KEGG   PATHWAY: puc05166
Entry
puc05166                    Pathway                                
Name
Human T-cell leukemia virus 1 infection - Panthera uncia (snow leopard)
Description
Human T-cell leukemia virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Expression of Tax, a viral regulatory protein is critical to the pathogenesis. Tax is a transcriptional co-factor that interfere several signaling pathways related to anti-apoptosis or cell proliferation. The modulation of the signaling by Tax involve its binding to transcription factors like CREB/ATF, NF-kappa B, and SRF.
Class
Human Diseases; Infectious disease: viral
Pathway map
puc05166  Human T-cell leukemia virus 1 infection
puc05166

Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125912696  solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
125918679  neuropilin-1 isoform X1 [KO:K06724]
125924410  myc proto-oncogene protein [KO:K04377]
125928536  transformation/transcription domain-associated protein isoform X1 [KO:K08874]
125912175  histone acetyltransferase KAT5 isoform X1 [KO:K11304] [EC:2.3.1.48]
125917183  G1/S-specific cyclin-D2 [KO:K10151]
125918030  G1/S-specific cyclin-D2 [KO:K10151]
125928080  integrin alpha-L isoform X1 [KO:K05718]
125920659  integrin beta-2 [KO:K06464]
125930551  intercellular adhesion molecule 1 isoform X1 [KO:K06490]
125937753  GTPase HRas isoform X1 [KO:K02833]
125918906  GTPase KRas isoform X1 [KO:K07827]
125912218  GTPase NRas [KO:K07828]
125910082  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125918032  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125918034  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125914884  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
125928028  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
125917982  T-cell surface glycoprotein CD4-like [KO:K06454]
125910063  talin-2 [KO:K06271]
125919391  talin-1 [KO:K06271]
125928904  ran-binding protein 3 isoform X1 [KO:K15304]
125915045  GTP-binding nuclear protein Ran [KO:K07936]
125936251  exportin-1 isoform X1 [KO:K14290]
125929051  calreticulin [KO:K08057]
125935362  calnexin isoform X1 [KO:K08054]
125922973  protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
125923333  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125932723  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125937053  calcineurin subunit B type 1 isoform X1 [KO:K06268]
125926203  calcineurin subunit B type 2 [KO:K06268]
125914768  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
125936041  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
125916650  nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
125909624  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
125919566  interleukin-2 receptor subunit beta [KO:K05069]
125931753  cytokine receptor common subunit gamma [KO:K05070]
125913423  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
125929213  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
125926570  LOW QUALITY PROTEIN: signal transducer and activator of transcription 5A-like [KO:K11223]
125926542  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
125923086  interleukin-2 [KO:K05429]
125938453  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
125938456  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
125938457  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
125938459  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
125938460  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-C*0201 alpha chain-like [KO:K06751]
125938463  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
125938464  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
125909955  beta-2-microglobulin [KO:K08055]
125925704  farnesyl pyrophosphate synthase isoform X1 [KO:K00787] [EC:2.5.1.1 2.5.1.10]
125933210  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
125935487  voltage-dependent anion-selective channel protein 1 [KO:K05862]
125923105  ADP/ATP translocase 4 [KO:K05863]
125923902  ADP/ATP translocase 1 [KO:K05863]
125931938  ADP/ATP translocase 2 [KO:K05863]
125932327  ADP/ATP translocase 3 [KO:K05863]
125928445  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
125932735  voltage-dependent anion-selective channel protein 2 [KO:K15040]
125938035  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 3-like [KO:K15041]
125923311  voltage-dependent anion-selective channel protein 3 [KO:K15041]
125938270  translocator protein 2 [KO:K05770]
125919669  translocator protein [KO:K05770]
125916408  protein VAC14 homolog isoform X1 [KO:K15305]
125914918  ran-specific GTPase-activating protein isoform X1 [KO:K15306]
125928331  mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
125923073  mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
125909842  mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
125933476  mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
125937448  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 1 [KO:K03348]
125923705  anaphase-promoting complex subunit 2 [KO:K03349]
125927327  cell division cycle protein 27 homolog isoform X1 [KO:K03350]
125922686  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
125914192  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
125933994  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
125914189  anaphase-promoting complex subunit 7 [KO:K03354]
125935544  cell division cycle protein 23 homolog [KO:K03355]
125923133  anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
125931716  anaphase-promoting complex subunit 10-like [KO:K03357]
125926243  anaphase-promoting complex subunit 11 [KO:K03358]
125926997  anaphase-promoting complex subunit CDC26 [KO:K03359]
125921989  anaphase-promoting complex subunit 13 [KO:K12456]
125937242  anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
125932710  anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
125912678  cell division cycle protein 20 homolog isoform X1 [KO:K03363]
125934467  securin isoform X1 [KO:K06635]
125919117  separin [KO:K02365] [EC:3.4.22.49]
125937565  G2/mitotic-specific cyclin-B2-like [KO:K21770]
125910050  G2/mitotic-specific cyclin-B2 [KO:K21770]
125915304  cyclin-dependent kinase 4 inhibitor B isoform X1 [KO:K04685]
125919257  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
125930010  G1/S-specific cyclin-D1 [KO:K04503]
125938244  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125938307  cyclin-dependent kinase inhibitor 1 [KO:K06625]
125918223  cyclin-A2 [KO:K06627]
125918226  cyclin-A2 [KO:K06627]
125933710  cyclin-A1 [KO:K06627]
125924535  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
125917277  G1/S-specific cyclin-E1 [KO:K06626]
125917289  G1/S-specific cyclin-E1 [KO:K06626]
125919210  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125933773  retinoblastoma-associated protein isoform X1 [KO:K06618]
125936106  transcription factor E2F1 [KO:K17454]
125912975  transcription factor E2F2 [KO:K09389]
125908499  transcription factor E2F3 [KO:K06620]
125917066  serine-protein kinase ATM-like [KO:K04728] [EC:2.7.11.1]
125917870  serine-protein kinase ATM-like [KO:K04728] [EC:2.7.11.1]
125921267  serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
125939340  serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
125914493  serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
125927023  LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
125913493  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125935698  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125929237  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
125921850  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125913143  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125921289  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125915806  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125909102  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125925091  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125921053  disks large homolog 1 isoform X1 [KO:K12076]
125933550  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125938466  tumor necrosis factor [KO:K03156]
125918761  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
125935639  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
125927589  dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
125916877  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
125917114  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
125933328  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125935352  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125912547  transcription factor Jun [KO:K04448]
125910810  matrilysin [KO:K01397] [EC:3.4.24.23]
125936904  interleukin-1 receptor type 1 isoform X1 [KO:K04386]
125936912  interleukin-1 receptor type 2 [KO:K04387]
125909406  T-cell surface glycoprotein CD3 delta chain [KO:K06450]
125909427  T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
125909383  T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
125926671  mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
125932873  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
125923306  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
125932096  NF-kappa-B essential modulator isoform X1 [KO:K07210]
125909567  NF-kappa-B inhibitor alpha [KO:K04734]
125923687  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125912163  transcription factor p65 [KO:K04735]
125927057  G protein pathway suppressor 2 [KO:K15307]
125918765  LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159]
125936517  tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
125919659  tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
125926656  mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
125915169  transcription factor RelB [KO:K09253]
125932909  nuclear factor NF-kappa-B p100 subunit [KO:K04469]
125915463  mRNA decay activator protein ZFP36 [KO:K15308]
125918586  interleukin-2 receptor subunit alpha [KO:K05068]
125923720  interleukin-15 [KO:K05433]
125918584  interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
125930836  interleukin-6 [KO:K05405]
125935135  granulocyte-macrophage colony-stimulating factor [KO:K05427]
125938465  lymphotoxin-alpha [KO:K05468]
125936704  bcl-2-like protein 1 isoform X1 [KO:K04570]
125932285  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
125915432  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
125925521  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
125908676  transforming growth factor beta-3 proprotein [KO:K13377]
125920171  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
125921386  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
125914628  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
125910090  mothers against decapentaplegic homolog 3 [KO:K23605]
125914595  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
125930396  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
125934726  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
125937626  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
125909634  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
125921018  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
125919005  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
125915408  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
125924401  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
125926198  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
125912461  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
125929088  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
125919497  nuclear transcription factor Y subunit beta [KO:K08065]
125938154  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
125938382  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
125938383  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
125938384  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
125938386  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
125938388  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
125938395  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
125938398  DLA class II histocompatibility antigen, DR-1 beta chain isoform X1 [KO:K06752]
125938399  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
125938400  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
125938216  LOW QUALITY PROTEIN: serum response factor [KO:K04378]
125925467  ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
125931642  ETS domain-containing protein Elk-1 [KO:K04375]
125934070  transcription factor PU.1 isoform X1 [KO:K09438]
125939028  protein C-ets-1 isoform X1 [KO:K02678]
125921688  protein C-ets-2 [KO:K21932]
125937996  TATA box-binding protein-like 1 [KO:K03120]
125939080  TATA-box-binding protein [KO:K03120]
125909477  LOW QUALITY PROTEIN: TATA box-binding protein-like 2 [KO:K03120]
125909334  protein c-Fos [KO:K04379]
125935552  early growth response protein 1 [KO:K09203]
125912391  fos-related antigen 1 [KO:K04502]
125932658  E3 SUMO-protein ligase EGR2 [KO:K12496]
125911260  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
125930188  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
125925743  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
125934155  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
125919439  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
125928859  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
125911819  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
125919632  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125930855  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
125938414  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
125929263  CREB-regulated transcription coactivator 1 isoform X1 [KO:K15309]
125927249  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
125920347  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
125921652  histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
125926541  histone acetyltransferase KAT2A [KO:K06062] [EC:2.3.1.48]
125928807  transcription factor E2-alpha isoform X1 [KO:K09063]
125923309  DNA polymerase beta [KO:K02330] [EC:2.7.7.7 4.2.99.-]
125912825  tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
125915138  apoptosis regulator BAX isoform X1 [KO:K02159]
125913467  cyclin-dependent kinase 4 inhibitor C [KO:K06622]
125934745  telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
125922614  homeobox protein MSX-1 [KO:K09341]
125933087  homeobox protein MSX-3-like [KO:K09341]
125934403  homeobox protein MSX-2 [KO:K09341]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17384582
  Authors
Matsuoka M, Jeang KT
  Title
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.
  Journal
Nat Rev Cancer 7:270-80 (2007)
DOI:10.1038/nrc2111
Reference
PMID:16155604
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
PMID:18702816
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
PMID:21994754
  Authors
Jones KS, Lambert S, Bouttier M, Benit L, Ruscetti FW, Hermine O, Pique C
  Title
Molecular aspects of HTLV-1 entry: functional domains of the HTLV-1 surface subunit (SU) and their relationships to the entry receptors.
  Journal
Viruses 3:794-810 (2011)
DOI:10.3390/v3060794
Reference
PMID:21114861
  Authors
Ghez D, Lepelletier Y, Jones KS, Pique C, Hermine O
  Title
Current concepts regarding the HTLV-1 receptor complex.
  Journal
Retrovirology 7:99 (2010)
DOI:10.1186/1742-4690-7-99
Reference
  Authors
Sinet F.
  Title
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: a number of proteins play a key role in the establishment and maintenance of viral infection.
  Journal
BioSciences Master Reviews, July 2013
Reference
PMID:18923409
  Authors
Sattentau Q
  Title
Avoiding the void: cell-to-cell spread of human viruses.
  Journal
Nat Rev Microbiol 6:815-26 (2008)
DOI:10.1038/nrmicro1972
Reference
PMID:15040584
  Authors
Vicente-Manzanares M, Sanchez-Madrid F
  Title
Role of the cytoskeleton during leukocyte responses.
  Journal
Nat Rev Immunol 4:110-22 (2004)
DOI:10.1038/nri1268
Reference
PMID:27334587
  Authors
Dutartre H, Claviere M, Journo C, Mahieux R
  Title
Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
  Journal
J Virol 90:7607-17 (2016)
DOI:10.1128/JVI.00407-16
Reference
PMID:15988028
  Authors
Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Luscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
  Title
A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
  Journal
Mol Cell Biol 25:6178-98 (2005)
DOI:10.1128/MCB.25.14.6178-6198.2005
Reference
PMID:21994758
  Authors
Edwards D, Fenizia C, Gold H, de Castro-Amarante MF, Buchmann C, Pise-Masison CA, Franchini G
  Title
Orf-I and orf-II-encoded proteins in HTLV-1 infection and persistence.
  Journal
Viruses 3:861-85 (2011)
DOI:10.3390/v3060861
Reference
PMID:26927155
  Authors
Nakano K, Watanabe T
  Title
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.
  Journal
Viruses 8:58 (2016)
DOI:10.3390/v8030058
Reference
PMID:22783232
  Authors
Shida H
  Title
Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses.
  Journal
Front Microbiol 3:179 (2012)
DOI:10.3389/fmicb.2012.00179
Reference
PMID:23248621
  Authors
Bai XT, Nicot C
  Title
Overview on HTLV-1 p12, p8, p30, p13: accomplices in persistent infection and viral pathogenesis.
  Journal
Front Microbiol 3:400 (2012)
DOI:10.3389/fmicb.2012.00400
Reference
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  Title
HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches.
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HTLV-1 p13, a small protein with a busy agenda.
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Mol Aspects Med 31:350-8 (2010)
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Retrovirology 1:20 (2004)
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Annu Rev Immunol 19:475-96 (2001)
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Inactivation of hTERT transcription by Tax.
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Oncogene 22:3734-41 (2003)
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Related
pathway
puc03013  Nucleocytoplasmic transport
puc04010  MAPK signaling pathway
puc04064  NF-kappa B signaling pathway
puc04110  Cell cycle
puc04115  p53 signaling pathway
puc04151  PI3K-Akt signaling pathway
puc04210  Apoptosis
puc04350  TGF-beta signaling pathway
puc04612  Antigen processing and presentation
puc04660  T cell receptor signaling pathway
puc04668  TNF signaling pathway
KO pathway
ko05166   
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