KEGG   ORTHOLOGY: K05859
Entry
K05859                      KO                                     

Name
PLCG2
Definition
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04020  Calcium signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04066  HIF-1 signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04072  Phospholipase D signaling pathway
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04611  Platelet activation
ko04613  Neutrophil extracellular trap formation
ko04625  C-type lectin receptor signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04750  Inflammatory mediator regulation of TRP channels
ko04919  Thyroid hormone signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04935  Growth hormone synthesis, secretion and action
ko05110  Vibrio cholerae infection
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05131  Shigellosis
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05171  Coronavirus disease - COVID-19
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05223  Non-small cell lung cancer
ko05225  Hepatocellular carcinoma
Module
M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H01743  Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation
H02159  Familial cold autoinflammatory syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04014 Ras signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04370 VEGF signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04064 NF-kappa B signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04066 HIF-1 signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04020 Calcium signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04070 Phosphatidylinositol signaling system
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04072 Phospholipase D signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04613 Neutrophil extracellular trap formation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04625 C-type lectin receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04650 Natural killer cell mediated cytotoxicity
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04662 B cell receptor signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04664 Fc epsilon RI signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04666 Fc gamma R-mediated phagocytosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04670 Leukocyte transendothelial migration
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04062 Chemokine signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04919 Thyroid hormone signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09158 Development and regeneration
   04360 Axon guidance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   04380 Osteoclast differentiation
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05206 MicroRNAs in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05205 Proteoglycans in cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05214 Glioma
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05223 Non-small cell lung cancer
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05171 Coronavirus disease - COVID-19
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05169 Epstein-Barr virus infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
   05131 Shigellosis
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
 Endocytosis
  Macropinocytosis
   Phospholipase C
    K05859  PLCG2; phosphatidylinositol phospholipase C, gamma-2
Other DBs
RN: R03332 R03435 R10952
GO: 0004435
Genes
HSA: 5336(PLCG2)
PTR: 454268(PLCG2)
PPS: 100984694(PLCG2)
GGO: 101133643(PLCG2)
PON: 100457650(PLCG2)
NLE: 100604145(PLCG2)
MCC: 714173(PLCG2)
MCF: 102117471(PLCG2)
CSAB: 103233371(PLCG2)
RRO: 104671624(PLCG2)
RBB: 108539491(PLCG2)
CJC: 100390347(PLCG2)
SBQ: 101030999(PLCG2)
MMU: 234779(Plcg2)
MCAL: 110300336(Plcg2)
MPAH: 110337392(Plcg2)
RNO: 29337(Plcg2)
MUN: 110550263(Plcg2)
CGE: 100752475(Plcg2)
NGI: 103725694 103748739
HGL: 101715321(Plcg2)
CCAN: 109696649(Plcg2)
OCU: 100340139(PLCG2)
TUP: 102483786(PLCG2)
CFA: 489692(PLCG2)
VVP: 112911890 112912331
AML: 100481994(PLCG2)
UMR: 103662093(PLCG2)
UAH: 113252535(PLCG2)
ORO: 101378505(PLCG2)
ELK: 111152978
FCA: 101080675(PLCG2)
PTG: 102963653(PLCG2)
PPAD: 109245637(PLCG2)
AJU: 106984018(PLCG2)
BTA: 100337091(PLCG2)
BOM: 102285300(PLCG2)
BIU: 109572707(PLCG2)
BBUB: 102396307(PLCG2)
CHX: 102180337(PLCG2)
OAS: 101122126(PLCG2)
SSC: 100518663(PLCG2)
CFR: 102514470(PLCG2)
CDK: 105089440(PLCG2)
BACU: 103014764(PLCG2)
LVE: 103070997(PLCG2)
OOR: 101285216(PLCG2)
DLE: 111179463(PLCG2)
PCAD: 102983230(PLCG2)
ECB: 100055670(PLCG2)
EPZ: 103558212(PLCG2)
EAI: 106832855(PLCG2)
MYB: 102261553(PLCG2)
MYD: 102773476(PLCG2)
MNA: 107524904(PLCG2)
HAI: 109378365(PLCG2)
DRO: 112300725(PLCG2)
PALE: 102883128(PLCG2)
RAY: 107521319(PLCG2)
MJV: 108400464(PLCG2)
LAV: 100658990(PLCG2)
TMU: 101346393
MDO: 100027579(PLCG2)
SHR: 100919206(PLCG2)
PCW: 110212621(PLCG2)
OAA: 100076776(PLCG2)
GGA: 415805(PLCG2)
MGP: 100549684(PLCG2)
CJO: 107319403(PLCG2)
NMEL: 110404260(PLCG2)
APLA: 101799246(PLCG2)
ACYG: 106044837
TGU: 100219388(PLCG2)
LSR: 110476350(PLCG2)
SCAN: 103816730(PLCG2)
GFR: 102039725(PLCG2)
FAB: 101811465(PLCG2)
PHI: 102103443(PLCG2)
PMAJ: 107209788(PLCG2)
CCAE: 111934454(PLCG2)
CCW: 104691823(PLCG2)
ETL: 114066562(PLCG2)
FPG: 101914329(PLCG2)
FCH: 102058636(PLCG2)
CLV: 102095823(PLCG2)
EGZ: 104133768(PLCG2)
NNI: 104014569(PLCG2)
ACUN: 113484485(PLCG2)
PADL: 103923865(PLCG2)
AAM: 106483269(PLCG2)
ASN: 102378303(PLCG2)
AMJ: 106736910(PLCG2)
PSS: 102454220(PLCG2)
CMY: 102930635(PLCG2)
CPIC: 101932685(PLCG2)
ACS: 100566814(plcg2)
PVT: 110085508(PLCG2)
PBI: 103052396(PLCG2)
PMUR: 107292601(PLCG2)
TSR: 106539149(PLCG2)
PMUA: 114601931(PLCG2)
GJA: 107105783(PLCG2)
XLA: 108714087(plcg2.L)
XTR: 100496686(plcg2)
NPR: 108786572(PLCG2)
DRE: 561747(plcg2)
SRX: 107722471 107738392
SANH: 107666218 107666222(plcg2) 107684680
SGH: 107559804(plcg2) 107587040 107587041
CCAR: 109047939 109057498
IPU: 108264222(plcg2)
PHYP: 113534527(plcg2)
AMEX: 103036277(plcg2)
EEE: 113577174(plcg2)
TRU: 101072923(plcg2)
TNG: GSTEN00016798G001
LCO: 104932460(plcg2)
MZE: 101479429(plcg2)
ONL: 100697485(plcg2)
OLA: 101157053(plcg2)
XMA: 102220131(plcg2)
XCO: 114137117(plcg2)
PRET: 103466833(plcg2)
CVG: 107084318(plcg2)
NFU: 107389305(plcg2)
KMR: 108237447(plcg2)
ALIM: 106536649(plcg2)
AOCE: 111563111(plcg2)
CSEM: 103379748(plcg2)
POV: 109641214(plcg2)
LCF: 108902239(plcg2)
SDU: 111229657(plcg2)
SLAL: 111647676(plcg2)
HCQ: 109513068(plcg2)
BPEC: 110169397(plcg2)
MALB: 109967271(plcg2)
SASA: 106573684(plcg2)
OTW: 112252303(plcg2)
SALP: 111952198(plcg2)
ELS: 105018577(plcg2)
SFM: 108926548 108926652(plcg2)
PKI: 111851875(plcg2)
LCM: 102358132(PLCG2)
CMK: 103175953(plcg2)
RTP: 109928136
API: 100161327
 » show all
Reference
PMID:2849563
  Authors
Ohta S, Matsui A, Nazawa Y, Kagawa Y
  Title
Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.
  Journal
FEBS Lett 242:31-5 (1988)
DOI:10.1016/0014-5793(88)80979-7
  Sequence
[hsa:5336]
Reference
  Authors
Bernal-Quiros M, Wu YY, Alarcon-Riquelme ME, Castillejo-Lopez C
  Title
BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.
  Journal
PLoS One 8:e59842 (2013)
DOI:10.1371/journal.pone.0059842
LinkDB

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