KEGG   PATHWAY: mcoc04014
Entry
mcoc04014                   Pathway                                
Name
Ras signaling pathway - Mastomys coucha (southern multimammate mouse)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
mcoc04014  Ras signaling pathway
mcoc04014

Other DBs
GO: 0032318
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116093773  Egf; pro-epidermal growth factor [KO:K04357]
116099176  Tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
116087087  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116095116  Fgf2; fibroblast growth factor 2 isoform X1 [KO:K18497]
116098343  Fgf6; fibroblast growth factor 6 [KO:K04358]
116100989  Fgf3; fibroblast growth factor 3 [KO:K04358]
116100990  Fgf4; fibroblast growth factor 4 [KO:K04358]
116101280  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116083356  Fgf10; fibroblast growth factor 10 [KO:K04358]
116093940  Fgf16; fibroblast growth factor 16 [KO:K04358]
116084437  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116084719  Fgf9; fibroblast growth factor 9 [KO:K04358]
116076064  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
116078435  Fgf18; fibroblast growth factor 18 [KO:K04358]
116071359  Fgf20; fibroblast growth factor 20 [KO:K04358]
116090856  Fgf7; fibroblast growth factor 7 [KO:K04358]
116100991  Fgf19; fibroblast growth factor 19 [KO:K22603]
116100498  Fgf21; fibroblast growth factor 21 [KO:K22429]
116098344  Fgf23; fibroblast growth factor 23 [KO:K22428]
116093520  Ngf; beta-nerve growth factor isoform X1 [KO:K02582]
116090620  Bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116099618  Ntf3; neurotrophin-3 isoform X1 [KO:K04356]
116102198  Ntf4; neurotrophin-4 [KO:K12457]
116101481  insulin-1 [KO:K04526]
116076407  Igf1; insulin-like growth factor I isoform X1 [KO:K05459]
116103249  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
116068639  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116076069  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
116093026  Pdgfc; platelet-derived growth factor C [KO:K05450]
116072446  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
116093601  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
116076467  Kitlg; kit ligand isoform X1 [KO:K05461]
116102173  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
116074720  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
116103472  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
116079820  Pgf; placenta growth factor [KO:K16859]
116069284  Vegfc; vascular endothelial growth factor C [KO:K05449]
116090438  Vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
116097489  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
116082804  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
116068986  Angpt2; angiopoietin-2 isoform X1 [KO:K05466]
116091151  Angpt4; angiopoietin-4 [KO:K05467]
116093165  Efna1; ephrin-A1 isoform X1 [KO:K05462]
116093166  Efna3; ephrin-A3 isoform X1 [KO:K05462]
116093175  Efna4; ephrin-A4 [KO:K05462]
116076345  Efna2; ephrin-A2 [KO:K05462]
116088835  Efna5; ephrin-A5 isoform X1 [KO:K05462]
116071392  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116069056  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
116103077  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116069961  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116082061  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116078356  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
116094433  high affinity nerve growth factor receptor-like [KO:K03176] [EC:2.7.10.1]
116093096  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
116082168  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
116068825  Insr; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
116102373  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116071260  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116087226  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116087228  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116071281  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116068778  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
116068780  Flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116078943  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116071284  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116098601  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116096241  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
116096958  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
116076719  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
116069645  Gab1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
116102583  Gab2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
116093178  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
116076241  Shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
116081462  Shc3; SHC-transforming protein 3 [KO:K17448]
116090849  Shc4; SHC-transforming protein 4 [KO:K17449]
116068338  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
116080813  Sos1; son of sevenless homolog 1 [KO:K03099]
116080934  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
116091317  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116070251  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
116090682  Rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
116103453  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
116079748  Rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
116101938  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
116084142  uncharacterized protein LOC116084142 [KO:K10784]
116084801  uncharacterized protein LOC116084801 [KO:K10784]
116088313  tyrosine-protein kinase ZAP-70 [KO:K07360] [EC:2.7.10.2]
116100904  Lat; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
116103776  Htr7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
116097142  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
116068597  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
116099581  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
116095064  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
116073026  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
116085348  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
116103521  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
116082206  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
116093923  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
116076327  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
116101712  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
116096080  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
116098540  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
116099017  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116069754  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
116078416  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
116097985  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
116078231  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
116093928  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116069698  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
116072459  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
116083194  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
116089804  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
116084963  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
116099710  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116102663  calmodulin-like [KO:K02183]
116101711  Calm3; calmodulin-3 [KO:K02183]
116082411  calmodulin-4 [KO:K02183]
116069997  calmodulin-like [KO:K02183]
116079808  Calm1; calmodulin-1 [KO:K02183]
116079993  Calm2; calmodulin-2 [KO:K02183]
116073523  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
116081777  calmodulin-like protein 3 [KO:K02183]
116099791  Kras; GTPase KRas isoform X1 [KO:K07827]
116093530  Nras; GTPase NRas [KO:K07828]
116072312  Mras; ras-related protein M-Ras [KO:K07831]
116102164  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
116102825  Rras2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
116079194  Nf1; neurofibromin isoform X1 [KO:K08052]
116083408  Rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
116073884  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
116068941  Rasa3; ras GTPase-activating protein 3 isoform X1 [KO:K12380]
116104677  ras GTPase-activating protein 4-like [KO:K17630]
116075470  Syngap1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
116068325  Rasal1; rasGAP-activating-like protein 1 isoform X1 [KO:K17632]
116101976  Rasal2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
116076225  Rasal3; RAS protein activator like-3 isoform X1 [KO:K17634]
116072255  Rassf1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
116098819  Rassf5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
116091355  Stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
116086106  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116075508  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116077969  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116102599  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
116085808  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116089228  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
116101918  Pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
116091004  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
116090694  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
116073981  Rhoa; transforming protein RhoA [KO:K04513]
116076329  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
116095058  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116097037  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116073929  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116096465  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116083721  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116069491  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116101889  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116104026  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116079779  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116086280  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
116103881  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116069014  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
116093825  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116103403  Rela; transcription factor p65 isoform X1 [KO:K04735]
116103467  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
116091179  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
116087162  Foxo4; forkhead box protein O4 [KO:K12358]
116070785  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
116079876  Ralgapa1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
116091084  Ralgapa2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
116091307  Ralgapb; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
116089898  Ralgds; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
116100998  Rgl1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
116074979  Rgl2; ral guanine nucleotide dissociation stimulator-like 2 [KO:K17636]
116081427  Rala; ras-related protein Ral-A [KO:K07834]
116097777  Ralb; ras-related protein Ral-B [KO:K07835]
116095022  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
116079039  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
116082215  Exoc2; exocyst complex component 2 [KO:K17637]
116076589  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
116068901  Rel; proto-oncogene c-Rel isoform X1 [KO:K09254]
116085336  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116067982  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116076765  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116088854  Ralbp1; ralA-binding protein 1 [KO:K08773]
116096877  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116078310  Afdn; afadin isoform X1 [KO:K05702]
116104003  Shoc2; leucine-rich repeat protein SHOC-2 isoform X1 [KO:K19613]
116099433  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116073764  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116076013  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116085898  Pla1a; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
116095624  Pla2g2e; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116096907  Pla2g2c; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116096908  Pla2g2f; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116096909  Pla2g2d; group IID secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
116096911  Pla2g5; calcium-dependent phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
116096913  Pla2g2a; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
116074363  Pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
116093782  Pla2g12a; group XIIA secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
116085596  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
116070520  Pla2g3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
116070835  Pla2g1b; phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
116100272  Pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
116100719  Pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
116090743  Pla2g4b; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
116090754  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
116090758  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
116090760  Pla2g4d; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
116075844  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
116103494  phospholipase A and acyltransferase 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
116073994  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
116073851  Ets1; protein C-ets-1 isoform X1 [KO:K02678]
116086178  Ets2; protein C-ets-2 [KO:K21932]
116104636  Brap; BRCA1-associated protein [KO:K10632] [EC:2.3.2.27]
116079024  Ksr1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
116068286  Ksr2; kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
116080810  Rapgef5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
116092927  ras-related protein Rap-1A-like [KO:K04353]
116093571  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
116075736  Rap1b; ras-related protein Rap-1b [KO:K07836]
116103808  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
116076783  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116102917  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116101512  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
116103360  Rin1; ras and Rab interactor 1 isoform X1 [KO:K17638]
116089976  Abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
116101837  Abl2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
116074344  Rab5a; ras-related protein Rab-5A [KO:K07887]
116076052  Rab5b; ras-related protein Rab-5B [KO:K07888]
116102056  LOW QUALITY PROTEIN: ras-related protein Rab-5C-like [KO:K07889]
116078733  Rab5c; ras-related protein Rab-5C [KO:K07889]
116080270  Arf6; ADP-ribosylation factor 6 [KO:K07941]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
mcoc04010  MAPK signaling pathway
mcoc04015  Rap1 signaling pathway
mcoc04020  Calcium signaling pathway
mcoc04144  Endocytosis
mcoc04151  PI3K-Akt signaling pathway
mcoc04660  T cell receptor signaling pathway
mcoc04720  Long-term potentiation
mcoc04810  Regulation of actin cytoskeleton
KO pathway
ko04014   
LinkDB

DBGET integrated database retrieval system