KEGG   PATHWAY: hcg04010
Entry
hcg04010                    Pathway                                
Name
MAPK signaling pathway - Hemicordylus capensis (graceful crag lizard)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
hcg04010  MAPK signaling pathway
hcg04010

Other DBs
GO: 0000165
Organism
Hemicordylus capensis (graceful crag lizard) [GN:hcg]
Gene
128321942  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
128321963  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
128322153  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
128322195  SOS1; son of sevenless homolog 1 [KO:K03099]
128322263  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
128322332  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
128322631  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
128323285  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
128323424  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
128323596  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
128323669  [KO:K04388] [EC:2.7.11.30]
128323771  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
128323793  SOS2; son of sevenless homolog 2 [KO:K03099]
128323827  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
128323861  INS; insulin [KO:K04526]
128323870  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
128323970  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
128324003  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
128324159  STK3; serine/threonine-protein kinase 3 [KO:K04412]
128324239  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
128324264  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
128324265  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
128324461  NRAS; GTPase NRas [KO:K07828]
128324507  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
128324514  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
128324617  JUN; transcription factor Jun [KO:K04448]
128324783  ARTN; artemin isoform X1 [KO:K25415]
128324853  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
128325184  RAP1A; ras-related protein Rap-1A [KO:K04353]
128325732  KRAS; GTPase KRas isoform X1 [KO:K07827]
128326143  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
128326240  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
128326253  FGF23; fibroblast growth factor 23 [KO:K22428]
128326254  FGF6; fibroblast growth factor 6 [KO:K04358]
128326333  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
128326355  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
128326359  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
128326448  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
128326455  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128326507  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
128326545  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
128326605  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
128326702  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
128326781  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
128326862  [KO:K04358]
128326894  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
128326984  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
128326986  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
128327061  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
128327130  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
128327323  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
128327329  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
128327338  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
128327511  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
128327546  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
128327605  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
128327609  FGF2; fibroblast growth factor 2 [KO:K18497]
128327634  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
128327693  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
128327743  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
128327849  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
128327913  FGF20; fibroblast growth factor 20 [KO:K04358]
128327973  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
128328047  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
128328058  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
128328186  KITLG; kit ligand isoform X1 [KO:K05461]
128328261  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
128328275  [KO:K04347]
128328379  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
128328404  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
128328417  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
128328467  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
128328550  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
128328711  [KO:K02583]
128328763  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
128328846  NTF4; neurotrophin-4 [KO:K12457]
128328878  AREG; amphiregulin [KO:K09782]
128328891  [KO:K16342] [EC:3.1.1.4]
128328892  [KO:K16342] [EC:3.1.1.4]
128329030  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
128329055  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
128329167  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
128329184  [KO:K04438]
128329277  EREG; proepiregulin isoform X1 [KO:K09784]
128329341  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
128329378  RRAS; ras-related protein R-Ras [KO:K07830]
128329427  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128329763  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
128330226  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
128330371  [KO:K07827]
128330376  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
128330406  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
128330409  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
128330410  [KO:K04380]
128330442  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
128330528  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
128330575  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
128330614  [KO:K04468] [EC:2.7.11.24]
128330637  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
128331404  [KO:K04451]
128331417  [KO:K04451]
128331536  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
128331588  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
128331637  [KO:K16342] [EC:3.1.1.4]
128331680  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
128331714  [KO:K04421] [EC:2.7.11.25]
128331715  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
128331716  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
128331717  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
128331898  FGF3; fibroblast growth factor 3 [KO:K04358]
128332006  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
128332060  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
128332070  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
128332457  [KO:K16859]
128332483  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
128332579  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
128332580  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
128332607  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
128332752  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
128332898  [KO:K03283]
128332903  [KO:K05466]
128332952  STMN1; stathmin isoform X1 [KO:K04381]
128332987  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
128332998  RELB; transcription factor RelB isoform X1 [KO:K09253]
128333061  PPM1N; probable protein phosphatase 1N isoform X1 [KO:K04457] [EC:3.1.3.16]
128333087  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
128333100  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
128333140  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
128333147  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
128333174  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
128333498  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128333575  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
128333600  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128333731  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
128333755  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
128333860  IL1B; interleukin-1 beta [KO:K04519]
128334186  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
128334239  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
128334460  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
128334488  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
128334701  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
128334748  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
128334803  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
128334828  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
128334882  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
128334916  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128335058  [KO:K16342] [EC:3.1.1.4]
128335153  FGF7; fibroblast growth factor 7 [KO:K04358]
128335316  FGF16; fibroblast growth factor 16 isoform X1 [KO:K04358]
128335359  [KO:K05096] [EC:2.7.10.1]
128335467  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
128335655  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
128335855  NF1; neurofibromin isoform X1 [KO:K08052]
128335859  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
128335980  CRK; adapter molecule crk isoform X1 [KO:K04438]
128335983  HSPB1; heat shock protein beta-1 [KO:K04455]
128336053  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
128336396  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
128336408  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
128336440  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
128336449  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
128336632  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
128336644  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
128336685  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
128336712  CACNG3; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
128336909  [KO:K13376]
128337031  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
128337035  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
128337036  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
128337086  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
128337151  [KO:K03283]
128337152  [KO:K03283]
128337178  RELA; transcription factor p65 isoform X1 [KO:K04735]
128337328  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
128337342  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
128337353  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
128337465  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
128337546  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K05448]
128337719  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
128337824  CRKL; crk-like protein [KO:K04438]
128337837  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
128337970  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128337983  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
128338410  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
128338681  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
128338845  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
128338848  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
128338973  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
128339275  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
128339324  [KO:K16342] [EC:3.1.1.4]
128339361  [KO:K16342] [EC:3.1.1.4]
128339410  [KO:K16342] [EC:3.1.1.4]
128339448  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
128339589  FGF19; fibroblast growth factor 19 [KO:K22603]
128339879  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
128339952  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
128340034  FGF4; fibroblast growth factor 4 [KO:K04358]
128340461  HRAS; GTPase HRas isoform X1 [KO:K02833]
128340746  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
128340804  [KO:K16342] [EC:3.1.1.4]
128340805  [KO:K16342] [EC:3.1.1.4]
128340806  [KO:K16342] [EC:3.1.1.4]
128340848  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
128340943  FOS; protein c-Fos [KO:K04379]
128341137  MAX; protein max isoform X1 [KO:K04453]
128341198  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
128341561  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
128341613  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
128341705  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
128341723  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
128341738  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
128341897  [KO:K03173] [EC:2.3.2.27]
128341991  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
128342121  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
128342176  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
128342430  EFNA2; ephrin-A2 [KO:K05462]
128342436  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
128342803  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
128342807  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
128342967  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
128343025  [KO:K04392]
128343120  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
128343152  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
128343163  JUND; transcription factor JunD [KO:K04449]
128343472  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128343561  FLNA; filamin-A isoform X1 [KO:K04437]
128343579  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
128343856  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
128344085  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
128344132  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
128344426  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
128344467  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
128344573  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
128344613  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
128344689  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
128344938  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
128344962  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
128345068  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
128345198  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
128345219  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
128345244  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
128345323  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
128345404  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
128345438  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
128345500  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
128345545  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
128345559  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
128345644  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
128345666  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
128345700  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
128345840  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128345853  RASA1; ras GTPase-activating protein 1 [KO:K04352]
128345884  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
128345962  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128346024  [KO:K03156]
128346030  [KO:K03158]
128346136  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
128346145  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
128346146  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
128346169  FGF22; fibroblast growth factor 22 [KO:K04358]
128346213  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
128346246  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
128346353  NRTN; neurturin [KO:K25414]
128346700  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128346705  DUSP9; dual specificity protein phosphatase 9 isoform X1 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
128346706  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128346848  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
128347113  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
128347312  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
128347342  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
128347407  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
128347668  [KO:K08052]
128347758  [KO:K04403]
128347805  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
128347941  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
128347983  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
128348139  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
128348140  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
128348168  FGF10; fibroblast growth factor 10 [KO:K04358]
128348190  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
128348637  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
128348881  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
128349162  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
128349372  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
128349526  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128349751  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
128349760  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128349805  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
128350094  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
128350146  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
128350167  VEGFD; vascular endothelial growth factor D [KO:K05449]
128350194  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
128350370  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
128350445  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
128350566  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
128350795  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
128350826  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
128350855  [KO:K04386]
128351152  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
128351199  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
128351224  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
128351249  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
128351521  PGF; placenta growth factor isoform X1 [KO:K16859]
128351582  PDGFD; platelet-derived growth factor D [KO:K05450]
128351712  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128351802  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
128351890  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
128351911  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
128351993  FGF9; fibroblast growth factor 9 [KO:K04358]
128352414  [KO:K16342] [EC:3.1.1.4]
128352430  SRF; serum response factor isoform X1 [KO:K04378]
128352519  RASA2; ras GTPase-activating protein 2 [KO:K08053]
128352540  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
128352626  [KO:K16342] [EC:3.1.1.4]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
hcg04070  Phosphatidylinositol signaling system
hcg04110  Cell cycle
hcg04115  p53 signaling pathway
hcg04210  Apoptosis
hcg04310  Wnt signaling pathway
KO pathway
ko04010   

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