KEGG   PATHWAY: pyu05169
Entry
pyu05169                    Pathway                                
Name
Epstein-Barr virus infection - Puma yagouaroundi (jaguarundi)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
pyu05169  Epstein-Barr virus infection
pyu05169

Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121022445  CR2; complement receptor type 2 isoform X1 [KO:K04012]
121022465  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
121021858  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
121023070  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
121026708  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
121026710  HLA class II histocompatibility antigen, DR beta 5 chain-like [KO:K06752]
121026711  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
121029254  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
121029256  HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752]
121029263  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
121029264  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
121029266  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
121029268  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
121029269  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
121026443  toll-like receptor 2 [KO:K10159]
121026463  toll-like receptor 2 [KO:K10159]
121033462  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
121038701  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
121025099  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
121043535  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121040322  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
121013336  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
121029788  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
121037105  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121012848  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
121025049  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
121031656  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
121031875  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121023959  RELA; transcription factor p65 [KO:K04735]
121022312  TNF; tumor necrosis factor [KO:K03156]
121028638  IL6; interleukin-6 isoform X1 [KO:K05405]
121034557  DDX58; antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
121012443  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
121032321  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
121040822  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
121021584  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
121022797  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
121018789  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
121034395  interferon alpha-2-like [KO:K05414]
121035166  interferon beta-like [KO:K05414]
121034394  interferon beta [KO:K05415]
121035993  IFNAR1; LOW QUALITY PROTEIN: interferon alpha/beta receptor 1 [KO:K05130]
121035995  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
121027253  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
121013973  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
121030838  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
121040920  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
121031553  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
121044344  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
121010306  OAS3; 2'-5'-oligoadenylate synthase 3 isoform X1 [KO:K14216] [EC:2.7.7.84]
121010310  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
121010317  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
121034105  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
121018837  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
121016588  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
121023867  FADD; FAS-associated death domain protein [KO:K02373]
121030909  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
121021909  BID; BH3-interacting domain death agonist [KO:K04726]
121044434  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
121032687  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
121018751  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
121029294  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
121034919  cytochrome c-like [KO:K08738]
121028606  cytochrome c [KO:K08738]
121030343  cytochrome c, testis-specific-like [KO:K08738]
121034013  cytochrome c-like [KO:K08738]
121040562  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
121021539  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
121039672  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
121031448  uncharacterized protein LOC121031448 [KO:K10784]
121028976  M1-specific T cell receptor beta chain-like [KO:K10785]
121035463  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
121035464  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
121035465  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
121015079  CD247; T-cell surface glycoprotein CD3 zeta chain isoform X1 [KO:K06453]
121028842  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
121032180  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
121011450  PSMC4; 26S proteasome regulatory subunit 6B isoform X1 [KO:K03063]
121031768  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
121043441  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
121015264  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
121034081  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
121014448  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
121044921  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 isoform X1 [KO:K03033]
121015294  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
121017138  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
121016766  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
121009729  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
121022775  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
121021062  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
121030609  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
121011508  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
121020003  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
121028710  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
121029258  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
121029257  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
121029279  tapasin isoform X1 [KO:K08058]
121041608  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
121014055  CALR; calreticulin isoform X1 [KO:K08057]
121022363  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
121023084  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
121023085  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like isoform X1 [KO:K06751]
121023100  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
121023114  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
121023115  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
121024246  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like isoform X1 [KO:K06751]
121024278  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
121016637  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
121041626  B2M; beta-2-microglobulin [KO:K08055]
121032117  SNW1; SNW domain-containing protein 1 [KO:K06063]
121042011  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
121025405  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
121029931  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
121010413  NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]
121045480  SAP30L; histone deacetylase complex subunit SAP30L [KO:K19202]
121027217  SAP30; histone deacetylase complex subunit SAP30 isoform X1 [KO:K19202]
121030720  CIR1; corepressor interacting with RBPJ 1 [KO:K06066]
121012135  RBPJL; recombining binding protein suppressor of hairless-like protein isoform X1 [KO:K06053]
121037213  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
121024515  HES1; transcription factor HES-1 [KO:K06054]
121013904  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
121023349  RUNX3; runt-related transcription factor 3 [KO:K09279]
121042977  MYC; myc proto-oncogene protein [KO:K04377]
121019544  USP7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
121040772  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
121015982  TP53; cellular tumor antigen p53 [KO:K04451]
121029363  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
121021432  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
121013741  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
121027286  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
121043455  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
121014378  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
121011741  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121045129  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
121018591  RELB; transcription factor RelB [KO:K09253]
121037160  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
121045448  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
121011486  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
121029520  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
121015745  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
121013900  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
121033019  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121036923  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121010516  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121020261  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
121020589  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
121015779  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
121015350  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
121024845  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
121040120  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
121029354  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121029356  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
121027214  JUN; transcription factor AP-1 [KO:K04448]
121037037  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
121020275  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
121033497  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
121012094  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
121043547  CD44; CD44 antigen isoform X1 [KO:K06256]
121022236  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
121027768  CD58; lymphocyte function-associated antigen 3 isoform X1 [KO:K06492]
121013964  ICAM1; intercellular adhesion molecule 1 isoform X1 [KO:K06490]
121014759  VIM; vimentin [KO:K07606]
121013398  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
121010992  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
121045024  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
121038252  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
121013735  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
121041744  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
121017559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121024937  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
121037046  BLNK; B-cell linker protein isoform X1 [KO:K07371]
121009974  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
121043524  SKP2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
121038909  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
121023852  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
121021950  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
121029442  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
121040857  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
121028738  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
121012858  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
121030311  CCNA2; cyclin-A2 [KO:K06627]
121042720  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
121011326  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
121040954  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
121012950  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
121012039  E2F1; transcription factor E2F1 [KO:K17454]
121023030  E2F2; transcription factor E2F2 [KO:K09389]
121020536  E2F3; transcription factor E2F3 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
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F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
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Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
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Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
pyu03050  Proteasome
pyu04010  MAPK signaling pathway
pyu04020  Calcium signaling pathway
pyu04064  NF-kappa B signaling pathway
pyu04110  Cell cycle
pyu04115  p53 signaling pathway
pyu04210  Apoptosis
pyu04612  Antigen processing and presentation
pyu04620  Toll-like receptor signaling pathway
pyu04622  RIG-I-like receptor signaling pathway
pyu04630  JAK-STAT signaling pathway
pyu04662  B cell receptor signaling pathway
KO pathway
ko05169   
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