KEGG   PATHWAY: pcoq05163
Entry
pcoq05163                   Pathway                                
Name
Human cytomegalovirus infection - Propithecus coquereli (Coquerel's sifaka)
Description
Human cytomegalovirus (HCMV) is an enveloped, double-stranded DNA virus that is a member of beta-herpesvirus family. HCMV is best known for causing significant morbidity and mortality in immunocompromised populations. As with other herpesviruses, HCMV gB and gH/gL envelope glycoproteins are essential for virus entry. HCMV gB could activate the PDGFRA, and induce activation of the oncogenic PI3-K/AKT pathway. Though it is unlikely that HCMV by itself can act as an oncogenic factor, HCMV may have an oncomodulatory role, to catalyze an oncogenic process that has already been initiated. US28, one of the four HCMV-encoded vGPCRs (US27, US28, UL33 and UL78), also has a specific role in the oncomodulatory properties. In addition, HCMV has developed numerous mechanisms for manipulating the host immune system. The virally encoded US2, US3, US6 and US11 gene products all interfere with major histocompatibility complex (MHC) class I antigen presentation. HCMV encodes several immediate early (IE) antiapoptotic proteins (IE1, IE2, vMIA and vICA). These proteins might avoid immune clearance of infected tumor cells by cytotoxic lymphocytes and NK cells.
Class
Human Diseases; Infectious disease: viral
Pathway map
pcoq05163  Human cytomegalovirus infection
pcoq05163

Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105807665  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105806636  TSC1; hamartin [KO:K07206]
105813061  TSC2; tuberin isoform X1 [KO:K07207]
105824616  RHEB; GTP-binding protein Rheb [KO:K07208]
105824883  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105815840  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105827360  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105813657  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
105824261  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105819687  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105824538  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105819191  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105827383  RELA; transcription factor p65 isoform X1 [KO:K04735]
105813943  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105824793  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105825853  SOS2; son of sevenless homolog 2 [KO:K03099]
105818006  SOS1; son of sevenless homolog 1 [KO:K03099]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105807545  KRAS; GTPase KRas [KO:K07827]
105810591  NRAS; GTPase NRas [KO:K07828]
105819002  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105811965  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105816821  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
105818043  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
105825770  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
105822640  integrin beta-3-like [KO:K06493]
105822028  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105805204  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105820016  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105819379  RHOA; transforming protein RhoA [KO:K04513]
105807017  cyclic GMP-AMP synthase-like [KO:K17834] [EC:2.7.7.86]
105811756  MB21D1; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
105812006  TMEM173; stimulator of interferon genes protein isoform X1 [KO:K12654]
105824183  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105809375  IRF3; interferon regulatory factor 3 [KO:K05411]
105827001  interferon alpha-5-like [KO:K05414]
105827006  IFNB1; interferon beta [KO:K05415]
105817905  TNF; tumor necrosis factor isoform X1 [KO:K03156]
105805081  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105816051  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
105823400  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105805435  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
105818690  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105820326  IL1B; interleukin-1 beta [KO:K04519]
105808263  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
105821530  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105813535  monocyte chemotactic protein 1B-like [KO:K14624]
105813849  CCL5; C-C motif chemokine 5 [KO:K12499]
105822820  CXCL8; interleukin-8 [KO:K10030]
105822445  IL6; interleukin-6 [KO:K05405]
105820912  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105806018  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105805044  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
105806301  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105821386  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105825893  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105827172  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105823098  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105819816  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105812945  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105815495  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105811873  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
105827297  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
105806167  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105806182  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105814456  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105812706  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
105807599  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105821681  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105820913  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
105826829  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
105826912  CALML3; calmodulin-like protein 3 [KO:K02183]
105826917  CALML5; calmodulin-like protein 5 [KO:K02183]
105807119  CALM1; calmodulin [KO:K02183]
105805895  CALM2; calmodulin [KO:K02183]
105817634  CALM3; calmodulin [KO:K02183]
105825283  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
105825498  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105821611  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
105812112  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105805391  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105821171  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105820432  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105823351  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105812762  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
105813187  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105821123  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
105813715  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105815218  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
105820872  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
105812499  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105821322  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105816960  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105812764  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105808688  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105818188  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105808848  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
105813348  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105813177  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
105823839  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105807940  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105813852  C-C motif chemokine 3-like [KO:K05408]
105813862  C-C motif chemokine 3-like [KO:K05408]
105813847  CCL4; C-C motif chemokine 4 [KO:K12964]
105820857  CX3CL1; fractalkine [KO:K05508]
105806081  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
105824802  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
105817609  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
105821992  ARHGEF11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
105810828  ARHGEF12; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12 [KO:K07532]
105809820  AKAP13; A-kinase anchor protein 13 [KO:K16529]
105816606  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
105814034  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
105825335  CTNNB1; catenin beta-1 [KO:K02105]
105807898  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
105825872  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
105806725  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
105814843  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
105820083  neuroendocrine secretory protein 55-like [KO:K04632]
105820084  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
105806400  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
105827423  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
105811323  MYC; myc proto-oncogene protein [KO:K04377]
105821988  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
105806352  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
105820249  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105807498  VEGFA; vascular endothelial growth factor A [KO:K05448]
105824710  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105812191  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
105812227  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105813949  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105813961  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105823945  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
105815570  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
105805232  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105820021  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105821904  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105811984  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
105809025  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105811104  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
105807372  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
105817861  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
105818048  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
105815381  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
105820421  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105810946  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105809569  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105825274  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
105813423  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105808008  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
105822386  CRKL; crk-like protein [KO:K04438]
105817361  CRK; adapter molecule crk isoform X1 [KO:K04438]
105815054  paxillin [KO:K05760]
105819254  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
105820834  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
105808764  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
105808775  C-X-C chemokine receptor type 2-like [KO:K05050]
105808778  C-X-C chemokine receptor type 2-like [KO:K05050]
105804907  CCR1; C-C chemokine receptor type 1 [KO:K04176]
105817505  CCR3; C-C chemokine receptor type 3 [KO:K04178]
105805826  CCR5; C-C chemokine receptor type 5 [KO:K04180]
105824378  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
105824379  TAP2; antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
105821685  TAPBP; tapasin [KO:K08058]
105814384  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
105806269  calreticulin-like [KO:K08057]
105807890  CALR; calreticulin [KO:K08057]
105817846  HLA class I histocompatibility antigen, B-8 alpha chain-like [KO:K06751]
105817910  HLA class I histocompatibility antigen, B-46 alpha chain-like [KO:K06751]
105817268  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
105817288  HLA class I histocompatibility antigen, B-14 alpha chain-like isoform X1 [KO:K06751]
105817290  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
105817294  HLA class I histocompatibility antigen, B-41 alpha chain-like [KO:K06751]
105814533  B2M; beta-2-microglobulin [KO:K08055]
105827003  CDKN2A; cyclin-dependent kinase inhibitor 2A [KO:K06621]
105812777  E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
105819395  TP53; cellular tumor antigen p53 [KO:K04451]
105812249  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105816738  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105820132  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
105813707  RB1; retinoblastoma-associated protein [KO:K06618]
105804948  E2F1; transcription factor E2F1 [KO:K17454]
105815699  E2F2; transcription factor E2F2 [KO:K09389]
105805737  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
105821114  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105822691  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
105827473  FADD; FAS-associated death domain protein [KO:K02373]
105819477  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105815816  BID; BH3-interacting domain death agonist [KO:K04726]
105809316  BAX; apoptosis regulator BAX [KO:K02159]
105821684  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105812509  cytochrome c-like [KO:K08738]
105807375  cytochrome c, somatic [KO:K08738]
105815609  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
105810555  cytochrome c-like [KO:K08738]
105825008  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105810111  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00584  Prostaglandin E2
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
Reference
PMID:19107226
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
PMID:24839861
  Authors
Roy S, Arav-Boger R
  Title
New cell-signaling pathways for controlling cytomegalovirus replication.
  Journal
Am J Transplant 14:1249-58 (2014)
DOI:10.1111/ajt.12725
Reference
PMID:14720582
  Authors
Cinatl J, Scholz M, Kotchetkov R, Vogel JU, Doerr HW
  Title
Molecular mechanisms of the modulatory effects of HCMV infection in tumor cell biology.
  Journal
Trends Mol Med 10:19-23 (2004)
DOI:10.1016/j.molmed.2003.11.002
Reference
PMID:15380778
  Authors
Evers DL, Wang X, Huang ES
  Title
Cellular stress and signal transduction responses to human cytomegalovirus infection.
  Journal
Microbes Infect 6:1084-93 (2004)
DOI:10.1016/j.micinf.2004.05.026
Reference
PMID:29547547
  Authors
Murray MJ, Peters NE, Reeves MB
  Title
Navigating the Host Cell Response during Entry into Sites of Latent Cytomegalovirus Infection.
  Journal
Pathogens 7:E30 (2018)
DOI:10.3390/pathogens7010030
Reference
PMID:27501260
  Authors
Campadelli-Fiume G, Collins-McMillen D, Gianni T, Yurochko AD
  Title
Integrins as Herpesvirus Receptors and Mediators of the Host Signalosome.
  Journal
Annu Rev Virol 3:215-236 (2016)
DOI:10.1146/annurev-virology-110615-035618
Reference
PMID:28132838
  Authors
Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB
  Title
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity.
  Journal
Cell Host Microbe 21:231-243 (2017)
DOI:10.1016/j.chom.2017.01.001
Reference
PMID:29082387
  Authors
Hancock MH, Nelson JA
  Title
Modulation of the NFkappab Signalling Pathway by Human Cytomegalovirus.
  Journal
Virology (Hyderabad) 1:104 (2017)
Reference
PMID:21383764
  Authors
Rahman MM, McFadden G
  Title
Modulation of NF-kappaB signalling by microbial pathogens.
  Journal
Nat Rev Microbiol 9:291-306 (2011)
DOI:10.1038/nrmicro2539
Reference
PMID:27060663
  Authors
Zhang J, Feng H, Xu S, Feng P
  Title
Hijacking GPCRs by viral pathogens and tumor.
  Journal
Biochem Pharmacol 114:69-81 (2016)
DOI:10.1016/j.bcp.2016.03.021
Reference
PMID:28035083
  Authors
Lee S, Chung YH, Lee C
  Title
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection.
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pathway
pcoq00590  Arachidonic acid metabolism
pcoq03050  Proteasome
pcoq04010  MAPK signaling pathway
pcoq04064  NF-kappa B signaling pathway
pcoq04110  Cell cycle
pcoq04150  mTOR signaling pathway
pcoq04151  PI3K-Akt signaling pathway
pcoq04210  Apoptosis
pcoq04612  Antigen processing and presentation
pcoq04623  Cytosolic DNA-sensing pathway
pcoq04630  JAK-STAT signaling pathway
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KO pathway
ko05163   
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