KEGG   PATHWAY: pvp05417
Entry
pvp05417                    Pathway                                
Name
Lipid and atherosclerosis - Pteropus vampyrus (large flying fox)
Description
Atherosclerosis is a chronic inflammatory disease marked by a narrowing of the arteries from lipid-rich plaques present within the walls of arterial blood vessels. It represents the root cause of the majority of cardiovascular diseases (CVDs) and their complications, including conditions such as coronary artery disease, myocardial infarction and stroke.  An elevated level of low density lipoprotein (LDL) cholesterol constitutes a major risk factor for genesis of atherosclerosis. LDL can accumulate within the blood vessel wall and undergo modification by oxidation. Oxidized LDL (oxLDL) leads to endothelial dysfunction leading to expression of adhesion molecules and recruitment of monocyte in subendothelial space. The monocytes proliferate, differentiate into macrophages, and take up the lipoproteins, forming cholesterol-engorged "foam cells." With the time, the foam cells die, leaving a 'necrotic core' of crystalline cholesterol and cell debris. Smooth muscle cells proliferate and migrate into the region, laying down a protective cap over the lesion. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), which mediates the recognition and internalization of oxLDL, is involved in all of these events critical in the pathogenesis of atherosclerosis.
Class
Human Diseases; Cardiovascular disease
Pathway map
pvp05417  Lipid and atherosclerosis
pvp05417

Disease
H02505  Atherosclerosis
Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288270  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
105288306  NCF4; neutrophil cytosol factor 4 [KO:K08012]
105288497  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105288781  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105288852  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105288866  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X2 [KO:K04515] [EC:2.7.11.17]
105288933  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105289440  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
105289473  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105289628  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
105289818  APOB; LOW QUALITY PROTEIN: apolipoprotein B-100 [KO:K14462]
105289903  IL12B; interleukin-12 subunit beta [KO:K05425]
105290033  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
105290063  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105290127  CALM1; calmodulin-1 [KO:K02183]
105290433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105290848  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
105291071  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
105291226  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105291271  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X4 [KO:K04430] [EC:2.7.12.2]
105291403  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
105291475  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
105291526  TLR2; toll-like receptor 2 [KO:K10159]
105291966  [KO:K14624]
105292278  MIB1; E3 ubiquitin-protein ligase MIB1 isoform X1 [KO:K10645] [EC:2.3.2.27]
105292339  CXCL8; interleukin-8 [KO:K10030]
105292342  [KO:K05505]
105292652  TLR4; toll-like receptor 4 [KO:K10160]
105292717  BCL2; apoptosis regulator Bcl-2 isoform X2 [KO:K02161]
105292913  CALM2; calmodulin-2 isoform X1 [KO:K02183]
105292998  CASP6; caspase-6 isoform X1 [KO:K04396] [EC:3.4.22.59]
105293029  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105293031  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105293104  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
105293152  IL6; interleukin-6 isoform X2 [KO:K05405]
105293163  [KO:K08738]
105293561  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105294412  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105294710  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105294857  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
105295040  NCF2; neutrophil cytosol factor 2 [KO:K08010]
105295171  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105295342  ABCA1; ATP-binding cassette sub-family A member 1 isoform X3 [KO:K05641]
105295461  ROCK2; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
105295518  CD36; platelet glycoprotein 4 [KO:K06259]
105295631  IL18; interleukin-18 [KO:K05482]
105295639  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
105295781  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105295872  TLR6; toll-like receptor 6 [KO:K10169]
105295896  OLR1; oxidized low-density lipoprotein receptor 1 isoform X2 [KO:K08763]
105295979  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105296040  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105296266  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105296491  LBP; LOW QUALITY PROTEIN: lipopolysaccharide-binding protein [KO:K05399]
105296513  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105296521  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
105296533  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105296657  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B [KO:K04722]
105296700  LY96; lymphocyte antigen 96 [KO:K05400]
105296799  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403]
105296884  RAP1A; ras-related protein Rap-1A [KO:K04353]
105297002  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
105297140  [KO:K02649]
105297238  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
105297322  CALM3; calmodulin-3 [KO:K02183]
105297437  [KO:K01388] [EC:3.4.24.7]
105297444  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
105297467  [KO:K01394] [EC:3.4.24.17]
105297485  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105297551  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105297760  ERN1; LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105297846  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105297848  BAD; bcl2-associated agonist of cell death [KO:K02158]
105297999  RELA; transcription factor p65 [KO:K04735]
105298070  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105298074  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
105298127  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
105298133  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
105298155  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
105298191  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
105298192  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
105298437  [KO:K05414]
105298613  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105298737  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105298936  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105299024  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
105299180  [KO:K02183]
105299213  FOS; proto-oncogene c-Fos [KO:K04379]
105299274  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
105299280  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105299441  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
105299444  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105299667  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
105299797  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105299812  SELE; E-selectin [KO:K06494]
105299832  SELP; LOW QUALITY PROTEIN: P-selectin [KO:K06496]
105299919  [KO:K08009]
105299978  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105300159  [KO:K04456] [EC:2.7.11.1]
105300580  ABCG1; ATP-binding cassette sub-family G member 1 [KO:K05679]
105300734  IKBKE; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
105300938  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
105300975  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
105301022  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105301035  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105301036  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105301058  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
105301110  VAV1; proto-oncogene vav [KO:K05730]
105301118  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105301512  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
105301733  IRF3; interferon regulatory factor 3 [KO:K05411]
105301762  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105302160  RAP1B; ras-related protein Rap-1b [KO:K07836]
105302307  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
105302383  RHOA; transforming protein RhoA [KO:K04513]
105302526  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
105302532  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105302767  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
105302941  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
105302942  [KO:K05730]
105303020  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105303144  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105303182  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105303187  VLDLR; very low-density lipoprotein receptor isoform X1 [KO:K20053]
105303192  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
105303424  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
105303436  JUN; transcription factor AP-1 [KO:K04448]
105303444  [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105303604  MIB2; E3 ubiquitin-protein ligase MIB2 [KO:K10645] [EC:2.3.2.27]
105303606  CALML6; calmodulin-like protein 6 [KO:K02183]
105303769  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105303982  IL1B; interleukin-1 beta [KO:K04519]
105304165  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105304504  PYCARD; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105304619  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105304977  CCL5; C-C motif chemokine 5 [KO:K12499]
105304981  [KO:K05408]
105305012  [KO:K05408]
105305278  AGER; advanced glycosylation end product-specific receptor isoform X9 [KO:K19722]
105305304  [KO:K03283]
105305325  TNF; tumor necrosis factor [KO:K03156]
105305503  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105305590  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
105305615  LDLR; LOW QUALITY PROTEIN: low-density lipoprotein receptor [KO:K12473]
105305666  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
105305707  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
105305747  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
105305876  IL12A; interleukin-12 subunit alpha [KO:K05406]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105305954  IRF7; interferon regulatory factor 7 [KO:K09447]
105306294  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105306836  [KO:K07408] [EC:1.14.14.1]
105306974  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105307045  CD40LG; CD40 ligand [KO:K03161]
105307139  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307342  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
105307347  POU2F2; POU domain, class 2, transcription factor 2 isoform X4 [KO:K09364]
105307377  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
105307477  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105307621  APOA1; apolipoprotein A-I [KO:K08757]
105307627  APOA4; apolipoprotein A-IV [KO:K08760]
105307700  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
105307748  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105308064  NOX1; NADPH oxidase 1 isoform X2 [KO:K08008]
105308212  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
105308244  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105308283  [KO:K04441] [EC:2.7.11.24]
105308488  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
105308561  [KO:K21421] [EC:1.-.-.-]
105308762  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105309141  IFNB1; interferon beta [KO:K05415]
105309143  [KO:K05414]
105309144  [KO:K05414]
105309148  [KO:K05414]
105309297  ERO1A; ERO1-like protein alpha isoform X1 [KO:K10950] [EC:1.8.4.-]
105309343  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
105309514  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
105309689  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105310426  [KO:K08012]
105310642  [KO:K04730] [EC:2.7.11.1]
105310743  HSP90B1; endoplasmin [KO:K09487]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00187  Cholesterol
C00338  Lipopolysaccharide
C00422  Triacylglycerol
C00704  Superoxide
C00865  Phospholipid
C01245  D-myo-Inositol 1,4,5-trisphosphate
C02530  Cholesterol ester
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22064431
  Authors
Weber C, Noels H
  Title
Atherosclerosis: current pathogenesis and therapeutic options.
  Journal
Nat Med 17:1410-22 (2011)
DOI:10.1038/nm.2538
Reference
PMID:25869663
  Authors
Tabas I, Garcia-Cardena G, Owens GK
  Title
Recent insights into the cellular biology of atherosclerosis.
  Journal
J Cell Biol 209:13-22 (2015)
DOI:10.1083/jcb.201412052
Reference
PMID:25614320
  Authors
Tall AR, Yvan-Charvet L
  Title
Cholesterol, inflammation and innate immunity.
  Journal
Nat Rev Immunol 15:104-16 (2015)
DOI:10.1038/nri3793
Reference
PMID:31336709
  Authors
Kattoor AJ, Goel A, Mehta JL
  Title
LOX-1: Regulation, Signaling and Its Role in Atherosclerosis.
  Journal
Antioxidants (Basel) 8:218 (2019)
DOI:10.3390/antiox8070218
Reference
PMID:11985903
  Authors
Mehta JL, Li D
  Title
Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor.
  Journal
J Am Coll Cardiol 39:1429-35 (2002)
DOI:10.1016/s0735-1097(02)01803-x
Reference
PMID:19286611
  Authors
Li D, Mehta JL
  Title
Intracellular signaling of LOX-1 in endothelial cell apoptosis.
  Journal
Circ Res 104:566-8 (2009)
DOI:10.1161/CIRCRESAHA.109.194209
Reference
PMID:24886290
  Authors
Lubrano V, Balzan S
  Title
LOX-1 and ROS, inseparable factors in the process of endothelial damage.
  Journal
Free Radic Res 48:841-8 (2014)
DOI:10.3109/10715762.2014.929122
Reference
PMID:23124189
  Authors
Xu S, Ogura S, Chen J, Little PJ, Moss J, Liu P
  Title
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.
  Journal
Cell Mol Life Sci 70:2859-72 (2013)
DOI:10.1007/s00018-012-1194-z
Reference
PMID:21947818
  Authors
Mitra S, Goyal T, Mehta JL
  Title
Oxidized LDL, LOX-1 and atherosclerosis.
  Journal
Cardiovasc Drugs Ther 25:419-29 (2011)
DOI:10.1007/s10557-011-6341-5
Reference
PMID:21338316
  Authors
Lu J, Mitra S, Wang X, Khaidakov M, Mehta JL
  Title
Oxidative stress and lectin-like ox-LDL-receptor LOX-1 in atherogenesis and tumorigenesis.
  Journal
Antioxid Redox Signal 15:2301-33 (2011)
DOI:10.1089/ars.2010.3792
Reference
PMID:20203069
  Authors
Ou HC, Song TY, Yeh YC, Huang CY, Yang SF, Chiu TH, Tsai KL, Chen KL, Wu YJ, Tsai CS, Chang LY, Kuo WW, Lee SD
  Title
EGCG protects against oxidized LDL-induced endothelial dysfunction by inhibiting LOX-1-mediated signaling.
  Journal
J Appl Physiol (1985) 108:1745-56 (2010)
DOI:10.1152/japplphysiol.00879.2009
Reference
PMID:17614937
  Authors
Chen XP, Zhang TT, Du GH
  Title
Lectin-like oxidized low-density lipoprotein receptor-1, a new promising target for the therapy of atherosclerosis?
  Journal
Cardiovasc Drug Rev 25:146-61 (2007)
DOI:10.1111/j.1527-3466.2007.00009.x
Reference
PMID:20181930
  Authors
Mattaliano MD, Wooters J, Shih HH, Paulsen JE
  Title
ROCK2 associates with lectin-like oxidized LDL receptor-1 and mediates oxidized LDL-induced IL-8 production.
  Journal
Am J Physiol Cell Physiol 298:C1180-7 (2010)
DOI:10.1152/ajpcell.00483.2009
Reference
PMID:27073018
  Authors
Salvador B, Arranz A, Francisco S, Cordoba L, Punzon C, Llamas MA, Fresno M
  Title
Modulation of endothelial function by Toll like receptors.
  Journal
Pharmacol Res 108:46-56 (2016)
DOI:10.1016/j.phrs.2016.03.038
Reference
PMID:23995626
  Authors
Moore KJ, Sheedy FJ, Fisher EA
  Title
Macrophages in atherosclerosis: a dynamic balance.
  Journal
Nat Rev Immunol 13:709-21 (2013)
DOI:10.1038/nri3520
Reference
PMID:25403963
  Authors
Butoi E, Gan AM, Manduteanu I
  Title
Molecular and functional interactions among monocytes/macrophages and smooth muscle cells and their relevance for atherosclerosis.
  Journal
Crit Rev Eukaryot Gene Expr 24:341-55 (2014)
DOI:10.1615/critreveukaryotgeneexpr.2014012157
Reference
PMID:24048132
  Authors
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Related
pathway
pvp04020  Calcium signaling pathway
pvp04115  p53 signaling pathway
pvp04141  Protein processing in endoplasmic reticulum
pvp04151  PI3K-Akt signaling pathway
pvp04210  Apoptosis
pvp04620  Toll-like receptor signaling pathway
pvp04621  NOD-like receptor signaling pathway
pvp04668  TNF signaling pathway
pvp04670  Leukocyte transendothelial migration
pvp04975  Fat digestion and absorption
pvp04979  Cholesterol metabolism
pvp05418  Fluid shear stress and atherosclerosis
KO pathway
ko05417   

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