ORTHOLOGY: K05859
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Entry
K05859 KO
Name
PLCG2
Definition
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Pathway
ko00562
Inositol phosphate metabolism
ko01100
Metabolic pathways
ko01521
EGFR tyrosine kinase inhibitor resistance
ko04012
ErbB signaling pathway
ko04014
Ras signaling pathway
ko04020
Calcium signaling pathway
ko04062
Chemokine signaling pathway
ko04064
NF-kappa B signaling pathway
ko04066
HIF-1 signaling pathway
ko04070
Phosphatidylinositol signaling system
ko04072
Phospholipase D signaling pathway
ko04360
Axon guidance
ko04370
VEGF signaling pathway
ko04380
Osteoclast differentiation
ko04611
Platelet activation
ko04613
Neutrophil extracellular trap formation
ko04625
C-type lectin receptor signaling pathway
ko04650
Natural killer cell mediated cytotoxicity
ko04662
B cell receptor signaling pathway
ko04664
Fc epsilon RI signaling pathway
ko04666
Fc gamma R-mediated phagocytosis
ko04670
Leukocyte transendothelial migration
ko04722
Neurotrophin signaling pathway
ko04750
Inflammatory mediator regulation of TRP channels
ko04919
Thyroid hormone signaling pathway
ko04933
AGE-RAGE signaling pathway in diabetic complications
ko04935
Growth hormone synthesis, secretion and action
ko05110
Vibrio cholerae infection
ko05120
Epithelial cell signaling in Helicobacter pylori infection
ko05131
Shigellosis
ko05167
Kaposi sarcoma-associated herpesvirus infection
ko05169
Epstein-Barr virus infection
ko05170
Human immunodeficiency virus 1 infection
ko05171
Coronavirus disease - COVID-19
ko05200
Pathways in cancer
ko05205
Proteoglycans in cancer
ko05206
MicroRNAs in cancer
ko05214
Glioma
ko05223
Non-small cell lung cancer
ko05225
Hepatocellular carcinoma
Module
M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H01743
Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulation
H02159
Familial cold autoinflammatory syndrome
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04014 Ras signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04370 VEGF signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04064 NF-kappa B signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04066 HIF-1 signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04020 Calcium signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04070 Phosphatidylinositol signaling system
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04072 Phospholipase D signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04613 Neutrophil extracellular trap formation
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04625 C-type lectin receptor signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04650 Natural killer cell mediated cytotoxicity
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04662 B cell receptor signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04664 Fc epsilon RI signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04666 Fc gamma R-mediated phagocytosis
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04670 Leukocyte transendothelial migration
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04062 Chemokine signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04919 Thyroid hormone signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09156 Nervous system
04722 Neurotrophin signaling pathway
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09158 Development and regeneration
04360 Axon guidance
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
04380 Osteoclast differentiation
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
05206 MicroRNAs in cancer
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
05205 Proteoglycans in cancer
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09162 Cancer: specific types
05225 Hepatocellular carcinoma
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
05214 Glioma
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
05223 Non-small cell lung cancer
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
05171 Coronavirus disease - COVID-19
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
05167 Kaposi sarcoma-associated herpesvirus infection
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
05169 Epstein-Barr virus infection
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09171 Infectious disease: bacterial
05110 Vibrio cholerae infection
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
05120 Epithelial cell signaling in Helicobacter pylori infection
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
05131 Shigellosis
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
Enzymes [BR:
ko01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
Membrane trafficking [BR:
ko04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
Endocytosis
Macropinocytosis
Phospholipase C
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2
BRITE hierarchy
Other DBs
RN:
R03332
R03435
R10952
GO:
0004435
Genes
HSA:
5336
(PLCG2)
PTR:
454268
(PLCG2)
PPS:
100984694
(PLCG2)
GGO:
101133643
(PLCG2)
PON:
100457650
(PLCG2)
NLE:
100604145
(PLCG2)
MCC:
714173
(PLCG2)
MCF:
102117471
(PLCG2)
CSAB:
103233371
(PLCG2)
RRO:
104671624
(PLCG2)
RBB:
108539491
(PLCG2)
CJC:
100390347
(PLCG2)
SBQ:
101030999
(PLCG2)
MMU:
234779
(Plcg2)
MCAL:
110300336
(Plcg2)
MPAH:
110337392
(Plcg2)
RNO:
29337
(Plcg2)
MUN:
110550263
(Plcg2)
CGE:
100752475
(Plcg2)
NGI:
103725694
103748739
HGL:
101715321
(Plcg2)
CCAN:
109696649
(Plcg2)
OCU:
100340139
(PLCG2)
TUP:
102483786
(PLCG2)
CFA:
489692
(PLCG2)
VVP:
112911890
112912331
AML:
100481994
(PLCG2)
UMR:
103662093
(PLCG2)
UAH:
113252535
(PLCG2)
ORO:
101378505
(PLCG2)
ELK:
111152978
FCA:
101080675
(PLCG2)
PTG:
102963653
(PLCG2)
PPAD:
109245637
(PLCG2)
AJU:
106984018
(PLCG2)
BTA:
100337091
(PLCG2)
BOM:
102285300
(PLCG2)
BIU:
109572707
(PLCG2)
BBUB:
102396307
(PLCG2)
CHX:
102180337
(PLCG2)
OAS:
101122126
(PLCG2)
SSC:
100518663
(PLCG2)
CFR:
102514470
(PLCG2)
CDK:
105089440
(PLCG2)
BACU:
103014764
(PLCG2)
LVE:
103070997
(PLCG2)
OOR:
101285216
(PLCG2)
DLE:
111179463
(PLCG2)
PCAD:
102983230
(PLCG2)
ECB:
100055670
(PLCG2)
EPZ:
103558212
(PLCG2)
EAI:
106832855
(PLCG2)
MYB:
102261553
(PLCG2)
MYD:
102773476
(PLCG2)
MNA:
107524904
(PLCG2)
HAI:
109378365
(PLCG2)
DRO:
112300725
(PLCG2)
PALE:
102883128
(PLCG2)
RAY:
107521319
(PLCG2)
MJV:
108400464
(PLCG2)
LAV:
100658990
(PLCG2)
TMU:
101346393
MDO:
100027579
(PLCG2)
SHR:
100919206
(PLCG2)
PCW:
110212621
(PLCG2)
OAA:
100076776
(PLCG2)
GGA:
415805
(PLCG2)
MGP:
100549684
(PLCG2)
CJO:
107319403
(PLCG2)
NMEL:
110404260
(PLCG2)
APLA:
101799246
(PLCG2)
ACYG:
106044837
TGU:
100219388
(PLCG2)
LSR:
110476350
(PLCG2)
SCAN:
103816730
(PLCG2)
GFR:
102039725
(PLCG2)
FAB:
101811465
(PLCG2)
PHI:
102103443
(PLCG2)
PMAJ:
107209788
(PLCG2)
CCAE:
111934454
(PLCG2)
CCW:
104691823
(PLCG2)
ETL:
114066562
(PLCG2)
FPG:
101914329
(PLCG2)
FCH:
102058636
(PLCG2)
CLV:
102095823
(PLCG2)
EGZ:
104133768
(PLCG2)
NNI:
104014569
(PLCG2)
ACUN:
113484485
(PLCG2)
PADL:
103923865
(PLCG2)
AAM:
106483269
(PLCG2)
ASN:
102378303
(PLCG2)
AMJ:
106736910
(PLCG2)
PSS:
102454220
(PLCG2)
CMY:
102930635
(PLCG2)
CPIC:
101932685
(PLCG2)
ACS:
100566814
(plcg2)
PVT:
110085508
(PLCG2)
PBI:
103052396
(PLCG2)
PMUR:
107292601
(PLCG2)
TSR:
106539149
(PLCG2)
PMUA:
114601931
(PLCG2)
GJA:
107105783
(PLCG2)
XLA:
108714087
(plcg2.L)
XTR:
100496686
(plcg2)
NPR:
108786572
(PLCG2)
DRE:
561747
(plcg2)
SRX:
107722471
107738392
SANH:
107666218
107666222
(plcg2)
107684680
SGH:
107559804
(plcg2)
107587040
107587041
CCAR:
109047939
109057498
IPU:
108264222
(plcg2)
PHYP:
113534527
(plcg2)
AMEX:
103036277
(plcg2)
EEE:
113577174
(plcg2)
TRU:
101072923
(plcg2)
TNG:
GSTEN00016798G001
LCO:
104932460
(plcg2)
MZE:
101479429
(plcg2)
ONL:
100697485
(plcg2)
OLA:
101157053
(plcg2)
XMA:
102220131
(plcg2)
XCO:
114137117
(plcg2)
PRET:
103466833
(plcg2)
CVG:
107084318
(plcg2)
NFU:
107389305
(plcg2)
KMR:
108237447
(plcg2)
ALIM:
106536649
(plcg2)
AOCE:
111563111
(plcg2)
CSEM:
103379748
(plcg2)
POV:
109641214
(plcg2)
LCF:
108902239
(plcg2)
SDU:
111229657
(plcg2)
SLAL:
111647676
(plcg2)
HCQ:
109513068
(plcg2)
BPEC:
110169397
(plcg2)
MALB:
109967271
(plcg2)
SASA:
106573684
(plcg2)
OTW:
112252303
(plcg2)
SALP:
111952198
(plcg2)
ELS:
105018577
(plcg2)
SFM:
108926548
108926652
(plcg2)
PKI:
111851875
(plcg2)
LCM:
102358132
(PLCG2)
CMK:
103175953
(plcg2)
RTP:
109928136
API:
100161327
» show all
Taxonomy
UniProt
Reference
PMID:
2849563
Authors
Ohta S, Matsui A, Nazawa Y, Kagawa Y
Title
Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes.
Journal
FEBS Lett 242:31-5 (1988)
DOI:
10.1016/0014-5793(88)80979-7
Sequence
[hsa:
5336
]
Reference
PMID:
23555801
Authors
Bernal-Quiros M, Wu YY, Alarcon-Riquelme ME, Castillejo-Lopez C
Title
BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.
Journal
PLoS One 8:e59842 (2013)
DOI:
10.1371/journal.pone.0059842
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integrated database retrieval system