KEGG   PATHWAY: llv05169
Entry
llv05169                    Pathway                                
Name
Epstein-Barr virus infection - Lutra lutra (Eurasian river otter)
Description
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly at an early age but remains mostly asymptomatic. EBV has been linked to a wide spectrum of human malignancies, including nasopharyngeal carcinoma and other hematologic cancers, like Hodgkin's lymphoma, Burkitt's lymphoma (BL), B-cell immunoblastic lymphoma in HIV patients, and posttransplant-associated lymphoproliferative diseases.  EBV has the unique ability to establish life-long latent infection in primary human B lymphocytes. During latent infection, EBV expresses a small subset of genes, including 6 nuclear antigens (EBNA-1, -2, -3A, -3B, -3C, and -LP), 3 latent membrane proteins (LMP-1, -2A, and -2B), 2 small noncoding RNAs (EBER-1 and 2). On the basis of these latent gene expression, three different latency patterns associated with the types of cancers are recognized.
Class
Human Diseases; Infectious disease: viral
Pathway map
llv05169  Epstein-Barr virus infection
llv05169

Organism
Lutra lutra (Eurasian river otter) [GN:llv]
Gene
125091077  B-lymphocyte antigen CD19-like isoform X1 [KO:K06465]
125101704  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752]
125101705  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
125101706  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like isoform X1 [KO:K06752]
125102650  HLA class II histocompatibility antigen, DM beta chain-like isoform X1 [KO:K06752]
125102651  HLA class II histocompatibility antigen, DM alpha chain-like [KO:K06752]
125103079  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
125103096  HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752]
125103134  RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
125103156  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
125103158  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
125103275  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
125093126  toll-like receptor 2 [KO:K10159]
125106441  myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
125106124  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
125091300  interleukin-1 receptor-associated kinase 1-like isoform X1 [KO:K04730] [EC:2.7.11.1]
125078866  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
125106336  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
125101867  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
125102400  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
125084339  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
125094028  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125091312  NF-kappa-B essential modulator isoform X1 [KO:K07210]
125105211  NF-kappa-B inhibitor alpha [KO:K04734]
125093224  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125078405  transcription factor p65 isoform X1 [KO:K04735]
125103142  tumor necrosis factor isoform X1 [KO:K03156]
125081177  interleukin-6 [KO:K05405]
125083628  antiviral innate immune response receptor RIG-I isoform X1 [KO:K12646] [EC:5.6.2.6]
125108204  mitochondrial antiviral-signaling protein-like [KO:K12648]
125103668  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
125106807  serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
125085960  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
125078240  interferon regulatory factor 7-like isoform X1 [KO:K09447]
125088511  interferon regulatory factor 3-like isoform X1 [KO:K05411]
125083482  interferon alpha-1/2-like [KO:K05414]
125083790  interferon alpha-2-like [KO:K05414]
125084017  interferon alpha-like [KO:K05414]
125084018  interferon alpha-1/2-like [KO:K05414]
125082970  interferon alpha-1/2-like [KO:K05414]
125083068  interferon alpha-1/2-like [KO:K05414]
125083069  interferon alpha-1/2-like [KO:K05414]
125083072  interferon alpha-1/2-like [KO:K05414]
125083073  interferon alpha-1/2-like [KO:K05414]
125083074  interferon alpha-1/2-like [KO:K05414]
125083075  interferon alpha-1/2-like [KO:K05414]
125083077  interferon alpha-1/2-like [KO:K05414]
125083078  interferon alpha-1/2-like [KO:K05414]
125083082  interferon alpha-1/2-like [KO:K05414]
125083083  interferon alpha-1/2-like [KO:K05414]
125083084  interferon alpha-1/2-like [KO:K05414]
125083789  interferon beta-like [KO:K05415]
125095023  interferon alpha/beta receptor 1-like [KO:K05130]
125095032  interferon alpha/beta receptor 2-like isoform X1 [KO:K05131]
125097987  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
125084878  non-receptor tyrosine-protein kinase TYK2-like isoform X1 [KO:K11219] [EC:2.7.10.2]
125095018  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
125106747  signal transducer and activator of transcription 2-like isoform X1 [KO:K11221]
125104318  interferon regulatory factor 9-like [KO:K04693]
125108791  interferon-induced, double-stranded RNA-activated protein kinase-like isoform X1 [KO:K16195] [EC:2.7.11.1]
125092389  interferon-induced, double-stranded RNA-activated protein kinase-like isoform X1 [KO:K16195] [EC:2.7.11.1]
125082013  2'-5'-oligoadenylate synthase 3-like isoform X1 [KO:K14216] [EC:2.7.7.84]
125082014  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2-like [KO:K14216] [EC:2.7.7.84]
125082372  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
125093857  C-X-C motif chemokine 10-like [KO:K12671]
125098897  ubiquitin-like protein ISG15 [KO:K12159]
125084890  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
125079328  FAS-associated death domain protein-like [KO:K02373]
125094998  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
125106056  BH3-interacting domain death agonist-like [KO:K04726]
125108514  bcl-2-like protein 11 isoform X1 [KO:K16341]
125081686  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
125086017  apoptosis regulator BAX-like [KO:K02159]
125089829  apoptosis regulator BAX [KO:K02159]
125102734  bcl-2 homologous antagonist/killer [KO:K14021]
125109865  LOW QUALITY PROTEIN: cytochrome c homolog [KO:K08738]
125080891  cytochrome c [KO:K08738]
125082666  cytochrome c-like [KO:K08738]
125106261  apoptotic protease-activating factor 1 [KO:K02084]
125098709  caspase-9-like isoform X1 [KO:K04399] [EC:3.4.22.62]
125091274  caspase-3 [KO:K02187] [EC:3.4.22.56]
125079621  T-cell surface glycoprotein CD3 epsilon chain-like isoform X1 [KO:K06451]
125080070  T-cell surface glycoprotein CD3 gamma chain-like [KO:K06452]
125080069  T-cell surface glycoprotein CD3 delta chain-like [KO:K06450]
125086307  T-cell surface glycoprotein CD3 zeta chain-like isoform X1 [KO:K06453]
125096092  26S proteasome regulatory subunit 7 [KO:K03061]
125081460  26S proteasome regulatory subunit 7 [KO:K03061]
125104108  26S proteasome regulatory subunit 4 [KO:K03062]
125089639  26S proteasome regulatory subunit 6B [KO:K03063]
125099654  26S proteasome regulatory subunit 10B-like [KO:K03064]
125103928  26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
125078966  26S proteasome regulatory subunit 6A [KO:K03065]
125087452  26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
125101380  26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
125095187  26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
125087556  26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
125087622  26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
125087268  26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
125110307  26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
125089556  26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
125079296  26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
125097439  26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
125095471  26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
125089490  26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
125108403  proteasomal ubiquitin receptor ADRM1 [KO:K06691]
125100241  26S proteasome complex subunit SEM1-like [KO:K10881]
125080895  26S proteasome complex subunit SEM1 [KO:K10881]
125103272  antigen peptide transporter 1-like [KO:K05653] [EC:7.4.2.14]
125103273  antigen peptide transporter 2-like isoform X1 [KO:K05654] [EC:7.4.2.14]
125102663  tapasin [KO:K08058]
125103878  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
125083988  calreticulin [KO:K08057]
125099812  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
125101548  uncharacterized protein LOC125101548 [KO:K06751]
125101549  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
125101800  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
125101803  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
125101804  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
125101807  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
125101827  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
125102525  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
125104891  beta-2-microglobulin-like [KO:K08055]
125104054  SNW domain-containing protein 1 [KO:K06063]
125082605  LOW QUALITY PROTEIN: SNW domain-containing protein 1-like [KO:K06063]
125104617  paired amphipathic helix protein Sin3a [KO:K11644]
125102513  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
125080019  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
125098208  histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
125106802  histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
125082364  nuclear receptor corepressor 2 isoform X1 [KO:K06065]
125100069  histone deacetylase complex subunit SAP30L isoform X1 [KO:K19202]
125092911  histone deacetylase complex subunit SAP30 [KO:K19202]
125102579  histone deacetylase complex subunit SAP30L-like [KO:K19202]
125095749  corepressor interacting with RBPJ 1 [KO:K06066]
125108601  recombining binding protein suppressor of hairless-like protein [KO:K06053]
125093605  recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
125102272  transcription factor HES-1 [KO:K06054]
125085651  aggrecan core protein-like isoform X1 [KO:K06468]
125098281  runt-related transcription factor 3 isoform X1 [KO:K09279]
125098611  myc proto-oncogene protein [KO:K04377]
125090164  ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
125107551  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
125087037  cellular tumor antigen p53 isoform X1 [KO:K04451]
125102743  cyclin-dependent kinase inhibitor 1 [KO:K06625]
125084011  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
125087160  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
125098822  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
125078755  DNA damage-binding protein 2 isoform X1 [KO:K10140]
125099728  DNA polymerase kappa-like [KO:K03511] [EC:2.7.7.7]
125085695  TNF receptor-associated factor 5 isoform X1 [KO:K09849]
125100627  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125103868  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125096824  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125099801  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125082268  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125097558  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
125086439  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125104283  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125089561  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125086838  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
125088662  transcription factor RelB isoform X1 [KO:K09253]
125084865  nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
125088780  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
125088499  NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
125101714  NF-kappa-B inhibitor epsilon [KO:K05872]
125087109  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
125085818  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
125099732  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125084526  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125093137  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125083298  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
125103136  receptor-interacting serine/threonine-protein kinase 1-like [KO:K02861] [EC:2.7.11.1]
125087473  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
125087142  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
125101777  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125103018  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125096321  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
125106184  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
125106185  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
125098159  transcription factor Jun [KO:K04448]
125083779  ectonucleoside triphosphate diphosphohydrolase 8-like isoform X1 [KO:K01510] [EC:3.6.1.5]
125084557  ectonucleoside triphosphate diphosphohydrolase 1-like isoform X1 [KO:K01510] [EC:3.6.1.5]
125106160  ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
125109530  tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K03160]
125078362  CD44 antigen isoform X1 [KO:K06256]
125090875  integrin alpha-L-like isoform X1 [KO:K05718]
125097671  lymphocyte function-associated antigen 3-like isoform X1 [KO:K06492]
125084958  intercellular adhesion molecule 1-like isoform X1 [KO:K06490]
125095918  LOW QUALITY PROTEIN: vimentin-like [KO:K07606]
125106656  vimentin [KO:K07606]
125102704  tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
125082365  tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
125086956  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
125096997  tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
125083174  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
125103904  E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
125090900  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
125101158  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
125091607  tyrosine-protein kinase BTK isoform X1 [KO:K07370] [EC:2.7.10.2]
125084618  B-cell linker protein isoform X1 [KO:K07371]
125089755  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
125099857  S-phase kinase-associated protein 2 [KO:K03875]
125106593  cyclin-dependent kinase inhibitor 1B [KO:K06624]
125078419  G1/S-specific cyclin-D1 [KO:K04503]
125105988  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
125102808  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125106397  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
125080451  LOW QUALITY PROTEIN: cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
125084483  LOW QUALITY PROTEIN: cyclin-A1-like [KO:K06627]
125093344  cyclin-A2 isoform X1 [KO:K06627]
125095240  cyclin-A1 [KO:K06627]
125096979  G1/S-specific cyclin-E2 [KO:K06626]
125089714  G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
125106521  LOW QUALITY PROTEIN: cyclin-dependent kinase 2-like [KO:K02206] [EC:2.7.11.22]
125096420  retinoblastoma-associated protein [KO:K06618]
125109172  transcription factor E2F1 isoform X1 [KO:K17454]
125097872  transcription factor E2F2 isoform X1 [KO:K09389]
125102168  transcription factor E2F3 isoform X1 [KO:K06620]
Compound
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15510157
  Authors
Young LS, Rickinson AB.
  Title
Epstein-Barr virus: 40 years on.
  Journal
Nat Rev Cancer 4:757-68 (2004)
DOI:10.1038/nrc1452
Reference
PMID:21372216
  Authors
Saha A, Robertson ES
  Title
Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes.
  Journal
Clin Cancer Res 17:3056-63 (2011)
DOI:10.1158/1078-0432.CCR-10-2578
Reference
PMID:21429244
  Authors
Ning S
  Title
Innate immune modulation in EBV infection.
  Journal
Herpesviridae 2:1 (2011)
DOI:10.1186/2042-4280-2-1
Reference
PMID:28408983
  Authors
Stanfield BA, Luftig MA
  Title
Recent advances in understanding Epstein-Barr virus.
  Journal
F1000Res 6:386 (2017)
DOI:10.12688/f1000research.10591.1
Reference
PMID:24586164
  Authors
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
  Title
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
  Journal
PLoS Pathog 10:e1003960 (2014)
DOI:10.1371/journal.ppat.1003960
Reference
PMID:23850008
  Authors
Rajsbaum R, Garcia-Sastre A
  Title
Viral evasion mechanisms of early antiviral responses involving regulation of ubiquitin pathways.
  Journal
Trends Microbiol 21:421-9 (2013)
DOI:10.1016/j.tim.2013.06.006
Reference
PMID:25704559
  Authors
Hoffmann HH, Schneider WM, Rice CM
  Title
Interferons and viruses: an evolutionary arms race of molecular interactions.
  Journal
Trends Immunol 36:124-38 (2015)
DOI:10.1016/j.it.2015.01.004
Reference
PMID:22110506
  Authors
Spender LC, Inman GJ
  Title
Inhibition of germinal centre apoptotic programmes by epstein-barr virus.
  Journal
Adv Hematol 2011:829525 (2011)
DOI:10.1155/2011/829525
Reference
PMID:23303627
  Authors
Fu Q, He C, Mao ZR
  Title
Epstein-Barr virus interactions with the Bcl-2 protein family and apoptosis in human tumor cells.
  Journal
J Zhejiang Univ Sci B 14:8-24 (2013)
DOI:10.1631/jzus.B1200189
Reference
PMID:29116588
  Authors
Wang Y, Banerjee S, Ding L, Cai C, Wei F, Cai Q
  Title
The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
  Journal
Virol Sin 32:357-368 (2017)
DOI:10.1007/s12250-017-4081-9
Reference
PMID:23435233
  Authors
Melchjorsen J
  Title
Learning from the messengers: innate sensing of viruses and cytokine regulation of immunity - clues for treatments and vaccines.
  Journal
Viruses 5:470-527 (2013)
DOI:10.3390/v5020470
Reference
PMID:19498380
  Authors
Hansen TH, Bouvier M
  Title
MHC class I antigen presentation: learning from viral evasion strategies.
  Journal
Nat Rev Immunol 9:503-13 (2009)
DOI:10.1038/nri2575
Reference
PMID:18977445
  Authors
Ressing ME, Horst D, Griffin BD, Tellam J, Zuo J, Khanna R, Rowe M, Wiertz EJ
  Title
Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.
  Journal
Semin Cancer Biol 18:397-408 (2008)
DOI:10.1016/j.semcancer.2008.10.008
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:27886133
  Authors
Ghosh Roy S, Robertson ES, Saha A
  Title
Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis.
  Journal
Biomolecules 6:E46 (2016)
DOI:10.3390/biom6040046
Reference
PMID:22249143
  Authors
Dawson CW, Port RJ, Young LS
  Title
The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC).
  Journal
Semin Cancer Biol 22:144-53 (2012)
DOI:10.1016/j.semcancer.2012.01.004
Reference
PMID:25613730
  Authors
Cai Q, Chen K, Young KH
  Title
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
  Journal
Exp Mol Med 47:e133 (2015)
DOI:10.1038/emm.2014.105
Reference
PMID:17601372
  Authors
Zheng H, Li LL, Hu DS, Deng XY, Cao Y
  Title
Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma.
  Journal
Cell Mol Immunol 4:185-96 (2007)
Reference
PMID:23793113
  Authors
Ersing I, Bernhardt K, Gewurz BE
  Title
NF-kappaB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1.
  Journal
Viruses 5:1587-606 (2013)
DOI:10.3390/v5061587
Reference
PMID:28835489
  Authors
Wang LW, Jiang S, Gewurz BE
  Title
Epstein-Barr Virus LMP1-Mediated Oncogenicity.
  Journal
J Virol 91:e01718-16 (2017)
DOI:10.1128/JVI.01718-16
Reference
PMID:12740915
  Authors
Mori N, Morishita M, Tsukazaki T, Yamamoto N
  Title
Repression of Smad-dependent transforming growth factor-beta signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-kappaB.
  Journal
Int J Cancer 105:661-8 (2003)
DOI:10.1002/ijc.11146
Reference
PMID:25873381
  Authors
Edwards RH, Marquitz AR, Raab-Traub N
  Title
Changes in expression induced by Epstein-Barr Virus LMP1-CTAR1: potential role of bcl3.
  Journal
MBio 6:e00441-15 (2015)
DOI:10.1128/mBio.00441-15
Reference
PMID:11905817
  Authors
Thorley-Lawson DA
  Title
Epstein-Barr virus: exploiting the immune system.
  Journal
Nat Rev Immunol 1:75-82 (2001)
DOI:10.1038/35095584
Reference
PMID:11669605
  Authors
Eliopoulos AG, Young LS
  Title
LMP1 structure and signal transduction.
  Journal
Semin Cancer Biol 11:435-44 (2001)
DOI:10.1006/scbi.2001.0410
Reference
PMID:14506283
  Authors
Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C, Frappier L
  Title
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP.
  Journal
J Biol Chem 278:47753-61 (2003)
DOI:10.1074/jbc.M307200200
Reference
PMID:25403939
  Authors
Kang H, Kiess A, Chung CH
  Title
Emerging biomarkers in head and neck cancer in the era of genomics.
  Journal
Nat Rev Clin Oncol 12:11-26 (2015)
DOI:10.1038/nrclinonc.2014.192
Reference
PMID:29932446
  Authors
Tornesello ML, Annunziata C, Tornesello AL, Buonaguro L, Buonaguro FM
  Title
Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.
  Journal
Cancers (Basel) 10:E213 (2018)
DOI:10.3390/cancers10070213
Reference
PMID:19649319
  Authors
Sato Y, Kamura T, Shirata N, Murata T, Kudoh A, Iwahori S, Nakayama S, Isomura H, Nishiyama Y, Tsurumi T
  Title
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex.
  Journal
PLoS Pathog 5:e1000530 (2009)
DOI:10.1371/journal.ppat.1000530
Reference
PMID:19244339
  Authors
Saha A, Murakami M, Kumar P, Bajaj B, Sims K, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2.
  Journal
J Virol 83:4652-69 (2009)
DOI:10.1128/JVI.02408-08
Reference
PMID:19394062
  Authors
Yi F, Saha A, Murakami M, Kumar P, Knight JS, Cai Q, Choudhuri T, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C targets p53 and modulates its transcriptional and apoptotic activities.
  Journal
Virology 388:236-47 (2009)
DOI:10.1016/j.virol.2009.03.027
Reference
PMID:25635182
  Authors
Kumar P, Murakami M, Kaul R, Saha A, Cai Q, Robertson ES
  Title
Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.
  Journal
Future Virol 4:79-91 (2009)
DOI:10.2217/17460794.4.1.79
Reference
PMID:10818681
  Authors
Longnecker R
  Title
Epstein-Barr virus latency: LMP2, a regulator or means for Epstein-Barr virus persistence?
  Journal
Adv Cancer Res 79:175-200 (2000)
DOI:10.1016/s0065-230x(00)79006-3
Reference
PMID:30116721
  Authors
El-Sharkawy A, Al Zaidan L, Malki A
  Title
Epstein-Barr Virus-Associated Malignancies: Roles of Viral Oncoproteins in Carcinogenesis.
  Journal
Front Oncol 8:265 (2018)
DOI:10.3389/fonc.2018.00265
Reference
PMID:12811813
  Authors
Dolcetti R, Masucci MG
  Title
Epstein-Barr virus: induction and control of cell transformation.
  Journal
J Cell Physiol 196:207-18 (2003)
DOI:10.1002/jcp.10263
Reference
PMID:21347341
  Authors
Saha A, Halder S, Upadhyay SK, Lu J, Kumar P, Murakami M, Cai Q, Robertson ES
  Title
Epstein-Barr virus nuclear antigen 3C facilitates G1-S transition by stabilizing and enhancing the function of cyclin D1.
  Journal
PLoS Pathog 7:e1001275 (2011)
DOI:10.1371/journal.ppat.1001275
Related
pathway
llv03050  Proteasome
llv04010  MAPK signaling pathway
llv04020  Calcium signaling pathway
llv04064  NF-kappa B signaling pathway
llv04110  Cell cycle
llv04115  p53 signaling pathway
llv04210  Apoptosis
llv04612  Antigen processing and presentation
llv04620  Toll-like receptor signaling pathway
llv04622  RIG-I-like receptor signaling pathway
llv04630  JAK-STAT signaling pathway
llv04662  B cell receptor signaling pathway
KO pathway
ko05169   
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