KEGG   PATHWAY: mna04010
Entry
mna04010                    Pathway                                
Name
MAPK signaling pathway - Miniopterus natalensis (Natal long-fingered bat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mna04010  MAPK signaling pathway
mna04010

Other DBs
GO: 0000165
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107541038  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
107536136  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
107546425  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
107534931  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
107546251  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
107541372  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
107529836  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
107533412  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
107531235  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
107536018  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
107527170  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
107540175  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
107530629  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
107546422  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
107529017  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
107537293  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
107528234  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
107531651  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
107531121  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
107545336  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
107544760  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
107530945  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
107538307  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
107540425  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
107540464  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
107544336  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
107543188  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
107538300  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107544745  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
107540426  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
107541162  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
107541527  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
107533406  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
107545505  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107545813  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107536108  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
107545969  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
107541035  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
107535084  RASGRF2; LOW QUALITY PROTEIN: ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
107542952  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
107542784  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
107541820  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
107532208  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
107527478  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
107533055  NF1; neurofibromin isoform X1 [KO:K08052]
107535058  RASA1; ras GTPase-activating protein 1 [KO:K04352]
107534703  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
107545324  RAP1A; ras-related protein Rap-1A [KO:K04353]
107526932  RAP1B; ras-related protein Rap-1b [KO:K07836]
107534373  EGF; pro-epidermal growth factor [KO:K04357]
107534497  EREG; proepiregulin [KO:K09784]
107534488  AREG; amphiregulin [KO:K09782]
107531500  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
107529795  FGF2; fibroblast growth factor 2 [KO:K18497]
107536980  FGF9; fibroblast growth factor 9 [KO:K04358]
107542543  FGF8; fibroblast growth factor 8 [KO:K04358]
107543550  FGF17; fibroblast growth factor 17 [KO:K04358]
107540349  FGF18; fibroblast growth factor 18 [KO:K04358]
107526261  FGF10; fibroblast growth factor 10 [KO:K04358]
107537102  FGF5; fibroblast growth factor 5 [KO:K04358]
107538886  FGF6; fibroblast growth factor 6 [KO:K04358]
107532758  FGF16; fibroblast growth factor 16 [KO:K04358]
107534875  FGF7; fibroblast growth factor 7 [KO:K04358]
107538572  FGF22; fibroblast growth factor 22 [KO:K04358]
107542168  fibroblast growth factor 3-like [KO:K04358]
107534042  FGF20; fibroblast growth factor 20 [KO:K04358]
107542172  FGF19; fibroblast growth factor 19 [KO:K22603]
107531851  FGF21; fibroblast growth factor 21 [KO:K22429]
107538868  FGF23; fibroblast growth factor 23 [KO:K22428]
107545260  NGF; beta-nerve growth factor [KO:K02582]
107531942  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
107544068  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
107531848  NTF4; neurotrophin-4 [KO:K12457]
107545147  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
107539909  IGF2; insulin-like growth factor II [KO:K13769]
107543141  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
107531241  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
107527538  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
107532411  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
107545236  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
107526843  KITLG; kit ligand isoform X1 [KO:K05461]
107531799  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
107536886  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
107539800  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
107533829  PGF; placenta growth factor isoform X1 [KO:K16859]
107541939  VEGFC; vascular endothelial growth factor C [KO:K05449]
107529497  FIGF; vascular endothelial growth factor D [KO:K05449]
107527167  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
107546022  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
107541961  ANGPT2; angiopoietin-2 [KO:K05466]
107527767  ANGPT4; angiopoietin-4 [KO:K05467]
107534535  EFNA2; ephrin-A2 [KO:K05462]
107544183  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
107543913  EFNA1; ephrin-A1 [KO:K05462]
107543917  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
107543752  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
107545968  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
107525704  NRTN; neurturin [KO:K25414]
107525679  PSPN; persephin [KO:K25416]
107525996  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107529006  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
107546211  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
107524731  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
107535065  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
107532684  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
107524118  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
107529769  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
107539187  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
107543738  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
107545009  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
107540632  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
107527774  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107532710  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
107535230  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
107535231  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
107532733  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
107534352  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
107534361  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
107528437  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
107532764  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
107528536  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
107543094  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
107541918  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
107532547  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
107536618  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
107525851  SOS2; son of sevenless homolog 2 [KO:K03099]
107541780  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
107542351  HRAS; GTPase HRas isoform X1 [KO:K02833]
107525258  KRAS; GTPase KRas [KO:K07827]
107545303  NRAS; GTPase NRas [KO:K07828]
107531795  RRAS; ras-related protein R-Ras [KO:K07829]
107546716  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
107532623  MRAS; ras-related protein M-Ras [KO:K07831]
107541381  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
107531103  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107534729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107533801  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107525695  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
107545525  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
107541504  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107530451  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107534595  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
107526738  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
107526793  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
107532955  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
107530622  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
107539953  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
107531265  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
107541393  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
107538796  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
107539494  MYC; myc proto-oncogene protein [KO:K04377]
107536933  SRF; serum response factor isoform X1 [KO:K04378]
107533821  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
107530997  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
107539824  STMN1; stathmin [KO:K04381]
107546298  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
107536544  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
107536549  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
107536550  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
107536561  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
107538974  TNF; tumor necrosis factor [KO:K03156]
107528654  IL1A; interleukin-1 alpha [KO:K04383]
107528631  IL1B; interleukin-1 beta [KO:K04519]
107534176  TGFB1; transforming growth factor beta-1 [KO:K13375]
107543622  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
107533843  TGFB3; transforming growth factor beta-3 isoform X1 [KO:K13377]
107544039  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
107532712  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
107527297  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
107544970  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
107526381  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
107543787  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
107543257  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
107537994  CD14; monocyte differentiation antigen CD14 [KO:K04391]
107537599  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
107545262  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
107539040  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107538414  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107540891  cell division control protein 42 homolog [KO:K04393]
107537536  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
107535740  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
107536208  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
107541596  DAXX; death domain-associated protein 6 [KO:K02308]
107524328  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
107538794  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
107528202  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
107531990  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
107534560  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
107533887  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
107531263  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
107545742  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
107533273  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
107541797  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
107532713  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
107532180  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
107524443  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
107527275  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
107530916  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
107526150  STK3; serine/threonine-protein kinase 3 [KO:K04412]
107533555  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
107524427  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
107527145  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
107533546  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
107528582  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
107530487  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
107536244  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
107534150  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
107524234  mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
107528308  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
107527317  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
107546566  mitogen-activated protein kinase kinase kinase MLT-like [KO:K04424] [EC:2.7.11.25]
107531250  mitogen-activated protein kinase kinase kinase MLT [KO:K04424] [EC:2.7.11.25]
107541967  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
107530984  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
107533446  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
107535728  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
107528513  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
107528797  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
107541486  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
107544551  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
107529906  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
107542219  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
107528394  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
107530272  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
107536032  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
107533394  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
107545550  FLNA; filamin-A [KO:K04437]
107535608  CRK; adapter molecule crk isoform X1 [KO:K04438]
107530545  CRKL; crk-like protein [KO:K04438]
107528069  ARRB2; beta-arrestin-2 [KO:K04439]
107524457  ARRB1; beta-arrestin-1 [KO:K04439]
107537133  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107527953  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107528432  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107545565  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
107545613  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
107536041  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
107536051  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
107529569  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
107538913  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
107540204  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
107531586  RPS6KA5; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
107542786  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
107536397  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
107541561  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
107527885  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
107536966  JUN; transcription factor AP-1 [KO:K04448]
107532468  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
107538830  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
107544572  TP53; cellular tumor antigen p53 [KO:K04451]
107546204  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
107545703  MAX; protein max isoform X1 [KO:K04453]
107535021  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
107526554  HSPB1; heat shock protein beta-1 [KO:K04455]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107525917  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
107526460  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
107542187  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
107536000  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
107535716  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
107525302  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107534513  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107534355  dual specificity protein phosphatase 16-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107543666  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107534091  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107536435  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107529155  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
107538934  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
107538789  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
107543578  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
107528839  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
107536763  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
107530348  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
107539014  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
107538950  heat shock 70 kDa protein 1 [KO:K03283]
107540605  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
107539280  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
107525835  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
107524519  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
107528285  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
107528876  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
107542599  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
107523913  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
107544156  IKBKG; NF-kappa-B essential modulator [KO:K07210]
107528767  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
107545508  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
107542628  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
107533544  RELA; transcription factor p65 [KO:K04735]
107536743  RELB; transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cell 141:1117-34 (2010)
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Skaper SD
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
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Reference
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Biochim Biophys Acta 1843:2563-2582 (2014)
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Related
pathway
mna04070  Phosphatidylinositol signaling system
mna04110  Cell cycle
mna04115  p53 signaling pathway
mna04210  Apoptosis
mna04310  Wnt signaling pathway
mna04668  TNF signaling pathway
KO pathway
ko04010   
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