KEGG   PATHWAY: chx05010
Entry
chx05010                    Pathway                                
Name
Alzheimer disease - Capra hircus (goat)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
chx05010  Alzheimer disease
chx05010

Disease
H00056  Alzheimer disease
Organism
Capra hircus (goat) [GN:chx]
Gene
100860742  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100860750  LPL; lipoprotein lipase precursor [KO:K01059] [EC:3.1.1.34]
100860782  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
100860785  IL6; interleukin-6 precursor [KO:K05405]
100860816  IL1B; interleukin-1 beta [KO:K04519]
100860820  MAPT; microtubule-associated protein tau isoform X16 [KO:K04380]
100860840  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
100860872  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
100860881  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
100860902  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100860904  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100860905  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100860921  SLC39A2; zinc transporter ZIP2 [KO:K14709]
100860948  SLC39A3; zinc transporter ZIP3 [KO:K14709]
100860949  SLC39A13; zinc transporter ZIP13 precursor [KO:K14719]
100861087  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100861133  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100861232  TNF; tumor necrosis factor [KO:K03156]
100861263  [KO:K00415]
100861284  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100861289  IL1A; LOW QUALITY PROTEIN: interleukin-1 alpha [KO:K04383]
100861292  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
100861313  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
100861316  SLC39A1; zinc transporter ZIP1 [KO:K14709]
100861343  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
100861349  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
100861351  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100861376  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
102168216  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
102168293  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
102168353  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
102168391  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102168407  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
102168455  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102168533  [KO:K00420]
102168606  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
102168736  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
102168873  AGER; advanced glycosylation end product-specific receptor isoform X2 [KO:K19722]
102168953  TUBB; tubulin beta chain [KO:K07375]
102168996  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102169203  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
102169259  WNT10B; protein Wnt-10b [KO:K01357]
102169368  SNCA; alpha-synuclein [KO:K04528]
102169370  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102169405  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
102169419  WNT9B; protein Wnt-9b [KO:K01064]
102169457  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102169649  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
102169697  CALM3; calmodulin [KO:K02183]
102169703  WNT3; proto-oncogene Wnt-3 [KO:K00312]
102169837  SLC39A5; zinc transporter ZIP5 [KO:K14711]
102169919  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
102169966  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102169976  [KO:K00413]
102170016  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
102170135  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102170314  APOE; apolipoprotein E [KO:K04524]
102170375  AXIN1; axin-1 isoform X1 [KO:K02157]
102170408  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102170430  APH1B; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]
102170617  FZD6; frizzled-6 [KO:K02376]
102170632  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
102170635  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
102170760  FADD; FAS-associated death domain protein [KO:K02373]
102170842  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
102170858  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102170877  [KO:K02272]
102170921  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
102171149  [KO:K00418]
102171224  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
102171428  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
102171521  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
102171561  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
102171591  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102171665  WNT7A; protein Wnt-7a [KO:K00572]
102171860  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
102171890  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
102172091  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
102172156  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102172164  CALM2; calmodulin isoform X1 [KO:K02183]
102172289  [KO:K00411] [EC:7.1.1.8]
102172376  [KO:K02266]
102172519  KRAS; GTPase KRas isoform X1 [KO:K07827]
102172642  PSMA7; proteasome subunit alpha type-7 isoform X1 [KO:K02731] [EC:3.4.25.1]
102172903  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
102172948  FZD7; frizzled-7 [KO:K02432]
102172952  [KO:K07375]
102173038  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102173075  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102173093  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
102173138  KLC4; kinesin light chain 4 [KO:K10407]
102173178  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102173290  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102173325  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
102173355  [KO:K02135]
102173516  SLC39A6; zinc transporter ZIP6 [KO:K14712]
102173562  [KO:K02272]
102173603  ATP5H; ATP synthase subunit d, mitochondrial [KO:K02138]
102173623  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
102173770  [KO:K02268]
102173809  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
102173837  [KO:K07374]
102173997  [KO:K08738]
102174051  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102174090  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
102174096  RELA; transcription factor p65 [KO:K04735]
102174119  SLC39A14; zinc transporter ZIP14 isoform X1 [KO:K14720]
102174360  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102174419  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
102174462  KLC2; kinesin light chain 2 [KO:K10407]
102174633  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
102174681  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102174706  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102174773  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
102174960  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
102174961  FZD10; frizzled-10 [KO:K02842]
102175024  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
102175136  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
102175285  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102175303  SLC39A9; zinc transporter ZIP9 [KO:K14715]
102175311  [KO:K02183]
102175498  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
102175557  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
102175610  [KO:K02270]
102175660  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102175703  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
102175724  FZD5; frizzled-5 [KO:K02375]
102175796  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
102175938  [KO:K21421] [EC:1.-.-.-]
102176032  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
102176071  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
102176106  BID; BH3-interacting domain death agonist [KO:K04726]
102176151  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
102176171  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
102176193  WNT8B; protein Wnt-8b [KO:K00714]
102176290  [KO:K00416]
102176310  WNT5B; protein Wnt-5b [KO:K00444]
102176363  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102176404  TUBA8; tubulin alpha-8 chain [KO:K07374]
102176546  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102176558  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
102176666  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102176723  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
102176768  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
102176770  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102176841  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
102176902  SLC39A4; zinc transporter ZIP4 [KO:K14710]
102176996  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
102177031  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102177097  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
102177130  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
102177187  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
102177332  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
102177339  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102177363  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
102177406  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102177410  TUBA1A; tubulin alpha-1A chain [KO:K07374]
102177417  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
102177419  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
102177435  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
102177551  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102177598  RTN3; reticulon-3 isoform X1 [KO:K20723]
102177846  [KO:K07374]
102177927  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102177934  [KO:K08333] [EC:2.7.11.1]
102177945  WNT10A; protein Wnt-10a [KO:K01357]
102178040  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
102178048  NOX1; NADPH oxidase 1 [KO:K08008]
102178062  TUBB4A; tubulin beta-4A chain [KO:K07375]
102178119  [KO:K07374]
102178323  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
102178409  TUBB6; tubulin beta-6 chain [KO:K07375]
102178426  [KO:K07374]
102178446  FZD3; frizzled-3 [KO:K02329]
102178499  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
102178700  [KO:K07374]
102178813  [KO:K05863]
102179036  [KO:K02267]
102179237  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
102179291  [KO:K02265]
102179296  [KO:K02263]
102179305  APBB1; amyloid beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
102179343  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102179361  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
102179415  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
102179638  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
102179643  IRS4; insulin receptor substrate 4 [KO:K17446]
102179705  CHRNA7; LOW QUALITY PROTEIN: neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
102179767  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102180014  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102180165  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
102180281  WNT2; protein Wnt-2 [KO:K00182]
102180348  AXIN2; axin-2 isoform X1 [KO:K04385]
102180353  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
102180448  FZD9; frizzled-9 [KO:K02842]
102180451  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
102180505  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102180576  [KO:K08960] [EC:2.7.11.1]
102180626  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
102180674  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
102180716  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
102180777  RB1CC1; RB1-inducible coiled-coil protein 1 [KO:K17589]
102180953  BACE1; beta-secretase 1 isoform X2 [KO:K04521] [EC:3.4.23.46]
102181016  [KO:K00134] [EC:1.2.1.12]
102181026  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
102181148  [KO:K07375]
102181181  [KO:K02266]
102181192  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
102181207  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
102181227  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
102181262  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102181496  CSNK1A1; casein kinase I isoform X2 [KO:K08957] [EC:2.7.11.1]
102181511  SLC39A12; zinc transporter ZIP12 isoform X2 [KO:K14718]
102181655  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
102181749  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
102181789  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
102181922  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
102182003  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
102182009  WNT2B; protein Wnt-2b [KO:K00182]
102182021  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
102182039  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
102182082  CSNK2B; casein kinase II subunit beta [KO:K03115]
102182190  DKK1; dickkopf-related protein 1 [KO:K02165]
102182202  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
102182415  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
102182444  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
102182487  SLC39A8; zinc transporter ZIP8 [KO:K14714]
102182568  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
102182602  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
102182696  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
102182774  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102182879  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
102183107  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
102183195  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
102183205  FZD1; frizzled-1 [KO:K02432]
102183281  NCSTN; nicastrin isoform X2 [KO:K06171]
102183547  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
102183616  [KO:K00417]
102183635  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
102183643  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X2 [KO:K03944]
102183940  [KO:K08957] [EC:2.7.11.1]
102184016  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
102184033  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102184049  WNT3A; protein Wnt-3a [KO:K00312]
102184053  WNT8A; protein Wnt-8a isoform X2 [KO:K00714]
102184096  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
102184122  FZD4; frizzled-4 [KO:K02354]
102184255  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102184256  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
102184322  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
102184414  [KO:K08957] [EC:2.7.11.1]
102184456  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
102184460  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
102184488  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
102184512  [KO:K02271]
102184724  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
102184768  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102184858  IRS1; insulin receptor substrate 1 [KO:K16172]
102184878  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
102184896  WNT9A; protein Wnt-9a [KO:K01064]
102184900  TUBB4B; tubulin beta-4B chain [KO:K07375]
102184937  [KO:K02267]
102184949  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
102185007  CALM1; calmodulin [KO:K02183]
102185042  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102185051  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
102185072  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102185248  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
102185490  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
102185511  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
102185575  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
102185667  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
102185716  ATG101; autophagy-related protein 101 [KO:K19730]
102186040  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102186141  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
102186286  [KO:K02271]
102186405  RTN4; reticulon-4 isoform X1 [KO:K20720]
102186449  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
102186463  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
102186623  PSMC4; 26S protease regulatory subunit 6B [KO:K03063]
102186668  HRAS; GTPase HRas isoform X1 [KO:K02833]
102186997  APP; amyloid beta A4 protein isoform X1 [KO:K04520]
102187059  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102187118  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
102187154  [KO:K00419]
102187161  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
102187178  PSMA8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
102187180  NRAS; GTPase NRas [KO:K07828]
102187246  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
102187248  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
102187374  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
102187430  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
102187450  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
102187496  [KO:K02270]
102187521  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102187560  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
102187765  [KO:K07374]
102187797  KLC3; kinesin light chain 3 [KO:K10407]
102187812  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
102187819  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
102187843  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102187882  BECN2; beclin-2 [KO:K08334]
102187906  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
102187983  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
102188021  [KO:K02273]
102188061  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
102188065  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
102188083  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
102188092  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
102188113  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
102188148  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102188264  [KO:K00414]
102188327  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
102188330  TUBB1; tubulin beta-1 chain isoform X2 [KO:K07375]
102188420  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
102188434  [KO:K02263]
102188440  FZD2; frizzled-2 [KO:K02235]
102188541  KIF5C; kinesin heavy chain [KO:K10396]
102188662  DKK2; dickkopf-related protein 2 [KO:K02165]
102188663  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
102188675  [KO:K02270]
102188710  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102188764  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
102188824  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102188830  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
102189010  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
102189176  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
102189432  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
102189537  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
102189653  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102189698  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
102189746  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102189802  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
102189930  BAD; bcl2-associated agonist of cell death [KO:K02158]
102189950  [KO:K04634]
102190150  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
102190237  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
102190297  [KO:K21398]
102190310  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102190520  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X4 [KO:K04368] [EC:2.7.12.2]
102190653  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
102190728  BECN1; beclin-1 [KO:K08334]
102190747  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
102190848  SHFM1; 26S proteasome complex subunit DSS1 [KO:K10881]
102190935  [KO:K21398]
102190980  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
102191015  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
102191052  RYR3; ryanodine receptor 3 [KO:K04963]
102191163  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
102191205  WNT16; protein Wnt-16 [KO:K01558]
102191650  SLC39A11; zinc transporter ZIP11 isoform X3 [KO:K14717]
102191741  [KO:K02264]
102191742  CTNNB1; catenin beta-1 [KO:K02105]
102191745  SLC39A10; zinc transporter ZIP10 [KO:K14716]
106501717  [KO:K08738]
106502750  FZD8; frizzled-8 [KO:K02375]
106502751  [KO:K02183]
106503755  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
108633170  [KO:K02272]
108633269  TUBB2A; tubulin beta-2A chain [KO:K07375]
108633307  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
108634037  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
108634040  FRAT1; proto-oncogene FRAT1 [KO:K03069]
108634241  INS; insulin [KO:K04526]
108634926  [KO:K08957] [EC:2.7.11.1]
108635087  [KO:K02270]
108635484  [KO:K08333] [EC:2.7.11.1]
108635646  [KO:K00419]
108636002  TUBA1C; tubulin alpha-1C chain [KO:K07374]
108636054  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
108637286  IRS2; insulin receptor substrate 2 [KO:K07187]
108637522  [KO:K21246]
108637658  WNT6; protein Wnt-6 [KO:K00445]
108638619  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
1485856  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
1485857  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
1485858  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
1485859  COX2; cytochrome c oxidase subunit II [KO:K02261]
1485860  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
1485861  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
1485862  COX3; cytochrome c oxidase subunit III [KO:K02262]
1485863  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
1485864  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
1485865  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
1485866  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
1485867  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
1485868  CYTB; cytochrome b [KO:K00412]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
Reference
PMID:15232608
  Authors
Dickson DW
  Title
Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
  Journal
J Clin Invest 114:23-7 (2004)
DOI:10.1172/JCI22317
Reference
PMID:15750290
  Authors
Takuma K, Yan SS, Stern DM, Yamada K
  Title
Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease.
  Journal
J Pharmacol Sci 97:312-6 (2005)
DOI:10.1254/jphs.CPJ04006X
Reference
PMID:18675468
  Authors
Bezprozvanny I, Mattson MP
  Title
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.
  Journal
Trends Neurosci 31:454-63 (2008)
DOI:10.1016/j.tins.2008.06.005
Reference
PMID:9848086
  Authors
Holscher C
  Title
Possible causes of Alzheimer's disease: amyloid fragments, free radicals, and calcium homeostasis.
  Journal
Neurobiol Dis 5:129-41 (1998)
DOI:10.1006/nbdi.1998.0193
Reference
PMID:18035450
  Authors
Bojarski L, Herms J, Kuznicki J
  Title
Calcium dysregulation in Alzheimer's disease.
  Journal
Neurochem Int 52:621-33 (2008)
DOI:10.1016/j.neuint.2007.10.002
Reference
PMID:25450339
  Authors
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N
  Title
Ion channels in the regulation of apoptosis.
  Journal
Biochim Biophys Acta 1848:2532-46 (2015)
DOI:10.1016/j.bbamem.2014.10.030
Reference
PMID:29890840
  Authors
Popugaeva E, Pchitskaya E, Bezprozvanny I
  Title
Dysregulation of Intracellular Calcium Signaling in Alzheimer's Disease.
  Journal
Antioxid Redox Signal 29:1176-1188 (2018)
DOI:10.1089/ars.2018.7506
Reference
PMID:25767489
  Authors
Tan Y, Deng Y, Qing H
  Title
Calcium channel blockers and Alzheimer's disease.
  Journal
Neural Regen Res 7:137-40 (2012)
DOI:10.3969/j.issn.1673-5374.2012.02.010
Reference
PMID:11484003
  Authors
Small DH, Mok SS, Bornstein JC
  Title
Alzheimer's disease and Abeta toxicity: from top to bottom.
  Journal
Nat Rev Neurosci 2:595-8 (2001)
DOI:10.1038/35086072
Reference
PMID:15177383
  Authors
Parihar MS, Hemnani T
  Title
Alzheimer's disease pathogenesis and therapeutic interventions.
  Journal
J Clin Neurosci 11:456-67 (2004)
DOI:10.1016/j.jocn.2003.12.007
Reference
PMID:17568632
  Authors
Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A
  Title
Presenilin-mediated signal transduction.
  Journal
Physiol Behav 92:93-7 (2007)
DOI:10.1016/j.physbeh.2007.05.053
Reference
PMID:22842534
  Authors
Honarnejad K, Herms J
  Title
Presenilins: role in calcium homeostasis.
  Journal
Int J Biochem Cell Biol 44:1983-6 (2012)
DOI:10.1016/j.biocel.2012.07.019
Reference
PMID:21663966
  Authors
Supnet C, Bezprozvanny I
  Title
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.
  Journal
Cell Calcium 50:303-9 (2011)
DOI:10.1016/j.ceca.2011.05.013
Reference
PMID:16677790
  Authors
Hauptmann S, Keil U, Scherping I, Bonert A, Eckert A, Muller WE
  Title
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease.
  Journal
Exp Gerontol 41:668-73 (2006)
DOI:10.1016/j.exger.2006.03.012
Reference
PMID:14557245
  Authors
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
  Title
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
  Journal
J Cell Biol 163:27-33 (2003)
DOI:10.1083/jcb.200304003
Reference
PMID:24051203
  Authors
Eckert A, Nisbet R, Grimm A, Gotz J
  Title
March separate, strike together--role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease.
  Journal
Biochim Biophys Acta 1842:1258-66 (2014)
DOI:10.1016/j.bbadis.2013.08.013
Reference
PMID:30741722
  Authors
Strickland MR, Holtzman DM
  Title
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1.
  Journal
J Clin Invest 129:969-971 (2019)
DOI:10.1172/JCI127578
Reference
PMID:10527810
  Authors
Ivins KJ, Thornton PL, Rohn TT, Cotman CW
  Title
Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.
  Journal
Neurobiol Dis 6:440-9 (1999)
DOI:10.1006/nbdi.1999.0268
Reference
PMID:31655116
  Authors
Sushma, Mondal AC
  Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
  Journal
Mol Cell Neurosci 101:103414 (2019)
DOI:10.1016/j.mcn.2019.103414
Reference
PMID:18648507
  Authors
Sanz-Blasco S, Valero RA, Rodriguez-Crespo I, Villalobos C, Nunez L
  Title
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
  Journal
PLoS One 3:e2718 (2008)
DOI:10.1371/journal.pone.0002718
Reference
PMID:20332425
  Authors
Mattson MP
  Title
ER calcium and Alzheimer's disease: in a state of flux.
  Journal
Sci Signal 3:pe10 (2010)
DOI:10.1126/scisignal.3114pe10
Reference
PMID:16394273
  Authors
Lee SY, Hwang DY, Kim YK, Lee JW, Shin IC, Oh KW, Lee MK, Lim JS, Yoon DY, Hwang SJ, Hong JT
  Title
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release.
  Journal
FASEB J 20:151-3 (2006)
DOI:10.1096/fj.05-4017fje;1
Reference
PMID:11551913
  Authors
Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, George-Hyslop PS, Tohyama M
  Title
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
  Journal
J Biol Chem 276:43446-54 (2001)
DOI:10.1074/jbc.M104096200
Reference
PMID:28057414
  Authors
Lane-Donovan C, Herz J
  Title
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.
  Journal
Trends Endocrinol Metab 28:273-284 (2017)
DOI:10.1016/j.tem.2016.12.001
Reference
PMID:27994051
  Authors
Wasser CR, Herz J
  Title
Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.
  Journal
J Biol Chem 292:1330-1338 (2017)
DOI:10.1074/jbc.R116.766782
Reference
PMID:21116052
  Authors
Lilja AM, Porras O, Storelli E, Nordberg A, Marutle A
  Title
Functional interactions of fibrillar and oligomeric amyloid-beta with alpha7 nicotinic receptors in Alzheimer's disease.
  Journal
J Alzheimers Dis 23:335-47 (2011)
DOI:10.3233/JAD-2010-101242
Reference
PMID:24847263
  Authors
Anastasio TJ
  Title
Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-beta on synaptic plasticity.
  Journal
Front Pharmacol 5:85 (2014)
DOI:10.3389/fphar.2014.00085
Reference
PMID:29378302
  Authors
Vargas LM, Cerpa W, Munoz FJ, Zanlungo S, Alvarez AR
  Title
Amyloid-beta oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease.
  Journal
Biochim Biophys Acta Mol Basis Dis 1864:1148-1159 (2018)
DOI:10.1016/j.bbadis.2018.01.023
Reference
PMID:25394486
  Authors
Tu S, Okamoto S, Lipton SA, Xu H
  Title
Oligomeric Abeta-induced synaptic dysfunction in Alzheimer's disease.
  Journal
Mol Neurodegener 9:48 (2014)
DOI:10.1186/1750-1326-9-48
Reference
PMID:31191253
  Authors
Palomer E, Buechler J, Salinas PC
  Title
Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.
  Journal
Front Cell Neurosci 13:227 (2019)
DOI:10.3389/fncel.2019.00227
Reference
PMID:27807401
  Authors
Vallee A, Lecarpentier Y
  Title
Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma.
  Journal
Front Neurosci 10:459 (2016)
DOI:10.3389/fnins.2016.00459
Reference
PMID:19903023
  Authors
Origlia N, Arancio O, Domenici L, Yan SS
  Title
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.
  Journal
Expert Rev Neurother 9:1635-45 (2009)
DOI:10.1586/ern.09.107
Reference
PMID:19464758
  Authors
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G
  Title
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease.
  Journal
Neurobiol Aging 32:763-77 (2011)
DOI:10.1016/j.neurobiolaging.2009.04.016
Reference
PMID:12805290
  Authors
Pigino G, Morfini G, Pelsman A, Mattson MP, Brady ST, Busciglio J
  Title
Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport.
  Journal
J Neurosci 23:4499-508 (2003)
DOI:10.1523/JNEUROSCI.23-11-04499.2003
Reference
PMID:15645263
  Authors
Roy S, Zhang B, Lee VM, Trojanowski JQ
  Title
Axonal transport defects: a common theme in neurodegenerative diseases.
  Journal
Acta Neuropathol 109:5-13 (2005)
DOI:10.1007/s00401-004-0952-x
Reference
PMID:26074767
  Authors
Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG
  Title
Soluble amyloid-beta oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.
  Journal
Front Cell Neurosci 9:191 (2015)
DOI:10.3389/fncel.2015.00191
Reference
PMID:24529521
  Authors
De Felice FG, Lourenco MV, Ferreira ST
  Title
How does brain insulin resistance develop in Alzheimer's disease?
  Journal
Alzheimers Dement 10:S26-32 (2014)
DOI:10.1016/j.jalz.2013.12.004
Reference
PMID:26136647
  Authors
Bedse G, Di Domenico F, Serviddio G, Cassano T
  Title
Aberrant insulin signaling in Alzheimer's disease: current knowledge.
  Journal
Front Neurosci 9:204 (2015)
DOI:10.3389/fnins.2015.00204
Reference
PMID:20101724
  Authors
Funderburk SF, Marcellino BK, Yue Z
  Title
Cell "self-eating" (autophagy) mechanism in Alzheimer's disease.
  Journal
Mt Sinai J Med 77:59-68 (2010)
DOI:10.1002/msj.20161
Related
pathway
chx00190  Oxidative phosphorylation
chx03050  Proteasome
chx04020  Calcium signaling pathway
chx04140  Autophagy - animal
chx04141  Protein processing in endoplasmic reticulum
chx04210  Apoptosis
chx04310  Wnt signaling pathway
chx04910  Insulin signaling pathway
chx04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

DBGET integrated database retrieval system