KEGG   PATHWAY: efus05132
Entry
efus05132                   Pathway                                
Name
Salmonella infection - Eptesicus fuscus (big brown bat)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
efus05132  Salmonella infection
efus05132

Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103294180  PODXL; podocalyxin [KO:K06817]
114229593  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
103296869  RAB5A; ras-related protein Rab-5A [KO:K07887]
103292407  RAB5B; ras-related protein Rab-5B [KO:K07888]
103293097  RAB5C; ras-related protein Rab-5C [KO:K07889]
103303864  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
103302274  RAB7A; ras-related protein Rab-7a [KO:K07897]
103297486  RAB7B; ras-related protein Rab-7b [KO:K07898]
103293008  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
103293722  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
103285622  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
103287325  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
103287022  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
103287346  VPS39; vam6/Vps39-like protein [KO:K20183]
103295023  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
103291846  RILP; rab-interacting lysosomal protein isoform X5 [KO:K13883]
103298032  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
103293792  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X2 [KO:K10414]
103283319  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X2 [KO:K10415]
103292594  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
103284554  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
103297237  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
103305434  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
103287106  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
103291655  DYNLL2; dynein light chain 2, cytoplasmic isoform X2 [KO:K10418]
103284392  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
103293423  DYNLRB1; dynein light chain roadblock-type 1 isoform X2 [KO:K10419]
103297935  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
103302500  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
103286565  dynein light chain Tctex-type 1-like [KO:K10420]
103291406  DCTN1; dynactin subunit 1 isoform X2 [KO:K04648]
103292465  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
103286460  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
103295758  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
103296303  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
103290288  DCTN6; dynactin subunit 6 isoform X1 [KO:K10428]
103288517  ACTR1A; alpha-centractin [KO:K16575]
103299656  ACTR1B; beta-centractin [KO:K16575]
103283701  ACTR10; actin-related protein 10 [KO:K16576]
103285264  tubulin alpha-1A chain [KO:K07374]
103289293  TUBA4A; tubulin alpha-4A chain [KO:K07374]
103289950  tubulin alpha-1C chain [KO:K07374]
103292767  tubulin alpha-1C chain-like [KO:K07374]
103286986  tubulin alpha-3 chain [KO:K07374]
103289292  tubulin alpha-1D chain [KO:K07374]
103287202  tubulin alpha-3 chain [KO:K07374]
103285518  TUBA1C; tubulin alpha-1C chain [KO:K07374]
129149800  tubulin alpha-1B chain [KO:K07374]
103298570  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
103284665  TUBB3; tubulin beta-3 chain [KO:K07375]
103295979  TUBB4B; tubulin beta-4B chain [KO:K07375]
103300490  TUBB; tubulin beta chain isoform X1 [KO:K07375]
103303526  TUBB1; tubulin beta-1 chain [KO:K07375]
103294185  TUBB4A; tubulin beta-4A chain [KO:K07375]
103302885  tubulin beta-2B chain isoform X1 [KO:K07375]
103302659  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
103297567  FYCO1; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
103302936  ARL8A; ADP-ribosylation factor-like protein 8A isoform X1 [KO:K07955]
103300440  ARL8B; ADP-ribosylation factor-like protein 8B isoform X1 [KO:K07955]
103292108  PLEKHM2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
103292468  KIF5A; kinesin heavy chain [KO:K10396]
103304046  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
103283420  KIF5C; kinesin heavy chain [KO:K10396]
103290962  KLC2; kinesin light chain 2 [KO:K10407]
103296647  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
103301389  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
103301801  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
103293442  ACBD3; Golgi resident protein GCP60 [KO:K23935]
103298865  RHOA; transforming protein RhoA [KO:K04513]
103295254  transforming protein RhoA-like [KO:K04513]
103285077  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
103298170  RAB9A; ras-related protein Rab-9A [KO:K07899]
103302158  RAB9B; ras-related protein Rab-9B [KO:K07900]
103297439  GCC2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
103301000  STX10; syntaxin-10 isoform X2 [KO:K23937]
103287355  PFN3; profilin-3 [KO:K05759]
103299860  PFN1; profilin-1 [KO:K05759]
103305459  PFN4; profilin-4 isoform X1 [KO:K05759]
103302962  PFN2; profilin-2 isoform X1 [KO:K05759]
103302227  FLNA; filamin-A isoform X1 [KO:K04437]
103298267  EXOC7; exocyst complex component 7 isoform X2 [KO:K07195]
103283707  EXOC5; exocyst complex component 5 isoform X1 [KO:K19984]
103294127  EXOC4; exocyst complex component 4 [KO:K06111]
103304189  EXOC2; exocyst complex component 2 [KO:K17637]
103293905  RALA; ras-related protein Ral-A [KO:K07834]
103299154  ACTB; actin, cytoplasmic 1 [KO:K05692]
103298235  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103291259  S100A10; protein S100-A10 [KO:K17274]
103302178  protein S100-A10-like [KO:K17274]
129151100  protein S100-A10 [KO:K17274]
103283842  ANXA2; annexin A2 isoform X2 [KO:K17092]
103301820  AHNAK2; protein AHNAK2 isoform X1 [KO:K23934]
114229337  AHNAK; neuroblast differentiation-associated protein AHNAK [KO:K23934]
103283668  RHOJ; rho-related GTP-binding protein RhoJ [KO:K07864]
103286669  ARHGEF26; rho guanine nucleotide exchange factor 26 [KO:K13744]
103293555  RHOG; rho-related GTP-binding protein RhoG [KO:K07863]
103291245  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
103302020  ELMO2; engulfment and cell motility protein 2 [KO:K18985]
103305588  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
103287051  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103294591  MYL5; myosin light chain 5 isoform X2 [KO:K12753]
103303626  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
103293324  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103286246  MYL10; myosin regulatory light chain 10 [KO:K12756]
103302989  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
114230017  myosin regulatory light chain 12B isoform X1 [KO:K12757]
103296328  MYL11; myosin regulatory light chain 11 isoform X2 [KO:K12758]
103284573  FHOD1; FH1/FH2 domain-containing protein 1 isoform X2 [KO:K23938]
103291971  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103289160  LOW QUALITY PROTEIN: cell division control protein 42 homolog [KO:K04393]
103286714  cell division control protein 42 homolog [KO:K04393]
103299146  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103285375  NCKAP1L; nck-associated protein 1-like [KO:K05750]
103283467  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
103291606  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
103304009  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
103304518  ABI1; abl interactor 1 isoform X1 [KO:K23649]
103295527  BRK1; protein BRICK1 [KO:K05752]
103288747  probable protein BRICK1 [KO:K05752]
129149692  protein BRICK1-like [KO:K05752]
103296736  WASF3; actin-binding protein WASF3 isoform X1 [KO:K06083]
103291478  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
103287752  ACTR3; actin-related protein 3 [KO:K18584]
103301769  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
103285957  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X2 [KO:K05757]
103285958  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
103289324  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
103287040  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X2 [KO:K05756]
103295429  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
103298511  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
103290021  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
103293618  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
103301610  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
103286637  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
103286747  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103296140  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103295411  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103293615  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
103285131  PIK3C2G; phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1 [KO:K00923] [EC:2.7.1.154]
103294595  PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
103297504  PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X2 [KO:K00923] [EC:2.7.1.154]
103288891  CYTH4; cytohesin-4 [KO:K18441]
103297663  CYTH2; cytohesin-2 isoform X1 [KO:K18441]
103298248  CYTH1; cytohesin-1 isoform X1 [KO:K18441]
103299145  CYTH3; cytohesin-3 [KO:K18441]
103283767  ARF6; ADP-ribosylation factor 6 [KO:K07941]
103292008  ADP-ribosylation factor 1-like isoform X1 [KO:K07937]
103292112  ADP-ribosylation factor 1-like [KO:K07937]
103292199  ADP-ribosylation factor 1-like isoform X1 [KO:K07937]
103295010  ARF1; ADP-ribosylation factor 1 [KO:K07937]
103293167  ADP-ribosylation factor 2-like isoform X1 [KO:K07937]
129150590  ADP-ribosylation factor 1-like [KO:K07937]
103300176  SNX33; sorting nexin-33 isoform X2 [KO:K17923]
103303108  SNX18; sorting nexin-18 [KO:K17923]
103297961  SNX9; sorting nexin-9 [KO:K17923]
103302636  WASL; actin nucleation-promoting factor WASL [KO:K23612]
103301120  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
103284904  TLR6; toll-like receptor 6 [KO:K10169]
103288450  TLR2; toll-like receptor 2 [KO:K10159]
103287175  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
103298161  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103289828  CD14; monocyte differentiation antigen CD14 [KO:K04391]
103295671  TLR4; toll-like receptor 4 [KO:K10160]
103293936  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
103293531  TLR5; toll-like receptor 5 [KO:K10168]
129147057  TLR9; toll-like receptor 9 [KO:K10161]
103302249  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
103285212  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X2 [KO:K04733] [EC:2.7.11.1]
103290874  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103293777  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
103288851  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103302357  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
103297850  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
103302255  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103288473  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
103288179  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103301979  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103299786  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103291087  RELA; transcription factor p65 isoform X1 [KO:K04735]
103291550  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
103296621  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
103298031  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
103288948  HSP90B1; endoplasmin isoform X1 [KO:K09487]
103301859  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
103285730  CSE1L; exportin-2 [KO:K18423]
103290748  KPNA1; importin subunit alpha-5 [KO:K23940]
103286695  KPNA4; importin subunit alpha-3 isoform X1 [KO:K23583]
103295628  KPNA3; importin subunit alpha-4 isoform X1 [KO:K23583]
103293604  RPS3; 40S ribosomal protein S3 [KO:K02985]
103302548  HRAS; GTPase HRas isoform X1 [KO:K02833]
103295757  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103283794  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
103294231  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103287001  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103296283  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103303990  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
103299424  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
103295508  MAPK14; mitogen-activated protein kinase 14 isoform X3 [KO:K04441] [EC:2.7.11.24]
103298650  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103298707  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
103295577  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103296845  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103295027  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X7 [KO:K04431] [EC:2.7.12.2]
103301660  MAPK9; mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
103292821  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103287875  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103283560  FOS; protein c-Fos [KO:K04379]
103284067  JUN; transcription factor Jun [KO:K04448]
103300478  TNF; tumor necrosis factor isoform X1 [KO:K03156]
103303246  IL1B; interleukin-1 beta [KO:K04519]
103292051  IL6; interleukin-6 [KO:K05405]
129150475  interleukin-8-like [KO:K10030]
129150773  CXCL8; interleukin-8 [KO:K10030]
103297942  CTNNB1; catenin beta-1 [KO:K02105]
103286726  TCF7; transcription factor 7 isoform X1 [KO:K02620]
103299070  TCF7L1; transcription factor 7-like 1 [KO:K04490]
103288569  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
103293875  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
103292358  MYC; myc proto-oncogene protein [KO:K04377]
103300985  PKN1; serine/threonine-protein kinase N1 isoform X2 [KO:K06071] [EC:2.7.11.13]
103304935  FBXO22; F-box only protein 22 [KO:K10302]
129152067  S-phase kinase-associated protein 1-like [KO:K03094]
129149958  S-phase kinase-associated protein 1 [KO:K03094]
103289002  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103295968  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103284564  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
103292960  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
103292961  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
103302882  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
103283408  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
103289010  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
103303250  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
103292606  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
129148816  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
103286737  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
103295138  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X2 [KO:K04722]
103291049  FADD; FAS-associated death domain protein [KO:K02373]
103290541  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103301469  RIPK3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
103297647  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103303014  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103292869  cytochrome c-like [KO:K08738]
103291881  cytochrome c [KO:K08738]
103305670  cytochrome c-like [KO:K08738]
103303075  cytochrome c-like [KO:K08738]
129150288  cytochrome c-like [KO:K08738]
103300565  cytochrome c-like [KO:K08738]
103303728  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
103295435  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103288572  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
103305566  RHOB; rho-related GTP-binding protein RhoB [KO:K07856]
103284921  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
103297766  RRAS; ras-related protein R-Ras [KO:K07829]
103284312  AKT2; RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
103301793  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103293483  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103284722  MLKL; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
103286353  TXN; thioredoxin [KO:K03671]
103288906  TXN2; thioredoxin, mitochondrial [KO:K03671]
103301652  thioredoxin-like [KO:K03671]
103298793  thioredoxin, mitochondrial-like [KO:K03671]
103295113  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
103305174  NAIP; baculoviral IAP repeat-containing protein 1 [KO:K12807]
103305480  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
103296229  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
103299256  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
103293786  IL18; interleukin-18 isoform X1 [KO:K05482]
103303785  caspase-1-like [KO:K04394] [EC:3.4.22.57 3.4.22.64]
114227918  caspase-1-like [KO:K04394] [EC:3.4.22.57 3.4.22.64]
103299257  caspase-13-like [KO:K04394] [EC:3.4.22.57 3.4.22.64]
103302716  GSDMD; gasdermin-D isoform X1 [KO:K20917]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
efus04010  MAPK signaling pathway
efus04064  NF-kappa B signaling pathway
efus04210  Apoptosis
efus04217  Necroptosis
efus04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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