KEGG   PATHWAY: lco04510
Entry
lco04510                    Pathway                                
Name
Focal adhesion - Larimichthys crocea (large yellow croaker)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
lco04510  Focal adhesion
lco04510

Other DBs
GO: 0005925
Organism
Larimichthys crocea (large yellow croaker) [GN:lco]
Gene
104927463  col1a2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
104933943  collagen alpha-1(I) chain [KO:K06236]
104932212  collagen alpha-1(I) chain [KO:K06236]
104919652  collagen alpha-1(II) chain isoform X1 [KO:K19719]
104919954  collagen alpha-1(II) chain isoform X1 [KO:K19719]
104919227  collagen alpha-4(IV) chain [KO:K06237]
104932354  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
104933376  collagen alpha-5(IV) chain-like isoform X1 [KO:K06237]
104933377  collagen alpha-4(IV) chain [KO:K06237]
104919232  collagen alpha-5(IV) chain isoform X1 [KO:K06237]
104928451  col4a1; collagen alpha-1(IV) chain [KO:K06237]
104935021  col4a6; collagen alpha-6(IV) chain isoform X2 [KO:K06237]
104934580  col4a5; collagen alpha-5(IV) chain isoform X3 [KO:K06237]
104928878  collagen alpha-2(VI) chain [KO:K06238]
104937519  collagen alpha-6(VI) chain isoform X1 [KO:K06238]
104938791  collagen alpha-6(VI) chain-like [KO:K06238]
104938747  col6a3; collagen alpha-3(VI) chain [KO:K06238]
104934206  collagen alpha-2(VI) chain isoform X2 [KO:K06238]
104934208  collagen alpha-1(VI) chain [KO:K06238]
104940384  collagen alpha-3(VI) chain-like isoform X1 [KO:K06238]
104919632  col9a3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
104925495  collagen alpha-1(IX) chain isoform X1 [KO:K08131]
104940202  col9a1; collagen alpha-1(IX) chain isoform X2 [KO:K08131]
104920416  col9a2; collagen alpha-2(IX) chain [KO:K08131]
104932776  collagen alpha-1(IX) chain isoform X1 [KO:K08131]
104934322  lama1; laminin subunit alpha-1 isoform X1 [KO:K05637]
104929878  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
104934349  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
104918308  lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
104922932  lama4; laminin subunit alpha-4 [KO:K06241]
104929904  laminin subunit beta-1 isoform X1 [KO:K05636]
104933728  lamb1; laminin subunit beta-1 isoform X1 [KO:K05636]
104931246  lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
104931248  laminin subunit beta-2 [KO:K06243]
104922486  lamb3; laminin subunit beta-3 [KO:K06244]
104933731  laminin subunit beta-4 [KO:K06245]
104937399  lamc1; laminin subunit gamma-1 [KO:K05635]
104937404  laminin subunit gamma-2 [KO:K06246]
104924923  lamc3; laminin subunit gamma-3 [KO:K06247]
109142191  chad; chondroadherin [KO:K06248]
104940675  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
104926707  thrombospondin-1-like [KO:K16857]
104934764  thrombospondin-1 [KO:K16857]
104937267  thrombospondin-3a [KO:K04659]
104922466  thrombospondin-4-B-like [KO:K04659]
104934561  thrombospondin-2 [KO:K04659]
104940043  thbs2; thrombospondin-2 isoform X1 [KO:K04659]
104920415  thrombospondin-4 [KO:K04659]
104921293  thrombospondin-4-B [KO:K04659]
104918250  fibronectin isoform X2 [KO:K05717]
104919608  fibronectin [KO:K05717]
104934406  vitronectin [KO:K06251]
104922848  vtn; vitronectin isoform X1 [KO:K06251]
104930867  tenascin isoform X1 [KO:K06252]
104930582  tnxb; tenascin-X isoform X1 [KO:K06252]
104930937  tenascin isoform X1 [KO:K06252]
104936863  tnn; tenascin-N isoform X3 [KO:K06252]
104929192  tnr; tenascin-R isoform X3 [KO:K06252]
104935217  von Willebrand factor [KO:K03900]
104935215  LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
104932737  itga1; integrin alpha-1 [KO:K06480]
104922975  itga2; integrin alpha-2 [KO:K06481]
104938137  itga2b; integrin alpha-IIb isoform X1 [KO:K06476]
104923253  itga3; integrin alpha-3 isoform X1 [KO:K06482]
104931903  integrin alpha-3 isoform X1 [KO:K06482]
104932944  itga4; integrin alpha-4 [KO:K06483]
104933214  integrin alpha-5 [KO:K06484]
104919896  integrin alpha-5 [KO:K06484]
104932606  integrin alpha-6 isoform X1 [KO:K06485]
104928702  integrin alpha-6 [KO:K06485]
104939938  itga7; integrin alpha-7 isoform X1 [KO:K06583]
104940363  itga8; integrin alpha-8 [KO:K06584]
104918624  itga9; integrin alpha-9 [KO:K06585]
104934675  itga10; integrin alpha-10 [KO:K06586]
104920461  itga11; integrin alpha-11 isoform X1 [KO:K06587]
104936932  integrin alpha-11 [KO:K06587]
104935588  itgav; integrin alpha-V [KO:K06487]
104924090  itgb1; integrin beta-1 isoform X1 [KO:K05719]
104934052  integrin beta-1 [KO:K05719]
104926218  integrin beta-3 [KO:K06493]
104930968  itgb3; integrin beta-3 [KO:K06493]
104924907  itgb4; integrin beta-4 isoform X1 [KO:K06525]
104926275  itgb5; integrin beta-5 [KO:K06588]
104918253  itgb6; integrin beta-6 [KO:K06589]
104936837  itgb8; integrin beta-8 [KO:K06591]
104917646  emp2; epithelial membrane protein 2 [KO:K26256]
104925707  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
104938193  platelet-derived growth factor subunit A [KO:K04359]
104925464  G-box-binding factor [KO:K17386]
104929855  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
104928604  pdgfc; platelet-derived growth factor C [KO:K05450]
104917921  egf; pro-epidermal growth factor [KO:K04357]
104935275  insulin-like growth factor I [KO:K05459]
104926290  igf1; insulin-like growth factor I precursor [KO:K05459]
104932871  vascular endothelial growth factor A-A isoform X2 [KO:K05448]
104925542  vegfb; vascular endothelial growth factor B [KO:K05448]
104925623  vascular endothelial growth factor A-A isoform X1 [KO:K05448]
104919815  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
104919793  vegfd; vascular endothelial growth factor D [KO:K05449]
104937628  vascular endothelial growth factor C [KO:K05449]
104936729  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
104918123  hgf; hepatocyte growth factor [KO:K05460]
104918795  hepatocyte growth factor isoform X2 [KO:K05460]
104919088  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
104919444  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104927056  platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104920736  igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104921706  LOW QUALITY PROTEIN: insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104919091  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
104917709  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104937534  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
104923474  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
104930066  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104931751  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
104926899  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
104937544  epithelial membrane protein 2 [KO:K26255]
109140122  epithelial membrane protein 2 [KO:K26255]
104923863  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
104928382  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
109140718  arhgap35; rho GTPase-activating protein 35 [KO:K05732]
104919724  rho GTPase-activating protein 35 [KO:K05732]
104924820  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
104933039  rho-related GTP-binding protein RhoA-C [KO:K04513]
104933314  transforming protein RhoA [KO:K04513]
104931794  rho-related GTP-binding protein RhoA-C [KO:K04513]
104932082  transforming protein RhoA [KO:K04513]
104918352  rho-related GTP-binding protein RhoA-B [KO:K04513]
104930407  diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
104917703  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
104924772  rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
104926776  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
104926365  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104927948  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104939604  myosin light chain 5 isoform X1 [KO:K12753]
104922971  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
104936390  LOW QUALITY PROTEIN: myosin regulatory light polypeptide 9 [KO:K12755]
104931269  myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
104918953  myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
104922583  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
104925296  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
104926897  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
104930230  mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
104926366  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
104930710  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
104919667  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104926887  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
104936456  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104924035  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
104928858  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
104927444  protein phosphatase 1 regulatory subunit 12B-like isoform X2 [KO:K12329]
104920398  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X2 [KO:K17457]
104932396  myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104932056  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
104931540  myosin light chain kinase 2, skeletal/cardiac muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
104939112  mylk; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104925897  myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104927553  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
104929257  phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
109142829  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
104930517  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
109136687  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
104922895  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
104921174  actin, cytoplasmic 2 [KO:K05692]
104932075  actb; actin, cytoplasmic 1 [KO:K05692]
104917873  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
104920011  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
104934898  calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
104934897  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
104934896  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
104918327  calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
104918337  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
104929780  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
104927498  alpha-actinin-4 isoform X1 [KO:K05699]
104933462  tln1; talin-1 [KO:K06271]
104917849  tln2; talin-2 isoform X4 [KO:K06271]
104918545  talin-2 isoform X1 [KO:K06271]
104935653  filamin-A isoform X1 [KO:K04437]
104936022  filamin-B isoform X1 [KO:K27392]
104936127  histone-lysine N-methyltransferase SETD1B isoform X1 [KO:K05760]
104927947  pxn; paxillin isoform X1 [KO:K05760]
104919841  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
104923817  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
104929014  zyxin [KO:K06273]
104921124  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
104939608  vinculin isoform X7 [KO:K05700]
109139843  vcl; vinculin [KO:K05700]
104936222  parvg; gamma-parvin isoform X1 [KO:K06275]
104936260  parva; alpha-parvin [KO:K06275]
104936221  parvb; beta-parvin isoform X1 [KO:K06275]
104923215  pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
104918516  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104940519  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104931217  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104924791  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104935530  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104936875  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
104922057  catenin beta-1 [KO:K02105]
104928105  catenin beta-1 [KO:K02105]
104918810  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
104927125  prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104929965  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
104917655  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
104929793  protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
104938545  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104919513  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104927097  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
104919391  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104934900  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104921281  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104933269  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104935068  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104928409  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104935222  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104930938  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
104921004  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
104934458  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X3 [KO:K02649]
104936542  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104929647  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
104923616  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
104918172  vav3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
104931257  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
104921172  vav1; proto-oncogene vav isoform X2 [KO:K05730]
104918062  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104918805  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104925434  rac2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
104927171  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104929536  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
104939638  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
104919114  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
104935297  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104931224  pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
104919803  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
104933198  serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
104924815  pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
104924679  cell division control protein 42 homolog isoform X1 [KO:K04393]
104932543  cell division control protein 42 homolog [KO:K04393]
104935006  cell division control protein 42 homolog [KO:K04393]
104923623  cell division control protein 42 homolog isoform X1 [KO:K04393]
104939488  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
104920874  adapter molecule crk [KO:K04438]
104920095  crkl; crk-like protein [KO:K04438]
104919174  adapter molecule crk [KO:K04438]
104924776  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
104924499  rapgef1; rap guanine nucleotide exchange factor 1 isoform X2 [KO:K06277]
104934753  rap guanine nucleotide exchange factor 1-like [KO:K06277]
104924467  ras-related protein Rap-1A [KO:K04353]
104919934  ras-related protein Rap-1A [KO:K04353]
104935802  rap1b; ras-related protein Rap-1b [KO:K07836]
104926477  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104922720  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
104924269  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
104928586  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104927418  jun; transcription factor AP-1 [KO:K04448]
104926010  transcription factor AP-1 [KO:K04448]
104937023  transcription factor AP-1 [KO:K04448]
104938610  braf; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
104931752  cav1; caveolin-1 [KO:K06278]
104920517  caveolin-2 [KO:K12958]
104931753  cav2; caveolin-2 [KO:K12958]
104930495  caveolin-2 [KO:K12958]
104930774  caveolin-2 [KO:K12958]
104920518  caveolin-3 isoform X1 [KO:K12959]
109139553  cav3; caveolin-3 [KO:K12959]
104922928  fyn; tyrosine-protein kinase Fyn isoform X2 [KO:K05703] [EC:2.7.10.2]
104931606  tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
104918187  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
104918475  shc2; SHC-transforming protein 2 isoform X2 [KO:K17447]
104928532  shc3; SHC-transforming protein 3 [KO:K17448]
109136640  shc4; SHC-transforming protein 4 isoform X1 [KO:K17449]
104929435  grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104935981  sos2; son of sevenless homolog 2 [KO:K03099]
104935443  sos1; son of sevenless homolog 1 [KO:K03099]
104920460  hras; GTPase HRas [KO:K02833]
104940217  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104922316  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104929510  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104932685  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104937405  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
104937240  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
104939589  G1/S-specific cyclin-D1 [KO:K04503]
104922121  G1/S-specific cyclin-D2-like [KO:K10151]
104939073  G1/S-specific cyclin-D2 [KO:K10151]
104926717  G1/S-specific cyclin-D2 [KO:K10151]
104927998  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
104934542  inhibitor of apoptosis protein [KO:K16060]
104938662  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
104928899  bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
104918293  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
104939569  apoptosis regulator Bcl-2-like [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
lco04010  MAPK signaling pathway
lco04060  Cytokine-cytokine receptor interaction
lco04070  Phosphatidylinositol signaling system
lco04110  Cell cycle
lco04310  Wnt signaling pathway
lco04512  ECM-receptor interaction
lco04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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