KEGG   PATHWAY: mlx05170
Entry
mlx05170                    Pathway                                
Name
Human immunodeficiency virus 1 infection - Mirounga leonina (Southern elephant seal)
Description
Human immunodeficiency virus type 1 (HIV-1) , the causative agent of AIDS (acquired immunodeficiency syndrome), is a lentivirus belonging to the Retroviridae family. The primary cell surface receptor for HIV-1, the CD4 protein, and the co-receptor for HIV-1, either CCR5 or CXCR4, are found on macrophages and T lymphocytes. At the earliest step, sequential binding of virus envelope (Env) glycoprotein gp120 to CD4 and the co-receptor CCR5 or CXCR4 facilitates HIV-1 entry and has the potential to trigger critical signaling that may favor viral replication. At advanced stages of the disease, HIV-1 infection results in dramatic induction of T-cell (CD4+ T and CD8+ T cell) apoptosis both in infected and uninfected bystander T cells, a hallmark of HIV-1 pathogenesis. On the contrary, macrophages are resistant to the cytopathic effect of HIV-1 and produce virus for longer periods of time.
Class
Human Diseases; Infectious disease: viral
Pathway map
mlx05170  Human immunodeficiency virus 1 infection
mlx05170

Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118025728  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
118016673  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
118025164  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
118016639  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
118021218  CUL1; cullin-1 [KO:K03347]
117998640  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
118012497  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
118004927  C-C chemokine receptor type 5 [KO:K04180]
118019030  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
118005775  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
118020679  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
118023770  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
118004424  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118020028  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118006556  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118016863  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118019468  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118006042  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118015244  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118022110  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
118018538  PXN; paxillin isoform X1 [KO:K05760]
118025226  CRK; adapter molecule crk isoform X1 [KO:K04438]
117999812  CRKL; crk-like protein [KO:K04438]
118022658  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118002024  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118014553  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118020008  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118016129  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
118024673  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118027047  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118016059  RELA; transcription factor p65 [KO:K04735]
118002212  FOS; proto-oncogene c-Fos [KO:K04379]
118019356  JUN; transcription factor AP-1 [KO:K04448]
118016000  BAD; bcl2-associated agonist of cell death [KO:K02158]
118016228  HRAS; GTPase HRas isoform X1 [KO:K02833]
118025572  KRAS; GTPase KRas isoform X1 [KO:K07827]
118000495  NRAS; GTPase NRas [KO:K07828]
118005431  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118003336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118004882  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117999637  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117999826  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118026266  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
118005532  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
118011488  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
118023528  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
118005236  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118025560  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118001326  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
118008161  CALM2; calmodulin-2 [KO:K02183]
118016596  calmodulin-1-like [KO:K02183]
118002566  CALM1; calmodulin-1 [KO:K02183]
118003137  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
118012486  calmodulin-like [KO:K02183]
118019658  CALML6; calmodulin-like protein 6 [KO:K02183]
117998176  CALM3; calmodulin-3 [KO:K02183]
118020691  calmodulin-1-like [KO:K02183]
118021620  CALML3; calmodulin-like protein 3 [KO:K02183]
118021903  calmodulin-like [KO:K02183]
118022080  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118027044  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118021556  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
118008037  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
118017875  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
118004651  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118023976  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
118023644  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118003690  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
118024347  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117999123  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117997993  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118020099  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
117999428  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
118025725  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
118006633  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
118003742  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
118002589  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
118015951  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
118012933  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
118009573  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118019223  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
118010631  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
118005543  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
117998037  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
118022245  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
118001310  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04545]
118017819  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
118003372  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
118020767  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
118019289  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
118005796  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
118021679  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
118020768  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
118024789  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
118018155  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117999338  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117998715  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
118024428  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
118004217  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
118006973  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
118012112  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
118022679  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
118011242  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
118002986  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
117999499  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
118018669  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
118016067  CFL1; cofilin-1 [KO:K05765]
118002823  cofilin-2 isoform X1 [KO:K05765]
118002873  cofilin-2 [KO:K05765]
118003941  CFL2; LOW QUALITY PROTEIN: cofilin-2 [KO:K05765]
118027255  TNF; tumor necrosis factor [KO:K03156]
118019994  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
118011353  BCL2L1; bcl-2-like protein 1 [KO:K04570]
118022230  TLR2; toll-like receptor 2 [KO:K10159]
118022538  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
118017761  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
118001922  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
118008943  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118014698  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
118015773  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
117998660  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
118001048  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
118001330  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118024839  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118009921  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118014480  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118002835  NF-kappa-B inhibitor alpha [KO:K04734]
118002880  NF-kappa-B inhibitor alpha [KO:K04734]
117998991  LOW QUALITY PROTEIN: interferon alpha-4-like [KO:K05414]
117998992  interferon alpha-1/2-like [KO:K05414]
117998993  interferon alpha-14-like [KO:K05414]
117999009  interferon alpha-2-like [KO:K05414]
117998994  IFNB1; interferon beta [KO:K05415]
118001095  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
118001265  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117997742  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
117997743  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
118022776  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118010368  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118026506  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118000892  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
118016696  STING1; stimulator of interferon genes protein [KO:K12654]
118008624  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
117998287  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
118026594  DNA dC->dU-editing enzyme APOBEC-3G-like isoform X1 [KO:K18750] [EC:3.5.4.-]
117998666  DNA dC->dU-editing enzyme APOBEC-3-like isoform X1 [KO:K18750] [EC:3.5.4.-]
118011453  SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1 [KO:K22544] [EC:3.1.5.-]
118004097  tripartite motif-containing protein 34-like isoform X1 [KO:K10648] [EC:2.3.2.27]
118006004  BST2; bone marrow stromal antigen 2 isoform X1 [KO:K06731]
118025746  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
118027395  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
118023691  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118014299  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
118017503  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
118000167  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
118024329  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118005180  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118014469  FASLG; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118012958  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
118016168  FADD; FAS-associated death domain protein [KO:K02373]
118012152  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118025823  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
117998245  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118000738  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
118004389  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118012283  cytochrome c, testis-specific [KO:K08738]
118019630  cytochrome c-like [KO:K08738]
118020883  cytochrome c [KO:K08738]
118019979  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
118010074  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
118013285  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
118013286  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
118013287  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
118014530  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
118001395  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
118001396  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
118001289  TAPBP; tapasin [KO:K08058]
118003414  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
118006090  CALR; calreticulin [KO:K08057]
118000898  putative HLA class I histocompatibility antigen, alpha chain H [KO:K06751]
118026501  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
118026743  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
118027349  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
118027378  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G [KO:K06751]
118018628  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
118023599  AP1G1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
118003157  AP1G2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
118005100  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
118006097  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
117999440  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
118007046  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
118012635  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
118003646  B2M; beta-2-microglobulin [KO:K08055]
118021740  ELOB; elongin-B [KO:K03873]
118022014  elongin-C-like [KO:K03872]
118014929  ELOC; elongin-C isoform X1 [KO:K03872]
118009201  elongin-C-like [KO:K03872]
118014748  elongin-C-like [KO:K03872]
118013183  CUL5; cullin-5 [KO:K10612]
118004598  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
118005381  DCAF1; DDB1- and CUL4-associated factor 1 isoform X1 [KO:K11789] [EC:2.7.11.1]
118015911  DDB1; DNA damage-binding protein 1 [KO:K10610]
118009219  CUL4A; cullin-4A isoform X1 [KO:K10609]
118012475  CUL4B; cullin-4B isoform X1 [KO:K10609]
118013186  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
118004694  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
118013370  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
118016681  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
118004074  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
118020573  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
118002147  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868]
118016867  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
118003405  CCNB2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
118010424  CCNB3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
118025943  LOW QUALITY PROTEIN: cyclin-dependent kinase 1-like [KO:K02087] [EC:2.7.11.22 2.7.11.23]
118019514  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
118019992  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:22749173
  Authors
Evans VA, Khoury G, Saleh S, Cameron PU, Lewin SR
  Title
HIV persistence: chemokines and their signalling pathways.
  Journal
Cytokine Growth Factor Rev 23:151-7 (2012)
DOI:10.1016/j.cytogfr.2012.05.002
Reference
PMID:23806647
  Authors
Abbas W, Herbein G
  Title
Plasma membrane signaling in HIV-1 infection.
  Journal
Biochim Biophys Acta 1838:1132-42 (2014)
DOI:10.1016/j.bbamem.2013.06.020
Reference
PMID:20041213
  Authors
Wu Y, Yoder A
  Title
Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.
  Journal
PLoS Pathog 5:e1000520 (2009)
DOI:10.1371/journal.ppat.1000520
Reference
PMID:22085380
  Authors
Choi WT, Duggineni S, Xu Y, Huang Z, An J
  Title
Drug discovery research targeting the CXC chemokine receptor 4 (CXCR4).
  Journal
J Med Chem 55:977-94 (2012)
DOI:10.1021/jm200568c
Reference
PMID:21321123
  Authors
Vorster PJ, Guo J, Yoder A, Wang W, Zheng Y, Xu X, Yu D, Spear M, Wu Y
  Title
LIM kinase 1 modulates cortical actin and CXCR4 cycling and is activated by HIV-1 to initiate viral infection.
  Journal
J Biol Chem 286:12554-64 (2011)
DOI:10.1074/jbc.M110.182238
Reference
PMID:15817946
  Authors
Das SR, Jameel S
  Title
Biology of the HIV Nef protein.
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Related
pathway
mlx03050  Proteasome
mlx04010  MAPK signaling pathway
mlx04020  Calcium signaling pathway
mlx04064  NF-kappa B signaling pathway
mlx04110  Cell cycle
mlx04141  Protein processing in endoplasmic reticulum
mlx04142  Lysosome
mlx04150  mTOR signaling pathway
mlx04151  PI3K-Akt signaling pathway
mlx04210  Apoptosis
mlx04612  Antigen processing and presentation
mlx04620  Toll-like receptor signaling pathway
mlx04623  Cytosolic DNA-sensing pathway
mlx04668  TNF signaling pathway
mlx04810  Regulation of actin cytoskeleton
KO pathway
ko05170   
LinkDB

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