KEGG   PATHWAY: aml05132
Entry
aml05132                    Pathway                                
Name
Salmonella infection - Ailuropoda melanoleuca (giant panda)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
aml05132  Salmonella infection
aml05132

Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100464041  PODXL; podocalyxin [KO:K06817]
100474611  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
100481281  RAB5A; ras-related protein Rab-5A [KO:K07887]
100468736  RAB5B; ras-related protein Rab-5B [KO:K07888]
100469007  RAB5C; ras-related protein Rab-5C [KO:K07889]
100465351  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100480073  RAB7A; ras-related protein Rab-7a [KO:K07897]
100475271  RAB7B; ras-related protein Rab-7b [KO:K07898]
100472762  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
100464285  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
100470346  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
100482222  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
100468472  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
100479213  VPS39; vam6/Vps39-like protein isoform X2 [KO:K20183]
100464972  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
100466568  RILP; rab-interacting lysosomal protein isoform X2 [KO:K13883]
100467615  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
100481681  DYNC2H1; LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
100465154  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
100483525  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
100470593  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
100464013  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
100475288  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 isoform X2 [KO:K10417]
100475205  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
100478628  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
100484588  dynein light chain 1, cytoplasmic [KO:K10418]
117798873  dynein light chain 1, cytoplasmic-like [KO:K10418]
100481075  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
100479703  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
100482230  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
117797415  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
100475411  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
100479564  DCTN2; dynactin subunit 2 isoform X6 [KO:K10424]
100478449  DCTN3; dynactin subunit 3 [KO:K10425]
100469749  DCTN4; dynactin subunit 4 isoform X2 [KO:K10426]
100477250  DCTN5; dynactin subunit 5 [KO:K10427]
100473534  DCTN6; dynactin subunit 6 isoform X2 [KO:K10428]
117797767  LOW QUALITY PROTEIN: dynactin subunit 6-like [KO:K10428]
117798362  LOW QUALITY PROTEIN: dynactin subunit 6-like [KO:K10428]
100475780  ACTR1A; alpha-centractin [KO:K16575]
100464465  ACTR1B; beta-centractin isoform X1 [KO:K16575]
100468471  ACTR10; actin-related protein 10 isoform X1 [KO:K16576]
100480515  tubulin alpha-8 chain [KO:K07374]
100468269  TUBA4B; LOW QUALITY PROTEIN: putative tubulin-like protein alpha-4B [KO:K07374]
100470688  LOW QUALITY PROTEIN: tubulin alpha-3 chain [KO:K07374]
100463766  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
100464995  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
100475162  LOW QUALITY PROTEIN: tubulin alpha-1C chain [KO:K07374]
100466505  tubulin alpha-4A chain isoform X2 [KO:K07374]
100468734  TUBB1; LOW QUALITY PROTEIN: tubulin beta-1 chain [KO:K07375]
100463763  TUBB4B; tubulin beta-4B chain [KO:K07375]
100484048  TUBB6; tubulin beta-6 chain [KO:K07375]
100470125  tubulin beta-2 chain [KO:K07375]
100468119  tubulin beta-3 chain [KO:K07375]
100478851  tubulin beta chain-like [KO:K07375]
105240041  tubulin beta chain [KO:K07375]
100475096  TUBB4A; tubulin beta-4A chain [KO:K07375]
100476093  TUBB; tubulin beta chain [KO:K07375]
117800503  tubulin beta-4B chain-like isoform X1 [KO:K07375]
100483562  FYCO1; FYVE and coiled-coil domain-containing protein 1 isoform X2 [KO:K21954]
100465387  ARL8A; ADP-ribosylation factor-like protein 8A isoform X2 [KO:K07955]
100467665  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
100482759  PLEKHM2; pleckstrin homology domain-containing family M member 2 [KO:K15348]
100479975  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
100474200  KIF5B; kinesin-1 heavy chain [KO:K10396]
100484204  KIF5C; kinesin heavy chain [KO:K10396]
100484737  KLC4; kinesin light chain 4 [KO:K10407]
100481191  KLC3; kinesin light chain 3 [KO:K10407]
100464655  KLC1; kinesin light chain 1 isoform X3 [KO:K10407]
100483172  KLC2; kinesin light chain 2 [KO:K10407]
100479112  ACBD3; Golgi resident protein GCP60 [KO:K23935]
100476723  RHOA; transforming protein RhoA [KO:K04513]
100472556  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
100484042  RAB9A; ras-related protein Rab-9A [KO:K07899]
100467180  RAB9B; ras-related protein Rab-9B [KO:K07900]
100466775  GCC2; GRIP and coiled-coil domain-containing protein 2 isoform X1 [KO:K20282]
100480932  STX10; syntaxin-10 isoform X1 [KO:K23937]
100475516  PFN3; profilin-3 [KO:K05759]
100471904  profilin-1 [KO:K05759]
100466871  PFN1; profilin-1 [KO:K05759]
100472573  PFN4; profilin-4 [KO:K05759]
100482217  profilin-1 [KO:K05759]
109490262  PFN2; profilin-2 [KO:K05759]
100467791  FLNA; filamin-A isoform X1 [KO:K04437]
100472763  EXOC7; exocyst complex component 7 isoform X2 [KO:K07195]
100475536  EXOC5; exocyst complex component 5 isoform X1 [KO:K19984]
100475239  EXOC4; exocyst complex component 4 [KO:K06111]
100465762  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
100484672  RALA; ras-related protein Ral-A [KO:K07834]
100466132  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100481739  actin [KO:K05692]
117800125  actin, cytoplasmic 1 [KO:K05692]
117800181  actin, cytoplasmic type 5 isoform X1 [KO:K05692]
117800361  actin, cytoplasmic 1-like [KO:K05692]
117800408  actin, cytoplasmic 1 [KO:K05692]
100468998  S100A10; protein S100-A10 [KO:K17274]
100468259  ANXA2; annexin A2 [KO:K17092]
117800111  annexin A2 [KO:K17092]
117800195  annexin A2-A-like [KO:K17092]
100464100  AHNAK; LOW QUALITY PROTEIN: neuroblast differentiation-associated protein AHNAK [KO:K23934]
109491180  AHNAK2; LOW QUALITY PROTEIN: protein AHNAK2 [KO:K23934]
100472995  RHOJ; rho-related GTP-binding protein RhoJ [KO:K07864]
100481614  ARHGEF26; rho guanine nucleotide exchange factor 26 [KO:K13744]
100470143  rho-related GTP-binding protein RhoG [KO:K07863]
100475758  RHOG; rho-related GTP-binding protein RhoG [KO:K07863]
100473639  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
100471977  ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
100466003  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100483724  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100480867  MYL5; myosin light chain 5 [KO:K12753]
100475493  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
100465571  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100480951  MYL10; myosin regulatory light chain 10 [KO:K12756]
100471142  myosin regulatory light chain 12B [KO:K12757]
100472299  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
117799888  myosin regulatory light chain 2, smooth muscle minor isoform-like isoform X1 [KO:K12757]
100480191  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
117799351  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
100463903  FHOD1; LOW QUALITY PROTEIN: FH1/FH2 domain-containing protein 1 [KO:K23938]
100465076  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100465648  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100479680  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
100470804  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
100475933  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
100467958  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
100465106  ABI1; abl interactor 1 isoform X1 [KO:K23649]
100469366  BRK1; protein BRICK1 [KO:K05752]
100476372  probable protein BRICK1 [KO:K05752]
100467351  WASF3; wiskott-Aldrich syndrome protein family member 3 isoform X1 [KO:K06083]
100464823  ACTR2; actin-related protein 2 [KO:K17260]
100464477  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
100476247  ACTR3; actin-related protein 3 [KO:K18584]
100483279  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
100483527  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
100483318  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
100464628  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
117799109  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
117799478  actin-related protein 2/3 complex subunit 3-A-like [KO:K05756]
105240100  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
100475576  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100478818  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100472811  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100481001  PAK3; serine/threonine-protein kinase PAK 3 isoform X8 [KO:K05733] [EC:2.7.11.1]
100467348  MYO6; unconventional myosin-VI isoform X3 [KO:K10358]
100463775  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100479294  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100479580  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100470322  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X2 [KO:K21289] [EC:2.7.1.153]
100481616  PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923] [EC:2.7.1.154]
100470614  PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X2 [KO:K00923] [EC:2.7.1.154]
100465834  PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
100466399  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
100478548  CYTH4; cytohesin-4 isoform X2 [KO:K18441]
100480332  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
100480412  CYTH2; cytohesin-2 isoform X2 [KO:K18441]
100473890  ARF6; ADP-ribosylation factor 6 [KO:K07941]
100473581  ARF1; ADP-ribosylation factor 1 isoform X1 [KO:K07937]
100471307  ADP-ribosylation factor 2 [KO:K07937]
117799821  ADP-ribosylation factor 1-like [KO:K07937]
100463542  SNX9; sorting nexin-9 [KO:K17923]
100471053  SNX18; LOW QUALITY PROTEIN: sorting nexin-18 [KO:K17923]
100478096  SNX33; sorting nexin-33 isoform X1 [KO:K17923]
100472179  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
100466002  DNM2; dynamin-2 isoform X8 [KO:K23484] [EC:3.6.5.5]
100472456  TLR6; toll-like receptor 6 isoform X2 [KO:K10169]
100465129  TLR2; toll-like receptor 2 [KO:K10159]
100470794  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X2 [KO:K05403]
100479307  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
100467208  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100472815  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100468714  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
100475654  TLR5; toll-like receptor 5 isoform X8 [KO:K10168]
100484977  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
100469127  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100483216  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100466506  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
100484077  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
100468085  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
100464125  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
100470223  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
100464675  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
100471679  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100466997  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100479663  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
100471414  HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079]
100467363  HSP90AA1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079]
117803466  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
100474020  HSP90B1; endoplasmin [KO:K09487]
100480506  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
100483977  CSE1L; exportin-2 [KO:K18423]
100464606  KPNA1; importin subunit alpha-5 [KO:K23940]
100473566  KPNA4; importin subunit alpha-3 [KO:K23583]
100483444  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
100469997  RPS3; 40S ribosomal protein S3 [KO:K02985]
100473836  HRAS; GTPase HRas isoform X1 [KO:K02833]
100482255  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100478039  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100465700  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100470035  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100472388  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100476678  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
100469111  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
100465223  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100465476  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
100480235  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100480483  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100475919  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100475975  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100477951  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100482196  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100477600  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100474867  FOS; proto-oncogene c-Fos [KO:K04379]
100483834  JUN; transcription factor AP-1 [KO:K04448]
100471563  TNF; tumor necrosis factor [KO:K03156]
100480874  IL1B; interleukin-1 beta [KO:K04519]
100477151  IL6; interleukin-6 precursor [KO:K05405]
117803984  interleukin-6-like [KO:K05405]
100472054  CXCL8; interleukin-8 [KO:K10030]
100477834  CTNNB1; catenin beta-1 [KO:K02105]
100476528  TCF7; transcription factor 7 isoform X2 [KO:K02620]
100480690  TCF7L1; transcription factor 7-like 1 [KO:K04490]
100467719  TCF7L2; transcription factor 7-like 2 isoform X6 [KO:K04491]
100465982  LEF1; lymphoid enhancer-binding factor 1 isoform X2 [KO:K04492]
100464396  MYC; myc proto-oncogene protein [KO:K04377]
100469677  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
100471238  FBXO22; F-box only protein 22 isoform X2 [KO:K10302]
100463880  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
100479926  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100474087  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100483589  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
100477152  baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
100477406  baculoviral IAP repeat-containing protein 2 [KO:K16060]
100469872  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
100478741  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
100480864  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
100475419  LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
117800152  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
117800205  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
100463573  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
105235183  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
100468003  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
100472842  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100465668  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X3 [KO:K08847] [EC:2.7.11.1]
100471095  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
100472241  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
100472074  cytochrome c [KO:K08738]
105241648  cytochrome c-like [KO:K08738]
100484344  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
100469056  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100471992  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
100469564  RHOB; rho-related GTP-binding protein RhoB [KO:K07856]
100469792  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
100467568  RRAS; ras-related protein R-Ras [KO:K07829]
100468763  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100480414  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100465793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100477286  TXN2; thioredoxin, mitochondrial isoform X2 [KO:K03671]
100477884  TXN; thioredoxin [KO:K03671]
109490451  thioredoxin [KO:K03671]
100468792  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
105236112  NAIP; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1 [KO:K12807]
100464785  NLRC4; LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4 [KO:K12805]
100475582  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
100484109  IL18; interleukin-18 [KO:K05482]
100464921  caspase-13 isoform X2 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
100484366  GSDMD; gasdermin-D isoform X1 [KO:K20917]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
aml04010  MAPK signaling pathway
aml04064  NF-kappa B signaling pathway
aml04210  Apoptosis
aml04217  Necroptosis
aml04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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