  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
105311216  [KO:K04685]
105311493  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
105311725  [KO:K06751]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
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Reference
PMID:21994754
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Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
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Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
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Retrovirology 7:99 (2010)
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Reference
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Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
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BioSciences Master Reviews, July 2013
Reference
PMID:18923409
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Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
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Nat Rev Microbiol 6:815-26 (2008)
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Reference
PMID:15040584
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  Title
Role of the cytoskeleton during leukocyte responses.
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Nat Rev Immunol 4:110-22 (2004)
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Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
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Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
PMID:18421579
  Authors
Taylor JM, Nicot C
  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
  Journal
Apoptosis 13:733-47 (2008)
DOI:10.1007/s10495-008-0208-7
Reference
PMID:15761473
  Authors
D'Agostino DM, Silic-Benussi M, Hiraragi H, Lairmore MD, Ciminale V
  Title
The human T-cell leukemia virus type 1 p13II protein: effects on mitochondrial function and cell growth.
  Journal
Cell Death Differ 12 Suppl 1:905-15 (2005)
DOI:10.1038/sj.cdd.4401576
Reference
PMID:20332002
  Authors
Silic-Benussi M, Biasiotto R, Andresen V, Franchini G, D'Agostino DM, Ciminale V
  Title
HTLV-1 p13, a small protein with a busy agenda.
  Journal
Mol Aspects Med 31:350-8 (2010)
DOI:10.1016/j.mam.2010.03.001
Reference
PMID:23741982
  Authors
Fuentes-Gonzalez AM, Contreras-Paredes A, Manzo-Merino J, Lizano M
  Title
The modulation of apoptosis by oncogenic viruses.
  Journal
Virol J 10:182 (2013)
DOI:10.1186/1743-422X-10-182
Reference
PMID:21743832
  Authors
Qu Z, Xiao G
  Title
Human T-cell lymphotropic virus: a model of NF-kappaB-associated tumorigenesis.
  Journal
Viruses 3:714-49 (2011)
DOI:10.3390/v3060714
Reference
PMID:21994767
  Authors
Saggioro D
  Title
Anti-apoptotic effect of Tax: an NF-kappaB path or a CREB way?
  Journal
Viruses 3:1001-14 (2011)
DOI:10.3390/v3071001
Reference
PMID:16036567
  Authors
Harhaj EW, Harhaj NS
  Title
Mechanisms of persistent NF-kappaB activation by HTLV-I tax.
  Journal
IUBMB Life 57:83-91 (2005)
DOI:10.1080/15216540500078715
Reference
PMID:16155602
  Authors
Sun SC, Yamaoka S
  Title
Activation of NF-kappaB by HTLV-I and implications for cell transformation.
  Journal
Oncogene 24:5952-64 (2005)
DOI:10.1038/sj.onc.1208969
Reference
PMID:9710600
  Authors
Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC
  Title
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.
  Journal
Mol Cell Biol 18:5157-65 (1998)
DOI:10.1128/MCB.18.9.5157
Reference
PMID:21315773
  Authors
Nakachi S, Nakazato T, Ishikawa C, Kimura R, Mann DA, Senba M, Masuzaki H, Mori N
  Title
Human T-cell leukemia virus type 1 tax transactivates the matrix metalloproteinase 7 gene via JunD/AP-1 signaling.
  Journal
Biochim Biophys Acta 1813:731-41 (2011)
DOI:10.1016/j.bbamcr.2011.02.002
Reference
PMID:26797638
  Authors
James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
  Journal
Pathogens 5:8 (2016)
DOI:10.3390/pathogens5010008
Reference
PMID:26324707
  Authors
Cherian MA, Baydoun HH, Al-Saleem J, Shkriabai N, Kvaratskhelia M, Green P, Ratner L
  Title
Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.
  Journal
J Biol Chem 290:26270-81 (2015)
DOI:10.1074/jbc.M115.684746
Reference
PMID:11264182
  Authors
Mori N, Morishita M, Tsukazaki T, Giam CZ, Kumatori A, Tanaka Y, Yamamoto N
  Title
Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.
  Journal
Blood 97:2137-44 (2001)
DOI:10.1182/blood.v97.7.2137
Reference
PMID:15310405
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
Reference
PMID:11244044
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
PMID:12802280
  Authors
Gabet AS, Mortreux F, Charneau P, Riou P, Duc-Dodon M, Wu Y, Jeang KT, Wattel E
  Title
Inactivation of hTERT transcription by Tax.
  Journal
Oncogene 22:3734-41 (2003)
DOI:10.1038/sj.onc.1206468
Related
pathway
pvp03013  Nucleocytoplasmic transport
pvp04010  MAPK signaling pathway
pvp04064  NF-kappa B signaling pathway
pvp04110  Cell cycle
pvp04115  p53 signaling pathway
pvp04151  PI3K-Akt signaling pathway
pvp04210  Apoptosis
pvp04350  TGF-beta signaling pathway
pvp04612  Antigen processing and presentation
pvp04660  T cell receptor signaling pathway
pvp04668  TNF signaling pathway
KO pathway
ko05166   

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